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  • 1
    Online Resource
    Online Resource
    S. Karger AG ; 2009
    In:  Obesity Facts Vol. 2, No. 5 ( 2009), p. 325-331
    In: Obesity Facts, S. Karger AG, Vol. 2, No. 5 ( 2009), p. 325-331
    Type of Medium: Online Resource
    ISSN: 1662-4033 , 1662-4025
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2009
    detail.hit.zdb_id: 2455819-9
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  • 2
    Online Resource
    Online Resource
    S. Karger AG ; 2011
    In:  Obesity Facts Vol. 4, No. s1 ( 2011), p. 3-12
    In: Obesity Facts, S. Karger AG, Vol. 4, No. s1 ( 2011), p. 3-12
    Type of Medium: Online Resource
    ISSN: 1662-4033 , 1662-4025
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2011
    detail.hit.zdb_id: 2455819-9
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  • 3
    In: Obesity Facts, S. Karger AG, Vol. 7, No. 5 ( 2014), p. 302-310
    Abstract: 〈 b 〉 〈 i 〉 Objective: 〈 /i 〉 〈 /b 〉 To determine whether rats reaching the same body mass, having been fed either a low-fat (LFD) or a high-fat diet (HFD), differ in white adipose tissue (WAT) deposition. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 In experiment 1, 22 Sprague-Dawley rats of the same age were divided into 11 rats with body mass below the batch median and fed a HFD, and 11 above the median and fed a LFD. In experiment 2, 20 Sprague-Dawley rats of the same age and starting body mass were randomised to either a HFD or LFD. When all groups reached similar final body mass, WAT was quantified using magnetic resonance imaging (MRI), dissection, and plasma leptin. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 In experiment 1, both groups reached similar final body mass at the same age; in experiment 2 the HFD group reached similar final body mass earlier than the LFD group. There were no significant differences in WAT as assessed by MRI or leptin between the HFD and LFD groups in both experiments. Dissection revealed a trend for higher retroperitoneal and epididymal adiposity in the HFD groups in both experiments. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 We conclude that at similar body mass, adiposity is independent of the macronutrient composition of the feeding regimen used to achieve it.
    Type of Medium: Online Resource
    ISSN: 1662-4025 , 1662-4033
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2014
    detail.hit.zdb_id: 2455819-9
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  • 4
    In: Obesity Facts, S. Karger AG, Vol. 15, No. 6 ( 2022), p. 736-752
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 This Clinical Practice Guideline (CPG) for the management of obesity in adults in Ireland, adapted from the Canadian CPG, defines obesity as a complex chronic disease characterised by excess or dysfunctional adiposity that impairs health. The guideline reflects substantial advances in the understanding of the determinants, pathophysiology, assessment, and treatment of obesity. 〈 b 〉 〈 i 〉 Summary: 〈 /i 〉 〈 /b 〉 It shifts the focus of obesity management toward improving patient-centred health outcomes, functional outcomes, and social and economic participation, rather than weight loss alone. It gives recommendations for care that are underpinned by evidence-based principles of chronic disease management; validate patients’ lived experiences; move beyond simplistic approaches of “eat less, move more” and address the root drivers of obesity. 〈 b 〉 〈 i 〉 Key Messages: 〈 /i 〉 〈 /b 〉 People living with obesity face substantial bias and stigma, which contribute to increased morbidity and mortality independent of body weight. Education is needed for all healthcare professionals in Ireland to address the gap in skills, increase knowledge of evidence-based practice, and eliminate bias and stigma in healthcare settings. We call for people living with obesity in Ireland to have access to evidence-informed care, including medical, medical nutrition therapy, physical activity and physical rehabilitation interventions, psychological interventions, pharmacotherapy, and bariatric surgery. This can be best achieved by resourcing and fully implementing the Model of Care for the Management of Adult Overweight and Obesity. To address health inequalities, we also call for the inclusion of obesity in the Structured Chronic Disease Management Programme and for pharmacotherapy reimbursement, to ensure equal access to treatment based on health-need rather than ability to pay.
    Type of Medium: Online Resource
    ISSN: 1662-4025 , 1662-4033
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2022
    detail.hit.zdb_id: 2455819-9
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  • 5
    In: Obesity Facts, S. Karger AG, Vol. 5, No. 3 ( 2012), p. 349-358
    Abstract: 〈 b 〉 〈 i 〉 Objective: 〈 /i 〉 〈 /b 〉 To investigate whether gastric bypass induces a higher activity of brown adipose tissue and greater levels of the brown adipose tissue-specific protein uncoupling protein-1 (UCP-1) in rats. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Gastric bypass rats and sham-operated controls (each n = 8) underwent whole body 〈 sup 〉 1 〈 /sup 〉 H-MR spectroscopy for analysis of body composition and 〈 sup 〉 18 〈 /sup 〉 F-fluorodeoxyglucose positron emission tomography combined with computed tomography ( 〈 sup 〉 18 〈 /sup 〉 F-FDG PET/CT) imaging for measurement of the metabolic activity of brown adipose tissue. Brown adipose tissue was harvested and weighed, and UCP-1 mRNA content was measured by Northern Blot technique. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Gastric bypass rats had a significantly lower percentage of whole body adipose tissue mass compared to sham-operated rats (p = 0.001). There was no difference in brown adipose tissue activity between the two groups (standardised uptake value sham 2.81 ± 0.58 vs. bypass 2.56 ± 0.46 ; p = 0.73). Furthermore, there was no difference in the UCP-1 mRNA content of brown adipose tissue between the two groups (sham 49.5 ± 13.2 vs. bypass 43.7 ± 13.1; p = 0.77). 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 Gastric bypass does not increase the activity of brown adipose tissue in rats suggesting that other mechanisms are involved to explain the increased energy expenditure after bypass surgery. Our results cannot justify the radiation dose of 〈 sup 〉 18 〈 /sup 〉 F-FDG PET/CT studies in humans to determine potential changes in brown adipose tissue after gastric bypass surgery.
    Type of Medium: Online Resource
    ISSN: 1662-4025 , 1662-4033
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2012
    detail.hit.zdb_id: 2455819-9
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  • 6
    In: Digestive Surgery, S. Karger AG, Vol. 31, No. 1 ( 2014), p. 25-32
    Abstract: Bariatric surgery is the most effective treatment of obesity and its associated diseases like type 2 diabetes mellitus. Given the obesity epidemic and the efficacy of surgical treatment, the number of surgical weight loss procedures has grown in recent years. Nevertheless, there is little consensus regarding the extent of preoperative investigations required prior to patients undergoing surgery. This article aims to discuss the available evidence on which preoperative tests are useful for the detection and treatment of conditions such as venous thromboembolism, obstructive sleep apnea syndrome and 〈 i 〉 Helicobacter pylori 〈 /i 〉 -positive gastritis prior to an operation. The present literature suggests that only a few preoperative investigations are essential, but that preoperative multidisciplinary care is beneficial.
    Type of Medium: Online Resource
    ISSN: 0253-4886 , 1421-9883
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2014
    detail.hit.zdb_id: 1468560-7
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  • 7
    Online Resource
    Online Resource
    S. Karger AG ; 2021
    In:  Nephron Vol. 145, No. 6 ( 2021), p. 585-594
    In: Nephron, S. Karger AG, Vol. 145, No. 6 ( 2021), p. 585-594
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 Surgical approaches to the treatment of obesity and type 2 diabetes, most notably the Roux-en-Y gastric bypass (RYGB) procedure, have been shown to be renoprotective, reducing the incidence of albuminuria and end-stage kidney disease over 15- to 20-year follow-up in patients with obesity. The tissue level effects of metabolic surgery on the diabetic kidney are not easily interrogated in clinical samples. However, elucidation of the cellular and molecular basis for the renoprotective effects of metabolic surgery is now emerging from a body of pre-clinical work in rodent models of diabetic kidney disease (DKD). 〈 b 〉 〈 i 〉 Summary: 〈 /i 〉 〈 /b 〉 Experimental metabolic surgery (RYGB, sleeve gastrectomy [SG], Roux-en-Y oesophagojejunostomy, and duodenojejunal bypass) exerts a pronounced albuminuria-lowering effect in rat models of DKD. Following RYGB in the Zucker diabetic fatty rat, glomerular histology is improved as demonstrated by reductions in podocyte stress, glomerulomegaly, and glomerulosclerosis. Glomerular ultrastructure improves after RYGB and after SG, manifested by quantifiable reductions in podocyte foot process effacement. The transcriptional programme underpinning these structural improvements has been characterized at the pathway level using RNA sequencing and is associated with a significant reduction in the activation of inflammatory and fibrotic responses. 〈 b 〉 〈 i 〉 Key Messages: 〈 /i 〉 〈 /b 〉 Experimental metabolic surgery reduces biochemical, histological, and molecular indices of DKD. These pre-clinical data support a growing interest in the potential utility of metabolic surgery as a therapeutic approach to slow renal functional decline in patients with obesity and DKD.
    Type of Medium: Online Resource
    ISSN: 1660-8151 , 2235-3186
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2021
    detail.hit.zdb_id: 2810853-X
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