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  • 1
    Online Resource
    Online Resource
    PROX1 Was Associated with LGR5 and Wnt Signaling and Contributed to Poor Prognosis in Gastric Cancer
    S. Karger AG ; 2022
    In:  Oncology Vol. 100, No. 11 ( 2022), p. 569-575
    Details
    In: Oncology, S. Karger AG, Vol. 100, No. 11 ( 2022), p. 569-575
    Abstract: 〈 b 〉 〈 i 〉 Introduction: 〈 /i 〉 〈 /b 〉 We investigated whether the expression of prospero homeobox protein-1 (PROX1) in gastric cancer (GC) could be a prognostic marker. We also focused on the relationship between PROX1 and LGR5 and Wnt/β-catenin activity in GC. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 A total of 196 patients who underwent potentially curative surgery were collected and reviewed retrospectively. Immunohistochemistry was conducted and evaluated the expression PROX1, LGR5, Wnt3a, and β-catenin expression. And we evaluated the relationship between PROX1 expression and clinicopathological features. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 The PROX1 low-expression group consisted of 105 patients (53.6%) and the high-expression group consisted of 91 patients (46.4%). For LGR5 expression, 76 patients (38.8%) were classified as low-expression, and 120 patients (61.2%) were classified as high-expression. The PROX1 low-expression group was significantly younger ( 〈 i 〉 p 〈 /i 〉 = 0.0095), had more intestinal type ( 〈 i 〉 p 〈 /i 〉 = 0.014), and had smaller tumor size ( 〈 i 〉 p 〈 /i 〉 = 0.013). The PROX1 high-expression group was significantly correlated with high LGR5 expression ( 〈 i 〉 p 〈 /i 〉 & #x3c; 0.0001) and high Wnt3a expression ( 〈 i 〉 p 〈 /i 〉 = 0.012). In addition, there were significantly more cases of postoperative recurrence in the PROX1 high-expression group ( 〈 i 〉 p 〈 /i 〉 = 0.013). 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 Our findings demonstrate that PROX1 correlated with the cancer stemness markers LGR5 and Wnt3a signaling in GC and had a poor prognosis including postoperative recurrence.
    Type of Medium: Online Resource
    ISSN: 0030-2414 , 1423-0232
    URL: Article
    DOI: 10.1159/000526734
    RVK:
    XH 3305
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2022
    detail.hit.zdb_id: 1483096-6
    detail.hit.zdb_id: 250101-6
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  • 2
    Online Resource
    Online Resource
    Presence of Cytokeratin 19-Expressing Cholangiocarcinoma-Like Tumour in a Liver Metastatic Lesion of Rectal Neuroendocrine Tumour
    S. Karger AG ; 2016
    In:  Case Reports in Gastroenterology Vol. 10, No. 2 ( 2016-8-12), p. 431-439
    Details
    In: Case Reports in Gastroenterology, S. Karger AG, Vol. 10, No. 2 ( 2016-8-12), p. 431-439
    Abstract: 〈 b 〉 〈 i 〉 Introduction: 〈 /i 〉 〈 /b 〉 Tumours with adenocarcinoma and neuroendocrine components have often been reported, although the reason underlying the dual components remains unclear. 〈 b 〉 〈 i 〉 Case Presentation: 〈 /i 〉 〈 /b 〉 A 43-year-old woman with multiple liver metastatic lesions of rectal neuroendocrine tumour underwent primary tumour resection and subsequent liver transplantation. Pathological examination indicated a cholangiocarcinoma-like tumour with gland formation, adjacent to a liver metastatic lesion of the neuroendocrine tumour. This tumour comprised atypical columnar epithelium, and stained positively for neuroendocrine markers and the ductal marker cytokeratin 19, indicating amphicrine properties and a partial cholangiocarcinoma phenotype – features not observed in the primary and metastatic neuroendocrine tumours. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 The presence of adenocarcinoma only at the metastatic site indicated that neuroendocrine tumour cells acquired stemness and differentiated into adenocarcinoma through metastasis, or that the adenocarcinoma newly arose from the adjacent epithelium influenced by the neuroendocrine tumour. We propose a novel mechanism for the pathogenesis of mixed tumours in neuroendocrine tumours.
    Type of Medium: Online Resource
    ISSN: 1662-0631
    URL: Article
    DOI: 10.1159/000446641
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2016
    detail.hit.zdb_id: 2440540-1
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  • 3
    Online Resource
    Online Resource
    Infiltration of Gastric Cancer Stroma by Tumor-Infiltrating Lymphocytes Correlates with mTOR Signaling
    S. Karger AG ; 2023
    In:  Oncology
    Details
    In: Oncology, S. Karger AG
    Abstract: Introduction: We investigated whether the infiltration of tumor-infiltrating lymphocytes (TILs) in gastric cancer (GC), as evaluated by hematoxylin & eosin (H & E) staining, could be a prognostic marker. We also explored on the relationship between TILs and mechanistic target of rapamycin (mTOR) and how it regulates immune effector responses in GC. Methods: A total of 183 patients with available data on TIL were included. TIL infiltration was evaluated using H & E staining. We also conducted immunohistochemistry to determine mTOR expression. Results: Positive TIL infiltration was defined as TILs ≥20%. There were 72 (39.3%) and 111 (60.7%) positive and negative cases, respectively. TILs positivity significantly correlated with both absence of lymph node metastasis (p = 0.037) and negative p-mTOR expression (p = 0.040). TIL infiltration correlated with a significantly better overall (p = 0.046) and disease-free (p = 0.020) survival. Conclusion: mTOR possibly suppresses TIL infiltration in GC. H & E staining is an effective tool for evaluating the immune status of GC patients. H & E staining may be used in clinical practice to monitor treatment response in GC.
    Type of Medium: Online Resource
    ISSN: 0030-2414 , 1423-0232
    URL: Article
    DOI: 10.1159/000531475
    RVK:
    XH 3305
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2023
    detail.hit.zdb_id: 1483096-6
    detail.hit.zdb_id: 250101-6
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  • 4
    Online Resource
    Online Resource
    Esophageal Squamous Cell Carcinoma with Marked Eosinophil Infiltration
    S. Karger AG ; 2011
    In:  Case Reports in Gastroenterology Vol. 5, No. 3 ( 2011), p. 648-653
    Details
    In: Case Reports in Gastroenterology, S. Karger AG, Vol. 5, No. 3 ( 2011), p. 648-653
    Type of Medium: Online Resource
    ISSN: 1662-0631
    URL: Article
    DOI: 10.1159/000332441
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2011
    detail.hit.zdb_id: 2440540-1
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  • 5
    Online Resource
    Online Resource
    High L-Type Amino Acid Transporter 1 Levels Are Associated with Chemotherapeutic Resistance in Gastric Cancer Patients
    S. Karger AG ; 2021
    In:  Oncology Vol. 99, No. 11 ( 2021), p. 732-739
    Details
    In: Oncology, S. Karger AG, Vol. 99, No. 11 ( 2021), p. 732-739
    Abstract: 〈 b 〉 〈 i 〉 Introduction: 〈 /i 〉 〈 /b 〉 We investigated whether the expression of L-type amino acid transporter 1 (LAT-1) in clinical gastric cancer (GC) patients could predict patient therapeutic response to postoperative adjuvant chemotherapy. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Immunohistochemistry was used to investigate LAT-1, CD98, and phosphorylated-mammalian target of rapamycin (p-mTOR) expression in 111 GC patients. To clarify whether LAT-1 influences the therapeutic effects of chemotherapy, the correlation between disease-free survival rates and LAT-1 was determined in 2 groups: 59 patients who did not undergo postoperative adjuvant chemotherapy and 52 patients who did undergo postoperative adjuvant chemotherapy. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 LAT-1 was significantly correlated with CD98 and p-mTOR expressions. We did not find any statistically significant correlation between LAT-1 and recurrence in the nontreated group. In contrast, a significant association was found between LAT-1 expression and disease-free survival in the chemotherapy group. Moreover, multivariate regression analysis demonstrated that LAT-1 was an independent predictor of disease-free survival in the postoperative adjuvant chemotherapy group ( 〈 i 〉 p 〈 /i 〉 = 0.012). 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 Our findings demonstrate that LAT-1 is a useful predictive marker for a successful postoperative adjuvant chemotherapy treatment.
    Type of Medium: Online Resource
    ISSN: 0030-2414 , 1423-0232
    URL: Article
    DOI: 10.1159/000517371
    RVK:
    XH 3305
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2021
    detail.hit.zdb_id: 1483096-6
    detail.hit.zdb_id: 250101-6
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  • 6
    Online Resource
    Online Resource
    18F-FAMT PET Is Useful to Distinguish between Specific Uptake and Nonspecific Uptake Compared to 18F-Flourodeoxyglucose Position Emission Tomography in Esophageal Cancer Patients
    S. Karger AG ; 2018
    In:  Digestive Surgery Vol. 35, No. 5 ( 2018), p. 383-388
    Details
    In: Digestive Surgery, S. Karger AG, Vol. 35, No. 5 ( 2018), p. 383-388
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 L-[3- 〈 sup 〉 18 〈 /sup 〉 F]-α-methyltyrosine ( 〈 sup 〉 18 〈 /sup 〉 F-FAMT) solely accumulates in tumor cells via an amino acid transport system. This selective uptake pattern results in a very high tumor-to-background ratio, enabling clear delineation of the tumor. The purpose of the present study was to assess the significance of 〈 sup 〉 18 〈 /sup 〉 F-FAMT PET, which shows little nonspecific uptake compared to 〈 sup 〉 18 〈 /sup 〉 F-flourodeoxyglucose position emission tomography (FDG PET) in esophageal cancer patients. 〈 b 〉 〈 i 〉 Methodology: 〈 /i 〉 〈 /b 〉 PET-CT studies with 〈 sup 〉 18 〈 /sup 〉 F-FAMT and 〈 sup 〉 18 〈 /sup 〉 F-FDG were performed as part of pretreatment work-up in 82 patients with histologically confirmed esophageal cancer. We evaluated nonspecific uptakes of 〈 sup 〉 18 〈 /sup 〉 F-FDG and 〈 sup 〉 18 〈 /sup 〉 F-FAMT PET. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 The nonspecific uptake of 〈 sup 〉 18 〈 /sup 〉 F-FAMT PET was lower than that of 〈 sup 〉 18 〈 /sup 〉 F-FDG PET ( 〈 i 〉 p = 〈 /i 〉 0.282). In the operation group, 26.1% demonstrated nonspecific uptake in 〈 sup 〉 18 〈 /sup 〉 F-FDG PET, whereas only 2.38% (1 case) demonstrated nonspecific uptake in 〈 sup 〉 18 〈 /sup 〉 F-FAMT PET ( 〈 i 〉 p = 〈 /i 〉 0.433). In the inoperable group, 47.5% showed nonspecific uptake in 〈 sup 〉 18 〈 /sup 〉 F-FDG PET, whereas 5.0% showed nonspecific uptake in 〈 sup 〉 18 〈 /sup 〉 F-FAMT PET ( 〈 i 〉 p = 〈 /i 〉 0.079). 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 A crucial point for the diagnostic value of PET is distinguishing specific and nonspecific uptake. 〈 sup 〉 18 〈 /sup 〉 F-FAMT-PET is a very superior modality with regard to the lower rate of nonspecific uptake in esophageal cancer.
    Type of Medium: Online Resource
    ISSN: 0253-4886 , 1421-9883
    URL: Article
    DOI: 10.1159/000480122
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2018
    detail.hit.zdb_id: 1468560-7
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  • 7
    Online Resource
    Online Resource
    Chest Pain after Endoscopic Submucosal Dissection for Esophageal Cancer: The Simple and Clinically Useful Surrogate Marker for Transmural Thermal Injury by Electrocoagulation
    S. Karger AG ; 2021
    In:  Digestion Vol. 102, No. 4 ( 2021), p. 607-614
    Details
    In: Digestion, S. Karger AG, Vol. 102, No. 4 ( 2021), p. 607-614
    Abstract: Background: Endoscopic submucosal dissection (ESD) of early esophageal cancer (EC) is becoming more widespread. Post-ESD coagulation syndrome (CS) has been proposed as temporary inflammatory signs that occur during the post-ESD period caused by transmural thermal injury by electrocoagulation. This retrospective study aimed to evaluate the association between chest pain and abnormal levels of inflammatory markers during the post-esophageal ESD period. We also investigate the clinical importance of chest pain to define the post-esophageal ESD CS. Methods: We examined 42 patients with thoracic EC who underwent ESD. Results: The incidence of chest pain after esophageal ESD is 35.7% and associated with elevation of WBC count on postoperative day 1 (WBC day 1) (p = 0.022). Multivariate logistic regression analysis using the procedure-related factors revealed that WBC day 1 was an independent predictive factor for chest pain (p = 0.034). The elevation of WBC count is associated with the resected esophageal circumference (p for trend = 0.018), specimen size (p = 0.031), and procedural time (p = 0.004). The incidence of post-esophageal ESD CS was estimated ranging from 11.9 to 54.8% using previously reported criteria. Conclusions: The incidence of chest pain after ESD was only associated with postoperative elevation of WBC day 1. In considering the elevation of WBC count associated with procedure-related factors, chest pain possibly reflected transmural thermal injury by electrocoagulation during ESD. Post-esophageal ESD chest pain is a simple and clinically useful surrogate marker for transmural thermal injury and is a vital sign of post-esophageal ESD CS.
    Type of Medium: Online Resource
    ISSN: 0012-2823 , 1421-9867
    URL: Article
    DOI: 10.1159/000510353
    RVK:
    XA 40650
    RVK:
    XA 10000
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2021
    detail.hit.zdb_id: 1482218-0
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  • 8
    Online Resource
    Online Resource
    Role of PD-L1 Expression during the Progression of Submucosal Gastric Cancer
    S. Karger AG ; 2021
    In:  Oncology Vol. 99, No. 1 ( 2021), p. 15-22
    Details
    In: Oncology, S. Karger AG, Vol. 99, No. 1 ( 2021), p. 15-22
    Abstract: Introduction: Programmed death-ligand 1 (PD-L1) expression is a prognostic marker for gastric cancer that correlates with tumor diameter and depth of penetration. But the role of PD-L1 and mechanism(s) employed in the initial phase of invasion in early gastric cancer is yet to be understood. Objective: This study aims to elucidate the role of PD-L1 during the progression of gastric cancer, specifically invading the submucosa beyond the lamina muscularis mucosa. Methods: Using 107 patients with pathological submucosal gastric cancer, we determined the expression of PD-L1 based on the staining of the cell membrane or cytoplasm of tumor cells in the central and invasive front of the tumor. Samples were categorized into 3 groups based on the intensity of PD-L1 expression. CD8+ lymphocytes expressing PD-1 and CD163+ macrophages were used to determine the number of cell nuclei at the invasive front, similar to PD-L1. CMTM6 levels were determined and used to stratify samples into 3 groups. Results: PD-L1 expression was higher in the invasive front (26.2%) than in the central portion of the tumors (7.4%; p 〈 0.001). Moreover, lymphatic and vascular invasion were more frequently observed in samples with high levels of PD-L1 (lymphatic invasion: 60.7 vs. 35.4%, p = 0.0026, and vascular invasion: 39.3 vs. 16.5%, p = 0.0018). There was no correlation between PD-L1 expression and the levels of PD-1, CD8, CD163, and CMTM6. Conclusions: PD-L1-expressing cancer cells at the invasive front of gastric cancer influence the initial stages of tumor invasion and lymphovascular permeation in early-stage gastric cancers. Immune checkpoint signaling may be the driving force in the invasive front during the invasion of the submucosa beyond the lamina muscularis mucosa.
    Type of Medium: Online Resource
    ISSN: 0030-2414 , 1423-0232
    URL: Article
    DOI: 10.1159/000509033
    RVK:
    XH 3305
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2021
    detail.hit.zdb_id: 1483096-6
    detail.hit.zdb_id: 250101-6
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