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  • SAGE Publications  (31)
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  • SAGE Publications  (31)
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  • 1
    Online-Ressource
    Online-Ressource
    SAGE Publications ; 2022
    In:  Cell Transplantation Vol. 31 ( 2022-01), p. 096368972211160-
    In: Cell Transplantation, SAGE Publications, Vol. 31 ( 2022-01), p. 096368972211160-
    Kurzfassung: Nasopharyngeal carcinoma (NPC) is a unique malignant tumor of the head and neck. Despite higher survival rates by the combination of radiotherapy and chemotherapy, the recurrence or metastasis of NPC still occurs at about 10%. Therefore, there is urgent demand to develop more effective in vivo models for preclinical trials to investigate the mechanisms of NPC development and progression and to explore better treatment approaches. In this study, we transplanted human NPC CNE1 cells into zebrafish embryos to establish a xenograft model of NPC, where the proliferation and invasion behaviors of NPC cells were investigated in vivo. Combining in vitro and in vivo analyses, we found that activating transcription factor 7 (ATF7) was involved in the occurrence and development of NPC regulated by peptidyl-prolyl cis- trans isomerase NIMA-interacting 1 (Pin1). The zebrafish NPC xenograft model established here thereby provides an in vivo tool for exploring the occurrence and development of NPC, which may help to identify new tumor markers and develop new therapeutic strategies for the treatment of NPC.
    Materialart: Online-Ressource
    ISSN: 0963-6897 , 1555-3892
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2022
    ZDB Id: 2020466-8
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 2
    In: Cancer Control, SAGE Publications, Vol. 29 ( 2022-01), p. 107327482110515-
    Kurzfassung: Skin cutaneous melanoma (SKCM) is a type of highly invasive cancer originated from melanocytes. It is reported that aberrant alternative splicing (AS) plays an important role in the neoplasia and metastasis of many types of cancer. Therefore, we investigated whether ASEs of pre-RNA have such an influence on the prognosis of SKCM and the related mechanism of ASEs in SKCM. The RNA-seq data and ASEs data for SKCM patients were obtained from the TCGA and TCGASpliceSeq database. The univariate Cox regression revealed 1265 overall survival-related splicing events (OS-SEs). Screened by Lasso regression, 4 OS-SEs were identified and used to construct an effective prediction model (AUC: .904), whose risk score was proved to be an independent prognostic factor. Furthermore, Kruskal–Wallis test and Mann–Whitney–Wilcoxon test showed that an aberrant splicing type of aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 (AIMP2) regulated by CDC-like kinase 1 (CLK1) was associated with the metastasis and stage of SKCM. Besides, the overlapped signal pathway for AIMP2 was galactose metabolism identified by the co-expression analysis. External database validation also confirmed that AIMP2, CLK1, and the galactose metabolism were associated with the metastasis and stage of SKCM patients. ChIP-seq and ATAC-seq methods further confirmed the transcription regulation of CLK1, AIMP2, and other key genes, whose cellular expression was detected by Single Cell Sequencing. In conclusion, we proposed that CLK1-regulated AIMP2-78704-ES might play a critical role in the tumorigenesis and metastasis of SKCM via galactose metabolism. Besides, we established an effective model with MTMR14-63114-ES, URI1-48867-ES, BATF2-16724-AP, and MED22-88025-AP to predict the metastasis and prognosis of SKCM patients.
    Materialart: Online-Ressource
    ISSN: 1073-2748 , 1073-2748
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2022
    ZDB Id: 2004182-2
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 3
    Online-Ressource
    Online-Ressource
    SAGE Publications ; 2022
    In:  Proceedings of the Institution of Mechanical Engineers, Part G: Journal of Aerospace Engineering Vol. 236, No. 7 ( 2022-06), p. 1450-1461
    In: Proceedings of the Institution of Mechanical Engineers, Part G: Journal of Aerospace Engineering, SAGE Publications, Vol. 236, No. 7 ( 2022-06), p. 1450-1461
    Kurzfassung: Combustion efficiency is the main factor affecting the performance of solid fuel rocket scramjet. To reveal the influence of combustor configuration on performance and further improve combustion efficiency, the influence of the width-height ratio of the rectangle-section combustor on the performance of solid fuel rocket scramjet is investigated numerically in this article. Three-dimensional compressible Reynolds-averaged Navier-Stokes equations coupled with shear stress transport k– ω turbulence model are employed to simulate the aerodynamics. The Euler–Lagrange approach is used to calculate the multiphase flow. Combustion of carbon particles is modeled by the improved Moving Flame Front model. Accuracy of the present numerical model is validated by the experimental data of a rectangle-section combustor from literature. Results show that as the width-height ratio increases, the combustion efficiency increases first and then decreases. The influence of cavity and its position on the performance are also investigated. Results show that cavity can significantly improve combustion efficiency. The effect of cavity position on performance is related to the distribution of particles.
    Materialart: Online-Ressource
    ISSN: 0954-4100 , 2041-3025
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2022
    ZDB Id: 2032759-6
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 4
    Online-Ressource
    Online-Ressource
    SAGE Publications ; 2020
    In:  Proceedings of the Institution of Mechanical Engineers, Part F: Journal of Rail and Rapid Transit Vol. 234, No. 2 ( 2020-02), p. 123-133
    In: Proceedings of the Institution of Mechanical Engineers, Part F: Journal of Rail and Rapid Transit, SAGE Publications, Vol. 234, No. 2 ( 2020-02), p. 123-133
    Kurzfassung: The gear transmission system of a high-speed train is the key component, which delivers the traction torque from the motor to the wheelset. It couples with the vehicle system via the suspension system, gear meshing and the wheel–rail interface. The dynamic performance of the transmission system directly affects the operational reliability or even the running safety of high-speed trains. In this study, the effects of wheel polygonalisation and wheel flat on the dynamic responses of the transmission system are investigated through simulations of a novel vehicle dynamics model. This model integrates the flexible gearbox housing, the time-varying mesh stiffness and the nonlinear gear tooth backlash, and the track irregularities to obtain more realistic responses of the traction transmission systems in a vehicle vibration environment, from motors to wheelsets, under the effects of the wheel flat and polygonal wear. The field experimental tests are implemented for a vehicle running along a main high-speed railway line in China. Subsequently, the developed dynamics model is validated with good agreement between the experimental and the theoretical results. The calculated results revealed that wheel flat and wheel polygonal wear caused a high-frequency fluctuation of both the longitudinal creep force and the gear mesh force, causing a violent and complex torsional vibration of the gear transmission system. Moreover, the flexible deformation of the gearbox housing, especially its resonance due to the wheel polygonal wear, contributed to the torsional vibration of the gear transmission system.
    Materialart: Online-Ressource
    ISSN: 0954-4097 , 2041-3017
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2020
    ZDB Id: 2024901-9
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 5
    Online-Ressource
    Online-Ressource
    SAGE Publications ; 2014
    In:  Experimental Biology and Medicine Vol. 239, No. 11 ( 2014-11), p. 1421-1432
    In: Experimental Biology and Medicine, SAGE Publications, Vol. 239, No. 11 ( 2014-11), p. 1421-1432
    Kurzfassung: The prevalence and incidence of Parkinson’s disease (PD) is increasing due to a prolonged life expectancy. This highlights the need for a better mechanistic understanding and new therapeutic approaches. However, traditional in vitro and in vivo experimental models to study PD are suboptimal, thus hampering the progress in the field. The epigenetic reprogramming of somatic cells to induced pluripotent stem cells (iPSCs) offers a unique way to overcome this problem, as these cells share many properties of embryonic stem cells (ESCs) including the potential to be transformed into different lineages. PD modeling with iPSCs is nowadays facilitated by the growing availability of high-efficiency neural-specific differentiation protocols and the possibility to correct or induce mutations as well as creating marker cell lines using designer nucleases. These technologies, together with steady advances in human genetics, will likely introduce profound changes in the way we interpret PD and develop new treatments. Here, we summarize the different PD iPSCs reported so far and discuss the challenges for disease modeling using these cell lines.
    Materialart: Online-Ressource
    ISSN: 1535-3702 , 1535-3699
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2014
    ZDB Id: 2020856-X
    SSG: 12
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 6
    Online-Ressource
    Online-Ressource
    SAGE Publications ; 2013
    In:  Advances in Mechanical Engineering Vol. 5 ( 2013-01), p. 757084-
    In: Advances in Mechanical Engineering, SAGE Publications, Vol. 5 ( 2013-01), p. 757084-
    Kurzfassung: Based on finite volume method, the interaction between base jet and supersonic flow around the rocket is simulated by Navier-Stokes equations with SST k-ω turbulence model and implicit algorithm. The pressure contours, the streamline patterns, and the variation of the aerodynamic characteristics of the rocket with the flying altitude, Mach number, and the angle of attack are shown and analyzed. Numerical results demonstrate that in supersonic flow, the base jet has a noticeable effect on the surface pressure of the body and the tails, leading to the decreases of the coefficients of the normal force, the pitching moment, and the pressure center. Furthermore, the higher the flying altitude, the more grave decreases of the coefficients of the normal force, the pitching moment and the pressure center. However, with the increase of Mach number, the more grave the decreases of the normal force coefficient and the pitch moment coefficient are found, while the less grave decrease is found with the pressure center coefficient. With the increase of the angle of attack, the more grave decreases are found with the coefficients of the normal force and the pitching moment, while the decrease of the pressure center coefficient remains almost the same.
    Materialart: Online-Ressource
    ISSN: 1687-8140 , 1687-8140
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2013
    ZDB Id: 2501620-9
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 7
    In: Neurorehabilitation and Neural Repair, SAGE Publications, Vol. 28, No. 3 ( 2014-03), p. 260-272
    Kurzfassung: Background. Swallowing dysfunction is intractable after acute stroke. Our understanding of the alterations in neural networks of patients with neurogenic dysphagia is still developing. Objective. The aim was to investigate cerebral cortical functional connectivity and subcortical structural connectivity related to swallowing in unilateral hemispheric stroke patients with dysphagia. Methods. We combined a resting-state functional connectivity with a white matter tract connectivity approach, recording 12 hemispheric stroke patients with dysphagia, 12 hemispheric stroke patients without dysphagia, and 12 healthy controls. Comparisons of the patterns in swallowing-related functional connectivity maps between patient groups and control subjects included ( a) seed-based functional connectivity maps calculated from the primary motor cortex (M1) and the supplementary motor area (SMA) to the entire brain, ( b) a swallowing-related functional connectivity network calculated among 20 specific regions of interest (ROIs), and ( c) structural connectivity described by the mean fractional anisotropy of fibers bound through the SMA and M1. Results. Stroke patients with dysphagia exhibited dysfunctional connectivity mainly in the sensorimotor-insula-putamen circuits based on seed-based analysis of the left and right M1 and SMA and decreased connectivity in the bilateral swallowing-related ROIs functional connectivity network. Additionally, white matter tract connectivity analysis revealed that the mean fractional anisotropy of the white matter tract was significantly reduced, especially in the left-to-right SMA and in the corticospinal tract. Conclusions. Our results indicate that dysphagia secondary to stroke is associated with disruptive functional and structural integrity in the large-scale brain networks involved in motor control, thus providing new insights into the neural remodeling associated with this disorder.
    Materialart: Online-Ressource
    ISSN: 1545-9683 , 1552-6844
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2014
    ZDB Id: 2100545-X
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 8
    In: The International Journal of High Performance Computing Applications, SAGE Publications
    Kurzfassung: The never-ending emergence of SARS-CoV-2 variations of concern (VOCs) has challenged the whole world for pandemic control. In order to develop effective drugs and vaccines, one needs to efficiently simulate SARS-CoV-2 spike receptor-binding domain (RBD) mutations and identify high-risk variants. We pretrain a large protein language model with approximately 408 million protein sequences and construct a high-throughput screening for the prediction of binding affinity and antibody escape. As the first work on SARS-CoV-2 RBD mutation simulation, we successfully identify mutations in the RBD regions of 5 VOCs and can screen millions of potential variants in seconds. Our workflow scales to 4096 NPUs with 96.5% scalability and 493.9× speedup in mixed-precision computing, while achieving a peak performance of 366.8 PFLOPS (reaching 34.9% theoretical peak) on Pengcheng Cloudbrain-II. Our method paves the way for simulating coronavirus evolution in order to prepare for a future pandemic that will inevitably take place. Our models are released at https://github.com/ZhiweiNiepku/SARS-CoV-2_mutation_simulation to facilitate future related work.
    Materialart: Online-Ressource
    ISSN: 1094-3420 , 1741-2846
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2023
    ZDB Id: 2017480-9
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 9
    Online-Ressource
    Online-Ressource
    SAGE Publications ; 2020
    In:  Journal of Vibration and Control Vol. 26, No. 23-24 ( 2020-12), p. 2113-2124
    In: Journal of Vibration and Control, SAGE Publications, Vol. 26, No. 23-24 ( 2020-12), p. 2113-2124
    Kurzfassung: Flywheels generate speed-related disturbances and induce micro-vibrations that influence the performance of high-sensitivity instruments on board. This study addresses dynamic modeling and disturbance force suppression of the flywheels due to its inherent characteristic structural modes. The disturbance force transmission of a rotating flywheel due to a unit radial force applied at the rim of the wheel body is reported using the three-dimensional finite element method and frequency response function–based substructuring method. The characteristic structural modes for the radial and axial disturbance forces are identified. The axial deformation–dominated flapping mode and the radial deformation–dominated transverse mode will contribute most to the axial and radial disturbance forces, respectively. A flexible ring structure, which is rested on the arms of the wheel body through independent viscoelastic pads and simultaneously in contact with the inner rim of the wheel body by independent resilient cushion members, is proposed to function as a damped dynamic vibration absorber. The modes of the dynamic vibration absorber and the modes of the flywheel equipped with the dynamic vibration absorber are analyzed. It is shown that the dynamic vibration absorber is effective to suppress both the radial and axial disturbance forces at the characteristic structural modes under different rotational speeds, provided that the loss factor of the complex elastic modulus for the viscoelastic pads is larger than 0.2 and the proportional damping constant for the stiffness matrix is larger than 6 Ns/m. Experimental analyses are conducted on a flywheel with a well-designed dynamic vibration absorber to validate the theoretical findings. Modal tests and disturbance force measurements are carried out for the flywheel with/without the dynamic vibration absorber. It is shown that the identified characteristic structural modes will contribute remarkable peaks for the radial and axial disturbance forces. The proposed dynamic vibration absorber is capable to suppress the high-frequency disturbance forces efficiently under different rotational speeds.
    Materialart: Online-Ressource
    ISSN: 1077-5463 , 1741-2986
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2020
    ZDB Id: 2070247-4
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 10
    In: Cell Transplantation, SAGE Publications
    Materialart: Online-Ressource
    ISSN: 0963-6897
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2017
    ZDB Id: 2020466-8
    Standort Signatur Einschränkungen Verfügbarkeit
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