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  • 1
    In: Journal of Social and Personal Relationships, SAGE Publications, Vol. 38, No. 5 ( 2021-05), p. 1553-1571
    Abstract: Despite a growing body of research on later-life relationship formation, little is known about the health predictors and outcomes of later-life Living-Apart-Together (LAT) relationships. A LAT living arrangement is understood to be a possible way for older adults with age-related limits to partner and balance the consequences of being single. Using both selection and resource models to capture the links between health and relationship status, we analyzed unpartnered people 50+ from the longitudinal Survey of Health, Ageing and Retirement in Europe. We examined who entered LAT or cohabiting relationships between Time 1 and 2, who remained unpartnered, and what effect the transition into one of these statuses had on the well-being of those who remained in that status at Time 3. The respondents in LAT relationships did not differ from their cohabiting counterparts in health indicators before the relationship formation, nor was there a difference in life satisfaction and well-being 2 years after partnering. Compared to unpartnered persons, LAT respondents reported better self-perceived health before relationship formation and slightly higher life satisfaction 2 years later. Health status does not influence the choice for a relationship form, but a LAT relationship may constitute a resourceful living arrangement in later life, which provides some support for both the selection and resource models.
    Type of Medium: Online Resource
    ISSN: 0265-4075 , 1460-3608
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2023968-3
    SSG: 5,2
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  • 2
    In: Journal of Endovascular Therapy, SAGE Publications, Vol. 9, No. 6 ( 2002-12), p. 842-854
    Abstract: To use local gene delivery to determine any district-specific influence of vascular endothelial growth factor (VEGF 165 ) on angiogenesis and arteriogenesis in arteries of distinct developmental origin. Methods: Coronary and peripheral arteries were chronically occluded in 30 Pietrain pigs using a percutaneous approach and blinded stent-graft. DNA was delivered to the adventitia in dosages corresponding to 10% of the body weight—adapted amount used in clinical trials. The coronary arteries in 12 animals and the peripheral arteries in 12 animals were treated or used as controls (no occlusion or occlusion with transfection of the β-galactosidase gene). Six additional animals were sacrificed at 1 or 3 weeks for expression analyses, while the other 24 animals were sacrificed at 5 months for expression analysis and histology. Angiography, polymerase chain reaction analyses, and immunohistochemistry were performed. Results: Expression of the VEGF gene was observed at 1 and 3 weeks following application, while transfected DNA was detected up to 5 months. New collaterals formed around occluded coronary arteries (2.63 ± 0.69 fold, p 〈 0.05 versus 1.24 ± 0.40 fold for peripheral arteries), and angiographic arterial area increase was more pronounced in coronary (2.49 ± 0.59 fold, p 〈 0.05) than peripheral arteries (1.49 ± 0.05 fold). There was no collateralization surrounding occluded peripheral arteries, but new arterial branches were seen (2.0 ± 0.28, p 〈 0.05 versus 1.07 ± 0.31 for coronary). Conclusions: The response to VEGF, whether it is predominantly angiogenesis or arteriogenesis, is dependent on the target vessel. These observed differences in the behavior of arteries may be related to their differing developmental origins, which may have important implications for future therapeutic strategies using VEGF in different vessels.
    Type of Medium: Online Resource
    ISSN: 1526-6028 , 1545-1550
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2002
    detail.hit.zdb_id: 2049858-5
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  • 3
    In: Cross-Cultural Research, SAGE Publications, Vol. 55, No. 4 ( 2021-10), p. 319-350
    Abstract: The current research aimed to examine the reasons people are single, that is, not in an intimate relationship, across eight different countries—Brazil, China, Czech Republic, Greece, Hungary, India, Japan, and the UK. We asked a large cross-cultural sample of single participants ( N = 6,822) to rate 92 different possible reasons for being single. These reasons were classified into 12 factors, including one’s perceived inability to find the right partner, the perception that one is not good at flirting, and the desire to focus on one’s career. Significant sex and age effects were found for most factors. The extracted factors were further classified into three separate domains: Perceived poor capacity to attract mates, desiring the freedom of choice, and currently being in between relationships. The domain structure, the relative importance of each factor and domain, as well as sex and age effects were relatively consistent across countries. There were also important differences however, including the differing effect sizes of sex and age effects between countries.
    Type of Medium: Online Resource
    ISSN: 1069-3971 , 1552-3578
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2004124-X
    SSG: 3,4
    SSG: 5,2
    SSG: 10
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  • 4
    In: Journal of Endovascular Therapy, SAGE Publications, Vol. 11, No. 1 ( 2004-02), p. 71-79
    Abstract: To compare an endovascular technique with a well established surgical approach to achieve long-term occlusions of large porcine arteries while preserving the integrity of periarterial tissue. Methods: The femoral arteries in 11 pigs were occluded using surgical techniques on one side and blinded stent-grafts in the contralateral vessel. Feasibility, safety, primary and long-term success, and the extent of vascularization were determined over a 3-month period by conventional angiography and histological analysis. A subgroup of animals (n=5) was treated with a locally administered plasmid coding for vascular endothelial growth factor (pVEGF 165 ) to compare both occlusion techniques under conditions of collateral growth induction. Results: The primary and long-term success rates for both occlusion models were 100%. Surgical occlusion of arteries resulted in a significant amount of scar dehiscence and local groin infection compared to the endograft-occluded side. There was no significant difference in capillary densities and collateralization of periarterial areas in a comparison of the occlusion technique: the cross-sectional area of the superficial femoral artery (SFA) was 300±24 mm 2 for endovascular occlusion versus 320±23 mm 2 for surgical occlusion (p=0.559). In the profunda femoris artery, respective values were 418±35 and 448±18 mm 2 (p=0.474). The local delivery of pVEGF 165 resulted in a significant increase in collateral growth in both occlusion models with comparable neovascularization: cross-sectional SFA area increased from 310±16 to 428±13 mm 2 (p 〈 0.0001); in the PFA, the area increased from 422±19 to 658±49 mm 2 (p 〈 0.0001). Conclusions: Endovascular arterial occlusions using blinded stent-grafts allow easy and safe creation of long-term occlusions. Previously described collateralization following surgical occlusions was not observed, indicating that those collaterals may be associated with wound healing rather than ischemia. The occlusion of arteries using blinded stent-grafts in pigs may therefore be an appropriate model for assessing the effects of angiogenic factors in vivo.
    Type of Medium: Online Resource
    ISSN: 1526-6028 , 1545-1550
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2004
    detail.hit.zdb_id: 2049858-5
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