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  • SAGE Publications  (63)
  • 1
    Online Resource
    Online Resource
    Effectiveness of Percutaneous Celiac Plexus Ablation in the Treatment of Severe Cancer Pain in Upper Abdomen and Evaluation of Health Economics
    SAGE Publications ; 2017
    In:  American Journal of Hospice and Palliative Medicine® Vol. 34, No. 2 ( 2017-03), p. 142-147
    Details
    In: American Journal of Hospice and Palliative Medicine®, SAGE Publications, Vol. 34, No. 2 ( 2017-03), p. 142-147
    Abstract: To compare the effectiveness, adverse effects, and cost-effectiveness of percutaneous neurolytic celiac plexus block (NCPB) versus traditional medication strategies for the treatment of patients with advanced cancer having severe upper abdominal cancer pain. Methods: This retrospective study included 81 patients with advanced upper abdominal cancer admitted to The Sixth People’s Hospital Affiliated to Shanghai Jiaotong University between January 2013 and July 2014. The patients were divided into percutaneous NCPB (treatment) and medication for pain (control) groups. The outcomes were measured in terms of Numeric Rating Scale (NRS) score and Karnofsky Performance Status (KPS) score before treatment and on the 3rd, 7th, 14th, and 28th days posttreatment. The effectiveness and cost-effectiveness of the therapy were assessed using analysis of the health economics. Results: The improvements in NRS score (1.42 ± 1.09 vs 4.03 ± 0.96, P 〈 .01) and KPS score (65.55 ± 9.09 vs 63.03 ± 8.961, P 〈 .01) in the treatment group were significantly superior compared to the control group on the 7th day of treatment, followed by no significant difference between the 2 groups on the 14th and the 28th day of treatment. Health economics evaluation revealed that the medicine-specific costs and total health care costs were significantly reduced in the treatment group compared to the control group ( P 〈 .05), but no significant differences between the 2 groups ( P 〉 .05) were seen in the costs of hospitalization, examinations, and treatment. Conclusion: The percutaneous NCPB method shows promising results and better cost-effectiveness for treating patients with advanced cancer having severe upper abdominal pain.
    Type of Medium: Online Resource
    ISSN: 1049-9091 , 1938-2715
    URL: Article
    DOI: 10.1177/1049909115625954
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2236674-X
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  • 2
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    Nimotuzumab plus platinum-based chemotherapy versus platinum-based chemotherapy alone in patients with recurrent or metastatic nasopharyngeal carcinoma
    SAGE Publications ; 2020
    In:  Therapeutic Advances in Medical Oncology Vol. 12 ( 2020-01), p. 175883592095373-
    Details
    In: Therapeutic Advances in Medical Oncology, SAGE Publications, Vol. 12 ( 2020-01), p. 175883592095373-
    Abstract: Palliative chemotherapy has been the mainstay treatment for patients with recurrent or metastatic nasopharyngeal carcinoma (R/M-NPC). However, little is known about the efficacy and toxicity of nimotuzumab (NTZ) – a monoclonal antibody drug targeting epidermal growth factor receptor – plus chemotherapy (CT) versus CT alone for these patients. Methods: The database at Cancer Hospital of Chinese Academy of Medical Sciences was queried for patients diagnosed with NPC who received CT with or without NTZ between 2004 and 2018. Treatment compliance, survival outcomes, and adverse effects were compared among these groups. Results: Records of 70 patients with R/M-NPC were reviewed: 21 (30%) received NTZ plus CT (NTZ+CT) and 49 (70%) received CT. CT regimens included gemcitabine plus platinum, taxane plus platinum (TP), and fluorouracil plus platinum. Comparing the CT group with NTZ+CT group, the median follow up was 62 months (range = 3–133) versus 59 months (range = 9–117); median progression free survival was 7.5 [95% confidence interval (CI) 6.552–8.381] months versus 8.5 (95% CI 6.091–10.976) months, p = 0.424; median overall survival (OS) was 25.6 (95% CI 18.888–32.379) months versus 48.6 (95% CI 35.619–61.581) months, p = 0.017, respectively. Multivariable analysis established treatment group (CT versus NTZ+CT) as an independent prognostic factor for OS (hazard ratio, 0.5; 95% CI 0.255–0.979; p = 0.043). No significant difference with regard to toxicities was observed between the two groups. Among them, a subgroup analysis was performed in 53 (75.7%) patients who received TP with or without NTZ, which showed similar results. Conclusion: Our findings suggested that NTZ+CT provides a novel treatment option and prolongs survival significantly for R/M-NPC.
    Type of Medium: Online Resource
    ISSN: 1758-8359 , 1758-8359
    URL: Article
    DOI: 10.1177/1758835920953738
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2503443-1
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  • 3
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    Modeling and experimental investigation of magnetically coupling bending-torsion piezoelectric energy harvester based on vortex-induced vibration
    SAGE Publications ; 2022
    In:  Journal of Intelligent Material Systems and Structures Vol. 33, No. 9 ( 2022-05), p. 1147-1160
    Details
    In: Journal of Intelligent Material Systems and Structures, SAGE Publications, Vol. 33, No. 9 ( 2022-05), p. 1147-1160
    Abstract: This paper presents a magnetically coupling bending-torsion piezoelectric energy harvester based on vortex-induced vibration from low-speed wind. The theoretical model of the energy harvester was formulated and validated by wind tunnel experiments. Numerical and experimental results showed that the power output and bandwidth of the proposed harvester are improved about 180% and 230% respectively compared with the nonmagnetic coupling harvester. Furthermore, the effects of cylinder, piezoelectric layer, load resistance, and magnetic nonlinear parameters on the harvester were investigated based on the distributed parameter model. The results showed that the length of cylinder hardly affect output power, but the diameter of cylinder presented complicated influences. The width of piezoelectric beam was negatively correlated with the torsion angle. With increasing the length of piezoelectric layer, an optimal wind velocity and load resistance can be obtained for the maximum output power. With decreasing of the distance between two magnets, the resonant bandwidth, the optimal power output, and torsion angle can be enhanced, respectively. Besides, the magnetic potential energy increased owing to the magnetically coupling, which led to the improvement of onset speed for the energy harvester. This study provides a guideline on improving the performance of bending-torsion vibration piezoelectric energy harvester.
    Type of Medium: Online Resource
    ISSN: 1045-389X , 1530-8138
    URL: Article
    DOI: 10.1177/1045389X211048229
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2088313-4
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  • 4
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    Expression of CUEDC2 in colorectal cancer with different invasion and migration abilities
    SAGE Publications ; 2019
    In:  Journal of International Medical Research Vol. 47, No. 2 ( 2019-02), p. 905-914
    Details
    In: Journal of International Medical Research, SAGE Publications, Vol. 47, No. 2 ( 2019-02), p. 905-914
    Abstract: To investigate CUE domain containing 2 ( CUEDC2) expression in colorectal cancer with different invasion and migration abilities. Methods Fresh colon cancer tissues, obtained from patients with or without lymph node metastasis who were treated at the Department of General Surgery, Chinese People's Liberation Army General Hospital, and SW620 and HT29 colorectal cancer cell lines, were analysed for CUEDC2 expression. Results Real-time polymerase chain reaction showed significantly higher CUEDC2 mRNA levels in colon cancer tissue from patients with ( n = 8) versus without ( n = 8) lymph node metastasis, and in SW620 versus HT29 cells. Western blots revealed significantly higher CUEDC2 protein levels in colon cancer tissues from patients with versus without lymph node metastasis, and in SW620 versus HT29 cells. Colorectal cancer tissues from patients with lymph node metastasis showed more intense immunohistochemical staining and moderate staining of cell nuclei and cytoplasm versus less intense/weak staining in tissues from patients without lymph node metastasis. Conclusions CUEDC2 is highly expressed in colorectal cancer tissues and colorectal cancer cell lines with high invasion and migration ability. CUEDC2 may be involved in promoting invasion and metastasis in colorectal cancer.
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    URL: Article
    DOI: 10.1177/0300060518813072
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2082422-1
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  • 5
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    Prevalence of co-infections with other sexually transmitted infections in patients newly diagnosed with anogenital warts in Guangzhou, China
    SAGE Publications ; 2020
    In:  International Journal of STD & AIDS Vol. 31, No. 11 ( 2020-10), p. 1073-1081
    Details
    In: International Journal of STD & AIDS, SAGE Publications, Vol. 31, No. 11 ( 2020-10), p. 1073-1081
    Abstract: Prevalence of co-infecting sexually transmitted infections (STIs) among patients newly diagnosed with anogenital warts is under-reported. Our objective is to determine the prevalence of six common STIs, Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG), Mycoplasma genitalium (MG), genital herpes (herpes simplex virus type 2 [HSV-2]), HIV, and syphilis for patients visiting a sexual health clinic in Guangzhou, China. Demographics, sexual health, and medical histories were collected at patient intake. Patients diagnosed with anogenital warts (N = 200) were invited to participate. We collected urine samples, and urethral, cervical, and rectal swabs to test for CT, NG, and MG, and blood samples for serological detection of HSV-2, syphilis, and HIV. Overall 49 (24.5%) had a co-infection (22.2% of men and 27.7% of women). All six STIs were observed among men: CT (6.8%), NG (3.4%), MG (5.1%), HIV (4.3%), HSV-2 (4.3%), and syphilis (1.7%). Women had fewer STIs, but at higher rates: CT (13.3%), MG (6.0%), and HSV-2 (8.4%). Individual men had up to two co-infections, while women had no more than one co-infection. Chlamydia was the most common STI. Patients aged 18–25 years (35.4%) had the highest prevalence. Although opportunistic screening is often applied for high-risk groups, expansion to patients with anogenital warts in all health-care settings would improve detection of problematic asymptomatic co-infections, thereby increasing China’s capacity to contribute toward global surveillance systems.
    Type of Medium: Online Resource
    ISSN: 0956-4624 , 1758-1052
    URL: Article
    DOI: 10.1177/0956462419890496
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2009782-7
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  • 6
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    Simultaneous determination of metolazone and valsartan in plasma by on-line SPE coupled with liquid chromatography/tandem mass spectrometry
    SAGE Publications ; 2017
    In:  European Journal of Mass Spectrometry Vol. 23, No. 5 ( 2017-10), p. 305-312
    Details
    In: European Journal of Mass Spectrometry, SAGE Publications, Vol. 23, No. 5 ( 2017-10), p. 305-312
    Abstract: Combination of metolazone (0.5 mg) and valsartan (80 mg) has been verified as a promising therapy treatment for hypertension. In order to facilitate to pharmacokinetic research, it needs a method for the simultaneously determination of metolazone and valsartan in biological samples. However, there are no relative reports so far. In order to facilitate to pharmacokinetic research, an on-line solid phase extraction coupled with liquid chromatography-tandem mass spectrometry method for the simultaneous determination of metolazone and valsartan in beagle dog plasma was developed and validated in this study. An on-line solid phase extraction column Retain PEP Javelin (10 mm × 2.1 mm) was used to remove impurities in plasma samples. The metolazone, valsartan and internal standard (losartan) were separated on a Poroshell 120 SB-C18 column (4.6 mm × 50 mm × 2.7 µm) with a gradient elution procedure. Acidified acetonitrile/water mixture was used as a mobile phase. The selected multiple-reaction monitoring mode in positive ion was performed and the parent to the product transitions m/z 366/259, m/z 436.2/291 and m/z 423.4/207 were used to measure the metolazone, valsartan and losartan. The method was linear over the range of 0.1–100 ng/mL and 1–1000 ng/mL for metolazone and valsartan, respectively. This method was validated in terms of specificity, linearity, sensitivity, precision, accuracy, matrix effect, and stability and then successfully applied to pharmacokinetic studies of the metolazone and valsartan combination tablets in beagle dogs.
    Type of Medium: Online Resource
    ISSN: 1469-0667 , 1751-6838
    URL: Article
    DOI: 10.1177/1469066717716726
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2021540-X
    detail.hit.zdb_id: 2021340-2
    SSG: 11
    SSG: 12
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  • 7
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    Experimental study of centrifugal pump as turbine with S-blade impeller
    SAGE Publications ; 2023
    In:  Proceedings of the Institution of Mechanical Engineers, Part E: Journal of Process Mechanical Engineering Vol. 237, No. 4 ( 2023-08), p. 1557-1565
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part E: Journal of Process Mechanical Engineering, SAGE Publications, Vol. 237, No. 4 ( 2023-08), p. 1557-1565
    Abstract: As a hydraulic energy recovery device, pump as turbine(PAT) has been applied widely in the seawater desalination and petrochemical industry. In order to improve the hydraulic performances, the blade inlet angle was redesigned by analyzing the velocity triangle of PAT impeller inlet, and an S-blade was proposed. Then, A new S-blade impeller was obtained by optimizing the impeller in a real case of centrifugal pump as turbine application, and it was compared with the original impeller through experiments. The results show that the efficiency of the new S-blade impeller is around 3% higher than that of the original blade with the fixed flow rate and head. Under the fixed speed, the shaft power of the new S-blade impeller is higher than that of the original blade, and the maximum deviation is 0.75 kW. The study could have important directive significance to blade optimization of PAT.
    Type of Medium: Online Resource
    ISSN: 0954-4089 , 2041-3009
    URL: Article
    DOI: 10.1177/09544089221123408
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2024897-0
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  • 8
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    A Patients-Based Statistical Model of Radiotherapy Dose Distribution in Nasopharyngeal Cancer
    SAGE Publications ; 2019
    In:  Dose-Response Vol. 17, No. 4 ( 2019-10-01), p. 155932581989235-
    Details
    In: Dose-Response, SAGE Publications, Vol. 17, No. 4 ( 2019-10-01), p. 155932581989235-
    Abstract: To develop a patients-based statistical model of dose distribution among patients with nasopharyngeal cancer (NPC). Methods and Materials: The dose distributions of 75 patients with NPC were acquired and preprocessed to generate a dose-template library. Subsequently, the dominant modes of dose distribution were extracted using principal component analysis (PCA). Leave-one-out cross-validation (LOOCV) was performed for evaluation. Residual reconstruction errors between the doses reconstructed using different dominating eigenvectors and the planned dose distribution were calculated to investigate the convergence characteristics. Three-dimensional Gamma analysis was performed to investigate the accuracy of dose reconstruction. Results: The first 29 components contained 90% of the variance in dose distribution, and 45 components accounted for more than 95% of the variance on average. The residual error of the LOOCV model for the cumulative sum of components over all patients decreased from 8.16 to 4.79 Gy when 1 to 74 components were included in the LOOCV model. The 3-dimensional Gamma analysis results implied that the PCA model was capable of dose distribution reconstruction, and the accuracy was especially satisfactory in the high-dose area. Conclusions: A PCA-based model of dose distribution variations in patients with NPC was developed, and its accuracy was determined. This model could serve as a predictor of 3-dimensional dose distribution.
    Type of Medium: Online Resource
    ISSN: 1559-3258 , 1559-3258
    URL: Article
    DOI: 10.1177/1559325819892359
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2440820-7
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  • 9
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    Long noncoding RNA AOC4P regulates tumor cell proliferation and invasion by epithelial–mesenchymal transition in gastric cancer
    SAGE Publications ; 2019
    In:  Therapeutic Advances in Gastroenterology Vol. 12 ( 2019-01), p. 175628481982769-
    Details
    In: Therapeutic Advances in Gastroenterology, SAGE Publications, Vol. 12 ( 2019-01), p. 175628481982769-
    Abstract: The clinical relevance and biological role of tissular AOC4P in gastric cancer (GC) remains to be clarified. Methods: The association between AOC4P expression and clinicopathological characteristics was investigated. In vitro, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), colony formation, wound healing and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assays were performed to explore the biological effects of AOC4P on GC cell proliferation, migration, invasion, and apoptosis in MGC-803 and BGC-823 cell lines. In vivo, animal experiments were conducted to confirm the in vitro findings. Quantitative real-time polymerase chain reaction, western blotting, and immunofluorescence were used to investigate the potential mechanisms. Results: Expression levels of AOC4P were significantly higher in tumor tissues than in noncancerous tissues, and patients with high levels of AOC4P had poor overall and disease-free survival. AOC4P expression was correlated with lymphovascular invasion. In vitro, knockdown of AOC4P inhibited tumor cell proliferation, migration, and invasion, and promoted apoptosis of MGC-803 and BGC-823 cells. In vivo, BGC-823 cells transfected with AOC4P siRNA formed smaller and lighter tumors than BGC-823 cells transfected with negative control siRNA in severe combined immunodeficiency mice. Additionally, the si- AOC4P group had less proliferating cells and more apoptotic cells in tumor xenografts compared with the negative control. Mechanistically, knockdown of AOC4P decreased the expression of vimentin and MMP9, while increasing the expression of E-cadherin. Immunofluorescence confirmed the relationship between AOC4P expression and E-cadherin, vimentin, and MMP9 levels in clinical GC specimens. Conclusions: AOC4P promotes tumorigenesis and progression partly through epithelial–mesenchymal transition in GC. Additionally, AOC4P may serve as a prognostic biomarker for clinical decision making.
    Type of Medium: Online Resource
    ISSN: 1756-2848 , 1756-2848
    URL: Article
    DOI: 10.1177/1756284819827697
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2440710-0
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  • 10
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    Investigation on the power loss and radial force characteristics of pump as turbine under gas–liquid two-phase condition
    SAGE Publications ; 2019
    In:  Advances in Mechanical Engineering Vol. 11, No. 4 ( 2019-04), p. 168781401984373-
    Details
    In: Advances in Mechanical Engineering, SAGE Publications, Vol. 11, No. 4 ( 2019-04), p. 168781401984373-
    Type of Medium: Online Resource
    ISSN: 1687-8140 , 1687-8140
    URL: Article
    DOI: 10.1177/1687814019843732
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2501620-9
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