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  • 11
    Online Resource
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    Manual or Computer-Based Literature Searches: Is One Best for Pharmacovigilance?
    SAGE Publications ; 1991
    In:  DICP Vol. 25, No. 2 ( 1991-02), p. 214-215
    Details
    In: DICP, SAGE Publications, Vol. 25, No. 2 ( 1991-02), p. 214-215
    Type of Medium: Online Resource
    ISSN: 1042-9611
    URL: Article
    DOI: 10.1177/106002809102500225
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1991
    detail.hit.zdb_id: 2053518-1
    SSG: 15,3
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  • 12
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    Patterns of Laxative Use in Self-Medication
    SAGE Publications ; 2009
    In:  Annals of Pharmacotherapy Vol. 43, No. 12 ( 2009-12), p. 2122-2123
    Details
    In: Annals of Pharmacotherapy, SAGE Publications, Vol. 43, No. 12 ( 2009-12), p. 2122-2123
    Type of Medium: Online Resource
    ISSN: 1060-0280 , 1542-6270
    URL: Article
    DOI: 10.1345/aph.1M019
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2009
    detail.hit.zdb_id: 2053518-1
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  • 13
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    The Paradox of Controversial Innovation: Insights From the Rise of Impressionism
    SAGE Publications ; 2017
    In:  Organization Studies Vol. 38, No. 5 ( 2017-05), p. 597-618
    Details
    In: Organization Studies, SAGE Publications, Vol. 38, No. 5 ( 2017-05), p. 597-618
    Abstract: This article considers the strategies developed by a coalition of innovators and supporters to contribute to the consecration of a controversial innovation that transgresses the established codes. It does so through the analysis of Impressionism (1874–1900) that provoked a dramatic shift from classical to modern art. The case study suggests that such consecration can be achieved while claiming the distinctiveness of the controversial innovation, instead of toning it down. The findings reveal the importance of distributed strategies developed by loosely coordinated coalition members. More specifically, they point to simultaneous, and potentially contradictory, strategies: strategies aimed to enforce the distinctiveness of this controversial innovation, and strategies aimed to extend support for it, insisting that contradictory tensions between those strategies can prove useful in achieving consecration. Overall, the article contributes to research on the consecration of controversial innovations, as well as to the literature on framing and brokerage.
    Type of Medium: Online Resource
    ISSN: 0170-8406 , 1741-3044
    URL: Article
    DOI: 10.1177/0170840616663237
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2050342-8
    detail.hit.zdb_id: 136437-6
    SSG: 3,4
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  • 14
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    Olfactory Bulb Volume in Patients with Sinonasal Disease
    SAGE Publications ; 2008
    In:  American Journal of Rhinology Vol. 22, No. 6 ( 2008-11), p. 598-601
    Details
    In: American Journal of Rhinology, SAGE Publications, Vol. 22, No. 6 ( 2008-11), p. 598-601
    Abstract: The aim of this study was to assess the volume of the olfactory bulb (OB) in patients with chronic rhinosinusitis (without nasal polyposis at the endoscopic evaluation) and to evaluate the correlation between this measure and the degree of sinonasal inflammation. Methods Patients with sinonasal disease (SND; n = 22) were compared with healthy controls (n = 16) using orthonasal and retronasal olfactory test results and OB volumes measurement calculated by planimetric manual contouring using standardized methods. The Lund-Mackay score (originally described for CT scan) was also used to gauge sinonasal inflammation (SND score). Results The two groups were not significantly different in terms of age or distribution of sex. Patients had significantly higher right- and left-sided SND scores than controls. There was no significant group difference between patients and controls with regard to OB volume. However, patients with an SND score ≥12 had larger OB volumes than patients with higher SND scores (p 〈 0.001). Even when controlling for the subjects’ age, a significant correlation was present between OB volume and SND score (r =-0.52; p = 0.001) with smaller OB volumes being associated with a higher degree of sinonasal pathology. Conclusion OB volume correlated with the SND score, which is an indicator of the degree of sinonasal inflammation. SND patients with a slight decrease or even normal olfactory function may already exhibit changes in their OB volume. This study also seems to emphasize the idea that OB volume changes are more sensitive to subtle changes in the olfactory system than results from psychophysical testing.
    Type of Medium: Online Resource
    ISSN: 1050-6586 , 1539-6290
    URL: Article
    DOI: 10.2500/ajr.2008.22.3237
    RVK:
    XA 20278
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2008
    detail.hit.zdb_id: 2083922-4
    detail.hit.zdb_id: 2554548-6
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  • 15
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    Is Hyperprolinemia Type I Actually a Benign Trait? Report of a Case With Severe Neurologic Involvement and Vigabatrin Intolerance
    SAGE Publications ; 2001
    In:  Journal of Child Neurology Vol. 16, No. 8 ( 2001-08), p. 622-623
    Details
    In: Journal of Child Neurology, SAGE Publications, Vol. 16, No. 8 ( 2001-08), p. 622-623
    Abstract: Hyperprolinemia type I is a deficiency of proline oxidase (McKusick 23950), leading to hyperprolinemia and iminoglycinuria, usually with renal involvement. Hyperprolinemia type I is considered a benign trait. We reported a case of hyperprolinemia type I with a severe neurologic disorder and without renal involvement. The patient had marked psychomotor delay and right hemiparesis. Epilepsy was characterized by status epilepticus or a cluster of seizures. Laboratory findings revealed elevated levels of proline in the serum, urine, and cerebrospinal fluid without Δ 1 -pyrroline 5-carboxylate dehydrogenase in the plasma or urine. Fluorescence in situ hybridization excluded a chromosome 22q11 deletion. Vigabatrin inhibits ornithine transaminase. Thus, vigabatrin could lead to a depletion of the normal pool of pyrroline 5-carboxylate dehydrogenase and could aggravate the clinical condition of the child. In this study, vigabatrin was discontinued. In the following months, the patient had marked psychomotor improvement, without modification of the epilepsy. We suggest that vigabatrin should be avoided in hyperprolinemia type I. (J Child Neurol 2001; 16:622-623)
    Type of Medium: Online Resource
    ISSN: 0883-0738 , 1708-8283
    URL: Article
    DOI: 10.1177/088307380101600820
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2001
    detail.hit.zdb_id: 2068710-2
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  • 16
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    Biochemical Studies on Acute Inflammation : II. The Effect of Dilantin
    SAGE Publications ; 1957
    In:  Journal of Dental Research Vol. 36, No. 6 ( 1957-12), p. 927-931
    Details
    In: Journal of Dental Research, SAGE Publications, Vol. 36, No. 6 ( 1957-12), p. 927-931
    Type of Medium: Online Resource
    ISSN: 0022-0345 , 1544-0591
    URL: Article
    DOI: 10.1177/00220345570360061801
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1957
    detail.hit.zdb_id: 2057074-0
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  • 17
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    Specific Changes of Erythroid Regulators and Hepcidin in Patients Infected by SARS-COV-2
    SAGE Publications ; 2022
    In:  Journal of Investigative Medicine Vol. 70, No. 4 ( 2022-04), p. 934-938
    Details
    In: Journal of Investigative Medicine, SAGE Publications, Vol. 70, No. 4 ( 2022-04), p. 934-938
    Abstract: Iron metabolism is tightly linked to infectious and inflammatory signals through hepcidin synthesis. To date, iron homeostasis during SARS-CoV-2 infection has not yet been described. The aim of this study is to characterize the hepcidin and erythroid regulators (growth differentiation factor 15 (GDF-15) and erythroferrone (ERFE)) by measuring concentrations in plasma in context of COVID-19 disease. We performed a single-center observational study of patients with COVID-19 to evaluate concentrations of main regulatory proteins involved in iron homeostasis, namely: hepcidin, ERFE and GDF-15. SARS-CoV-2 infection (COVID-19 + ) was defined by a positive RT-PCR. Sixteen patients with COVID-19 + were gender-matched and age-matched to 16 patients with a sepsis unrelated to SARS-CoV-2 (COVID-19 − ) and were compared with non-parametric statistic test. Clinical and hematological parameters, plasma iron, transferrin, transferrin saturation, ferritin, soluble transferrin receptor and C reactive protein were not statistically different between both groups. Median plasma hepcidin concentrations were higher in the COVID-19 + group (44.1 (IQR 16.55–70.48) vs 14.2 (IQR 5.95–18.98) nmol/L, p=0.003), while median ERFE and GDF-15 concentrations were lower in the COVID-19 + group (0.16 (IQR 0.01–0.73) vs 0.89 (IQR 0.19–3.82) ng/mL, p=0.035; 2003 (IQR 1355–2447) vs 4713 (IQR 2082–7774) pg/mL, p=0015), respectively) compared with the COVID-19 − group. This is the first study reporting lower ERFE and GDF-15 median concentrations in patients with COVID-19 + compared with patients with COVID-19 − , associated with an increased median concentration of hepcidin in the COVID-19 + group compared with COVID19 − group.
    Type of Medium: Online Resource
    ISSN: 1081-5589 , 1708-8267
    URL: Article
    DOI: 10.1136/jim-2021-002270
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
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  • 18
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    Antiretroviral Efficacy and Virological Profile of a Zidovudine/Lamivudine/Tenofovir Disoproxil Fumarate Combination Therapy in Antiretroviral-Naive Patients
    SAGE Publications ; 2006
    In:  Antiviral Therapy Vol. 11, No. 6 ( 2006-08), p. 827-830
    Details
    In: Antiviral Therapy, SAGE Publications, Vol. 11, No. 6 ( 2006-08), p. 827-830
    Abstract: To study the antiviral efficacy and the mutations selected by a triple therapy with zidovudine (AZT), lamivudine (3TC) and tenofovir disoproxil fumarate (TDF). Methods Antiretroviral-naive patients received 300 mg AZT/150 mg 3TC twice a day plus 300 mg TDF once a day in an open pilot study. Follow-up was assessed at baseline therapy (M0) and at months 1, 3, 6, 9 and 12. Reverse transcriptase (RT) genotypic resistance analysis and in selected cases, a recombinant drug susceptibility and replication capacity assay were performed from plasma RNA at baseline and in case of virological failure (VF); that is, rebound of viral load 〉 50 copies/ml on therapy. Results Twenty-four patients were included. At baseline, the median CD4 + T-cell count was 443 cells/μl and the median plasma viral load (VL) was 4.38 log 10 copies/ml. RT resistance mutations were observed at M0 in 4 patients. At M12, the proportion of patients with a VL 〈 50 copies/ml reached 88% using an on-treatment analysis and 67% with an intent-to-treat analysis. The median increase in CD4 + T cells at M12 was 94 cells/μl. Four patients had a VF on therapy: two with wild-type viruses, one with selection of M184V and thymidine analogue mutations (TAMs) on a background of TAMs, and one with selection of K65R and M184V, with a replication capacity at 2.4%. Conclusion The virological response in our study demonstrates the antiviral efficacy of the AZT/3TC/TDF combination therapy, which needs further evaluation. The moderate frequency of selection of K65R could be due to the presence of AZT in the regimen.
    Type of Medium: Online Resource
    ISSN: 1359-6535 , 2040-2058
    URL: Article
    DOI: 10.1177/135965350601100615
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2006
    detail.hit.zdb_id: 2118396-X
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  • 19
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    Resected EGFR -mutated non-small-cell lung cancers: incidence and outcomes in a European population (GFPC Exerpos Study)
    SAGE Publications ; 2024
    In:  Therapeutic Advances in Medical Oncology Vol. 16 ( 2024-01)
    Details
    In: Therapeutic Advances in Medical Oncology, SAGE Publications, Vol. 16 ( 2024-01)
    Abstract: Few epidemiological data are available on surgically treated Caucasian patients with non-small-cell lung cancers (NSCLCs) harboring epidermal growth factor receptor ( EGFR) mutations. The main objective of this study was to describe, in the real-world setting, these patients’ incidence, clinical, and tumoral characteristics. Methods: The participating centers included all consecutive localized non-squamous NSCLC patients undergoing surgery between January 2018 and December 2019 in France. EGFR status was determined retrospectively when not available before surgery. Results: The study includes 1391 no squamous NSCLC patients from 16 centers; EGFR status was determined before surgery in 692 (49.7%) of the cases and conducted as part of the study for 699 (50.3%); 171 (12.3%) were EGFR mutated; median age: 70 (range: 36–88) years; female: 59.6%; never smokers: 75.7%; non-squamous histology 97.7%, programmed death ligand-1 expression 0%/1–49%/⩾50 in 60.5%/25.7%/13.8%, respectively. Surgery was predominantly lobectomy (81%) or segmentectomy (14.9%), with systematic lymph node dissection in 95.9%. Resection completeness was R0 for 97%. Post-surgery staging was as follows: IA: 52%, IB: 16%, IIA: 4%, IIB: 10%, IIIA: 16%, and IIIB: 0.05%; EGFR mutation exon was Del19/exon 21 ( L858R)/20/18 in 37.4%/36.8%/14%, and 6.4% of cases, respectively; 31 (18%) patients received adjuvant treatment (chemotherapy: 93%, EGFR tyrosine kinase inhibitor: 0%, radiotherapy: 20%). After a median follow-up of 31 (95% confidence interval: 29.6–33.1) months, 45 (26%) patients relapsed: 11/45 (24%) locally and 34 (76%) with metastatic progression. Median disease-free survival (DFS) and overall survival were not reached and 3-year DFS was 60%. Conclusion: This real-world analysis provides the incidence and outcomes of resected EGFR-mutated NSCLCs in a European patient cohort.
    Type of Medium: Online Resource
    ISSN: 1758-8359 , 1758-8359
    URL: Article
    DOI: 10.1177/17588359241236451
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2024
    detail.hit.zdb_id: 2503443-1
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  • 20
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    Synthesis of three dissymmetrical pentaamines via bisaminals of linear tetraamines
    SAGE Publications ; 2006
    In:  Journal of Chemical Research Vol. 2006, No. 6 ( 2006-06), p. 356-358
    Details
    In: Journal of Chemical Research, SAGE Publications, Vol. 2006, No. 6 ( 2006-06), p. 356-358
    Abstract: Bisaminals of linear tetraamines were selectively N-monofunctionalised with acrylonitrile in a Michael-type addition giving rise, after reduction, to three open-chain dissymmetrical pentaamines, bearing a new aminopropyl group on one terminal nitrogen atom.
    Type of Medium: Online Resource
    ISSN: 1747-5198 , 2047-6507
    URL: Article
    DOI: 10.3184/030823406777946860
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2006
    detail.hit.zdb_id: 3010810-X
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