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  • 11
    Online Resource
    Online Resource
    Pilot study of contrast-free MRI reveals significantly impaired calf skeletal muscle perfusion in diabetes with incompressible peripheral arteries
    SAGE Publications ; 2021
    In:  Vascular Medicine Vol. 26, No. 4 ( 2021-08), p. 367-373
    Details
    In: Vascular Medicine, SAGE Publications, Vol. 26, No. 4 ( 2021-08), p. 367-373
    Abstract: Patients with diabetes mellitus (DM) are more likely to have densely calcified lesions in the below-the-knee tibial arteries. However, the relationship between peripheral arterial calcification and local skeletal muscle perfusion has not been explored. Thirty subjects were prospectively recruited into three groups in this pilot study: (1) Non-DM: 10 people without DM; (2) DM, ABI 〈 1.3: 10 people with DM and normal ankle–brachial index (ABI) (0.9–1.3); and (3) DM, ABI ⩾ 1.3: 10 people with DM and ABI ⩾ 1.3. All subjects underwent calf perfusion measurements at rest and during an isometric plantarflexion contraction exercise within the magnetic resonance imaging (MRI) system. The noncontrast MRI techniques were applied to quantitatively assess skeletal muscle blood flow (SMBF) and oxygen extraction fraction (SMOEF) in medial gastrocnemius and soleus muscles. Both SMBF and SMOEF reserves were calculated as the ratio of the exercise value to the resting value. Exercise SMBF and SMOEF values in the medial gastrocnemius muscle were lower in the two DM groups than in the non-DM group ( p 〈 0.05). The SMBF reserve in medial gastrocnemius was significantly lower in the DM, ABI ⩾ 1.3 group compared to the DM, ABI 〈 1.3 group ( p 〈 0.05). This study demonstrates that people with DM and calcified arteries had lower perfusion in gastrocnemius muscle compared to those without DM and those with DM and a normal ABI.
    Type of Medium: Online Resource
    ISSN: 1358-863X , 1477-0377
    URL: Article
    DOI: 10.1177/1358863X21996465
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2027562-6
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  • 12
    Online Resource
    Online Resource
    Thermodynamic properties of cotton dyeing with indigo dyes in non-aqueous media of liquid paraffin and D5
    SAGE Publications ; 2021
    In:  Textile Research Journal Vol. 91, No. 21-22 ( 2021-11), p. 2692-2704
    Details
    In: Textile Research Journal, SAGE Publications, Vol. 91, No. 21-22 ( 2021-11), p. 2692-2704
    Abstract: On the basis of investigation into the dyeing equilibrium of cotton fibers with indigo dyes in decamethylcyclopentasiloxane (D5), liquid paraffin and water, the thermodynamic properties of cotton dyeing with indigo dyes in non-aqueous medium systems were studied in comparison with aqueous dyeing. The main works involved are as follows: firstly, the adsorption isotherms were created; then, the three theoretical adsorption models of Nernst, Langmuir and Freundlich were used to fit the adsorption isotherms created; finally, the thermodynamic parameters were calculated. The results showed that the adsorption isotherms were all in line with the Freundlich model. The order of dyeing affinity was in the sequence: liquid paraffin  〉  D5  〉  water. The dyeing entropy in the three media showed positive values, which is mainly attributed to the adsorption of both indigo-leuco and water onto cotton fibers, thus reducing the ice-like structure formed among the water molecules in the dyeing system and the hydrophobic bonding structure formed among the non-aqueous medium molecules, then leading to an increase in the system disorder. The dyeing heat in the three media also showed positive values, due mainly to the absorption of thermal energy to “melt” the ice-like structure and to “break” the hydrophobic bonding structure. These dyeing thermodynamic properties are conducive to understanding and interpreting the dyeing performance and behavior of indigo dyes in non-aqueous dyeing systems.
    Type of Medium: Online Resource
    ISSN: 0040-5175 , 1746-7748
    URL: Article
    DOI: 10.1177/00405175211011773
    RVK:
    ZS 0001
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2209596-2
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  • 13
    Online Resource
    Online Resource
    Clinical Effects and Safety of Electroacupuncture for the Treatment of Post-Stroke Depression: A Systematic Review and Meta-Analysis of Randomised Controlled Trials
    SAGE Publications ; 2018
    In:  Acupuncture in Medicine Vol. 36, No. 5 ( 2018-10), p. 284-293
    Details
    In: Acupuncture in Medicine, SAGE Publications, Vol. 36, No. 5 ( 2018-10), p. 284-293
    Abstract: The aim of this systematic review was to assess the efficacy/effectiveness and safety of electroacupuncture (EA) in the treatment of post-stroke depression (PSD). Methods A comprehensive literature search in the Pubmed, Embase, CENTRAL, ISI Web of Science, CNKI and Wanfang databases was conducted, and all relevant randomised controlled trials (RCTs) were screened for eligibility by two independent reviewers. The Cochrane Collaboration's tool and Jadad score were used to assess the risk of bias of included studies, and only RCTs scoring ≥3 were included in a meta-analysis. Results 18 RCTs involving a total of 813 participants (mean age 61.6 years) in the EA groups and 723 participants (mean age 61.9 years) in the control groups were included. The included studies had an average 3 point Jadad score. PSD was diagnosed according to the Chinese Classification of Cerebrovascular Disease (CCCD) and the Chinese Classification of Mental Disease (CCMD) criteria. There was no significant difference between EA and antidepressants (fluoxetine 10–40 mg/day, citalopram 20 mg/day, sertraline 50 mg/day) in terms of the Hamilton Depression Rating Scale (HAMD) scores at week 4 after treatment (standardised mean difference (SMD) −0.11, 95% CI −0.31 to 0.10), at week 6 after treatment (SMD 0.04, 95% CI −0.43 to 0.51) or at week 8 after treatment (SMD −0.01, 95% CI −0.23 to 0.22). However, the combined incidence of adverse events in the EA groups was significantly lower than in the antidepressant groups (RR 0.21, 95% CI 0.14 to 0.33). Conclusion There was no significant difference between EA and antidepressants in the severity of depression, however EA caused fewer adverse events than antidepressants. Additional larger scale RCTs with rigorous study design are required.
    Type of Medium: Online Resource
    ISSN: 0964-5284 , 1759-9873
    URL: Article
    DOI: 10.1136/acupmed-2016-011300
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2126127-1
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  • 14
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    Online Resource
    Facilitators of and barriers to implementing a traditional Chinese medicine collaborative model of care for axial spondyloarthritis: a qualitative study
    SAGE Publications ; 2021
    In:  Acupuncture in Medicine Vol. 39, No. 6 ( 2021-12), p. 629-636
    Details
    In: Acupuncture in Medicine, SAGE Publications, Vol. 39, No. 6 ( 2021-12), p. 629-636
    Abstract: Conventional therapy may be inadequate for many patients with axial spondyloarthritis (axSpA). Traditional Chinese medicine (TCM) may be a viable alternative, but its effectiveness for axSpA is unknown. We are currently conducting a pragmatic randomised controlled trial (RCT) to investigate the effectiveness of a TCM collaborative model of care (TCMCMC), which combines usual rheumatologic care with acupuncture for patients with axSpA. This nested qualitative sub-study aims to identify facilitators of and barriers to the implementation of the TCMCMC. Methods: We conducted individual in-depth interviews with participants who had completed the acupuncture regimen to elicit opinions on the facilitators of and barriers to the implementation of the TCMCMC. The interviews were transcribed and analysed using thematic analysis. Results: Twelve participants were included, with data saturation occurring after 10 interviews. The analysis revealed both a number of important ‘facilitators’ and ‘barriers’. Facilitators to the implementation of the TCMCMC included effectiveness of TCM to relieve symptoms, inadequacy of conventional treatment and positive social perceptions of TCM. Barriers included scepticism towards TCM, inability of TCM to provide instant relief, needle-related discomfort, variable effectiveness of TCM influenced by physicians’ skills and experience and the high cost of TCM. Recommendations to overcome barriers included further patient education about TCM. Conclusion: Policymakers should take into account the various feasibility factors identified in this study when developing and implementing a TCMCMC. Trial registration number: NCT03420404 (ClinicalTrials.gov)
    Type of Medium: Online Resource
    ISSN: 0964-5284 , 1759-9873
    URL: Article
    DOI: 10.1177/09645284211009543
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2126127-1
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  • 15
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    Online Resource
    Downregulation of miR-199a-3p in Hepatocellular Carcinoma and Its Relevant Molecular Mechanism via GEO, TCGA Database and In Silico Analyses
    SAGE Publications ; 2020
    In:  Technology in Cancer Research & Treatment Vol. 19 ( 2020-01-01), p. 153303382097967-
    Details
    In: Technology in Cancer Research & Treatment, SAGE Publications, Vol. 19 ( 2020-01-01), p. 153303382097967-
    Abstract: Existing reports have demonstrated that miR-199a-3p plays a role as a tumor suppressor in a variety of human cancers. This study aims to further validate the expression of miR-199a-3p in HCC and to explore its underlying mechanisms by using multiple data sets. Chip data or sequencing data and quantitative reverse transcription polymerase chain reaction (qRT-PCR) were integrated to assess the expression of miR-199a-3p in HCC. The potential targets and transcription factor regulatory network of miR-199a-3p in HCC were determined and possible biological mechanism of miR-199a-3p was analyzed with bioinformatics methods. In the results, miR-199a-3p expression was significantly lower in HCC tissues compared to normal tissues according to chip data or sequencing data and qRT-PCR. Moreover, 455 targets of miR-199a-3p were confirmed, and these genes were involved in the PI3K-Akt signaling pathway, pathways in cancer, and focal adhesions. LAMA4 was considered a key target of miR-199a-3p. In CMTCN, 11 co-regulatory pairs, 3 TF-FFLs, and 2 composite-FFLs were constructed. In conclusion, miR-199a-3p was down regulated in HCC and LAMA4 may be a potential target of miR-199a-3p in HCC.
    Type of Medium: Online Resource
    ISSN: 1533-0346 , 1533-0338
    URL: Article
    DOI: 10.1177/1533033820979670
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2146365-7
    detail.hit.zdb_id: 2220436-2
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  • 16
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    Online Resource
    Polymorphism of Rs9387478 Correlates with Overall Survival in Female Nonsmoking Patients with Lung Cancer
    SAGE Publications ; 2016
    In:  The International Journal of Biological Markers Vol. 31, No. 2 ( 2016-04), p. 144-152
    Details
    In: The International Journal of Biological Markers, SAGE Publications, Vol. 31, No. 2 ( 2016-04), p. 144-152
    Abstract: Our previous study identified rs9387478 as a new susceptibility locus associated with lung cancer in never-smoking women in Asia; however, the clinical and prognostic significance of this finding is not known. Methods We analyzed the relationship between the rs9387478 single nucleotide polymorphism and i) clinical parameters and ii) overall survival time in 505 female nonsmoking lung cancer patients, using the chi-square test and Kaplan-Meier analysis with the log-rank test, respectively. We further established the epidermal growth factor receptor (EGFR) mutation status and assessed its association with rs9387478 genotypes as well as the efficacy of EGFR tyrosine kinase inhibitors. Results The frequency of the AA genotype was significantly higher in the EGFR-mutation-negative group than in the EGFR-mutation-positive group (32% vs. 16%, χ 2 = 13.025, p = 0.011). Patients with the CC genotype had a better overall survival time than patients with the AA/AC genotype (median survival time: 54.2 vs. 32.9 months, χ 2 = 4.593, p = 0.032). The distribution of rs9387478 genotypes differed according to the clinical disease stage. Conclusions This study indicates that the rs9387478 genotype was associated with overall survival in nonsmoking female patients with lung cancer, although it was not significant after adjusting for multiple testing. The identification of the location of the rs9387478 single nucleotide polymorphism in the genomic interval containing the DCBLD1 and ROS1 genes, together with the finding that the rs9387478 polymorphism correlates with EGFR mutation status, may have important implications for therapeutic approaches targeting EGFR or ROS1 in patients with lung cancer.
    Type of Medium: Online Resource
    ISSN: 1724-6008 , 1724-6008
    URL: Article
    DOI: 10.5301/jbm.5000180
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 1475778-3
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  • 17
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    Effect of midazolam on delirium in critically ill patients: a propensity score analysis
    SAGE Publications ; 2022
    In:  Journal of International Medical Research Vol. 50, No. 4 ( 2022-04), p. 030006052210886-
    Details
    In: Journal of International Medical Research, SAGE Publications, Vol. 50, No. 4 ( 2022-04), p. 030006052210886-
    Abstract: To observe the association between exposure to midazolam within 24 hours prior to delirium assessment and the risk of delirium. Methods We performed a systematic cohort study with two sets of cohorts to estimate the relative risks of outcomes among patients administered midazolam within 24 hours prior to delirium assessment. Propensity score matching was performed to generate a balanced 1:1 matched cohort and identify potential prognostic factors. The outcomes included the odds of delirium, mortality, length of intensive care unit stay, length of hospitalization, and odds of being discharged home. Results A total of 78,364 patients were included in this study, of whom 22,159 (28.28%) had positive records. Propensity matching successfully balanced covariates for 9348 patients (4674 per group). Compared with no administration of midazolam, midazolam administration was associated with a significantly higher risk of delirium, higher mortality, and a longer intensive care unit stay. Patients treated with midazolam were relatively less likely to be discharged home. There was no significant difference in hospitalization duration. Conclusions Midazolam may be an independent risk factor for delirium in critically ill patients.
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    URL: Article
    DOI: 10.1177/03000605221088695
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2082422-1
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  • 18
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    Up-regulation of KLF17 expression increases the sensitivity of gastric cancer to 5-fluorouracil
    SAGE Publications ; 2021
    In:  International Journal of Immunopathology and Pharmacology Vol. 35 ( 2021-01), p. 205873842110109-
    Details
    In: International Journal of Immunopathology and Pharmacology, SAGE Publications, Vol. 35 ( 2021-01), p. 205873842110109-
    Abstract: It has been reported that the expression of Krüppel-like factor 17 (KLF17) was associated with the occurrence, development, invasion, metastasis and chemotherapy resistance of various tumors. However, the detailed mechanisms by which KLF17 promotes chemotherapy resistance in gastric cancer (GC) have not been fully investigated. In the present study, we collected the GC tissues and non-tumor tissues (matched adjacent normal tissues with corresponding GC tissues) of 60 GC patients, used qRT-PCR, Western blot and immunohistochemistry assay to analyze the relationship between the expression of KLF17 and the clinical pathological data of the patients. The effect of KLF17 on the sensitivity of GC cell lines to 5-fluorouracil (5-FU), and the potential mechanism were detected by MTS assay, Flow cytometry assay, and Western blot. Compared with non-tumor tissues, the expression level of KLF17 in GC tissue was significantly down-regulated, and the expression level of KLF17 in GES-1 cell line and GC cell lines also had a similar trend. Down-regulated expression of KLF17 is related to tumor size, invasion, regional lymph node metastasis, and TNM staging. Furthermore, through upregulating the expression of KLF17, the sensitivity of BGC-823 and SGC-7901 cell lines to 5-FU was obviously increased. Mechanistically, upregulation the expression of KLF17 can inhibit the expressions of P-glycoprotein (P-gp), multidrug resistance protein 1 (MRP1), and B-Cell lymphoma-2 (BCL-2), which have been reported to be associated with drug resistance and cell proliferation. Collectively, these data implied that KLF17 has the biological effect of inhibiting chemotherapy resistance of GC, and it could be a potential strategy for the GC chemotherapy resistance.
    Type of Medium: Online Resource
    ISSN: 2058-7384 , 2058-7384
    URL: Article
    DOI: 10.1177/20587384211010925
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2505963-4
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  • 19
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    Application of the intrinsic time-scale decomposition method to fault diagnosis of wind turbine bearing
    SAGE Publications ; 2012
    In:  Journal of Vibration and Control Vol. 18, No. 2 ( 2012-02), p. 240-245
    Details
    In: Journal of Vibration and Control, SAGE Publications, Vol. 18, No. 2 ( 2012-02), p. 240-245
    Abstract: A fault diagnosis method of wind turbine bearing based on intrinsic time-scale decomposition (ITD) is put forward. In the proposed method, the vibration signal of the main bearing is decomposed into several proper rotation components by the ITD method. The frequency centers of the proper rotation components that contain predominant energy are computed and considered as fault feature vectors. The nearest neighbor algorithm is applied to identify the fault types of the wind turbine bearing. The experimental data of the wind turbine spherical roller bearing in four conditions (normal, outer race fault, inner race fault and roller fault) are applied to evaluate the performance of the proposed method. The results demonstrate the feasibility and accuracy of this approach for the diagnosis of the wind turbine bearing faults under uncertain conditions.
    Type of Medium: Online Resource
    ISSN: 1077-5463 , 1741-2986
    URL: Article
    DOI: 10.1177/1077546311403185
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2012
    detail.hit.zdb_id: 2070247-4
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  • 20
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    The evaluation of potential for the exploration and development of coalbed methane resources based on an improved uncertainty measure optimization model
    SAGE Publications ; 2019
    In:  Energy Exploration & Exploitation Vol. 37, No. 1 ( 2019-01), p. 315-331
    Details
    In: Energy Exploration & Exploitation, SAGE Publications, Vol. 37, No. 1 ( 2019-01), p. 315-331
    Abstract: The recognition criteria of credible degree in uncertainty measure theory are improved based on the concept of distance discriminant and used to evaluate the potential for exploration and development of coalbed methane. This paper uses a systematic approach to establish a mathematical model based on entropy weight and improved uncertainty measure theory. In this model, uncertainty influence factors were analyzed qualitatively and quantitatively using data for the Muli coalfield of Qinghai province, China. The uncertainty measure function is based on experimental data, and the weight of index is determined by entropy weight theory. Optimization credible degree recognition criteria were used to evaluate the potential for coalbed methane exploration and development of six mines in the Muli coalfield. These data indicate that evaluation results obtained using entropy weight and improved uncertainty measure theory have practical application and can effectively assess the exploration and development potential of coalbed methane in a coal basin.
    Type of Medium: Online Resource
    ISSN: 0144-5987 , 2048-4054
    URL: Article
    DOI: 10.1177/0144598718797099
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2026571-2
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