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  • 1
    Online Resource
    Online Resource
    Global impact of COVID-19 on stroke care
    SAGE Publications ; 2021
    In:  International Journal of Stroke Vol. 16, No. 5 ( 2021-07), p. 573-584
    Details
    In: International Journal of Stroke, SAGE Publications, Vol. 16, No. 5 ( 2021-07), p. 573-584
    Abstract: The COVID-19 pandemic led to profound changes in the organization of health care systems worldwide. Aims We sought to measure the global impact of the COVID-19 pandemic on the volumes for mechanical thrombectomy, stroke, and intracranial hemorrhage hospitalizations over a three-month period at the height of the pandemic (1 March–31 May 2020) compared with two control three-month periods (immediately preceding and one year prior). Methods Retrospective, observational, international study, across 6 continents, 40 countries, and 187 comprehensive stroke centers. The diagnoses were identified by their ICD-10 codes and/or classifications in stroke databases at participating centers. Results The hospitalization volumes for any stroke, intracranial hemorrhage, and mechanical thrombectomy were 26,699, 4002, and 5191 in the three months immediately before versus 21,576, 3540, and 4533 during the first three pandemic months, representing declines of 19.2% (95%CI, −19.7 to −18.7), 11.5% (95%CI, −12.6 to −10.6), and 12.7% (95%CI, −13.6 to −11.8), respectively. The decreases were noted across centers with high, mid, and low COVID-19 hospitalization burden, and also across high, mid, and low volume stroke/mechanical thrombectomy centers. High-volume COVID-19 centers (−20.5%) had greater declines in mechanical thrombectomy volumes than mid- (−10.1%) and low-volume (−8.7%) centers (p  〈  0.0001). There was a 1.5% stroke rate across 54,366 COVID-19 hospitalizations. SARS-CoV-2 infection was noted in 3.9% (784/20,250) of all stroke admissions. Conclusion The COVID-19 pandemic was associated with a global decline in the volume of overall stroke hospitalizations, mechanical thrombectomy procedures, and intracranial hemorrhage admission volumes. Despite geographic variations, these volume reductions were observed regardless of COVID-19 hospitalization burden and pre-pandemic stroke/mechanical thrombectomy volumes.
    Type of Medium: Online Resource
    ISSN: 1747-4930 , 1747-4949
    URL: Article
    DOI: 10.1177/1747493021991652
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2211666-7
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  • 2
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    On-Line Monitoring of the Buffer Capacity of Particleboard Furnish by Near-Infrared Spectroscopy
    SAGE Publications ; 2006
    In:  Applied Spectroscopy Vol. 60, No. 10 ( 2006-10), p. 1204-1209
    Details
    In: Applied Spectroscopy, SAGE Publications, Vol. 60, No. 10 ( 2006-10), p. 1204-1209
    Abstract: This paper reports on a study of on-line monitoring of the buffer capacity of particleboard furnish using near-infrared (NIR) spectroscopy and multivariate analysis models (chemometrics). The buffer capacity of wood furnish is known to affect the quality of polymerization and the curing rates of urea-formaldehyde (UF) resins, which may affect the mechanical properties of manufactured panel. The first phase of the study consisted of building multivariate calibration and validation models from NIR spectroscopy data to predict the buffer capacity of particleboard furnish in a laboratory environment. During this phase, a spectrometer (Ocean Optics USB2000) operating in the 550–1100 nm spectral range was evaluated. The second phase of the study took place at a North American particleboard plant over several weeks. Several multivariate calibration models were constructed and tested on-line during a four-day test period. The on-line root mean square error of prediction (RMSEP) and the coefficient of variation (CV) for buffer capacity predictions ranged from 3.45 to 0.92 and 22.4% to 5.8%, respectively.
    Type of Medium: Online Resource
    ISSN: 0003-7028 , 1943-3530
    URL: Article
    DOI: 10.1366/000370206778664734
    RVK:
    VA 2367
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2006
    detail.hit.zdb_id: 1474251-2
    SSG: 11
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  • 3
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    Experiences of an Emergency Department Visit Among Older Adults and Their Families: Qualitative Findings From a Mixed-Methods Study
    SAGE Publications ; 2020
    In:  Journal of Patient Experience Vol. 7, No. 3 ( 2020-06), p. 346-356
    Details
    In: Journal of Patient Experience, SAGE Publications, Vol. 7, No. 3 ( 2020-06), p. 346-356
    Abstract: Emergency department (ED) visits are critical events for older adults, but little is known regarding their experiences, particularly about their physical needs, the involvement of accompanying family members, and the transition back to the community. Objective: To explore experiences of an ED visit among patients aged 75 and older. Methods: In a mixed-methods study, a cohort of patients aged 75 and older (or a family member) discharged from the ED back to the community was recruited from 4 urban EDs. A week following discharge, structured telephone interviews supplemented with open-ended questions were conducted. A subsample (76 patients, 32 family members) was purposefully selected. Verbatim transcripts of responses to the open-ended questions were thematically analyzed. Results: Experiences related to physical needs included comfort, equipment supporting mobility and autonomy, help when needed, and access to drink and food. Family members required opportunities to provide patient support and greater involvement in their care. At discharge, patients/families required adequate discharge education, resolution of their health problem, information on medications, and greater certainty about planned follow-up medical and home care services. Conclusions: Our findings suggest several areas that could be targeted to improve patient and family perceptions of the care at an ED visit.
    Type of Medium: Online Resource
    ISSN: 2374-3735 , 2374-3743
    URL: Article
    DOI: 10.1177/2374373519837238
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2857285-3
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  • 4
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    Sex differences in the prevalence of peripheral artery disease in patients undergoing coronary catheterization
    SAGE Publications ; 2010
    In:  Vascular Medicine Vol. 15, No. 6 ( 2010-12), p. 443-450
    Details
    In: Vascular Medicine, SAGE Publications, Vol. 15, No. 6 ( 2010-12), p. 443-450
    Abstract: To determine whether there are sex differences in the prevalence of peripheral artery disease, we performed an observational study of 1014 men and 547 women, aged ≥ 40 years, referred for elective coronary angiography. Women were slightly older, more obese, had higher low-density lipoprotein cholesterol (LDL-C) levels and systolic blood pressure (BP), and were more likely to be African American. Women had higher high-density lipoprotein cholesterol (HDL-C) levels, lower diastolic BP, and were less likely to smoke or to have a history of cardiovascular disease. Women had less prevalent (62% vs 81%) and less severe coronary artery disease (CAD) ( p 〈 0.001 for both) by coronary angiography, but more prevalent peripheral artery disease (PAD) as determined by the ankle—brachial index (ABI) than men (23.6% versus 17.2%). Independent predictors of lower ABI were female sex, black race, older age, tobacco use, CAD, diabetes, and triglyceride level. In a full multivariable logistic regression model, women had a risk-adjusted odds ratio for PAD of 1.78 (95% CI 1.25—2.54) relative to men. Among patients referred for coronary angiography, women have less prevalent and less severe CAD, but more prevalent PAD, a sex difference that is not explained by traditional cardiovascular disease risk factors or CAD severity. Clinical Trial Registration—URL: http://clinicaltrials.gov. Unique identifier: NCT00380185
    Type of Medium: Online Resource
    ISSN: 1358-863X , 1477-0377
    URL: Article
    DOI: 10.1177/1358863X10388345
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2010
    detail.hit.zdb_id: 2027562-6
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  • 5
    Online Resource
    Online Resource
    Developing and Testing a Tool for Human Factors Design and Evaluation
    SAGE Publications ; 2013
    In:  Proceedings of the Human Factors and Ergonomics Society Annual Meeting Vol. 57, No. 1 ( 2013-09), p. 1992-1996
    Details
    In: Proceedings of the Human Factors and Ergonomics Society Annual Meeting, SAGE Publications, Vol. 57, No. 1 ( 2013-09), p. 1992-1996
    Abstract: Designing complex systems such as those used in spaceflight operations requires a coordinated effort among a variety of engineering teams. In these large-scale efforts, it is not uncommon for human factors issues to be missed until late in the design process, perhaps when an integration test is performed. To help solve this problem, TiER1 Performance Solutions and Alion Science and Technology developed H-FAST (Human Factors Analysis Support Tool). H-FAST is a research and development effort to increase human factors awareness among design engineers, facilitate communication between human factors engineers and design engineers, and promote the application of human factors best practices earlier in the design cycle. H-FAST also provides detailed guidance regarding human factors evaluations and the capability to store data and provide feedback on the results of these evaluations. In this paper, we describe the development strategy for H-FAST and report on our progress to date. In particular, we describe the identification and development of relevant human factors information to include in the tool, discuss the methods and results of a user test at NASA, and provide an overview of our plans forward.
    Type of Medium: Online Resource
    ISSN: 2169-5067 , 1071-1813
    URL: Article
    DOI: 10.1177/1541931213571445
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2013
    detail.hit.zdb_id: 2415770-3
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  • 6
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    Online Resource
    Five-Year Follow up of Once-Daily Therapy with Emtricitabine, Didanosine and Efavirenz (Montana ANRS 091 Trial)
    SAGE Publications ; 2007
    In:  Antiviral Therapy Vol. 12, No. 3 ( 2007-04), p. 417-422
    Details
    In: Antiviral Therapy, SAGE Publications, Vol. 12, No. 3 ( 2007-04), p. 417-422
    Abstract: Once-daily combination therapy with emtricitabine, didanosine and efavirenz has been highly effective in clinical trials but its long-term efficacy and safety has not been previously reported. Methods This multicentre, single-arm, open-label trial enrolled 40 antiretroviral-naive HIV-1-infected patients who received a once-daily regimen of emtricitabine, didanosine and efavirenz. The objective was to assess the long-term effects of this combination on plasma HIV RNA levels, CD4 + T-cell counts, safety and tolerability. Results After 5 years, 73% and 68% of patients had plasma HIV RNA levels 〈 400 and 〈 50 copies/ml, respectively, in an intent-to-treat, missing-equals-failure analysis. Genotypic resistance on treatment emerged in six patients. There was a significant increase in CD4 + T-cell count of 294x10 6 cells/l. Only six patients discontinued study treatment, because of non-severe adverse events. Lipodystrophy was infrequent, and lipid and glucose profiles were favourable with a significant increase in high-density lipoprotein cholesterol. Conclusions A convenient once-daily regimen of emtricitabine, didanosine and efavirenz provided durable antiretroviral response and was well tolerated through 5 years of therapy.
    Type of Medium: Online Resource
    ISSN: 1359-6535 , 2040-2058
    URL: Article
    DOI: 10.1177/135965350701200315
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2007
    detail.hit.zdb_id: 2118396-X
    SSG: 15,3
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  • 7
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    The demise of a model? The state of collective bargaining and worker representation in Germany
    SAGE Publications ; 2017
    In:  Economic and Industrial Democracy Vol. 38, No. 2 ( 2017-05), p. 193-234
    Details
    In: Economic and Industrial Democracy, SAGE Publications, Vol. 38, No. 2 ( 2017-05), p. 193-234
    Abstract: This article investigates collective bargaining trends in the German private sector since 2000. Using data from the IAB Establishment Panel and the German Establishment History Panel, it provides both cross-sectional and longitudinal evidence on these developments. It confirms that the hemorrhaging of sectoral bargaining, first observed in the 1980s and 1990s, is ongoing. Furthermore, works councils are also in decline, so that the dual system also displays erosion. For their part, any increases in collective bargaining at firm level have been minimal in recent years, while the behavior of newly-founded and closing establishments does not seem to lie at the root of a burgeoning collective bargaining free sector. Although there are few obvious signs of an organic reversal of the process, some revitalization of the bargaining system from above is implied by the labor policies of the new coalition government.
    Type of Medium: Online Resource
    ISSN: 0143-831X , 1461-7099
    URL: Article
    DOI: 10.1177/0143831X14559784
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 1498600-0
    SSG: 3,4
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  • 8
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    ROC Curves and the Areas under Them for Dichotomized Tests : Empirical Findings for Logistically and Normally Distributed Diagnostic Test Results
    SAGE Publications ; 1994
    In:  Medical Decision Making Vol. 14, No. 4 ( 1994-10), p. 374-381
    Details
    In: Medical Decision Making, SAGE Publications, Vol. 14, No. 4 ( 1994-10), p. 374-381
    Abstract: Many measures, including sensitivity and specificity, predictive values, and likelihood ratios, are available for the assessment of diagnostic tests. A drawback of the use of these measures is that continuous test results are often dichotomized, with consequent loss of information. Receiver operating characteristic (ROC) curves do not depend on discrimination thresholds, and therefore the area under the ROC curve (AUC) is one of the preferred measures. Although quantitative test results are often presented dichotomized, it would be convenient still to be able to estimate the ROC curve and the AUC. The authors present equations for such estimates when only one pair of a true- and a false-positive rate is given, for inherently logistically and normally distributed data. Illustrative empirical data are provided for both distributions. In contradiction to earlier reports, the authors also show that differential disease verification may skew the ROC curve. The ROC curve is thus not invariant to selection bias. Key words: diagnosis; test assessment; ROC curves; verification bias; sensitivity; specificity; colorectal carcinoma; acute myocardial infarction. (Med Decis Making 1994;14:374-381)
    Type of Medium: Online Resource
    ISSN: 0272-989X , 1552-681X
    URL: Article
    DOI: 10.1177/0272989X9401400408
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1994
    detail.hit.zdb_id: 2040405-0
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  • 9
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    Effect of vitamin B12 and folic acid supplementation on biomarkers of endothelial function and inflammation among elderly individuals with hyperhomocysteinemia
    SAGE Publications ; 2016
    In:  Vascular Medicine Vol. 21, No. 2 ( 2016-04), p. 91-98
    Details
    In: Vascular Medicine, SAGE Publications, Vol. 21, No. 2 ( 2016-04), p. 91-98
    Abstract: B-vitamin trials failed to demonstrate beneficial effects on cardiovascular outcomes, but hyperhomocysteinemia still stands out as an independent cardiovascular risk factor, particularly in elderly individuals. B-vitamins may influence early vascular dysfunction, such as endothelial dysfunction, or may have adverse effects, for example on inflammation. We investigated the effect of B-vitamins on endothelial function and inflammation within an interventional study. This study was conducted within the framework of the B-PROOF trial, which included 2919 hyperhomocysteinemic elderly individuals, who received daily vitamin B12 (500 μg) and folic acid (400 μg) or placebo for 2 years. Using an electrochemiluminescence platform, we measured intercellular adhesion molecule 1 (ICAM-1), vascular adhesion molecule 1 (VCAM-1), serum amyloid A (SAA), vascular endothelial growth factor (VEGF) and C-reactive protein (CRP) at baseline and follow-up in a subsample of 522 participants (271 intervention group; 251 placebo). Treatment effects were analyzed with ANCOVA. The participants had a mean age of 72 years, and 55% of them were male. At the 2-year follow-up, B-vitamins did not change the ICAM-1 (+36% change in the intervention group versus +32% change in the placebo group; p = 0.72), VCAM-1 (+27% vs +25%; p = 0.39), VEGF (–1% vs +4%; p = 0.40), SAA (+34% vs +38%; p = 0.85) or CRP levels (+26% vs +36%; p = 0.70) as compared to placebo. In conclusion, in elderly patients with hyperhomocysteinemia, vitamin B12 and folic acid are unlikely to influence either endothelial function or low-grade systemic inflammation. ClinicalTrials.gov Identifier: NCT00696514
    Type of Medium: Online Resource
    ISSN: 1358-863X , 1477-0377
    URL: Article
    DOI: 10.1177/1358863X15622281
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2027562-6
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  • 10
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    Preface
    SAGE Publications ; 1956
    In:  Acta Radiologica Vol. Original Series, Volume 46, No. 142 Suppl ( 1956-12-01), p. 7-7
    Details
    In: Acta Radiologica, SAGE Publications, Vol. Original Series, Volume 46, No. 142 Suppl ( 1956-12-01), p. 7-7
    Type of Medium: Online Resource
    ISSN: 0284-1851 , 1600-0455
    URL: Article
    DOI: 10.1177/0284185156046S14201
    RVK:
    XA 10000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1956
    detail.hit.zdb_id: 2024579-8
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