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  • 1
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    Online Resource
    Genetic Polymorphisms in Activating Transcription Factor 3 Binding Site and the Prognosis of Early-Stage Non-Small Cell Lung Cancer
    S. Karger AG ; 2021
    In:  Oncology Vol. 99, No. 5 ( 2021), p. 336-344
    Details
    In: Oncology, S. Karger AG, Vol. 99, No. 5 ( 2021), p. 336-344
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 Activating transcription factor 3 (ATF3) plays a significant role in cancer development and progression. We investigated the association between variants in expression quantitative trait loci (eQTLs) within ATF3 binding regions and the prognosis of non-small cell lung cancer (NSCLC) after surgery. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 A total of 772 patients with NSCLC who underwent curative surgery were enrolled. Using a public database (http://galaxyproject.org), we selected 104 single nucleotide polymorphisms (SNPs) in eQTLs in the ATF3 binding regions. The association of those SNPs with disease-free survival (DFS) was evaluated. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Among those SNPs, 〈 i 〉 HAX1 〈 /i 〉 rs11265425T & #x3e;G was associated with significantly worse DFS (aHR = 1.30, 95% CI = 1.00–1.69, 〈 i 〉 p 〈 /i 〉 = 0.05), and 〈 i 〉 ME3 〈 /i 〉 rs10400291C & #x3e;A was associated with significantly better DFS (aHR = 0.66, 95% CI = 0.46–0.95, 〈 i 〉 p 〈 /i 〉 = 0.03). Regarding 〈 i 〉 HAX1 〈 /i 〉 rs11265425T & #x3e;G, the significant association remained only in adenocarcinoma, and the association was significant only in squamous cell carcinoma regarding 〈 i 〉 ME3 〈 /i 〉 rs10400291C & #x3e;A. ChIP-qPCR assays showed that the two variants reside in active enhancers where H3K27Ac and ATF3 binding occurs. Promoter assays showed that rs11265425 G allele had significantly higher 〈 i 〉 HAX1 〈 /i 〉 promoter activity than T allele. 〈 i 〉 HAX1 〈 /i 〉 RNA expression was significantly higher in tumor than in normal lung, and higher in rs11265425 TG+GG genotypes than in TT genotype. Conversely, 〈 i 〉 ME3 〈 /i 〉 expression was significantly lower in tumor than in normal lung, and higher in rs10400291 AA genotype than in CC+CA genotypes. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 In conclusion, this study shows that the functional polymorphisms in ATF3 binding sites, 〈 i 〉 HAX1 〈 /i 〉 rs11265425T & #x3e;G and 〈 i 〉 ME3 〈 /i 〉 rs10400291C & #x3e;A are associated with the clinical outcomes of patients in surgically resected NSCLC.
    Type of Medium: Online Resource
    ISSN: 0030-2414 , 1423-0232
    URL: Article
    DOI: 10.1159/000514131
    RVK:
    XH 3305
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2021
    detail.hit.zdb_id: 1483096-6
    detail.hit.zdb_id: 250101-6
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  • 2
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    Genetic Variants in One-Carbon Metabolism Pathway Predict Survival Outcomes of Early-Stage Non-Small Cell Lung Cancer
    S. Karger AG ; 2020
    In:  Oncology Vol. 98, No. 12 ( 2020), p. 897-904
    Details
    In: Oncology, S. Karger AG, Vol. 98, No. 12 ( 2020), p. 897-904
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 This study was conducted to investigate the association between genetic variants in one-carbon metabolism and survival outcomes of surgically resected non-small cell lung cancer (NSCLC). 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 We genotyped 41 potentially functional variants of 19 key genes in the one-carbon metabolism pathway among 750 NSCLC patients who underwent curative surgery. The association between genetic variants and overall survival (OS)/disease-free survival (DFS) were analyzed. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Among the 41 single-nucleotide polymorphisms (SNPs) analyzed, 4 SNPs ( 〈 i 〉 MTHFD1L 〈 /i 〉 rs6919680T & #x3e;G and rs3849794T & #x3e;C, 〈 i 〉 MTR 〈 /i 〉 rs2853523C & #x3e;A, and 〈 i 〉 MTHFR 〈 /i 〉 rs4846049G & #x3e;T) were significantly associated with survival outcomes. 〈 i 〉 MTHFD1L 〈 /i 〉 rs6919680T & #x3e;G and 〈 i 〉 MTR 〈 /i 〉 rs2853523C & #x3e;A were significantly associated with better OS (adjusted hazard ratio [aHR] = 0.73, 95% confidence interval [CI] = 0.54–0.99, 〈 i 〉 p 〈 /i 〉 = 0.04) and worse OS (aHR = 2.14, 95% CI = 1.13–4.07, 〈 i 〉 p 〈 /i 〉 = 0.02), respectively. 〈 i 〉 MTHFD1L 〈 /i 〉 rs3849794T & #x3e;C and 〈 i 〉 MTHFR 〈 /i 〉 rs4846049G & #x3e;T were significantly associated with worse DFS (aHR = 1.41, 95% CI = 1.08–1.83, 〈 i 〉 p 〈 /i 〉 = 0.01; and aHR = 1.97, 95% CI = 1.10–3.53, 〈 i 〉 p 〈 /i 〉 = 0.02, respectively). When the patients were divided according to histology, the associations were significant only in squamous cell carcinoma (SCC), but not in adenocarcinoma (AC). In SCC, 〈 i 〉 MTHFD1L 〈 /i 〉 rs6919680T & #x3e;G and 〈 i 〉 MTR 〈 /i 〉 rs2853523C & #x3e;A were significantly associated with better OS (aHR = 0.64, 95% CI = 0.41–1.00, 〈 i 〉 p 〈 /i 〉 = 0.05) and worse OS (aHR = 2.77, 95% CI = 1.11–6.91, 〈 i 〉 p 〈 /i 〉 = 0.03), respectively, and 〈 i 〉 MTHFD1L 〈 /i 〉 rs3849794T & #x3e;C and 〈 i 〉 MTHFR 〈 /i 〉 rs4846049G & #x3e;T were significantly associated with worse DFS (aHR = 1.73, 95% CI = 1.17–2.56, 〈 i 〉 p 〈 /i 〉 = 0.01; and aHR = 2.78, 95% CI = 1.12–6.88, 〈 i 〉 p 〈 /i 〉 = 0.03, respectively). 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 Our results suggest that the genetic variants in the one-carbon metabolism pathway could be used as biomarkers for predicting the clinical outcomes of patients with early-stage NSCLC.
    Type of Medium: Online Resource
    ISSN: 0030-2414 , 1423-0232
    URL: Article
    DOI: 10.1159/000509658
    RVK:
    XH 3305
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2020
    detail.hit.zdb_id: 1483096-6
    detail.hit.zdb_id: 250101-6
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  • 3
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    Genetic Variants in Histone Modification Regions Predict Clinical Outcomes of Pemetrexed Chemotherapy in Lung Adenocarcinoma
    S. Karger AG ; 2023
    In:  Oncology Vol. 101, No. 2 ( 2023), p. 96-104
    Details
    In: Oncology, S. Karger AG, Vol. 101, No. 2 ( 2023), p. 96-104
    Abstract: 〈 b 〉 〈 i 〉 Objective: 〈 /i 〉 〈 /b 〉 This study was conducted to investigate the association between genetic variants in histone modification regions and clinical outcomes of PEM chemotherapy in patients with lung adenocarcinoma. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Potentially functional SNPs were selected using integrated analysis of ChIP-seq and RNA-seq. The associations of 279 SNPs with chemotherapy response and overall survival (OS) were analyzed in 314 lung adenocarcinoma patients who underwent PEM chemotherapy. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Among the SNPs investigated, 18 were significantly associated with response to chemotherapy, while 28 with OS. Of these SNPs, rs549794A & #x3e;G in an enhancer which is expected to regulate the expression of 〈 i 〉 ribosomal protein S3 〈 /i 〉 ( 〈 i 〉 RPS3 〈 /i 〉 ) gene was significantly associated with both worse response to chemotherapy and worse OS (adjusted odds ratio = 0.59, 95% CI = 0.36–0.97, 〈 i 〉 p 〈 /i 〉 = 0.04; adjusted hazard ratio = 1.44, 95% CI = 1.09–1.91, 〈 i 〉 p 〈 /i 〉 = 0.01, respectively). Previous studies suggested that RPS3, a multi-functional protein with various extraribosomal activities, may play a role in chemotherapy resistance. Therefore, it is postulated that rs549794-induced change in the expression level of RPS3 may affect the response to PEM chemotherapy and consequently the survival outcomes in lung adenocarcinoma patients. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 This study suggests that genetic variants in the histone modification regions may be useful for the prediction of clinical outcomes of PEM chemotherapy in advanced lung adenocarcinoma.
    Type of Medium: Online Resource
    ISSN: 0030-2414 , 1423-0232
    URL: Article
    DOI: 10.1159/000527492
    RVK:
    XH 3305
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2023
    detail.hit.zdb_id: 1483096-6
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  • 4
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    Changes of Plasma Tissue Factor and Tissue Factor Pathway Inhibitor Antigen Levels and Induction of Tissue Factor Expression on the Monocytes in Coronary Artery Disease
    S. Karger AG ; 2000
    In:  Cardiology Vol. 93, No. 1-2 ( 2000), p. 31-36
    Details
    In: Cardiology, S. Karger AG, Vol. 93, No. 1-2 ( 2000), p. 31-36
    Abstract: 〈 i 〉 Background: 〈 /i 〉 Several studies have shown that thrombosis and inflammation play an important role in the pathogenesis of coronary artery disease (CAD). Tissue factor (TF) is responsible for the thrombogenicity of the atherosclerotic plaque and plays a key in triggering thrombin generation. The aim of this study was to assess the levels of TF and tissue factor pathway inhibitor (TFPI) in patients with angiographically documented CAD and also to evaluate TF induction on monocytes in vitro in the presence of these plasmas from patients with CAD. 〈 i 〉 Methods: 〈 /i 〉 Plasma antigen levels of soluble TF and TFPI were measured in 65 CAD patients and 22 healthy controls. Surface TF expression on monocytes from a healthy donor treated with plasma samples was evaluated by flow cytometry with a direct double-color immunofluorescence technique. 〈 i 〉 Results: 〈 /i 〉 Significantly elevated levels of both TF and TFPI were found in CAD patients compared with healthy controls (303.6 ± 134.1 vs. 187.3 ± 108.7 pg/ml, p 〈 0.05; 85.2 ± 48.6 vs. 65.0 ± 29.0 ng/ml, p 〈 0.05). By flow cytometry, monocytes from a healthy donor displayed higher TF antigen expression when incubated in the presence of CAD plasmas than in control plasmas (34.6 ± 10.7 vs. 23.2 ± 10.2%, p 〈 0.05). 〈 i 〉 Conclusions: 〈 /i 〉 The high levels of circulating TF are present in CAD, which were not sufficiently inhibited by the elevated TFPI plasma levels. Although the source of circulating TF is unclear, TF induction of monocytes by plasma from CAD patients may contribute to the hypercoagulable state.
    Type of Medium: Online Resource
    ISSN: 0008-6312 , 1421-9751
    URL: Article
    DOI: 10.1159/000006999
    RVK:
    XA 36200
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2000
    detail.hit.zdb_id: 1482041-9
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  • 5
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    Polymorphisms in Glycolysis-Related Genes Are Associated with Clinical Outcomes of Paclitaxel-Cisplatin Chemotherapy in Non-Small Cell Lung Cancer
    S. Karger AG ; 2020
    In:  Oncology Vol. 98, No. 7 ( 2020), p. 468-477
    Details
    In: Oncology, S. Karger AG, Vol. 98, No. 7 ( 2020), p. 468-477
    Abstract: 〈 b 〉 〈 i 〉 Objective: 〈 /i 〉 〈 /b 〉 This study was conducted to investigate whether polymorphisms in glycolysis-related genes are associated with clinical outcomes of patients with advanced-stage non-small cell lung cancer (NSCLC) undergoing chemotherapy. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 A total of 377 patients with NSCLC were enrolled. Sixty-five single-nucleotide polymorphisms in 26 genes involved in the glycolytic pathway were evaluated. The associations of the variants with the chemotherapy response and overall survival (OS) were analyzed. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Among the 65 variants investigated, 〈 i 〉 PFKL 〈 /i 〉 rs2073436C & #x3e;G and 〈 i 〉 GPI 〈 /i 〉 rs7248411C & #x3e;G significantly correlated with clinical outcomes after chemotherapy in multivariate analyses. 〈 i 〉 PFKL 〈 /i 〉 rs2073436C & #x3e;G was significantly associated with both a worse response to chemotherapy (adjusted odds ratio [aOR] = 0.64, 95% CI = 0.45–0.90, 〈 i 〉 p 〈 /i 〉 = 0.01) and a worse OS (adjusted hazard ratio [aHR] = 1.35, 95% CI = 1.14–1.61, 〈 i 〉 p 〈 /i 〉 = 0.001). 〈 i 〉 GPI 〈 /i 〉 rs7248411C & #x3e;G was significantly associated with both a better chemotherapy response (aOR = 1.58, 95% CI = 1.07–2.23, 〈 i 〉 p 〈 /i 〉 = 0.02) and a better OS (aHR = 0.80, 95% CI = 0.66–0.98, 〈 i 〉 p 〈 /i 〉 = 0.03). When stratified by tumor histology, 〈 i 〉 PFKL 〈 /i 〉 rs2073436C & #x3e;G was significantly associated with OS only in squamous cell carcinoma, whereas 〈 i 〉 GPI 〈 /i 〉 rs7248411C & #x3e;G exhibited a significant association with the chemotherapy response and OS only in adenocarcinoma. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 This result suggests that the 〈 i 〉 PFKL 〈 /i 〉 rs2073436C & #x3e;G and 〈 i 〉 GPI 〈 /i 〉 rs7248411C & #x3e;G are useful for predicting the clinical outcome of first-line paclitaxel-cisplatin chemotherapy in NSCLC.
    Type of Medium: Online Resource
    ISSN: 0030-2414 , 1423-0232
    URL: Article
    DOI: 10.1159/000504175
    RVK:
    XH 3305
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2020
    detail.hit.zdb_id: 1483096-6
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  • 6
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    Absence of Association between Two 〈i〉HECTD2〈/i〉 Polymorphisms and Sporadic Creutzfeldt-Jakob Disease
    S. Karger AG ; 2011
    In:  Dementia and Geriatric Cognitive Disorders Vol. 31, No. 2 ( 2011), p. 146-151
    Details
    In: Dementia and Geriatric Cognitive Disorders, S. Karger AG, Vol. 31, No. 2 ( 2011), p. 146-151
    Abstract: 〈 i 〉 Background: 〈 /i 〉 HECT (homologous to E6-AP carboxyl terminus) E3 ubiquitin ligases are fundamental components of the eukaryotic ubiquitin-proteasome system and are involved in the pathogenesis of several human diseases, including polyglutamine diseases. 〈 i 〉 HECTD2 〈 /i 〉 , an E3 ubiquitin ligase, has been linked to the incubation time of prion disease in mice, and its polymorphisms have been associated with sporadic Creutzfeldt-Jakob disease (CJD) in the British population. 〈 i 〉 Objective: 〈 /i 〉 To investigate whether 2 〈 i 〉 HECTD2 〈 /i 〉 polymorphisms, –247G→A (rs7081363) and +16066T→A (rs12249854), are associated with sporadic CJD in the Korean population. 〈 i 〉 Methods: 〈 /i 〉 We compared the genotype, allele and haplotype frequencies of the 2 〈 i 〉 HECTD2 〈 /i 〉 polymorphisms in 205 sporadic CJD patients to those of 208 healthy Koreans. 〈 i 〉 Results and Conclusion: 〈 /i 〉 Our study does not show significant differences in the genotype and allele frequencies of these 2 polymorphisms between sporadic CJD and normal controls. Significant differences in the haplotype frequencies of these 2 polymorphisms were not observed between sporadic CJD and normal controls either. Our results indicate that these 2 〈 i 〉 HECTD2 〈 /i 〉 polymorphisms are not associated with genetic susceptibility to sporadic CJD in a Korean population. This is the first genetic association study of 〈 i 〉 HECTD2 〈 /i 〉 with sporadic CJD in an Asian population.
    Type of Medium: Online Resource
    ISSN: 1420-8008 , 1421-9824
    URL: Article
    DOI: 10.1159/000324133
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2011
    detail.hit.zdb_id: 1482186-2
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  • 7
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    Genetic Association of a Cathepsin D Polymorphism and Sporadic Creutzfeldt-Jakob Disease
    S. Karger AG ; 2009
    In:  Dementia and Geriatric Cognitive Disorders Vol. 28, No. 4 ( 2009), p. 302-306
    Details
    In: Dementia and Geriatric Cognitive Disorders, S. Karger AG, Vol. 28, No. 4 ( 2009), p. 302-306
    Abstract: 〈 i 〉 Background: 〈 /i 〉 Cathepsin D is the most abundant lysosomal and endosomal aspartyl protease; it shows beta and gamma secretase activity in vitro by cleaving the amyloid precursor protein into amyloid beta protein. In recent studies, cathepsin D was co-localized with PrP 〈 sup 〉 Sc 〈 /sup 〉 , the disease-associated form of the prion disease, and abnormal expression of cathepsin D correlated with tissue damage in brains of sporadic Creutzfeldt-Jakob disease (CJD). 〈 i 〉 Objective: 〈 /i 〉 To investigate whether a polymorphism at position 224, C224T, on exon 2 of the cathepsin D gene ( 〈 i 〉 CTSD) 〈 /i 〉 is associated with sporadic CJD in the Korean population. 〈 i 〉 Methods: 〈 /i 〉 We compared the genotype and allele frequencies at this polymorphism site in 172 sporadic CJD patients with those in 197 healthy Koreans. 〈 i 〉 Results and Conclusion: 〈 /i 〉 Our study does not show a significant difference in genotype (p = 0.901) and allele (p = 0.509) frequencies of 〈 i 〉 CTSD 〈 /i 〉 C224T between sporadic CJD patients and normal controls. This was the first genetic association study of 〈 i 〉 CTSD 〈 /i 〉 in a sporadic CJD population.
    Type of Medium: Online Resource
    ISSN: 1420-8008 , 1421-9824
    URL: Article
    DOI: 10.1159/000246343
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2009
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  • 8
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    A High Ki67/BCL2 Index Could Predict Lower Disease-Free and Overall Survival in Intestinal-Type Gastric Cancer
    S. Karger AG ; 2017
    In:  European Surgical Research Vol. 58, No. 3-4 ( 2017), p. 158-168
    Details
    In: European Surgical Research, S. Karger AG, Vol. 58, No. 3-4 ( 2017), p. 158-168
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 The heterogeneity of gastric cancer makes the identification of potential prognostic indicators particularly important. The Ki67 and BCL2 proteins are known prognostic markers for different types of cancer. Ki67 is associated with cell proliferation, whereas BCL2 has antiproliferative roles. A combined marker based on these opposite functions might provide improved prognostic information in gastric cancer. 〈 b 〉 〈 i 〉 Method: 〈 /i 〉 〈 /b 〉 Ki67 and BCL2 expression was assessed in 276 gastric adenocarcinoma tissue microarrays. A Ki67/BCL2 index based on the relative expression of each protein was divided into low- and high-risk groups using receiver operating characteristic curves. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 A high Ki67/BCL2 index significantly correlated with advanced stage, recurrence, intestinal type, high histologic grade, and lymphatic and perineural invasion (all p 〈 0.05). Univariate and multivariate analyses revealed a significant relationship between disease-free or overall survival and the Ki67/BCL2 index in intestinal-type gastric cancer (all p 〈 0.05). 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 A combined marker using Ki67 and BCL2 could be a useful indicator for predicting survival in patients with intestinal-type gastric cancer.
    Type of Medium: Online Resource
    ISSN: 0014-312X , 1421-9921
    URL: Article
    DOI: 10.1159/000448945
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2017
    detail.hit.zdb_id: 1468505-X
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  • 9
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    Adjuvant Hepatic Arterial Infusional Chemotherapy with 5-Fluorouracil and Cisplatin after Curative Resection of Hepatocellular Carcinoma
    S. Karger AG ; 2011
    In:  Oncology Vol. 81, No. 3-4 ( 2011), p. 184-191
    Details
    In: Oncology, S. Karger AG, Vol. 81, No. 3-4 ( 2011), p. 184-191
    Abstract: 〈 i 〉 Objectives: 〈 /i 〉 We investigated whether adjuvant hepatic arterial infusional chemotherapy (HAIC) with 5-fluorouracil (5-FU) and cisplatin reduces the recurrence of hepatocellular carcinoma (HCC) after curative resection. 〈 i 〉 Methods: 〈 /i 〉 Between January 2006 and December 2008, 31 HCC patients received four cycles of adjuvant HAIC with 5-FU and cisplatin via port system after curative resection. During the same period, 62 patients, who did not take any adjuvant therapy, were selected as controls. 〈 i 〉 Results: 〈 /i 〉 Tumor characteristics, such as distribution of TNM stage, pathologic differentiation, portal vein invasion, or microscopic invasion did not differ between control and adjuvant groups. During follow-up, recurrence developed in 11 adjuvant (35.5%) and 24 control patients (38.7%; p = 0.823). Tumor progression after recurrence was the cause of death in 2 adjuvant (28.6%) and 7 control patients (38.8%; p = 0.912). The 2-year recurrence rate was 9.1% in the adjuvant group and 4.2% in the control group, with the median recurrence-free survival time being 10.5 and 7.5 months, respectively (p = 0.324). The 3-year cumulative survival rate was 73.3% in the adjuvant group and 68.3% in the control group (p = 0.355). 〈 i 〉 Conclusion: 〈 /i 〉 Adjuvant HAIC with 5-FU and cisplatin did not offer any beneficial effect on the recurrence after curative resection of HCC.
    Type of Medium: Online Resource
    ISSN: 0030-2414 , 1423-0232
    URL: Article
    DOI: 10.1159/000333827
    RVK:
    XH 3305
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2011
    detail.hit.zdb_id: 1483096-6
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  • 10
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    Spontaneous Hepatic Infarction in a Patient with Gallbladder Cancer
    S. Karger AG ; 2016
    In:  Case Reports in Oncology Vol. 9, No. 2 ( 2016-6-14), p. 321-327
    Details
    In: Case Reports in Oncology, S. Karger AG, Vol. 9, No. 2 ( 2016-6-14), p. 321-327
    Abstract: Hepatic infarction is known as a rare disease entity in nontransplant patients. Although a few cases of hepatic infarction have been reported to be linked with invasive procedures, trauma, and hypercoagulability, a case of spontaneous hepatic infarction in a nontransplanted patient has hardly ever been reported. However, many clinical situations of patients with cancer, in particular biliary cancer, can predispose nontransplant patients to hepatic infarction. Besides, the clinical outcome of hepatic infarction in patients with cancer can be worse than in patients with other etiologies. As for treatment, anticoagulation treatment is usually recommended. However, because of its multifactorial etiology and combined complications, treatment of hepatic infarction is difficult and not simple. Herein, we report a case of fatal hepatic infarction that occurred spontaneously during the course of treatment in a patient with gallbladder cancer. Hepatic infarction should be considered as a possible fatal complication in patients during treatment of biliary malignancies.
    Type of Medium: Online Resource
    ISSN: 1662-6575
    URL: Article
    DOI: 10.1159/000446911
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2016
    detail.hit.zdb_id: 2458961-5
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