In:
Stereotactic and Functional Neurosurgery, S. Karger AG, Vol. 77, No. 1-4 ( 2001), p. 61-67
Abstract:
To determine the optimal stimulation site within the subthalamic nucleus (STN), monopolar stimulation of four electrode contacts and the resulting effects on parkinsonian symptoms were evaluated in 10 consecutive patients. The UPDRS score for rigidity and akinesia improved significantly after stimulation at each of the contacts, compared to the pre-evaluation state (Fisher’s test, p 〈 0.05). The most significant improvement was obtained after stimulation at contact-2 (rigidity: 74.4 ± 20.4%, akinesia: 53.7 ± 14.3%) (Fisher’s test, p 〈 0.001). Contact-2 was located at the dorsal border of the STN at a mean distance of 0.3 ± 0.7 mm. DBS at the dorsal border of the STN, where the stimulation affects the neurons as well as their axonal fibers, produces the greatest clinical improvement in parkinsonian symptoms.
Type of Medium:
Online Resource
ISSN:
1011-6125
,
1423-0372
Language:
English
Publisher:
S. Karger AG
Publication Date:
2001
detail.hit.zdb_id:
1483576-9
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