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  • SAGE Publications  (22)
  • 1
    Online-Ressource
    Online-Ressource
    Prednisone plus IVIg compared with prednisone or IVIg for immune thrombocytopenia in pregnancy: a national retrospective cohort study
    SAGE Publications ; 2022
    In:  Therapeutic Advances in Hematology Vol. 13 ( 2022-01), p. 204062072210952-
    Details
    In: Therapeutic Advances in Hematology, SAGE Publications, Vol. 13 ( 2022-01), p. 204062072210952-
    Kurzfassung: The responses of intravenous immunoglobulin (IVIg) or corticosteroids as the initial treatment on pregnancy with ITP were unsatisfactory. This study aimed to assess the safety and effectiveness of prednisone plus IVIg versus prednisone or IVIg in pregnant patients with immune thrombocytopenia (ITP). Methods: Between 1 January 2010 and 31 December 2020, 970 pregnancies diagnosed with ITP at 19 collaborative centers in China were reviewed in this observational study. A total of 513 pregnancies (52.89%) received no intervention. Concerning the remaining pregnancies, 151 (33.04%) pregnancies received an initial treatment of prednisone plus IVIg, 105 (22.98%) pregnancies received IVIg alone, and 172 (37.64%) pregnancies only received prednisone. Results: Regarding the maternal response to the initial treatment, no differences were found among the three treatment groups (41.1% for prednisone plus IVIg, 33.1% for prednisone, and 38.1% for IVIg). However, a significant difference was observed in the time to response between the prednisone plus IVIg group (4.39 ± 2.54 days) and prednisone group (7.29 ± 5.01 days; p   〈  0.001), and between the IVIg group (6.71 ± 4.85 days) and prednisone group ( p  〈  0.001). The median prednisone duration in the monotherapy group was 27 days (range, 8–195 days), whereas that in the combination group was 14 days (range, 6–85 days). No significant differences were found among these three treatment groups in neonatal outcomes, particularly concerning the neonatal platelet counts. The time to response in the combination treatment group was shorter than prednisone monotherapy. The duration of prednisone application in combination group was shorter than prednisone monotherapy. The combined therapy showed a lower predelivery platelet transfusion rate than IVIg alone. Conclusion: These findings suggest that prednisone plus IVIg may represent a potential combination therapy for pregnant patients with ITP.
    Materialart: Online-Ressource
    ISSN: 2040-6207 , 2040-6215
    URL: Article
    DOI: 10.1177/20406207221095226
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2022
    ZDB Id: 2585183-4
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 2
    Online-Ressource
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    Effects of Prepregnancy Body Mass Index and Gestational Weight Gain on Pregnancy Outcomes
    SAGE Publications ; 2015
    In:  Asia Pacific Journal of Public Health Vol. 27, No. 6 ( 2015-09), p. 620-630
    Details
    In: Asia Pacific Journal of Public Health, SAGE Publications, Vol. 27, No. 6 ( 2015-09), p. 620-630
    Kurzfassung: To investigate the single and joint effects of prepregnancy body mass index (BMI) and gestational weight gain (GWG) on pregnancy outcomes, electronic medical records of 14 196 women who delivered singleton live infant at a maternal and child health hospital in Beijing, China, in 2012 were reviewed. Logistic regression was used to assess the associations, adjusting for maternal age, height, education, parity, and offspring sex. Women of high prepregnancy BMI or excessive GWG had higher risks of gestational diabetes mellitus, hypertensive disorders in pregnancy, postpartum hemorrhage, caesarean delivery, macrosomia, and large for gestational age infant, while women of inadequate GWG had higher risks of preterm delivery, low birth weight, and small for gestational age infant. Findings suggest that antenatal care providers should help pregnant women control their GWG to normal.
    Materialart: Online-Ressource
    ISSN: 1010-5395 , 1941-2479
    URL: Article
    DOI: 10.1177/1010539515589810
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2015
    ZDB Id: 2394975-2
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 3
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    Inhibitory Effects of Indigowoad Root Polysaccharides on Porcine Reproductive and Respiratory Syndrome Virus Replication In Vitro
    SAGE Publications ; 2011
    In:  Antiviral Therapy Vol. 16, No. 3 ( 2011-04), p. 357-363
    Details
    In: Antiviral Therapy, SAGE Publications, Vol. 16, No. 3 ( 2011-04), p. 357-363
    Kurzfassung: Indigowoad root polysaccharide (IRPS) is a natural polysaccharide isolated from the traditional Chinese medicinal herb Radix Isatidis, and has many kinds of biological activities. However, the IRPS antiviral activity, especially the anti-porcine reproductive and respiratory syndrome virus (PRRSV) effect, has not been evaluated. Methods PRRSV was propagated in the MARC-145 cell line, and viral titre was determined by cytopathic effect and expressed as the 50% tissue culture infection dose (TCID 50 ) in the current study. The cell cytotoxic effect of IRPS toward MARC-145 was evaluated by MTT assay firstly, then the inhibitory effects of IRPS on PRRSV replication in vitro were investigated by determining the effect of IRPS upon a single replicative cycle of PRRSV in MARC- 145 cells. The effects of IRPS on viral RNA and protein synthesis in PRRSV-infected cells were investigated using real-time PCR and double-antibody (sandwich) ELISA. Results IRPS was able to effectively suppress the infectivity of the PRRSV in a dose-dependent manner, especially by adding IRPS during the PRRSV infection. IRPS could affect the attachment of PRRSV to MARC-145 cells, and also inhibit the viral RNA and protein synthesis. Conclusions IRPS has an antiviral effect on PRRSV replication in MARC-145 cells and might be useful in medical development for antiviral research. However, the precise mechanism of the host and viral targets of IRPS are unknown, so further studies should be conducted to investigate the precise mechanism of IRPS inhibitory effect on PRRSV infection.
    Materialart: Online-Ressource
    ISSN: 1359-6535 , 2040-2058
    URL: Article
    DOI: 10.3851/IMP1755
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2011
    ZDB Id: 2118396-X
    SSG: 15,3
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 4
    Online-Ressource
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    A Novel Norclerodane Diterpenoid from the Roots of Croton crassifolius
    SAGE Publications ; 2015
    In:  Natural Product Communications Vol. 10, No. 11 ( 2015-11), p. 1934578X1501001-
    Details
    In: Natural Product Communications, SAGE Publications, Vol. 10, No. 11 ( 2015-11), p. 1934578X1501001-
    Kurzfassung: A chemical investigation of Croton crassifolius afforded a novel norclerodane diterpenoid (1) with an unprecedented six-membered oxygen ring between C-1 and C-12, together with three known compounds. The structure of the new compound was elucidated based on spectroscopic (IR, 1D, and 2D NMR) and HR-ESI-MS techniques. This report describes the first example of a natural norclerodane with a 4 H-chromene ring system.
    Materialart: Online-Ressource
    ISSN: 1934-578X , 1555-9475
    URL: Article
    DOI: 10.1177/1934578X1501001128
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2015
    ZDB Id: 2430442-6
    SSG: 15,3
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 5
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    Design of flexure revolute joint based on double compliant curved beam
    SAGE Publications ; 2019
    In:  Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science Vol. 233, No. 13 ( 2019-07), p. 4521-4530
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science, SAGE Publications, Vol. 233, No. 13 ( 2019-07), p. 4521-4530
    Kurzfassung: In view of the problems of low accuracy and large impact caused by flexure joints during the deployable process, design of an integrated flexure revolute joint for folding mechanisms is important. Using a double compliant curved beam as a flexible unit of a joint, the revolute joint is designed based on the method of compliance and stiffness ellipsoids. The geometrical constraints model of the curved beam is established to define the design range of the unit. The total error model, which is obtained by the analysis of single-parameter errors, is used to choose the size of the unit with the smallest error. The finite element models of the flexure joints are established to analyze the rotational stiffness, translational stiffness, and the maximum rotational angle of the joints. The rotational angle of one flexure revolute joint in one direction can reach 35.7°. The rotational angle of the series flexure revolute joint in one direction can achieve 51°. The experiments of single and series flexure joints are carried out to verify the correctness of the design and for the analysis of the flexure joint.
    Materialart: Online-Ressource
    ISSN: 0954-4062 , 2041-2983
    URL: Article
    DOI: 10.1177/0954406219833085
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2019
    ZDB Id: 2024890-8
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 6
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    A Simple and Efficient Synthesis of Novel Aryloxy-Functionalised 4,4′-bi-1,2,4-Triazoles
    SAGE Publications ; 2016
    In:  Journal of Chemical Research Vol. 40, No. 5 ( 2016-05), p. 293-295
    Details
    In: Journal of Chemical Research, SAGE Publications, Vol. 40, No. 5 ( 2016-05), p. 293-295
    Kurzfassung: A simple and efficient strategy for the synthesis of novel aryloxy-functionalised 4,4′-bi-1,2,4-triazoles was successfully explored by nucleophilic aromatic substitution of tetrachloro-4,4′-bi-1,2,4-triazole by various phenols using Cs 2 CO 3 as catalyst. The syntheses were achieved in 25–94% yields.
    Materialart: Online-Ressource
    ISSN: 1747-5198 , 2047-6507
    URL: Article
    DOI: 10.3184/174751916X14604745689762
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2016
    ZDB Id: 3010810-X
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 7
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    Interferon-α-induced CD100 on naïve CD8 + T cells enhances antiviral responses to hepatitis C infection through CD72 signal transduction
    SAGE Publications ; 2017
    In:  Journal of International Medical Research Vol. 45, No. 1 ( 2017-02), p. 89-100
    Details
    In: Journal of International Medical Research, SAGE Publications, Vol. 45, No. 1 ( 2017-02), p. 89-100
    Kurzfassung: We investigated the effects of CD100 on naïve CD8 + T cells during hepatitis C virus (HCV) infection after interferon-α (IFN-α) therapy to clarify the mechanism underlying the effect of IFN-α in enhancing the antiviral response. Methods The CD100 molecules on subsets of CD8 + T cells were analysed with flow cytometry. The effects of CD100-overexpressing naïve CD8 + T cells were determined with ELISAs and an MTT cytotoxicity assay. The role of CD100–CD72 signal transduction was analysed with a neutralization and transwell assays. Results HCV infection reduced CD100 expression on CD8 + T cells, whereas IFN-α treatment significantly increased CD100 expression on naïve CD8 + T cells. The increased CD100 interacted with the CD72 receptor and enhanced PBMC cytokine secretion (IFN-γ and tumour necrosis factor-α) and cytotoxicity. Conclusions IFN-α-induced CD100 on naïve CD8 + T cells promotes PBMC cytokine secretion and cytotoxicity through CD100–CD72 signalling during HCV infection.
    Materialart: Online-Ressource
    ISSN: 0300-0605 , 1473-2300
    URL: Article
    DOI: 10.1177/0300060516676136
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2017
    ZDB Id: 2082422-1
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 8
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    Effectiveness of butylphthalide on cerebral autoregulation in ischemic stroke patients with large artery atherosclerosis (EBCAS study): A randomized, controlled, multicenter trial
    SAGE Publications ; 2023
    In:  Journal of Cerebral Blood Flow & Metabolism
    Details
    In: Journal of Cerebral Blood Flow & Metabolism, SAGE Publications
    Kurzfassung: Finding appropriate drugs to improve cerebral autoregulation (CA) in patients with acute ischemic stroke (AIS) is necessary to improve prognosis. We aimed to investigate the effect of butylphthalide on CA in patients with AIS. In this randomized controlled trial, 99 patients were 2:1 randomized to butylphthalide or placebo group. The butylphthalide group received intravenous infusion with a preconfigured butylphthalide-sodium chloride solution for 14 days and an oral butylphthalide capsule for additional 76 days. The placebo group synchronously received an intravenous infusion of 100 mL 0.9% saline and an oral butylphthalide simulation capsule. The transfer function parameter, phase difference (PD), and gain were used to quantify CA. The primary outcomes were CA levels on the affected side on day 14 and day 90. Eighty patients completed the follow-up (52 in the butylphthalide group and 28 in the placebo group). The PD of the affected side on 14 days or discharge and on 90 days was higher in the butylphthalide group than in the placebo group. The differences in safety outcomes were not significant. Therefore, butylphthalide treatment for 90 days can significantly improve CA in patients with AIS. Trial registration: ClinicalTrial.gov: NCT03413202
    Materialart: Online-Ressource
    ISSN: 0271-678X , 1559-7016
    URL: Article
    DOI: 10.1177/0271678X231168507
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2023
    ZDB Id: 2039456-1
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 9
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    Prediction of cervical lymph node metastasis with contrast-enhanced ultrasound and association between presence of BRAF V600E and extrathyroidal extension in papillary thyroid carcinoma
    SAGE Publications ; 2020
    In:  Therapeutic Advances in Medical Oncology Vol. 12 ( 2020-01), p. 175883592094236-
    Details
    In: Therapeutic Advances in Medical Oncology, SAGE Publications, Vol. 12 ( 2020-01), p. 175883592094236-
    Kurzfassung: This study aimed to evaluate the correlation between cervical lymph node metastasis (CLNM) and each of the ultrasound features, immunohistochemical factors, and B-type Raf (BRAF V600E ) mutation. Methods: A retrospective analysis was performed on 405 patients with single papillary thyroid carcinoma (PTC) nodules, all of whom underwent preoperative sonographic examinations, including gray-scale ultrasound, color Doppler ultrasound, and contrast-enhanced ultrasound (CEUS). All PTC patients were evaluated using 14 clinical and sonographic features, eight immunohistochemical factors, and BRAF V600E . Multivariate analyses were performed to identify the risk factors for CLNM, and an equation for CLNM was established. The diagnostic value of each modality was compared with a receiver operating characteristic (ROC) curve. Results: Among the 405 PTC nodules removed surgically, CLNM was confirmed in 138 patients, whereas extrathyroidal extension was confirmed in 185 patients. Multivariate analyses indicated significant differences between CLNM and non-CLNM groups in three conventional ultrasound features ( p  〈  0.05), whereas other sonographic features, eight immunohistochemical factors, and BRAF V600E did not indicate significant differences. A ROC curve of 0.757 in the equation exhibited a significant difference compared with the solo factors ( p  〈  0.05 for all). Hyper or isoechoic enhancement at peak time on CEUS was associated with CLNM, whereas the presence of the BRAF V600E mutation was associated with extrathyroidal extensions although BRAF appeared to be uncorrelated with CLNM in the present study. Conclusion: Intensity at peak time, homogeneity, and size are the three most significant features in predicting CLNM in PTC patients, and the presence of the BRAF V600E mutation was associated with extrathyroidal extensions when PTCs showed a hyper or isoechoic enhancement at peak time in CEUS.
    Materialart: Online-Ressource
    ISSN: 1758-8359 , 1758-8359
    URL: Article
    DOI: 10.1177/1758835920942367
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2020
    ZDB Id: 2503443-1
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 10
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    Survivin induces defects in apoptosis in eosinophils in intestine with food allergy
    SAGE Publications ; 2019
    In:  Innate Immunity Vol. 25, No. 4 ( 2019-05), p. 244-254
    Details
    In: Innate Immunity, SAGE Publications, Vol. 25, No. 4 ( 2019-05), p. 244-254
    Kurzfassung: Survivin is an anti-apoptosis protein that may be associated with the development of eosinophilia; the latter is associated with the pathogenesis of many immune disorders. Here we report that less apoptotic eosinophils (Eos) were induced in those isolated from mice suffering from food allergy (FA) than those from naive mice after treating with cisplatin in vitro. Exposure to cisplatin induced more Fas ligand (FasL) expression in Eos isolated from naive mice than in those of FA mouse. Survivin was detected in the intestinal tissue extracts in much higher amounts in the FA group than in the naive group. Immunohistochemistry showed that epithelial cells were the major source of survivin in the intestine. Exposure to IL-4 or IL-13 up-regulated the expression of survivin in intestinal epithelial cells. Survivin interfered with the expression of FasL in Eos. Inhibition of survivin attenuated the eosinophilia-related inflammation in the intestine. In conclusion, intestinal epithelial cell-produced survivin induced defects in apoptosis in Eos to contribute to eosinophilia in the intestine. Inhibition of survivin can suppress the eosinophilia-related intestinal inflammation. The data suggest that survivin may be a novel target for the treatment of FA.
    Materialart: Online-Ressource
    ISSN: 1753-4259 , 1753-4267
    URL: Article
    DOI: 10.1177/1753425919829554
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2019
    ZDB Id: 2381250-3
    Standort Signatur Einschränkungen Verfügbarkeit
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