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  • SAGE Publications  (10)
  • 1
    Online Resource
    Online Resource
    An association between the location of white matter changes and the behavioral and psychological symptoms of dementia in Alzheimer's disease patients
    SAGE Publications ; 2016
    In:  Translational Neuroscience and Clinics Vol. 2, No. 1 ( 2016), p. 8-16
    Details
    In: Translational Neuroscience and Clinics, SAGE Publications, Vol. 2, No. 1 ( 2016), p. 8-16
    Type of Medium: Online Resource
    ISSN: 2096-0441
    URL: Article
    DOI: 10.18679/CN11-6030/R.2016.010
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
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  • 2
    Online Resource
    Online Resource
    An Association between the Location of White Matter Changes and the Behavioral and Psychological Symptoms of Dementia in Alzheimer's Disease Patients
    SAGE Publications ; 2016
    In:  Translational Neuroscience and Clinics Vol. 2, No. 1 ( 2016-03), p. 8-16
    Details
    In: Translational Neuroscience and Clinics, SAGE Publications, Vol. 2, No. 1 ( 2016-03), p. 8-16
    Abstract: The frontal lobe may be involved in circuits associated with depression, apathy, aggression, and other psychiatric symptoms. Although white matter changes (WMC) are related to the severity of behavioral and psychological symptoms of dementia (BPSD) in patients with Alzheimer's disease (AD), it is unclear which part of the WMC may play the most important role in BPSD. This study was designed to investigate the relationship between the location of WMC and the severity of BPSD in AD patients. Methods Among patients diagnosed with Alzheimer's disease between 2009 and 2014, 387 patients were retrospectively reviewed after those with pre-existing organic brain syndrome, psychiatric diseases, or toxic-metabolic encephalopathy were excluded. Patients' demographic and laboratory data, WMC measured with brain computed tomography and scored using the age-related white matter changes (ARWMC) scale, and neuropsychological tests, including the cognitive abilities screening instrument (CASI), the Mini-Mental State Examination (MMSE), the clinical dementia rating scale with sum-box (CDR-SB), and the neuropsychiatric inventory (NPI) were analyzed. Results There was no significant difference in the NPI between patients with and without a history of stroke, hypertension, and diabetes. No significant difference in the NPI was identified between different sexes or different Apolipoprotein E (APOE) alleles. The NPI score was significantly correlated with the duration of education (r = −0.4515, P = 0.0172), CASI (r = −0.2915, P 〈 0.0001), MMSE (r = −0.8476, P 〈 0.0001), and CDR-SB (r = 2.2839, P 〈 0.0001). WMC in the right frontal lobe showed a significant difference in NPI in comparison to those without WMC (P = 0.0255). After adjusting for age, duration of education, and CASI, WMC in the right frontal lobe remained significantly associated with the NPI score (β = 3.8934, P = 0.042). Conclusions WMC involving the right frontal lobe may play an important role in the BPSD in AD patients during their dementia diagnosis. Further studies are necessary to confirm whether controlling the risk factors of WMC can slow the progression of BPSD.
    Type of Medium: Online Resource
    ISSN: 2096-0441
    URL: Article
    DOI: 10.18679/CN11-6030_R.2016.010
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
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  • 3
    Online Resource
    Online Resource
    Role of Plasma methylated SEPT9 for Predicting Microvascular Invasion and Tumor Proliferation in Hepatocellular Carcinoma
    SAGE Publications ; 2022
    In:  Technology in Cancer Research & Treatment Vol. 21 ( 2022-01), p. 153303382211445-
    Details
    In: Technology in Cancer Research & Treatment, SAGE Publications, Vol. 21 ( 2022-01), p. 153303382211445-
    Abstract: Background: Methylated SEPT9 (mSEPT9) has a role in the occurrence and development of hepatocellular carcinoma (HCC). Here, we studied the significance of plasma mSEPT9 for predicting prognosis-associated pathological parameters in patients with HCC. Methods: We retrospectively analyzed data from 205 subjects, including 111 HCC patients, 53 patients with at-risk liver disease (ARD) and 41 healthy donors (HDs). Analysis of plasma mSEPT9 was performed using methylation-specific polymerase chain reaction. Levels of mSEPT9 among different groups were compared using a nonparametric Mann-Whitney U test or a one-way ANOVA test. Correlations between pretreatment plasma mSEPT9 and clinicopathological characteristics were analyzed using the Chi-square. Univariate and multivariate analyses were used to identify factors related to microvascular invasion (MVI). Performance of variables for MVI prediction was evaluated by receiver operating characteristics curve. Results: A specific increase of plasma mSEPT9 in HCC was found when compared with ARD and HDs (HCC vs ARD, P  =  1.1  ×  10 −5 and HCC vs HDs, P   =  3.7  ×  10 −10 ). Pretreatment plasma mSEPT9 was significantly correlated tumor number ( P  =  .004), tumor size ( P  =  4.6  ×  10 −5 ), MVI ( P  =  .002) and Barcelona Clinic Liver Cancer stage ( P  =  .012). Levels of plasma mSEPT9 correlated significantly with Ki67 expression in tumor ( r  =  0.356, P  =  1.3  ×  10 −4 ). Univariate and multivariate analyses showed that plasma mSEPT9 and serum protein induced by vitamin K absence or antagonist-II (PIVKA-II) were independent predictors for MVI. A combination of these 2 markers exhibited a larger areas under the curve (areas under the curve [AUC]  =  0.72) than mSEPT9 or PIVKA alone (AUC  =  0.67 and 0.65), especially in early-stage HCC. Conclusions: Plasma mSEPT9 is a promising noninvasive biomarker for predicting MVI and tumor proliferation in HCC. Integration plasma mSEPT9 detection into clinical settings might facilitate the patient management.
    Type of Medium: Online Resource
    ISSN: 1533-0346 , 1533-0338
    URL: Article
    DOI: 10.1177/15330338221144510
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2146365-7
    detail.hit.zdb_id: 2220436-2
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  • 4
    Online Resource
    Online Resource
    Empirical study of travel mode forecasting improvement for the combined revealed preference/stated preference data–based discrete choice model
    SAGE Publications ; 2016
    In:  Advances in Mechanical Engineering Vol. 8, No. 1 ( 2016-01-01), p. 168781401562483-
    Details
    In: Advances in Mechanical Engineering, SAGE Publications, Vol. 8, No. 1 ( 2016-01-01), p. 168781401562483-
    Abstract: The combined revealed preference/stated preference data–based discrete choice model has provided the actual choice-making restraints as well as reduced the prediction errors. But the random error variance of alternatives belonging to different data would impact its universality. In this article, we studied the traffic corridor between Chengdu and Longquan with the revealed preference/stated preference joint model, and the single stated preference data model separately predicted the choice probability of each mode. We found the revealed preference/stated preference joint model is universal only when there is a significant difference between the random error terms in different data. The single stated preference data would amplify the travelers’ preference and cause prediction error. We proposed a universal way that uses revealed preference data to modify the single stated preference data parameter estimation results to achieve the composite utility and reduce the prediction error. And the result suggests that prediction results are more reasonable based on the composite utility than the results based on the single stated preference data, especially forecasting the mode share of bus. The future metro line will be the main travel mode in this corridor, and 45% of passenger flow will transfer to the metro.
    Type of Medium: Online Resource
    ISSN: 1687-8140 , 1687-8140
    URL: Article
    DOI: 10.1177/1687814015624836
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2501620-9
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  • 5
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    Online Resource
    An Improved Background-Correction Algorithm for Raman Spectroscopy Based on the Wavelet Transform
    SAGE Publications ; 2018
    In:  Applied Spectroscopy ( 2018-11-29), p. 000370281880511-
    Details
    In: Applied Spectroscopy, SAGE Publications, ( 2018-11-29), p. 000370281880511-
    Type of Medium: Online Resource
    ISSN: 0003-7028 , 1943-3530
    URL: Article
    DOI: 10.1177/0003702818805116
    RVK:
    VA 2367
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 1474251-2
    SSG: 11
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  • 6
    Online Resource
    Online Resource
    Hypoxia-induced RNASEH2A limits activation of cGAS-STING signaling in HCC and predicts poor prognosis
    SAGE Publications ; 2022
    In:  Tumori Journal Vol. 108, No. 1 ( 2022-02), p. 63-76
    Details
    In: Tumori Journal, SAGE Publications, Vol. 108, No. 1 ( 2022-02), p. 63-76
    Abstract: Hypoxia is a hallmark of solid cancers, including hepatocellular carcinoma (HCC). There is scarce information about how hypoxia avoids immunologic stress and maintains a cancer-promoting microenvironment. Methods: The Cancer Genome Atlas, RNA-seq data, and Oncomine database were used to discover the correlation of RNASEH2A with tumor progression; then expression of RNASEH2A mRNA and protein were detected in HCC tissues and cells subjected to hypoxia or with the treatment of CoCl 2 via real-time quantitative polymerase chain reaction and immunochemistry assays. Finally, the effect of RNASEH2A on cell proliferation and the involved signaling pathway was explored further. Results: RNASEH2A was positively correlated with tumor grade, size, vascular invasion, and poor prognosis. The expression of RNASEH2A mRNA and protein were increased and dependent on hypoxia-inducible factor 2α in HCC tissues and cell lines. Knockout of RNASEH2A in HCC cells greatly reduced cell proliferation and induced the transcription of multiple cGAS-STING (cyclic GMP–AMP synthase–stimulator of interferon genes) targeted type 1 interferon-related genes, including IFIT1, USP18, and CXCL10, which suggests knockout of RNASEH2A may produce immunologic stress and tumor suppressive effects. Conclusions: RNASEH2A plays a critical role and potentially predicts patient outcomes in HCC, which uncovers a new mechanism that RNASEH2A contributes to limit immunologic stress of cancer cells in the context of hypoxia.
    Type of Medium: Online Resource
    ISSN: 0300-8916 , 2038-2529
    URL: Article
    DOI: 10.1177/03008916211026019
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 280962-X
    detail.hit.zdb_id: 2267832-3
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  • 7
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    Online Resource
    Short-term effectiveness of medial unicompartmental knee arthroplasty in young patients aged less than or equal to 60 years
    SAGE Publications ; 2020
    In:  Journal of Orthopaedic Surgery Vol. 28, No. 3 ( 2020-05-01), p. 230949902094511-
    Details
    In: Journal of Orthopaedic Surgery, SAGE Publications, Vol. 28, No. 3 ( 2020-05-01), p. 230949902094511-
    Abstract: The treatment for young patients with advanced knee arthritis by Oxford unicompartmental knee arthroplasty (Oxford-UKA) is still controversial. A relative few studies were published about Asian patients. We evaluated midterm results of Oxford-UKA in young patients aged less than or equal to 60 years. Methods: Between December 2009 and December 2018, 95 patients (109 knees) (mean age 57.48 years; range: 33–60 years) were included. The mean follow-up period was 3.0 years (range: 1.0–9.5 years). The functional outcomes and pain score of the knee before and after surgery were examined. Results: To the last follow-up, no patient died, six patients (nine knees) were lost and one patient underwent total knee revision in case of unexplained postoperative pain. The patients demonstrated significant improvement in range of knee motion (103.65 vs. 115.96, p 〈 0.05), Oxford Knee Score (40.0 vs. 14.4, p 〈 0.05), Hospital for Special Surgery Score (56.0 vs. 85.7, p 〈 0.05), and Visual Analogue Score (VAS) (5.23 vs. 1.08, p 〈 0.05) before and after surgery. Conclusion: Our midterm results showed that the Oxford-UKA was a reliable and effective treatment option for young patients aged less than or equal to 60 years with anterior medial osteoarthritis. The knee pain can be effectively relieved and excellent functional activities of the knee joint can be obtained after surgery.
    Type of Medium: Online Resource
    ISSN: 2309-4990 , 2309-4990
    URL: Article
    DOI: 10.1177/2309499020945118
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2128854-9
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  • 8
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    A standardized technique for lateral unicompartmental knee arthroplasty
    SAGE Publications ; 2023
    In:  Journal of Orthopaedic Surgery Vol. 31, No. 1 ( 2023-01), p. 102255362311640-
    Details
    In: Journal of Orthopaedic Surgery, SAGE Publications, Vol. 31, No. 1 ( 2023-01), p. 102255362311640-
    Abstract: We developed a new standardized procedure for lateral unicompartmental knee arthroplasty (UKA) to maximize the benefits and minimize the risks of surgery in patients with osteoarthritis (OA). Methods This retrospective study recruited patients who underwent lateral UKA at our hospital between January 2014 and January 2016. Demographic characteristics and preoperative and postoperative American Knee Society (AKS) clinical scores (including pain, clinical, and knee mobility scores) were collected. Results A total of 158 patients (35 male and 123 female) who underwent 160 lateral UKAs were analyzed. Their AKS clinical scores (0–100 points) improved from 53.1 ± 4.1 (range 45–62) preoperatively to 97.0 ± 1.7 (range 92–99) ( p 〈 0.001) postoperatively with additional improvements of 9.1 ± 1.8 (range 3–14) to 47.3 ± 1.5 (range 45–49) ( p 〈 0.001) for pain, 49.7 ± 9.7 (range 35–70) to 97.1 ± 4.1 (range 90–100) ( p 〈 0.001) for function, and 105.0 ± 4.4° (equivalent to ∼100–115°) to 125.5 ± 5.3° (∼110–135°) ( p 〈 0.001) for a range of motion (ROM). No patients required reoperations or revisions. Two patients were readmitted within 60 days due to severe knee swelling. Conclusion The lateral UKA protocol was reproducible and the patients had a good postoperative outcomes. Yet, large-scale, multi-center, prospective studies are needed to further confirm our findings.
    Type of Medium: Online Resource
    ISSN: 1022-5536 , 2309-4990
    URL: Article
    DOI: 10.1177/10225536231164028
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2128854-9
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  • 9
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    Rolling Stock Allocation and Timetabling for Urban Rail Transit Network with Multiple Depots
    SAGE Publications ; 2022
    In:  Transportation Research Record: Journal of the Transportation Research Board Vol. 2676, No. 11 ( 2022-11), p. 422-435
    Details
    In: Transportation Research Record: Journal of the Transportation Research Board, SAGE Publications, Vol. 2676, No. 11 ( 2022-11), p. 422-435
    Abstract: Rolling stock management and train timetabling are two challenging but very related issues in urban rail systems. The former is to allocate a certain fleet of trains to each depot, and the latter determines the arrival and departure times of train services according to the available rolling stock at each depot. While most existing studies consider these two tasks for a single line, this study focuses on the integrated optimization of rolling stock allocation, train timetabling, and rolling stock circulation for a whole network, where each depot can serve multiple connected lines and the trains can change lines in one operational cycle (i.e., one day). A time-space network is constructed to model the rolling stock circulation among multiple lines and depots, and a novel integer linear programming model is proposed to jointly optimize the allocation of rolling stock and train timetables for the involved lines. The objective function maximizes the service quality provided to passengers with minimized rolling stock investment cost. Numerical experiments based on the real-world data of the Beijing rail transit network are conducted to validate the effectiveness of this approach. The results demonstrate that the proposed approach can reduce the fleet size of rolling stock by 5% while providing the same service quality to passengers.
    Type of Medium: Online Resource
    ISSN: 0361-1981 , 2169-4052
    URL: Article
    DOI: 10.1177/03611981221093323
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2403378-9
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  • 10
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    Fast-curing halogen-free flame-retardant epoxy resins and their application in glass fiber-reinforced composites
    SAGE Publications ; 2019
    In:  Textile Research Journal Vol. 89, No. 18 ( 2019-09), p. 3700-3707
    Details
    In: Textile Research Journal, SAGE Publications, Vol. 89, No. 18 ( 2019-09), p. 3700-3707
    Abstract: A series of novel fast-curing halogen-free flame-retardant epoxy resins were formulated and used to prepare glass fiber-reinforced composites. Dynamic mechanical analysis showed that the optimized epoxy system could be completely cured in 0.5 h at 150℃ and had a glass transition temperature ( T g ) of above 130℃. The optimized epoxy system was also used as matrix resin to make glass fiber prepregs and composite panels. The flame-retardant properties of the glass fiber-reinforced composites were investigated, including the limiting oxygen index (LOI) and flaming, smoke and toxicity properties. The glass fiber-reinforced composite had good flame retardancy with a UL-94 V-1 rating and high LOI of ∼36%. More significantly, the composite based on the flame-retardant epoxy resin showed lower smoke density compared with those based on phenolic resins. Finally, the glass fiber prepregs were used to fabricate honeycomb sandwich composites. The peel strength of the epoxy-based composites was almost twice that of the composites based on phenolic resin.
    Type of Medium: Online Resource
    ISSN: 0040-5175 , 1746-7748
    URL: Article
    DOI: 10.1177/0040517518819845
    RVK:
    ZS 0001
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2209596-2
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