In:
Acta Radiologica, SAGE Publications, Vol. 60, No. 5 ( 2019-05), p. 569-577
Abstract:
Intravoxel incoherent motion magnetic resonance imaging (IVIM-MRI) acquires tumor perfusion information without injection of contrast medium, which is promising in tumor assessment. However, its consistency with dynamic contrast-enhanced MRI (DCE-MRI), a more widely used method for tumor perfusion evaluation, is not revealed in rectal cancer. Purpose In this study, we aimed to investigate the correlation of perfusion-sensitive parameters derived from IVIM-MRI with DCE-MRI and measurement reproducibility of IVIM-MRI parameters in rectal cancer. Material and Methods Forty-seven rectal cancer patients underwent IVIM-MRI with 16 b-values and DCE-MRI. The perfusion fraction ( f), pseudo-diffusion coefficient ( D*), and f· D* were measured by two radiologists independently and correlated with the transfer constant ( K trans ), reflux constant ( k ep ), and extravascular extracellular fractional volume ( v e ) obtained from DCE-MRI. Results Pearson’s correlation analyses of IVIM-MRI and DCE-MRI parameters showed fair to moderate correlation between f and K trans ( r = 0.461, P = 0.001), followed by f and k ep ( r = 0.430, P = 0.003), f·D*, and K trans ( r = 0.425, P = 0.003), f·D*, and k ep ( r = 0.384, P = 0.008). There was no significant correlation between v e and f, v e and D*, v e and f· D*, D* and K trans , and D* and k ep . The reproducibility of IVIM-MRI measurements was moderate. For parameter f, intraclass correlation coefficient (ICC) = 0.71 (0.53–0.82), coefficient of variation (CV) = 13.05 ± 0.02%, limit of agreement (LoA) = −0.05–0.04; for parameter D*, ICC = 0.55 (0.32–0.72), CV = 20.28 ± 3.23%, LoA = −9.6–8.4. Conclusion Perfusion-sensitive parameters derived from IVIM-MRI correlated fairly to moderately with DCE-MRI in rectal cancer patients and showed moderate measurement reproducibility. IVIM-MRI supplements routine high-resolution MRI without contrast enhancement to provide information of tumor microcirculation.
Type of Medium:
Online Resource
ISSN:
0284-1851
,
1600-0455
DOI:
10.1177/0284185118791201
Language:
English
Publisher:
SAGE Publications
Publication Date:
2019
detail.hit.zdb_id:
2024579-8
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