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  • 1
    Online Resource
    Online Resource
    Sex bias in diagnostic delay in bronchiectasis: An analysis of the Spanish Historical Registry of Bronchiectasis
    SAGE Publications ; 2017
    In:  Chronic Respiratory Disease Vol. 14, No. 4 ( 2017-11), p. 360-369
    Details
    In: Chronic Respiratory Disease, SAGE Publications, Vol. 14, No. 4 ( 2017-11), p. 360-369
    Abstract: Diagnostic delay is common in most respiratory diseases, particularly in bronchiectasis. However, sex bias in diagnostic delay has not been studied to date. Objective: Assessment of diagnostic delay in bronchiectasis by sex. Methods: The Spanish Historical Registry of Bronchiectasis recruited adults diagnosed with bronchiectasis from 2002 to 2011 in 36 centres in Spain. From a total of 2113 patients registered we studied 2099, of whom 1125 (53.6%) were women. Results: No differences were found for sex or age (61.0 ± 20.6, p = 0.88) or for localization of bronchiectasis ( p = 0.31). Bronchiectasis of unknown aetiology and secondary to asthma, childhood infections and tuberculosis was more common in women (all ps 〈 0.05). More men than women were chronic obstructive pulmonary disease-related bronchiectasis and colonized by Haemophilus influenzae ( p 〈 0.001 for both). Onset of symptoms was earlier in women. The diagnostic delay for women with bronchiectasis was 2.1 years more than for men ( p = 0.001). Discussion: We recorded a substantial delay in the diagnosis of bronchiectasis. This delay was significantly longer in women than in men ( 〉 2 years). Independent factors associated with this sex bias were age at onset of symptoms, smoking history, daily expectoration and reduced lung function.
    Type of Medium: Online Resource
    ISSN: 1479-9731 , 1479-9731
    URL: Article
    DOI: 10.1177/1479972317702139
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2222367-8
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  • 2
    Online Resource
    Online Resource
    Skin Color and Self-Perceptions of Immigrant and U.S.-Born Latinas : The Moderating Role of Racial Socialization and Ethnic Identity
    SAGE Publications ; 2009
    In:  Hispanic Journal of Behavioral Sciences Vol. 31, No. 3 ( 2009-08), p. 357-374
    Details
    In: Hispanic Journal of Behavioral Sciences, SAGE Publications, Vol. 31, No. 3 ( 2009-08), p. 357-374
    Abstract: Research has increasingly identified race as a salient characteristic that affects one's life experiences and psychological well-being. However, little is known about how skin color affects the emotional health of Latinos. The present study examined how skin color relates to the self-perceptions of immigrant (N = 26) and U.S.-born (N = 55) Latina college women. Results indicate that immigrant Latina participants with darker skin tend to have poorer self-perceptions than their U.S.-born peers, including lower self-esteem, lower feelings of attractiveness, and a desire to change their skin color to be lighter. Both racial socialization and ethnic identity served to buffer Latinas from the negative self-perceptions associated with darker skin. These findings suggest that skin color may be a particularly central risk factor for immigrant Latinas' well-being, and racial socialization and ethnic identity may serve as important protective factors.
    Type of Medium: Online Resource
    ISSN: 0739-9863 , 1552-6364
    URL: Article
    DOI: 10.1177/0739986309336913
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2009
    detail.hit.zdb_id: 2067258-5
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  • 3
    Online Resource
    Online Resource
    Inflammatory and Prothrombotic Biomarkers Associated With the Severity of COVID-19 Infection
    SAGE Publications ; 2021
    In:  Clinical and Applied Thrombosis/Hemostasis Vol. 27 ( 2021-01-01), p. 107602962199909-
    Details
    In: Clinical and Applied Thrombosis/Hemostasis, SAGE Publications, Vol. 27 ( 2021-01-01), p. 107602962199909-
    Abstract: Among COVID-19 hospitalized patients, high incidence of alterations in inflammatory and coagulation biomarkers correlates with a poor prognosis. Comorbidities such as chronic degenerative diseases are frequently associated with complications in COVID-19 patients. The aim of this study was to evaluate inflammatory and procoagulant biomarkers in COVID-19 patients from a public hospital in Mexico. Blood was sampled within the first 48 h after admission in 119 confirmed COVID-19 patients that were classified in 3 groups according to oxygen demand, evolution and the severity of the disease as follows: 1) Non severe: nasal cannula or oxygen mask; 2) Severe: high flow nasal cannula and 3) Death: mechanical ventilation eventually leading to fatal outcome. Blood samples from 20 healthy donors were included as a Control Group. Analysis of inflammatory and coagulation biomarkers including D-dimer, interleukin 6, interleukin 8, PAI-1, P-selectin and VWF was performed in plasma. Routine laboratory and clinical biomarkers were also included and compared among groups. Concentrations of D-dimer (14.5 ± 13.8 µg/ml) and PAI-1 (1223 ± 889.6 ng/ml) were significantly elevated in severe COVID-19 patients (P 〈 0.0001). A significant difference was found in interleukin-6, PAI-1 and P-selectin in non-severe and healthy donors when compared to Severe COVID-19 and deceased patients (P 〈 0.001). VWF levels were also significantly different between severe patients (153.5 ± 24.3 UI/dl) and non-severe ones (133.9 ± 20.2 UI/dl) (P 〈 0.0001). WBC and glucose levels were also significantly elevated in patients with Severe COVID-19. Plasma concentrations of all prothrombotic biomarkers were significantly higher in patients with a fatal outcome.
    Type of Medium: Online Resource
    ISSN: 1076-0296 , 1938-2723
    URL: Article
    DOI: 10.1177/1076029621999099
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2230591-9
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  • 4
    Online Resource
    Online Resource
    Recent Findings on Platelet Activation, vWF Multimers and Other Thrombotic Biomarkers Associated with Critical COVID-19
    SAGE Publications ; 2022
    In:  Clinical and Applied Thrombosis/Hemostasis Vol. 28 ( 2022-01), p. 107602962211357-
    Details
    In: Clinical and Applied Thrombosis/Hemostasis, SAGE Publications, Vol. 28 ( 2022-01), p. 107602962211357-
    Abstract: Mortality rate in patients with COVID-19 increases in those admitted to the ICU. Activation of the coagulation system is associated with the worse disease outcomes. The aim of this study was to evaluate platelet activation and thrombotic biomarkers in hospitalized patients with COVID-19 during the second and third infection waves of the pandemic during 2021, following a previous report that included patients from the first wave. Sixty five patients were recruited and classified according to disease outcome; 10 healthy donors were included as a control group. Among prothrombotic biomarkers, t-PA concentrations ( p  〈  .0001), PAI-1 (0.0032) and D dimer ( p = .0011) were higher in patients who developed critical COVID-19. We also found platelet activation via αIIbβIII expression ( p  〈  .0001) and higher presence of vWF-HMWM in severe COVID-19 ( p  〈  .0001). Several prothrombotic biomarkers are found to be increased since hospital admission in patients which lately present a worse disease outcome (ICU admission/death), among these, platelet activation, vWF increased plasma concentration and presence of HMWM seem to be of special interest. New studies regarding the predictive value of thrombotic biomarkers are needed as SARS-CoV-2 variants continue to emerge.
    Type of Medium: Online Resource
    ISSN: 1076-0296 , 1938-2723
    URL: Article
    DOI: 10.1177/10760296221135792
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2230591-9
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  • 5
    Online Resource
    Online Resource
    Desarrollo de un proceso participativo para el diagnóstico de salud comunitaria en estudiantes de la Universidad Miguel Hernández: Proyecto #beUMHealthy
    SAGE Publications ; 2022
    In:  Global Health Promotion Vol. 29, No. 2 ( 2022-06), p. 136-140
    Details
    In: Global Health Promotion, SAGE Publications, Vol. 29, No. 2 ( 2022-06), p. 136-140
    Abstract: Los procesos participativos permiten analizar, comprender, debatir y promover la acción colectiva en asuntos significativos para una comunidad. Estas metodologías activas favorecen la identificación de necesidades y activos en salud para elaborar un diagnóstico de salud comunitaria y promover acciones colectivas. En este sentido, la aplicación de los procesos participativos en el contexto universitario resulta de gran interés para el fortalecimiento de las universidades como comunidades promotoras de la salud. En este trabajo se describe el desarrollo del proceso participativo #beUMHealthy, cuyo objetivo principal fue potenciar el debate sobre la salud y las iniciativas de promoción de la salud en el alumnado de la Universidad Miguel Hernández (UMH). El proyecto se desarrolló entre mayo y noviembre del 2019. Se recogieron 22 participaciones mediante WhatsApp y 173 cuestionarios diligenciados en línea. Este proceso permitió identificar necesidades y activos en salud en el alumnado de la UMH y obtener propuestas para su mejora. Esta información se usará para promover acciones futuras que incrementen la salud de la comunidad universitaria.
    Type of Medium: Online Resource
    ISSN: 1757-9759 , 1757-9767
    URL: Article
    DOI: 10.1177/17579759211015912
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2502152-7
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