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  • 11
    Online Resource
    Online Resource
    Running ahead of evolution—AI-based simulation for predicting future high-risk SARS-CoV-2 variants
    SAGE Publications ; 2023
    In:  The International Journal of High Performance Computing Applications
    Details
    In: The International Journal of High Performance Computing Applications, SAGE Publications
    Abstract: The never-ending emergence of SARS-CoV-2 variations of concern (VOCs) has challenged the whole world for pandemic control. In order to develop effective drugs and vaccines, one needs to efficiently simulate SARS-CoV-2 spike receptor-binding domain (RBD) mutations and identify high-risk variants. We pretrain a large protein language model with approximately 408 million protein sequences and construct a high-throughput screening for the prediction of binding affinity and antibody escape. As the first work on SARS-CoV-2 RBD mutation simulation, we successfully identify mutations in the RBD regions of 5 VOCs and can screen millions of potential variants in seconds. Our workflow scales to 4096 NPUs with 96.5% scalability and 493.9× speedup in mixed-precision computing, while achieving a peak performance of 366.8 PFLOPS (reaching 34.9% theoretical peak) on Pengcheng Cloudbrain-II. Our method paves the way for simulating coronavirus evolution in order to prepare for a future pandemic that will inevitably take place. Our models are released at https://github.com/ZhiweiNiepku/SARS-CoV-2_mutation_simulation to facilitate future related work.
    Type of Medium: Online Resource
    ISSN: 1094-3420 , 1741-2846
    URL: Article
    DOI: 10.1177/10943420231188077
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2017480-9
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  • 12
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    Simulation of the effect of nonuniform fouling thickness on an axial compressor stage performance
    SAGE Publications ; 2021
    In:  Advances in Mechanical Engineering Vol. 13, No. 7 ( 2021-07), p. 168781402110304-
    Details
    In: Advances in Mechanical Engineering, SAGE Publications, Vol. 13, No. 7 ( 2021-07), p. 168781402110304-
    Abstract: This paper focuses on the numerical simulation of the flow status in the compressor with the condition of fouling. NASA stage 35 was considered as the object, and the commercial code ANSYS CFX was used. The deposition rate of contaminants on the surface was considered to be different along the height of the blade. A data from related study shows that the deposition rate of the contaminant on the side close to the hub is higher than the side near the shroud part. Based on the deposition law, this paper simulated the fouling of the compressor blades by changing the thickness on the blade surface. This subject only changed the thickness of the stator blade surface because of a data showing that the fouling on the stator blade surface is almost double that on the rotor blade surface. In the condition that the roughness value of the blade surface is constant, only the stable working range of the compressor is effected by the change of the surface thickness of the stator blade. There is a positive relationship between the value of compressor minimum flow rate and the value of thickness increment. After fouling the total pressure ratio and isentropic efficiency degenerated 1.59% and 3.76%, respectively.
    Type of Medium: Online Resource
    ISSN: 1687-8140 , 1687-8140
    URL: Article
    DOI: 10.1177/16878140211030403
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2501620-9
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  • 13
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    Molecular fingerprint of precancerous lesions in breast atypical hyperplasia
    SAGE Publications ; 2020
    In:  Journal of International Medical Research Vol. 48, No. 6 ( 2020-06), p. 030006052093161-
    Details
    In: Journal of International Medical Research, SAGE Publications, Vol. 48, No. 6 ( 2020-06), p. 030006052093161-
    Abstract: To identify atypical hyperplasia (AH) of the breast by shell-isolated nanoparticle-enhanced Raman spectroscopy (SHINERS), and to explore the molecular fingerprinting characteristics of breast AH. Methods Breast hyperplasia was studied in 11 hospitals across China from January 2015 to December 2016. All patients completed questionnaires on women’s health. The differences between patients with and without breast AH were compared. AH breast lesions were detected by Raman spectroscopy followed by the SHINERS technique. Results There were no significant differences in clinical features and risk-related factors between patients with breast AH (n = 37) and the control group (n = 2576). Fifteen cases of breast AH lesions were detected by Raman spectroscopy. The main different Raman peaks in patients with AH appeared at 880, 1001, 1086, 1156, 1260, and 1610 cm −1 , attributed to the different vibrational modes of nucleic acids, β-carotene, and proteins. Shell-isolated nanoparticles had different enhancement effects on the nucleic acid, protein, and lipid components in AH. Conclusion Raman spectroscopy can detect characteristic molecular changes in breast AH lesions, and may thus be useful for the non-invasive early diagnosis and for investigating the mechanism of tumorigenesis in patients with breast AH.
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    URL: Article
    DOI: 10.1177/0300060520931616
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2082422-1
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  • 14
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    Current status of aspiration thrombectomy for acute stroke patients in China: data from ANGEL-ACT Registry
    SAGE Publications ; 2021
    In:  Therapeutic Advances in Neurological Disorders Vol. 14 ( 2021-01), p. 175628642110077-
    Details
    In: Therapeutic Advances in Neurological Disorders, SAGE Publications, Vol. 14 ( 2021-01), p. 175628642110077-
    Abstract: Although noninferior to stent retriever (SR) as first-line approach for endovascular treatment (EVT) of acute large vessel occlusion (LVO) stroke, little is known about the current status of direct aspiration (DA) as first-line thrombectomy in China. This analysis of a prospective, nationwide registry (ANGEL-ACT) aimed to investigate the prevalence and comparative effectiveness of DA-first thrombectomy in a real-world practice in China. Methods: All patients receiving thrombectomy were screened from a prospective cohort of LVO patients undergoing EVT at 111 hospitals in China between November 2017 and March 2019, and divided into two groups based upon which type of thrombectomy was attempted first (“DA-first” and “SR-first”). The following outcome measures were compared using logistic regression models with adjustment: successful recanalization after first-device alone and all procedures, use of rescue treatment, intracranial hemorrhage (ICH) within 24 h, and modified Rankin Scale (mRS) score at 90 days. Results: A total of 1225 patients, 102 (8.3%) in DA-first group and 1123 (91.7%) in SR-first group, were included. Patients receiving DA-first had less often successful recanalization after first-device alone [30.4 versus 66.4%; odds ratio (OR) = 0.23, 95% confidence interval (CI) = 0.15–0.37], more frequent rescue treatment (62.8 versus 27.0%; OR = 4.55, 95% CI = 2.92–7.08) and ICH (35.4 versus 22.1%; OR = 1.78, 95% CI = 1.12–2.83) than those receiving SR-first; however, no significant difference was found in successful recanalization after all procedures (84.3 versus 90.3%; p = 0.18) and 90-day mRS (median: 3 versus 3 points; p = 0.90) between both groups. Conclusion: This real-world registry suggested that DA-first thrombectomy for acute stroke patients lagged behind in China during the study period. Far fewer DA-first than SR-first thrombectomies were performed, and DA-first was associated with lower first-device recanalization, more frequently requiring rescue treatment, and increased ICH risk. Clinical Trial Registration: ClinicalTrials.gov , NCT03370939.
    Type of Medium: Online Resource
    ISSN: 1756-2864 , 1756-2864
    URL: Article
    DOI: 10.1177/17562864211007715
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2442245-9
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  • 15
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    An open label, safety study of Asian patients with advanced non-small-cell lung cancer receiving second-line nivolumab monotherapy (CheckMate 870)
    SAGE Publications ; 2022
    In:  Therapeutic Advances in Medical Oncology Vol. 14 ( 2022-01), p. 175883592211383-
    Details
    In: Therapeutic Advances in Medical Oncology, SAGE Publications, Vol. 14 ( 2022-01), p. 175883592211383-
    Abstract: Nivolumab has been approved in China as second-line treatment for advanced non-small-cell lung cancer (NSCLC) via weight-based infusion, based on the CheckMate 078 study. We investigated the safety and efficacy of 240 mg flat-dose nivolumab in patients with advanced NSCLC, including those with hepatitis B virus (HBV) and epidermal growth factor receptor ( EGFR) mutation/ALK receptor tyrosine kinase ( ALK) translocation due to high prevalence in China. Methods: CheckMate 870 was a single-arm, open-label, phase IIIb trial in Asian (primarily Chinese) patients with previously treated advanced NSCLC. Patients received flat-dose nivolumab 240 mg every 2 weeks (Q2W) for up to 2 years. The primary endpoint was the incidence and severity of treatment-related select adverse events (TRsAEs) in non-HBV patients; secondary and exploratory endpoints included severity of high-grade TRsAEs in HBV-infected patients, and safety, efficacy and patient-reported outcomes (PROs) in the whole population. Results: Out of 404 patients enrolled, 400 received treatment. Median (standard deviation) age was 60.5 (8.68) years and the majority were male (78.5%). At a median follow-up of 37.6 months, no Grade 5 TRsAEs were reported, and the frequency of Grade 3–4 TRsAEs was low (0.0–5.9%) in non-HBV and HBV NSCLC patients. Median overall survival (OS) and progression-free survival (PFS) in all treated patients were 14.7 (12.3–18.1) and 3.6 (2.3–3.8) months, respectively. Median OS was 14.2 (12.3–18.1) and 22.3 (10.0–NA) months for non-HBV and HBV-infected patients, 19.3 (11.2–31.7) and 13.7 (11.5–18.1) months for EGFR-positive and wild-type subgroups, and 19.3 (12.9–23.5) and 13.3 (10.9–17.7) months for those with programmed death-ligand 1 (PD-L1) expression ⩾1% and 〈 1%, respectively. No notable changes from baseline were observed in PROs throughout the study. Conclusion: Nivolumab 240 mg infusion Q2W was well tolerated, efficacious, and maintained health status and quality of life in Asian patients with previously treated advanced NSCLC regardless of HBV, EGFR, or PD-L1 status.
    Type of Medium: Online Resource
    ISSN: 1758-8359 , 1758-8359
    URL: Article
    DOI: 10.1177/17588359221138380
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2503443-1
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  • 16
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    Spillover and Re-Spillover in China’s Collaborative Innovation
    SAGE Publications ; 2023
    In:  International Regional Science Review Vol. 46, No. 1 ( 2023-01), p. 38-68
    Details
    In: International Regional Science Review, SAGE Publications, Vol. 46, No. 1 ( 2023-01), p. 38-68
    Abstract: The spillover effect serves as the basis of regional collaborative innovation. Existing research on innovation spillover focuses on the overall impact of a region's innovation factors on local and other regions' innovation activities. However, re-spillover may occur since the flow of innovation factors between any two regions may influence the innovation in third-party regions. This study quantifies labor flow, capital flow, and institutional learning between regions in China using a gravity model and a social network analysis model, and then applies a spatial econometric model to investigate innovation spillover and re-spillover. The results show that re-spillover can better explain levels of regional innovation. Capital, government support, labour flow, capital flow, and institutional learning have a positive spillover effect on local innovation, while labour flow also has positive spillover effects to other regions.
    Type of Medium: Online Resource
    ISSN: 0160-0176 , 1552-6925
    URL: Article
    DOI: 10.1177/01600176221092315
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2011485-0
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  • 17
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    Transplantation of Sertoli-Islet Cell Aggregates Formed by Microgravity: Prolonged Survival in Diabetic Rats
    SAGE Publications ; 2009
    In:  Experimental Biology and Medicine Vol. 234, No. 5 ( 2009-05), p. 595-603
    Details
    In: Experimental Biology and Medicine, SAGE Publications, Vol. 234, No. 5 ( 2009-05), p. 595-603
    Abstract: Transplantation of pancreatic islets is a potentially attractive treatment for type I diabetes. We generated the transplantable, tissue-like aggregates composed of Sertoli cells and islets in rotating wall vessel bioreactors, SICA (Sertoli-islet cell aggregates), to improve their biological function in vitro and in vivo. The isolated islet equivalent and Sertoli cells were purified from Wistar rats and cocultured for 5 days in bioreactor to generate SICA. The SICA, islets aggregates, and fresh isolated islets were transplanted under the kidney capsule of diabetic Sprague-Dawley (SD) rats, respectively. The functions of different grafts were ascertained by blood glucose level measurements and an in vivo glucose tolerance test. In response to elevated glucose, insulin secretion from SICA was 1.4-fold higher ( P 〈 0.05, n = 5) than islet aggregates cultured alone. Of the rats that received SICA, 90% (9/10) remained normoglycemic at 60 days post-transplantation, and the survival significantly increased compared with recipients bearing homotypic islets aggregates or freshly isolated islets. The former responded similarly with healthy rats to the glucose tolerance test. Our results support the usefulness of SICA for the treatment of type 1 diabetes without any immunosuppressive agents.
    Type of Medium: Online Resource
    ISSN: 1535-3702 , 1535-3699
    URL: Article
    DOI: 10.3181/0812-RM-359
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2009
    detail.hit.zdb_id: 2020856-X
    SSG: 12
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  • 18
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    Intravenous dexmedetomidine versus intravenous clonidine for post spinal anesthesia shivering: a meta-analysis of randomized controlled trials
    SAGE Publications ; 2020
    In:  Scottish Medical Journal Vol. 65, No. 3 ( 2020-08), p. 94-102
    Details
    In: Scottish Medical Journal, SAGE Publications, Vol. 65, No. 3 ( 2020-08), p. 94-102
    Abstract: Dexmedetomidine and clonidine are the most extensively studied drugs for shivering treatment, because α 2 -adrenergic agonists can reduce the shivering threshold. The objective of this meta-analysis was to compare the efficacy and complications of dexmedetomidine with those of clonidine, when used for control of post spinal anesthesia shivering. Methods Electronic databases were searched for randomized controlled trials (RCT) comparing the effect of dexmedetomidine versus clonidine for control of post spinal anesthesia shivering. The endpoints were effective rate of shivering treatment, time to cease shivering, recurrent rate of shivering and complications. Results Six studies comprising 340 adult patients were included in this meta-analysis. Dexmedetomidine had higher effective rate of shivering treatment (odds ratio [OR]: 4.11, 95% confidence interval (CI): [1.53, 11.07] , P = 0.005), shorter time to cease shivering (Mean differences (MD)=–1.91; 95% CI [–3.66, –0.15], P = 0.03), lower recurrent rate of shivering (OR = 0.30; 95% CI [0.12, 0.75] , P = 0.01), compared to clonidine. Dexmedetomidine had a lower rate of hypotension and higher incidence of sedation than clonidine. Conclusions Dexmedetomidine is superior to clonidine when used for shivering treatment after spinal anesthesia, because of higher incidence of effective rate and sedation, faster control of shivering, lower incidence of recurrent rate and hypotention.
    Type of Medium: Online Resource
    ISSN: 0036-9330 , 2045-6441
    URL: Article
    DOI: 10.1177/0036933020936283
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2141765-9
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  • 19
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    bHLH13 Regulates Jasmonate-Mediated Defense Responses and Growth
    SAGE Publications ; 2018
    In:  Evolutionary Bioinformatics Vol. 14 ( 2018-01), p. 117693431879026-
    Details
    In: Evolutionary Bioinformatics, SAGE Publications, Vol. 14 ( 2018-01), p. 117693431879026-
    Type of Medium: Online Resource
    ISSN: 1176-9343 , 1176-9343
    URL: Article
    DOI: 10.1177/1176934318790265
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2227610-5
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  • 20
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    Association of blood pressure in the supine position with target organ damage in subjects over 60 years old
    SAGE Publications ; 2017
    In:  Journal of International Medical Research Vol. 45, No. 1 ( 2017-02), p. 123-133
    Details
    In: Journal of International Medical Research, SAGE Publications, Vol. 45, No. 1 ( 2017-02), p. 123-133
    Abstract: Toexplore the correlation between blood pressure in the supine position and target organ damage in subjects over 60 years of age. Methods In 2444 individuals, we investigated the association of systolic blood pressure (SBP) in the supine position with the target organ damage indices microalbuminuria (ALBU), brachial–ankle pulse wave velocity (baPWV), and carotid intima–media thickness (IMT). Supine hypertension (SH) is defined as systolic blood pressure ≥ 140 mmHg and/or diastolic blood pressure ≥ 90 mmHg. Subjects were assigned to either the SH group (1275 cases) or the non-SH group (1169 cases). Results The levels of ALBU, baPWV, and IMT, as well as the percentage of participants with ALBU  〉  30 mg/L, baPWV ≥ 1400 cm/s, and IMT ≥ 1 mm, were significantly higher in the SH group than in the non-SH group. Multivariate logistic regression analysis showed that SH was an independent risk factor for baPWV and IMT, but the relationship with ALBU was not statistically significant after correction for confounding factors. Conclusions SH is a risk factor for target organ damage, as expressed by the indices baPWV and IMT. The association of SH with kidney damage requires further study.
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    URL: Article
    DOI: 10.1177/0300060516677175
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2082422-1
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