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  • 1
    Online Resource
    Online Resource
    Analysis of All-Terrain Vehicle Trauma Data: Implications for Increased Regulation and Injury Prevention
    SAGE Publications ; 2017
    In:  The American Surgeon Vol. 83, No. 4 ( 2017-04), p. 348-353
    Details
    In: The American Surgeon, SAGE Publications, Vol. 83, No. 4 ( 2017-04), p. 348-353
    Abstract: To determine the incidence and severity of all-terrain vehicle crashes (ATVCs) compared with motorcycle crashes (MCCs) in all critically injured patients. Prospective data were retrospectively reviewed on 1840 patients involved in ATVCs and MCCs admitted to a rural level one trauma center over 16 years. ATVC patients (n = 655) were younger (25 vs 38, P 〈 0.0001), more likely female (20% vs 11%, P 〈 0.001), less severely injured (13.5 vs 16, P 〈 0.0001), had similar Glasgow Coma Score (13.3 vs 13.4, p = NS), less helmet use (6% vs 69%, P 〈 0.0001), more closed head injuries (59.7% vs 54.3%, P 〈 0.05), more facial injuries (16.9% vs 12.5%, P 〈 0.05), and lower mortality rate (2.8% vs 5.9%, P 〈 0.01) compared with MCC patients (n = 1172). Pediatric patients involved in ATVC were more common (29.8% vs 4.8%, P 〈 0.001), had decreased helmet use (12% vs 59%, P 〈 0.001) and decreased mortality (3.5% vs 14.3%, P 〈 0.01). Further injury prevention efforts regarding helmet use and increased regulations regarding ATVCs are needed to decrease the morbidity associated with these recreational vehicles.
    Type of Medium: Online Resource
    ISSN: 0003-1348 , 1555-9823
    URL: Article
    DOI: 10.1177/000313481708300420
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
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  • 2
    Online Resource
    Online Resource
    The Association of Biomarkers of Inflammation and Extracellular Matrix Degradation With the Risk of Abdominal Aortic Aneurysm: The ARIC Study
    SAGE Publications ; 2019
    In:  Angiology Vol. 70, No. 2 ( 2019-02), p. 130-140
    Details
    In: Angiology, SAGE Publications, Vol. 70, No. 2 ( 2019-02), p. 130-140
    Abstract: Animal and human laboratory studies suggest that the pathogenesis of abdominal aortic aneurysms (AAAs) involves inflammation and degradation and remodeling of the extracellular matrix. This study prospectively assessed the association between biomarkers for these mechanisms and the presence of AAA during 24 years of follow-up in the Atherosclerosis Risk in Communities (ARIC) study. The ARIC prospectively identified clinically diagnosed AAAs in 15 792 men and women from baseline in 1987 to 1989 to 2011 using hospital discharge codes and death records. Additional asymptomatic AAAs were detected by an abdominal ultrasound scan in 2011 to 2013. Matrix metalloproteinase (MMP)-3, MMP-9, interleukin 6 (IL-6), N-terminal propeptide of Type III procollagen (PIIINP), and osteopontin were measured in blood samples collected between 1987 and 1992 in participants with AAA (544 clinically diagnosed AAAs and 72 ultrasound-detected AAAs) and a random sample of 723 participants selected from baseline and matched with AAAs by age, race and sex. Higher concentrations of MMP-9 and IL-6 were associated with future risk of clinically diagnosed AAA (hazard ratios [95% confidence intervals]: 1.55 [1.22-1.97] and 1.87 [1.48-2.35], respectively, comparing highest versus lowest tertiles) after multivariable adjustment ( P for trend 〈 .001). Matrix metalloproteinase-9 was also associated with ultrasound-detected AAA. In conclusion, blood concentrations of MMP-9 and IL-6 measured in middle age predicted the risk of AAA during 24 years of follow-up.
    Type of Medium: Online Resource
    ISSN: 0003-3197 , 1940-1574
    URL: Article
    DOI: 10.1177/0003319718785278
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2065911-8
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  • 3
    Online Resource
    Online Resource
    Sex differences in cerebral venous sinus thrombosis after adenoviral vaccination against COVID-19
    SAGE Publications ; 2023
    In:  European Stroke Journal
    Details
    In: European Stroke Journal, SAGE Publications
    Abstract: Cerebral venous sinus thrombosis associated with vaccine-induced immune thrombotic thrombocytopenia (CVST-VITT) is a severe disease with high mortality. There are few data on sex differences in CVST-VITT. The aim of our study was to investigate the differences in presentation, treatment, clinical course, complications, and outcome of CVST-VITT between women and men. Patients and methods: We used data from an ongoing international registry on CVST-VITT. VITT was diagnosed according to the Pavord criteria. We compared the characteristics of CVST-VITT in women and men. Results: Of 133 patients with possible, probable, or definite CVST-VITT, 102 (77%) were women. Women were slightly younger [median age 42 (IQR 28–54) vs 45 (28–56)], presented more often with coma (26% vs 10%) and had a lower platelet count at presentation [median (IQR) 50x10 9 /L (28–79) vs 68 (30–125)] than men. The nadir platelet count was lower in women [median (IQR) 34 (19–62) vs 53 (20–92)] . More women received endovascular treatment than men (15% vs 6%). Rates of treatment with intravenous immunoglobulins were similar (63% vs 66%), as were new venous thromboembolic events (14% vs 14%) and major bleeding complications (30% vs 20%). Rates of good functional outcome (modified Rankin Scale 0-2, 42% vs 45%) and in-hospital death (39% vs 41%) did not differ. Discussion and conclusions: Three quarters of CVST-VITT patients in this study were women. Women were more severely affected at presentation, but clinical course and outcome did not differ between women and men. VITT-specific treatments were overall similar, but more women received endovascular treatment.
    Type of Medium: Online Resource
    ISSN: 2396-9873 , 2396-9881
    URL: Article
    DOI: 10.1177/23969873231185213
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2851287-X
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  • 4
    Online Resource
    Online Resource
    Exposure to American Football and Neuropsychiatric Health in Former National Football League Players: Findings From the Football Players Health Study
    SAGE Publications ; 2019
    In:  The American Journal of Sports Medicine Vol. 47, No. 12 ( 2019-10), p. 2871-2880
    Details
    In: The American Journal of Sports Medicine, SAGE Publications, Vol. 47, No. 12 ( 2019-10), p. 2871-2880
    Abstract: Former American football players have a higher prevalence of cognitive impairment than that of the US general population. It remains unknown what aspects of playing football are associated with neuropsychiatric outcomes. Hypothesis: It was hypothesized that seasons of professional football, playing position, and experience of concussions were associated with cognition-related quality of life (QOL) and indicators of depression and anxiety. Study Design: Descriptive epidemiology study. Methods: The authors examined whether seasons of professional football, playing position, and experience of concussions, as measured by self-report of 10 symptoms, were associated with cognition-related QOL and indicators of depression and anxiety in a cross-sectional survey conducted 2015 to 2017. Cognition-related QOL was measured by the short form of the Quality of Life in Neurological Disorders: Applied Cognition–General Concerns. The Patient Health Questionnaire–4 measured depression and anxiety symptoms. Of 13,720 eligible men with apparently valid contact information, 3506 players returned a questionnaire at the time of this analysis (response rate = 25.6%). Results: Seasons of professional play (risk ratio [RR] per 5 seasons = 1.19, 95% CI = 1.06-1.34) and playing position were associated with cognition-related QOL. Each 5 seasons of play was associated with 9% increased risk of indicators of depression at borderline statistical significance ( P = .05). When compared with former kickers, punters, and quarterbacks, men who played any other position had a higher risk of poor cognition-related QOL, depression, and anxiety. Concussion symptoms were strongly associated with poor cognition-related QOL (highest concussion quartile, RR = 22.3, P 〈 .001), depression (highest quartile, RR = 6.0, P 〈 .0001), and anxiety (highest quartile, RR = 6.4, P 〈 .0001), even 20 years after last professional play. Conclusion: The data suggest that seasons of play and playing position in the NFL are associated with lasting neuropsychiatric health deficits. Additionally, poor cognition-related QOL, depression, and anxiety appear to be associated with concussion in the long term.
    Type of Medium: Online Resource
    ISSN: 0363-5465 , 1552-3365
    URL: Article
    DOI: 10.1177/0363546519868989
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2063945-4
    SSG: 31
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  • 5
    Online Resource
    Online Resource
    The Alive Study: A Longitudinal Study of HIV-1 Infection in Intravenous Drug Users: Description of Methods
    SAGE Publications ; 1991
    In:  Journal of Drug Issues Vol. 21, No. 4 ( 1991-10), p. 759-776
    Details
    In: Journal of Drug Issues, SAGE Publications, Vol. 21, No. 4 ( 1991-10), p. 759-776
    Abstract: To identify risk factors for infection with the human immunodeficiency virus (HIV) and for progression to the acquired immunodeficiency syndrome (AIDS) among intravenous drug users, we established a cohort in Baltimore Maryland in 1988–1989. Intravenous drug users were recruited by extensive community outreach to undergo interview and confidential HIV testing in a special study site. During 13 months of recruitment, 2,921 intravenous drug users were enrolled of whome 24 percent were HIV seropositive; 90 percent returned to receive test results. Methodological issues for enhancing recruitment and retention of drug users are discussed.
    Type of Medium: Online Resource
    ISSN: 0022-0426 , 1945-1369
    URL: Article
    DOI: 10.1177/002204269102100406
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1991
    detail.hit.zdb_id: 2051257-0
    SSG: 2,1
    SSG: 15,3
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