In:
Natural Product Communications, SAGE Publications, Vol. 2, No. 6 ( 2007-06), p. 1934578X0700200-
Kurzfassung:
American trypanosomiasis, Chagas disease, is a great cause of human morbidity and mortality in the Neotropics. Although there is currently no effective treatment for this parasitic disease, a number of potential biochemical targets have been identified, including the cysteine protease cruzain. Croton draco Cham. & Schldl. (Euphorbiaceae), commonly known as sangre de drago, is used in traditional medicine for a number of maladies. In this study, Croton draco bark essential oil has been shown to inhibit the activity of cruzain. The bark oil has been analyzed by GC-MS and the major components found to be β-caryophyllene (31.9%), caryophyllene oxide (22.0%), 1,8-cineole (6.2%), and α-humulene (5.6%). The major components have been tested for cruzain inhibitory activity, but show minimal activity, so it is not clear if the activity of Croton draco bark oil is due to a synergistic effect of the essential oil components or due to very active minor components. Croton draco bark oil has also been tested for cytotoxic activity against a panel of human tumor cell lines, but shows little activity.
Materialart:
Online-Ressource
ISSN:
1934-578X
,
1555-9475
DOI:
10.1177/1934578X0700200613
Sprache:
Englisch
Verlag:
SAGE Publications
Publikationsdatum:
2007
ZDB Id:
2430442-6
SSG:
15,3
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