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  • 1
    Online Resource
    Online Resource
    Radiation Therapy for Rectal Cancer: Current Status and Future Directions
    SAGE Publications ; 2010
    In:  Cancer Control Vol. 17, No. 1 ( 2010-01), p. 25-34
    Details
    In: Cancer Control, SAGE Publications, Vol. 17, No. 1 ( 2010-01), p. 25-34
    Type of Medium: Online Resource
    ISSN: 1073-2748 , 1073-2748
    URL: Article
    DOI: 10.1177/107327481001700104
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2010
    detail.hit.zdb_id: 2004182-2
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  • 2
    Online Resource
    Online Resource
    Primary Bladder Preservation Treatment for Urothelial Bladder Cancer
    SAGE Publications ; 2013
    In:  Cancer Control Vol. 20, No. 3 ( 2013-07), p. 188-199
    Details
    In: Cancer Control, SAGE Publications, Vol. 20, No. 3 ( 2013-07), p. 188-199
    Abstract: Significant advancements have occurred in surgical procedures and chemoradiation therapy for bladder preservation. Methods This review addresses primary treatment options for bladder cancer, including an overview of bladder-sparing strategies. Results Surgical series demonstrate that highly selected patients with cT2N0M0 urothelial bladder cancers can be managed with partial cystectomy and bilateral pelvic lymphadenectomy. For patients with cT2N0M0 to cT4aN0M0 urothelial bladder cancers, neoadjuvant chemotherapy followed by radical cystectomy or maximal transurethral resection of the bladder tumor (TURBT) followed by chemoradiation therapy results in equivalent survival rates. However, each treatment option has a different impact on quality of life. Current chemoradiation therapy trials are evaluating novel approaches to improve outcomes. Conclusions Maximal TURBT followed by chemoradiation therapy demonstrated equivalent survival with radical cystectomy while preserving bladder function in the majority of patients. Future efforts will be directed toward improving survival and quality of life.
    Type of Medium: Online Resource
    ISSN: 1073-2748 , 1073-2748
    URL: Article
    DOI: 10.1177/107327481302000307
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2013
    detail.hit.zdb_id: 2004182-2
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  • 3
    Online Resource
    Online Resource
    Extracorporeal Blood Oxygenation and Ozonation (EBOO): A Controlled Trial in Patients with Peripheral Artery Disease
    SAGE Publications ; 2005
    In:  The International Journal of Artificial Organs Vol. 28, No. 10 ( 2005-10), p. 1039-1050
    Details
    In: The International Journal of Artificial Organs, SAGE Publications, Vol. 28, No. 10 ( 2005-10), p. 1039-1050
    Abstract: Since 1990 our group has been using extracorporeal circulation to ozonate blood by an original method, known as extracorporeal blood oxygenation and ozonation (EBOO), with the aim of amplifying the results observed with ozone autohemotherapy. Objective To verify the hypothesis that EBOO improves the skin lesions typical of peripheral artery disease (PAD) patients. Methods Twenty-eight patients with PAD were randomized to receive EBOO or intravenous prostacyclin in a controlled clinical trial. The primary efficacy parameters were regression of skin lesions and pain, and improvement in quality of life and vascularisation. Results Patients treated with EBOO showed highly significant regression of skin lesions with respect to patients treated with prostacyclin. Other parameters that were significantly different in the two groups of patients were pain, pruritus, heavy legs and well-being. No significant differences in vascularisation of the lower limbs before and after treatment were found in either group. No side effects or complications were recorded during the 210 EBOO treatments. Conclusion EBOO was much more effective than prostacyclin for treating skin lesions in PAD patients and also had a positive effect on patient general condition without any apparent change in arterial circulation. This suggests other mechanisms of action of EBOO.
    Type of Medium: Online Resource
    ISSN: 0391-3988 , 1724-6040
    URL: Article
    DOI: 10.1177/039139880502801012
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2005
    detail.hit.zdb_id: 1474999-3
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  • 4
    Online Resource
    Online Resource
    Heparin Coating of Extracorporeal Circuits Inhibits Cytokine Release from Mononuclear Cells during Cardiac Operations
    SAGE Publications ; 2000
    In:  The International Journal of Artificial Organs Vol. 23, No. 4 ( 2000-04), p. 250-255
    Details
    In: The International Journal of Artificial Organs, SAGE Publications, Vol. 23, No. 4 ( 2000-04), p. 250-255
    Abstract: To evalute whether the production of interleukin 2 (IL 2), interlukin 6 (IL 6) and interlukin 10 (IL 10) from stimulated peripheal blood mononuclear cells (PBMC) was affected by coating extracorporeal circuits in patients undergoing cardiopulmonary bypass (CPB). In addition, postoperative clinical parameters were compared between patients with heparin-coated and uncoated CPB. Design Prospective, controlled in vivo/ex vivo study. Procedure Blood samples were drawn immediately before, at the end and 24 hours after the end of CPB using either a conventional circuit (n=10) or a heparin-coated circuit (n=10) in patients undergoing CPB. Cytokine release on the supernatants of activated PBMC was detected. Cardiopulmonary parameters were measured before CPB, at ICU admission, 3 hours and 24 hours after ICU admission in both groups of patients. Statistical difference intragroups and between groups were investigated with the analysis of variance for repeated measures. Results IL 6 and IL 10 release was significantly less (p 〈 0.05) in the heparin-coated group. No differences in clinical parameters were observed between the two groups. Conclusions These results suggest that with the use of heparin-coated circuits there is a lower production of IL 6 and IL 10 from isolated PBMC than with uncoated circuits.
    Type of Medium: Online Resource
    ISSN: 0391-3988 , 1724-6040
    URL: Article
    DOI: 10.1177/039139880002300407
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2000
    detail.hit.zdb_id: 1474999-3
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  • 5
    Online Resource
    Online Resource
    Respiratory Function in CAPD
    SAGE Publications ; 1984
    In:  The International Journal of Artificial Organs Vol. 7, No. 2 ( 1984-03), p. 67-72
    Details
    In: The International Journal of Artificial Organs, SAGE Publications, Vol. 7, No. 2 ( 1984-03), p. 67-72
    Type of Medium: Online Resource
    ISSN: 0391-3988 , 1724-6040
    URL: Article
    DOI: 10.1177/039139888400700204
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1984
    detail.hit.zdb_id: 1474999-3
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  • 6
    Online Resource
    Online Resource
    Emerging Technologies in Prostate Cancer Radiation Therapy: Improving the Therapeutic Window
    SAGE Publications ; 2010
    In:  Cancer Control Vol. 17, No. 4 ( 2010-10), p. 223-232
    Details
    In: Cancer Control, SAGE Publications, Vol. 17, No. 4 ( 2010-10), p. 223-232
    Abstract: Radiation therapy is a standard of care in the treatment of prostate cancer. Relatively recent advances in technologies in the delivery of radiation therapy are altering our current approach to treatment of prostate cancer. Methods This review discusses the results of retrospective, prospective, and randomized clinical trials that have evaluated clinical outcomes in prostate cancer treated with newer radiation therapy technologies. Results Randomized trials have demonstrated that higher doses of radiation therapy improve clinical outcomes but with increased toxicity to normal tissue. The introduction of more conformal radiation therapy techniques such as intensity-modulated radiation therapy, proton therapy, stereotactic body radiotherapy, and brachytherapy have allowed for further dose escalation with simultaneous reduction in toxicity. However, use of more conformal treatments requires a better understanding of prostate motion and the ability to track prostate movements in real time. Conclusions Technological advancements have improved radiation dose delivery to the prostate and have reduced normal tissue toxicity. Randomized trials are warranted to ultimately evaluate clinical benefit and outcomes.
    Type of Medium: Online Resource
    ISSN: 1073-2748 , 1073-2748
    URL: Article
    DOI: 10.1177/107327481001700403
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2010
    detail.hit.zdb_id: 2004182-2
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  • 7
    Online Resource
    Online Resource
    Radiation Therapy and Esophageal Cancer
    SAGE Publications ; 2013
    In:  Cancer Control Vol. 20, No. 2 ( 2013-04), p. 97-110
    Details
    In: Cancer Control, SAGE Publications, Vol. 20, No. 2 ( 2013-04), p. 97-110
    Abstract: Squamous cell carcinoma and adenocarcinoma account for more than 90% of all esophageal cancer cases. Although the incidence of squamous cell carcinoma has declined, the incidence of adenocarcinoma has risen due to increases in obesity and gastroesophageal reflux disease. Methods The authors examine the role of radiation therapy alone (external beam and brachytherapy) for the management of esophageal cancer or combined with other modalities. The impact on staging and appropriate stratification of patients referred for curative vs palliative intent with modalities is reviewed. The authors also explore the role of emerging radiation technologies. Results Current data show that neoadjuvant chemoradiotherapy followed by surgical resection is the accepted standard of care, with 3-year overall survival rates ranging from 30% to 60%. The benefit of adjuvant radiation therapy is limited to patients with node-positive cancer. The survival benefit of surgical resection after chemoradiotherapy remains controversial. External beam radiation therapy alone results in few long-term survivors and is considered palliative at best. Radiation dose-escalation has failed to improve local control or survival. Brachytherapy can provide better long-term palliation of dysphagia than metal stent placement. Although three-dimensional conformal treatment planning is the accepted standard, the roles of IMRT and proton therapy are evolving and potentially reduce adverse events due to better sparing of normal tissue. Conclusions Future directions will evaluate the benefit of induction chemotherapy followed by chemoradiotherapy, the role of surgery in locally advanced disease, and the identification of responders prior to treatment based on microarray analysis.
    Type of Medium: Online Resource
    ISSN: 1073-2748 , 1073-2748
    URL: Article
    DOI: 10.1177/107327481302000203
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2013
    detail.hit.zdb_id: 2004182-2
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