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  • 1
    Online-Ressource
    Online-Ressource
    Ramadan Fasting in a Patient with Chronic Myeloid Leukemia Receiving Nilotinib as Upfront
    S. Karger AG ; 2020
    In:  Case Reports in Oncology Vol. 13, No. 2 ( 2020-6-15), p. 664-667
    Details
    In: Case Reports in Oncology, S. Karger AG, Vol. 13, No. 2 ( 2020-6-15), p. 664-667
    Kurzfassung: Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm classically described as triphasic disease: chronic, accelerated, and blast crisis. There are many unmet needs and unanswered questions about CML. Intermittent fasting in patients with CML on tyrosine kinase inhibitors is among these unmet needs. Here we report the effect of intermittent fasting on response to nilotinib as upfront in a 49-year-old female Muslim who fasted during Ramadan and took her medication once instead of twice daily and remained in major molecular response.
    Materialart: Online-Ressource
    ISSN: 1662-6575
    URL: Article
    DOI: 10.1159/000507508
    Sprache: Englisch
    Verlag: S. Karger AG
    Publikationsdatum: 2020
    ZDB Id: 2458961-5
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 2
    Online-Ressource
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    The Course of COVID-19 in a Patient with Aplastic Anemia and Paroxysmal Nocturnal Hemoglobinuria Clone: A Case Report and Literature Review
    S. Karger AG ; 2021
    In:  Dubai Medical Journal Vol. 4, No. 3 ( 2021-8-26), p. 235-238
    Details
    In: Dubai Medical Journal, S. Karger AG, Vol. 4, No. 3 ( 2021-8-26), p. 235-238
    Kurzfassung: 〈 b 〉 〈 i 〉 Introduction: 〈 /i 〉 〈 /b 〉 Aplastic anemia (AA) and paroxysmal nocturnal hemoglobinuria (PNH) are bone marrow failure syndromes. A 20–40% of patients with AA have a PNH clone at diagnosis. To date, there are little data about the course of COVID-19 in patients with AA and PNH. 〈 b 〉 〈 i 〉 Case Presentation: 〈 /i 〉 〈 /b 〉 A 36-year-old gentleman, who was previously diagnosed as a case of AA with PNH clones off immune-suppressive therapy, presented with fever and cough and was diagnosed with mild pneumonia due to COVID-19 with positive nasopharyngeal swab polymerase chain reaction (PCR) for severe acute respiratory syndrome coronavirus 2. His clinical course was benign except transient thrombocytopenia. He was asymptomatic after day 4, and viral PCR was negative on day 21. 〈 b 〉 〈 i 〉 Discussion: 〈 /i 〉 〈 /b 〉 Though studies have shown that COVID-19 is associated with lymphopenia, our patient had a normal to high lymphocyte count. The neutrophil to lymphocyte ratio (NLR) was & #x3c;1 during COVID-19, which correlates with the mild course of the disease. To know whether elevated lymphocyte count, low NLR, and benign course of COVID-19 is a standard feature for all patients with underlying AA, we need more case reports and series. The significance of this case report is that it describes the course of COVID-19 in a patient with AA and PNH clones and, up to our knowledge, is the first report showcasing the association between these rare combinations of diseases.
    Materialart: Online-Ressource
    ISSN: 2571-726X
    URL: Article
    DOI: 10.1159/000517737
    Sprache: Englisch
    Verlag: S. Karger AG
    Publikationsdatum: 2021
    ZDB Id: 2938789-9
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 3
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    Adenocarcinoma de pulmón que simula tuberculosis miliar
    S. Karger AG ; 2020
    In:  Kompass Neumología Vol. 2, No. 2-3 ( 2020), p. 76-80
    Details
    In: Kompass Neumología, S. Karger AG, Vol. 2, No. 2-3 ( 2020), p. 76-80
    Kurzfassung: Las sombras miliares en imágenes del tórax tienen diagnósticos diferenciales muy diversos. La etiología más común es infecciosa, como la tuberculosis (TB) miliar y la histoplasmosis, pero las sombras miliares pueden ser la presentación de la sarcoidosis, neumoconiosis y metástasis secundaria al pulmón de cánceres primarios de tiroides, riñón y trofoblastos, así como del sarcoma. Presentamos el caso de un paciente indio, masculino, quien refirió una historia de dos meses con tos seca y dificultad respiratoria. Imágenes del tórax mostraron nódulos miliares bilaterales, difusos. La impresión inicial fue TB pulmonar miliar. Una posterior broncoscopía con biopsia transbronquial confirmó el diagnóstico de adenocarcinoma mucinoso pulmonar con metástasis al cerebro, una presentación rara e inusual de cáncer de pulmón primario. El tumor fue positivo para ALK5A4 y PD-L1, y se inició inmunoterapia con un inhibidor de tirosina quinasa, con respuesta favorable.
    Materialart: Online-Ressource
    ISSN: 2624-9065 , 2624-9073
    URL: Article
    DOI: 10.1159/000510451
    Sprache: Englisch
    Verlag: S. Karger AG
    Publikationsdatum: 2020
    ZDB Id: 2986459-8
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 4
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    Chronic Myeloid Leukemia in a Patient with Hepatitis B Virus Infection: A Case Report
    S. Karger AG ; 2021
    In:  Case Reports in Oncology Vol. 14, No. 2 ( 2021-6-24), p. 1004-1009
    Details
    In: Case Reports in Oncology, S. Karger AG, Vol. 14, No. 2 ( 2021-6-24), p. 1004-1009
    Kurzfassung: Chronic myeloid leukemia (CML) is a myeloproliferative disorder diagnosed by demonstrating the Philadelphia chromosome (Ph) or the BCR-ABL fusion gene. Tyrosine kinase inhibitors (TKIs) are the standard of therapy. There are increasing reports of hepatitis B virus reactivation (HBVr) in patients on this treatment. We report a case of a 46-year-old male patient diagnosed to have CML in the chronic phase and resolved hepatitis B infection. He was treated with imatinib as upfront therapy for CML and with lamivudine as prophylaxis against HBVr. The patient tolerated both treatments well with no adverse effects. The aim is to address the deficiencies in the literature in regard to managing these patients, prevention, and follow-up.
    Materialart: Online-Ressource
    ISSN: 1662-6575
    URL: Article
    DOI: 10.1159/000516747
    Sprache: Englisch
    Verlag: S. Karger AG
    Publikationsdatum: 2021
    ZDB Id: 2458961-5
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 5
    Online-Ressource
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    Langerhans Cell Histiocytosis with Good Response to Low-Dose Imatinib: Case Report and Literature Review
    S. Karger AG ; 2023
    In:  Case Reports in Oncology
    Details
    In: Case Reports in Oncology, S. Karger AG
    Kurzfassung: Langerhans cell histiocytosis (LCH) is a rare neoplastic disease characterized by infiltration of histiocytes and dendritic cells into body organs. While treatment is better established in pediatrics, there is still no consensus on therapy in the adult population. Imatinib has shown promising results in some case reports and a small clinical trial. We present here a fifty-nine-year-old patient with LCH in the lung, liver, and bone who responded well to an imatinib dose of 100 mg daily. Her symptoms improved within 3 months of treatment, and subsequent positron emission tomography-computed tomography (PET/CT) showed resolution of 18F-fluorodeoxyglucose (FDG)-avid lesions.
    Materialart: Online-Ressource
    ISSN: 1662-6575
    URL: Article
    DOI: 10.1159/000531230
    Sprache: Englisch
    Verlag: S. Karger AG
    Publikationsdatum: 2023
    ZDB Id: 2458961-5
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 6
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    Confirmed Coronavirus Disease-19 (COVID-19) in a Male with Chronic Myeloid Leukemia Complicated by Febrile Neutropenia and Acute Respiratory Distress Syndrome
    S. Karger AG ; 2020
    In:  Case Reports in Oncology Vol. 13, No. 2 ( 2020-5-19), p. 569-577
    Details
    In: Case Reports in Oncology, S. Karger AG, Vol. 13, No. 2 ( 2020-5-19), p. 569-577
    Kurzfassung: Coronavirus disease-19 is a respiratory viral disease that commonly presents with mild symptoms. However, it can cause serious complications such as acute respiratory disease, especially in patients with comorbidities. As it is a new disease, the full picture of the disease and its complications are not yet fully understood. Moreover, the patients at risk of complications are not well identified; and the data about the risk in patients with hematological malignancies is limited. Here, we report a 65-year-old male with accelerated phase chronic myeloid leukemia, on dasatinib, tested positive for coronavirus disease-19, then complicated with febrile neutropenia acute respiratory distress syndrome.
    Materialart: Online-Ressource
    ISSN: 1662-6575
    URL: Article
    DOI: 10.1159/000508378
    Sprache: Englisch
    Verlag: S. Karger AG
    Publikationsdatum: 2020
    ZDB Id: 2458961-5
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 7
    Online-Ressource
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    Chronic Myeloid Leukemia following Exposure to Radioactive Iodine (I〈sup〉131〈/sup〉): A Systematic Review
    S. Karger AG ; 2023
    In:  Oncology Vol. 101, No. 6 ( 2023), p. 362-368
    Details
    In: Oncology, S. Karger AG, Vol. 101, No. 6 ( 2023), p. 362-368
    Kurzfassung: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 Therapy-related leukemia is a term that describes the occurrence of leukemia following exposure to hematotoxins and radiation to emphasize the difference from leukemia that arises de novo. Many agents and host factors contribute to this entity of leukemias. Therapy-related acute myeloid leukemia has an extensive literature review in contrast to therapy-related chronic myeloid leukemia (t-CML). Radioactive iodine (RAI), an established agent in the management of differentiated thyroid carcinomas, has raised concern due to its possible carcinogenic effects. 〈 b 〉 〈 i 〉 Summary: 〈 /i 〉 〈 /b 〉 In this article, we reviewed all the reports from the 1960s to date related to t-CML following RAI on Google Scholar and PubMed. We have identified 14 reports and found that most reports were for men under the age of 60 years with primary papillary thyroid carcinoma and mixed follicular-papillary thyroid carcinoma who developed t-CML mainly between 4 and 7 years after exposure to varying doses of I 〈 sup 〉 131 〈 /sup 〉 . However, the mean dose was 287.78 millicuries (mCi). It was reported that a statistically significant increase in leukemia following RAI therapy (relative risk of 2.5 for I 〈 sup 〉 131 〈 /sup 〉 vs. no I 〈 sup 〉 131 〈 /sup 〉 ). Also, there was a linear relationship between the cumulative dose of I 〈 sup 〉 131 〈 /sup 〉 and the risk of leukemia. Doses higher than 100 mCi were associated with a greater risk of developing secondary leukemia, and most of the leukemias developed within the initial 10 years of exposure. The precise mechanism through which RAI provokes leukemia is largely unclear. A few mechanisms have been proposed. 〈 b 〉 〈 i 〉 Key Messages: 〈 /i 〉 〈 /b 〉 Although the risk for t-CML appears to be low based on current reports and does not represent a contraindication to RAI therapy, it should not be disregarded. We suggest including it in the risk-benefit discussion before initiating this therapy. Long-term follow-up for patients is advisable for those who received doses over 100 mCi with a complete blood count, possibly yearly, for the first 10 years. The new onset of significant leukocytosis post RAI exposure should raise the suspicion for t-CML. Further studies are needed to establish or refute a causal relationship.
    Materialart: Online-Ressource
    ISSN: 0030-2414 , 1423-0232
    URL: Article
    DOI: 10.1159/000530463
    RVK:
    XH 3305
    Sprache: Englisch
    Verlag: S. Karger AG
    Publikationsdatum: 2023
    ZDB Id: 1483096-6
    ZDB Id: 250101-6
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 8
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    Adenocarcinoma of the Lung Mimicking Miliary Tuberculosis
    S. Karger AG ; 2020
    In:  Case Reports in Oncology Vol. 13, No. 1 ( 2020-2-13), p. 139-144
    Details
    In: Case Reports in Oncology, S. Karger AG, Vol. 13, No. 1 ( 2020-2-13), p. 139-144
    Kurzfassung: Miliary shadows on chest imaging have wide differential diagnoses. The most common etiology is infectious, such as miliary tuberculosis (TB) and histoplasmosis, but miliary shadows can be the presentation of sarcoidosis, pneumoconiosis, and secondary metastasis to the lungs from primary cancers of the thyroid, kidney, and trophoblasts as well as sarcomas. Here we present the case of a 35-year-old Indian male who presented with a 2-month history of dry cough and shortness of breath. Chest imaging showed diffuse bilateral miliary nodules. The initial impression was that of miliary pulmonary TB. Subsequent bronchoscopy with a transbronchial biopsy confirmed the diagnosis of pulmonary mucinous adenocarcinoma with brain metastasis, which is a rare and unusual presentation of primary lung cancer. The tumor was positive for ALK5A4 and PD-L1, and the patient was started on tyrosine kinase inhibitor immunotherapy, with a favorable response.
    Materialart: Online-Ressource
    ISSN: 1662-6575
    URL: Article
    DOI: 10.1159/000505685
    Sprache: Englisch
    Verlag: S. Karger AG
    Publikationsdatum: 2020
    ZDB Id: 2458961-5
    Standort Signatur Einschränkungen Verfügbarkeit
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