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  • 1
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    Online Resource
    Human Sociobiology: A Holistic Approach.
    SAGE Publications ; 1983
    In:  Contemporary Sociology Vol. 12, No. 1 ( 1983-01), p. 17-
    Details
    In: Contemporary Sociology, SAGE Publications, Vol. 12, No. 1 ( 1983-01), p. 17-
    Type of Medium: Online Resource
    ISSN: 0094-3061
    URL: Article
    DOI: 10.2307/2068145
    RVK:
    MN 1000
    Language: Unknown
    Publisher: SAGE Publications
    Publication Date: 1983
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    detail.hit.zdb_id: 2010085-1
    SSG: 3,4
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  • 2
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    Microfluidics on foil: State of the art and new developments
    SAGE Publications ; 2008
    In:  Proceedings of the Institution of Mechanical Engineers, Part B: Journal of Engineering Manufacture Vol. 222, No. 1 ( 2008-01-01), p. 107-116
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part B: Journal of Engineering Manufacture, SAGE Publications, Vol. 222, No. 1 ( 2008-01-01), p. 107-116
    Abstract: The concept of microfluidics on foil opens up new opportunities for combining the advantages of having a flexible substrate with reel-to-reel processing, which has the potential to be the basis for extremely cheap micro products. To reach this goal, foil substrates must be combined with micro-manufacturing technologies that are well adapted to these substrates. Some technologies are already available, some are the subject of current research, and some still have to be conceived. In the current paper, technologies such as reel-to-reel embossing, reel-to-reel laminating, and laser ablation/cutting as well as laser welding will be discussed. The discussions include a brief review of the state of the art as well as a report on latest research results stemming from research by the present authors. Furthermore, this paper shows the vision of what can be achieved if foil-based technologies, such as polymer (opto-)electronics and microfluidics are combined. A polymer electronics-based alcohol sensor is presented as an example system.
    Type of Medium: Online Resource
    ISSN: 0954-4054 , 2041-2975
    URL: Article
    DOI: 10.1243/09544054JEM866
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2008
    detail.hit.zdb_id: 2032745-6
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  • 3
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    Analysis of Pepsin in Tracheoesophageal Puncture Sites
    SAGE Publications ; 2010
    In:  Annals of Otology, Rhinology & Laryngology Vol. 119, No. 12 ( 2010-12), p. 799-805
    Details
    In: Annals of Otology, Rhinology & Laryngology, SAGE Publications, Vol. 119, No. 12 ( 2010-12), p. 799-805
    Abstract: Tracheoesophageal puncture (TEP) and prosthesis insertion is a well-established method of voice rehabilitation after laryngectomy. Maintenance of the prosthesis and tract can be challenging, and reflux to the TEP site has been proposed as a cause. The sites of TEP were evaluated for the presence of pepsin in tissue biopsy specimens and tract secretions to explore this association. Methods: Patients with TEP were interviewed for a history of symptoms related to reflux, medication use history, TEP voice quality, and incidence of TEP complications. Tissue biopsy specimens and tract secretions were obtained from TEP sites and analyzed for the presence of pepsin via sodium dodecyl sulfate–polyacrylamide gel electrophoresis Western blot analysis. Results: Twelve of 17 patients (47%) had some history of preoperative or postoperative symptoms of gastroesophageal reflux disease or laryngopharyngeal reflux. Pepsin was present within the TEP site in a total of 10 of 17 patients (58%; 7 of 17 tissue biopsy specimens and 6 of 7 secretion samples). There were no statistically significant associations between the presence of pepsin and sex, reflux history, use of acid suppressive medicine, or time since laryngectomy. Conclusions: Reflux with subsequent pepsin deposition into the TEP tract occurs in a majority of laryngectomy patients. Further studies on the effect of reflux on the health and function of the TEP tract are warranted.
    Type of Medium: Online Resource
    ISSN: 0003-4894 , 1943-572X
    URL: Article
    DOI: 10.1177/000348941011901203
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2010
    detail.hit.zdb_id: 2033055-8
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  • 4
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    Association of Social Determinants of Health with Time to Diagnosis and Treatment Outcomes in Idiopathic Subglottic Stenosis
    SAGE Publications ; 2021
    In:  Annals of Otology, Rhinology & Laryngology Vol. 130, No. 10 ( 2021-10), p. 1116-1124
    Details
    In: Annals of Otology, Rhinology & Laryngology, SAGE Publications, Vol. 130, No. 10 ( 2021-10), p. 1116-1124
    Abstract: To examine whether social determinants of health (SDH) factors are associated with time to diagnosis, treatment selection, and time to recurrent surgical intervention in idiopathic subglottic stenosis (iSGS) patients. Methods: Adult patients with diagnosed iSGS were recruited prospectively (2015-2017) via clinical providers as part of the North American Airway Collaborative (NoAAC) and via an online iSGS support community on Facebook. Patient-specific SDH factors included highest educational attainment (self-reported), median household income (matched from home zip code via U.S. Census data), and number of close friends (self-reported) as a measure of social support. Main outcomes of interest were time to disease diagnosis (years from symptom onset), treatment selection (endoscopic dilation [ED] vs cricotracheal resection [CTR] vs endoscopic resection with adjuvant medical therapy [ERMT]), and time to recurrent surgical intervention (number of days from initial surgical procedure) as a surrogate for disease recurrence. Results: The total 810 participants were 98.5% female, 97.2% Caucasian, and had a median age of 50 years (IQR, 43-58). The cohort had a median household income of $62 307 (IQR, $50 345-$79 773), a median of 7 close friends (IQR, 4-10), and 64.7% of patients completed college or graduate school. Education, income, and number of friends were not associated with time to diagnosis via multivariable linear regression modeling. Univariable multinominal logistic regression demonstrated an association between education and income for selecting ED versus ERMT, but no associations were noted for CTR. No associations were noted for time to recurrent surgical procedure via Kaplan Meier modeling and Cox proportional hazards regression. Conclusions: Patient education, income, and social support were not associated with time to diagnosis or time to disease recurrence. This suggests additional patient, procedure, or disease-specific factors contribute to the observed variations in iSGS surgical outcomes.
    Type of Medium: Online Resource
    ISSN: 0003-4894 , 1943-572X
    URL: Article
    DOI: 10.1177/0003489421995283
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2033055-8
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  • 5
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    Online Resource
    Statistical methods for unidirectional switch designs: Past, present, and future
    SAGE Publications ; 2018
    In:  Statistical Methods in Medical Research Vol. 27, No. 9 ( 2018-09), p. 2872-2882
    Details
    In: Statistical Methods in Medical Research, SAGE Publications, Vol. 27, No. 9 ( 2018-09), p. 2872-2882
    Abstract: Clinical trials may apply or use a sequential introduction of a new treatment to determine its efficacy or effectiveness with respect to a control treatment. The reasons for choosing a particular switch design have different origins. For instance, they may be implemented for ethical or logistic reasons or for studying disease-modifying effects. Large-scale pragmatic trials with complex interventions often use stepped wedge designs (SWDs), where all participants start at the control group, and during the trial, the control treatment is switched to the new intervention at different moments. They typically use cross-sectional data and cluster randomization. On the other hand, new drugs for inhibition of cognitive decline in Alzheimer’s or Parkinson’s disease typically use delayed start designs (DSDs). Here, participants start in a parallel group design and at a certain moment in the trial, (part of) the control group switches to the new treatment. The studies are longitudinal in nature, and individuals are being randomized. Statistical methods for these unidirectional switch designs (USD) are quite complex and incomparable, and they have been developed by various authors under different terminologies, model specifications, and assumptions. This imposes unnecessary barriers for researchers to compare results or choose the most appropriate method for their own needs. This paper provides an overview of past and current statistical developments for the USDs (SWD and DSD). All designs are formulated in a unified framework of treatment patterns to make comparisons between switch designs easier. The focus is primarily on statistical models, methods of estimation, sample size calculation, and optimal designs for estimation of the treatment effect. Other relevant open issues are being discussed as well to provide suggestions for future research in USDs.
    Type of Medium: Online Resource
    ISSN: 0962-2802 , 1477-0334
    URL: Article
    DOI: 10.1177/0962280216689280
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2001539-2
    detail.hit.zdb_id: 1136948-6
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  • 6
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    Attention Network Test reveals alerting network dysfunction in multiple sclerosis
    SAGE Publications ; 2010
    In:  Multiple Sclerosis Journal Vol. 16, No. 1 ( 2010-01), p. 93-99
    Details
    In: Multiple Sclerosis Journal, SAGE Publications, Vol. 16, No. 1 ( 2010-01), p. 93-99
    Abstract: Attention is one of the cognitive domains typically affected in multiple sclerosis. The Attention Network Test was developed to measure the function of the three distinct attentional networks, alerting, orienting, and executive control. The Attention Network Test has been performed in various neuropsychiatric conditions, but not in multiple sclerosis. Our objective was to investigate functions of attentional networks in multiple sclerosis by means of the Attention Network Test. Patients with relapsing—remitting multiple sclerosis (n = 57) and healthy controls (n = 57) matched for age, sex, and education performed the Attention Network Test. Significant differences between patients and controls were detected in the alerting network (p = 0.003), in contrast to the orienting (p = 0.696) and the conflict (p = 0.114) network of visual attention. Mean reaction time in the Attention Network Test was significantly longer in multiple sclerosis patients than in controls (p = 0.032), Multiple sclerosis patients benefited less from alerting cues for conflict resolution compared with healthy controls. The Attention Network Test revealed specific alterations of the attention network in multiple sclerosis patients which were not explained by an overall cognitive slowing.
    Type of Medium: Online Resource
    ISSN: 1352-4585 , 1477-0970
    URL: Article
    DOI: 10.1177/1352458509350308
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2010
    detail.hit.zdb_id: 2008225-3
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  • 7
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    Comparison of three software systems for semi-automatic volumetry of pulmonary nodules on baseline and follow-up CT examinations
    SAGE Publications ; 2014
    In:  Acta Radiologica Vol. 55, No. 6 ( 2014-07), p. 691-698
    Details
    In: Acta Radiologica, SAGE Publications, Vol. 55, No. 6 ( 2014-07), p. 691-698
    Abstract: Early diagnosis of lung cancer in a treatable stage is the main purpose of lung cancer screening by computed tomography (CT). Accurate three-dimensional size and growth measurements are essential to assess the risk of malignancy. Nodule volumes can be calculated by using semi-automated volumetric software. Systematic differences in volume measurements between packages could influence nodule categorization and management decisions. Purpose To compare volumetric measurements of solid pulmonary nodules on baseline and follow-up CT scans as well as the volume doubling time (VDT) for three software packages. Material and Methods From a Lung Cancer Screening study (NELSON), 50 participants were randomly selected from the baseline round. The study population comprised participants with at least one pulmonary nodule at the baseline and consecutive CT examination. The volume of each nodule was determined for both time points using three semi-automated software packages (P 1 , P 2 , and P 3 ). Manual modification was performed when automated assessment was visually inaccurate. VDT was calculated to evaluate nodule growth. Volume, VDT, and nodule management were compared for the three software packages, using P 1 as the reference standard. Results In 25 participants, 147 nodules were present on both examinations (volume: 12.0–436.6 mm 3 ). Initial segmentation at baseline was evaluated to be satisfactory in 93.9% of nodules for P 1 , 84.4 % for P 2 , and 88.4% for P 3 . Significant difference was found in measured volume between P 1 and the other two packages ( P  〈  0.001). P 2 overestimated the volume by 38 ± 24%, and P 3 by 50 ± 22%. At baseline, there was consensus on nodule size categorization in 80% for P 1 & P 2 and 74% for P 1 & P 3 . At follow-up, consensus on VDT categorization was present in 47% for P 1 & P 2 and 44% for P 1 & P 3 . Conclusion Software packages for lung nodule evaluation yield significant differences in volumetric measurements and VDT. This variation affects the classification of lung nodules, especially in follow-up examinations.
    Type of Medium: Online Resource
    ISSN: 0284-1851 , 1600-0455
    URL: Article
    DOI: 10.1177/0284185113508177
    RVK:
    XA 10000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2014
    detail.hit.zdb_id: 2024579-8
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  • 8
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    Online Resource
    The Effect of Smoking and Body Mass Index on The Complication Rate of Alloplastic Breast Reconstruction
    SAGE Publications ; 2020
    In:  Scandinavian Journal of Surgery Vol. 109, No. 2 ( 2020-06), p. 143-150
    Details
    In: Scandinavian Journal of Surgery, SAGE Publications, Vol. 109, No. 2 ( 2020-06), p. 143-150
    Abstract: The aim of this study was to evaluate the effect of smoking and body mass index on the occurrence of complications after alloplastic breast reconstruction. Materials and Methods: A consecutive series of 56 patients treated with immediate or delayed alloplastic breast reconstruction, including six cases combined with latissimus dorsi flap, at three hospitals between 2012 and 2018 were included. Complications were scored and defined according to Clavien–Dindo. To evaluate the impact of smoking, body mass index, and other potential risk factors on the occurrence of any and severe complications, univariate and multivariate logistic regression analyses were applied to estimate odds ratios and 95% confidence intervals. Results: In 56 patients, 22 patients had a complication. As much as 46% of smokers had severe complications compared to 18% of non-smokers. Of patients with body mass index ⩾ 25, 40% had severe complications compared to 10% with body mass index  〈  25. Smokers had eight times more chance of developing severe complications than non-smokers (OR adjusted  = 8.0, p = 0.02). Patients with body mass index ⩾ 25 had almost 10 times more severe complications compared to patients with body mass index ⩽ 25 (OR adjusted  = 9.9, p = 0.009). No other risk factors were significant. Conclusion: Smoking and body mass index ⩾ 25 both increased the complication rate to such an extent that patients should be informed about their increased risk for complications following alloplastic breast reconstruction and on these grounds surgeons may delay alloplastic breast reconstruction. It is an ethical dilemma whether one should deny overweight and obese patients and those who smoke an immediate alloplastic breast reconstruction. For both life style interventions, adequate guidance should be made available.
    Type of Medium: Online Resource
    ISSN: 1457-4969 , 1799-7267
    URL: Article
    DOI: 10.1177/1457496919826711
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2486211-3
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  • 9
    Online Resource
    Online Resource
    Boiler Installations on the Continent, and Future Problems
    SAGE Publications ; 1946
    In:  Proceedings of the Institution of Mechanical Engineers Vol. 155, No. 1 ( 1946-06), p. 387-400
    Details
    In: Proceedings of the Institution of Mechanical Engineers, SAGE Publications, Vol. 155, No. 1 ( 1946-06), p. 387-400
    Abstract: On account of the diverse fuel situation on the Continent, boiler development since the 1914–18 war has been very different from that of Great Britain. The paper shows how combustion appliances such as travelling-grate stokers, grates for inferior coal, for lignites, and for pulverized fuel combustion, have been designed. It became necessary for boiler installations to be designed for higher pressures and, over a comparatively short period, extensive experiments were carried out which led to various new designs in boilers, superheaters, economizers, air heaters, etc. A possible line of future development is covered by reference to a scheme put into operation in 1930 by the West Moravian Electricity Works, Ltd., and the author concludes that two types of power station, i.e. the low pressure pit-head station for the burning of inferior fuel, and the high-pressure power station with district heating in towns, using fuels of low ash and water content, would form the ideal combination for the future.
    Type of Medium: Online Resource
    ISSN: 0020-3483 , 2058-1203
    URL: Article
    DOI: 10.1243/PIME_PROC_1946_155_056_02
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1946
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  • 10
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    The association between stress and headache: A longitudinal population-based study
    SAGE Publications ; 2015
    In:  Cephalalgia Vol. 35, No. 10 ( 2015-09), p. 853-863
    Details
    In: Cephalalgia, SAGE Publications, Vol. 35, No. 10 ( 2015-09), p. 853-863
    Abstract: We studied the association between stress intensity and headache frequency for tension-type headache (TTH), migraine and migraine with coexisting TTH (MigTTH). Method We studied a population-based sample of 5159 participants (21–71 years) who were asked quarterly between March 2010 and April 2012 about headache and stress. Log-linear regression in the framework of generalized estimating equations was used to estimate regression coefficients presented as percent changes to describe the association between stress intensity (modified visual analog scale (VAS) from 0 to 100) and headache frequency (days/month) stratified by headache subtypes and age groups and adjusted for sex, age, frequent intake of acute pain drugs, drinking, smoking, BMI and education. Results TTH was reported in 31% participants (48.1 ± 12.5years, 51.5% women, 2.2 ± 3.9 mean headache days/month, 52.3 ± 26.7 mean stress), migraine in 14% (44.8 ± 11.3years, 73.3%, 4.5 ± 5.2 days/month, 62.4 ± 23.3), MigTTH in 10.6% (43.5 ± 11.5 years, 61.0%, 3.6 ± 4.8 days/month, 58.6 ± 24.1), 23.6% were unclassifiable, and 20.8% had no headache. In participants with TTH an increase of 10 points on VAS was associated with an increase of headaches days/month of 6.0% (adjusted). Higher effects were observed in younger age groups (21–30/31–40/41–50/51–60/61–71 years: 9.8/10.2/7.0/6.5/3.5%). Slightly lower effects were observed for migraine (4.3%, 8.1/5.1/3.4/6.3/0.3%) and MigTTH (4.2%, 5.5/6.8/6.9/5.8/–0.7%). Conclusion Our study provides evidence for an association between stress intensity and headache frequency.
    Type of Medium: Online Resource
    ISSN: 0333-1024 , 1468-2982
    URL: Article
    DOI: 10.1177/0333102414563087
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2019999-5
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