In:
Liver Cancer, S. Karger AG, Vol. 11, No. 4 ( 2022), p. 368-382
Kurzfassung:
〈 b 〉 〈 i 〉 Introduction: 〈 /i 〉 〈 /b 〉 Lenvatinib is the first-line treatment for advanced hepatocellular carcinoma (HCC). We aimed to compare the clinical outcomes of lenvatinib plus drug-eluting beads transarterial chemoembolization (DEB-TACE) versus lenvatinib alone in real-world practice. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 This retrospective analysis included 142 consecutive patients who received lenvatinib plus DEB-TACE and 69 patients who received lenvatinib alone as first-line treatment from 15 Chinese academic centers from November 2018 to November 2019. Overall survival (OS), progression-free survival (PFS), objective response rate (ORR) were evaluated by modified Response Evaluation Criteria in Solid Tumors criteria, and safety profiles were compared between the two groups. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 The median OS and PFS were significantly longer in the combined therapy group than in the monotherapy group in whole cohort (median OS, 15.9 vs. 8.6 months, 〈 i 〉 p 〈 /i 〉 = 0.0022; median PFS, 8.6 vs. 4.4 months, 〈 i 〉 p 〈 /i 〉 & #x3c; 0.001) and after propensity score matching analysis (median OS, 13.8 vs. 7.8 months, 〈 i 〉 p 〈 /i 〉 = 0.03; median PFS, 7.8 vs. 4.5 months, 〈 i 〉 p 〈 /i 〉 = 0.009). Moreover, the treatment option was an independent prognostic factor for OS and PFS with adjustment based upon baseline characteristics (adjusted hazard ratio [HR]: 0.53, 95% confidence interval [CI] : 0.36–0.78, 〈 i 〉 p 〈 /i 〉 = 0.001, and adjusted HR: 0.42, 95% CI: 0.30–0.60, 〈 i 〉 p 〈 /i 〉 & #x3c; 0.001, respectively) and propensity score (adjusted HR: 0.52, 95% CI: 0.36–0.76, 〈 i 〉 p 〈 /i 〉 = 0.001, and adjusted HR: 0.46, 95% CI: 0.33–0.64, 〈 i 〉 p 〈 /i 〉 & #x3c; 0.001, respectively). Moreover, a greater ORR was observed in the combined group (ORR: 46.48% vs. 13.05%, 〈 i 〉 p 〈 /i 〉 & #x3c; 0.001). Furthermore, the most common adverse events (AEs) were elevated aspartate aminotransferase (54.9%) and fatigue (46.4%) in the lenvatinib plus DEB-TACE group and lenvatinib group, respectively. Most AEs were mild-to-moderate and manageable. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 With well-tolerated safety, lenvatinib plus DEB-TACE was more effective than lenvatinib monotherapy in improving OS, PFS, and ORR. Thus, it may be a promising treatment for advanced HCC. Future prospective studies confirming these findings are warranted.
Materialart:
Online-Ressource
ISSN:
2235-1795
,
1664-5553
Sprache:
Englisch
Verlag:
S. Karger AG
Publikationsdatum:
2022
ZDB Id:
2666925-0
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