In:
Acta Radiologica, SAGE Publications, Vol. 60, No. 8 ( 2019-08), p. 962-968
Abstract:
Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is widely used for the diagnosis and prognostic assessment of head and neck squamous cell carcinoma (HNSCC). However, no research on grading HNSCC using DCE-MRI has been found. We hypothesize that DCE-MRI can grade the HNSCC non-invasively. Purpose To verify the hypothesis that DCE-MRI can grade the HNSCC non-invasively. Material and Methods Forty-two patients with histopathologically proved HNSCC from September 2013 to February 2016 were retrospectively analyzed. Chi-square test was used to compare patterns of time intensity curves (TICs) between well and poorly differentiated HNSCC. Two-sample t-test was performed to calculate the difference of volume transfer constant (K trans ), extravascular extracellular volume fraction (V e ), and initial area under the curve (iAUC) between groups. The diagnostic ability and cut-off value were assessed by receiver operator characteristic analysis. Results Most TICs of HNSCC are type III; no difference between well and poorly differentiated HNSCC has been found ( P 〉 0.05). The value of K trans , V e , and iAUC for well and poorly differentiated HNSCC are (0.218 ± 0.048; 0.383 ± 0.074) min −1 , (0.605 ± 0.108; 0.712 ± 0.150), and (27.552 ± 6.238; 43.157 ± 9.148), respectively. K trans , V e , and iAUC are higher in poorly differentiated HNSCC, compared with well differentiated HNSCC ( P 〈 0.001, 0.013, and 〈 0.001, respectively). K trans has the greatest diagnostic significance with Youden’s index being 0.859 by cut-off value 0.270 min −1 . The diagnostic sensitivity and specificity were 95.0% and 90.9%, respectively. Conclusion The K trans , V e , and iAUC of HNSCC can be reliable quantitative parameters for evaluating well and poorly differentiated HNSCC where K trans has the highest value.
Type of Medium:
Online Resource
ISSN:
0284-1851
,
1600-0455
DOI:
10.1177/0284185118809543
Language:
English
Publisher:
SAGE Publications
Publication Date:
2019
detail.hit.zdb_id:
2024579-8
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