GLORIA

GEOMAR Library Ocean Research Information Access

X

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Online Resource
    Online Resource
    Risk of Dementia in Diabetic Patients with Hyperglycemic Crisis: A Nationwide Taiwanese Population-Based Cohort Study
    S. Karger AG ; 2020
    In:  Neuroepidemiology Vol. 54, No. 5 ( 2020), p. 419-426
    Details
    In: Neuroepidemiology, S. Karger AG, Vol. 54, No. 5 ( 2020), p. 419-426
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 A hyperglycemic crisis episode (HCE) signifies poor control of diabetes and may increase the risk of dementia via microvascular and macrovascular injuries. 〈 b 〉 〈 i 〉 Objectives: 〈 /i 〉 〈 /b 〉 We conducted this study to clarify this issue, which remains unclear. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Using the Taiwan National Health Insurance Database, we identified 9,466 diabetic patients with HCE and the identical number of diabetic patients without HCE who were matched by age and sex for this nationwide population-based cohort study. The risk of dementia was compared between the 2 cohorts by following up until 2014. Investigation of independent predictors of dementia was also done. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 In the overall analysis, the risk of dementia between the 2 cohorts was not different. However, stratified analyses showed that patients with HCE had a higher risk of subsequent dementia in the age subgroup of 45−54 and 55–64 years (adjusted odds ratio [AOR]: 2.4, 95% confidence interval [CI] : 1.6–3.6, and AOR: 1.2, 95% CI: 1.0–1.5, respectively). In the overall analysis, older age, female sex, ≥3 HCEs, hypertension, hyperlipidemia, depression, cerebrovascular disease, Parkinson’s disease, and head injury were independent predictors. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 HCE increased the risk of dementia in diabetic patients aged 45–64 years. Dementia was predicted by ≥3 HCEs. Prevention of recurrent HCE, control of comorbidities, and close follow-up of cognitive decline and dementia are suggested in patients with HCE.
    Type of Medium: Online Resource
    ISSN: 0251-5350 , 1423-0208
    URL: Article
    DOI: 10.1159/000509754
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2020
    detail.hit.zdb_id: 1483032-2
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 2
    Online Resource
    Online Resource
    Pharmacokinetics of Isoflurane: Uptake in the Body
    S. Karger AG ; 2003
    In:  Pharmacology Vol. 69, No. 3 ( 2003), p. 132-137
    Details
    In: Pharmacology, S. Karger AG, Vol. 69, No. 3 ( 2003), p. 132-137
    Abstract: We investigated the effect of the inspired isoflurane concentration (C 〈 sub 〉 I 〈 /sub 〉 iso) on body uptake by comparing the isoflurane concentration in the pulmonary artery blood (PAiso) and that in the arterial blood (Aiso) in 16 patients undergoing coronary artery bypass grafting surgery during the 1st, hour of isoflurane anesthesia. The patients received standardized anesthetics consisting of fentanyl and thiopental and were then allocated to receive either 1% or 2% C 〈 sub 〉 I 〈 /sub 〉 iso (n = 8 in each group). C 〈 sub 〉 I 〈 /sub 〉 iso and end-tidal isoflurane concentration (C 〈 sub 〉 E 〈 /sub 〉 iso) were measured by infrared analysis, and Aiso and PAiso were analyzed by gas chromatography. The cardiac output was measured by thermodilution by use of a pulmonary artery catheter. The body tissue could be represented by the gradient C 〈 sub 〉 I 〈 /sub 〉 iso–C 〈 sub 〉 E 〈 /sub 〉 iso or Aiso–PAiso over time, respectively. The 2% inspired isoflurane group had twice the gradients (either C 〈 sub 〉 I 〈 /sub 〉 iso–C 〈 sub 〉 E 〈 /sub 〉 iso or Aiso-PAiso) than the 1% inspired isoflurance group. Additionally, both C 〈 sub 〉 I 〈 /sub 〉 iso–C 〈 sub 〉 E 〈 /sub 〉 iso and Aiso–PAiso were nearly constant over the hour of the study. The inspired concentration-dependent and near- constant uptake of isoflurane over time has important implications 〈 i 〉 which enable us to apply the uptake pattern of isoflurane to clinical practice. 〈 /i 〉
    Type of Medium: Online Resource
    ISSN: 0031-7012 , 1423-0313
    URL: Article
    DOI: 10.1159/000072665
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2003
    detail.hit.zdb_id: 1483550-2
    SSG: 15,3
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 3
    Online Resource
    Online Resource
    Pharmacokinetics of Isoflurane: Uptake in the Brain
    S. Karger AG ; 2003
    In:  Pharmacology Vol. 69, No. 2 ( 2003), p. 102-107
    Details
    In: Pharmacology, S. Karger AG, Vol. 69, No. 2 ( 2003), p. 102-107
    Abstract: We studied the effect of the inspired isoflurane concentration (C 〈 sub 〉 I 〈 /sub 〉 iso) on the pharmacokinetics of isoflurane uptake in the brain by comparing the isoflurane concentration in internal jugular-bulb blood (Jiso) with that in arterial blood (Aiso), and analyzed this by gas chromatography. Sixteen patients (aged 43–76 years) undergoing colorectal surgery were enrolled, and anesthesia was maintained with a constant C 〈 sub 〉 I 〈 /sub 〉 iso of either 1% (group 1, n = 8) or 2% (group 2, n = 8) during the 1st hour of isoflurane anesthesia. Under constant volume-controlled ventilation, we measured the C 〈 sub 〉 I 〈 /sub 〉 iso and the end-tidal isoflurane concentration (C 〈 sub 〉 E 〈 /sub 〉 iso) at the mouthpiece by infrared analysis. Our results demonstrate that it takes 40 min for the brain tissue concentration to equal Aiso for 1% C 〈 sub 〉 I 〈 /sub 〉 iso, and 50 min for 2% C 〈 sub 〉 I 〈 /sub 〉 iso. The Aiso (and/or Jiso) for 2% C 〈 sub 〉 I 〈 /sub 〉 iso was approximately double when compared to that for 1% C 〈 sub 〉 I 〈 /sub 〉 iso. Except during the initial wash-in period of the functional residual capacity in the first 3 min, the differences between C 〈 sub 〉 I 〈 /sub 〉 iso and C 〈 sub 〉 E 〈 /sub 〉 iso revealed that the body uptake of isoflurane for 2% C 〈 sub 〉 I 〈 /sub 〉 iso was twice that for 1% C 〈 sub 〉 I 〈 /sub 〉 iso. These results demonstrate that the pharmacokinetics of isoflurane uptake in the brain is time-dependent for Jiso to equal Aiso, and the midpoint between Aiso and Jiso (likely representing the isoflurane concentration in brain tissue) was dependent on C 〈 sub 〉 I 〈 /sub 〉 iso.
    Type of Medium: Online Resource
    ISSN: 0031-7012 , 1423-0313
    URL: Article
    DOI: 10.1159/000072363
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2003
    detail.hit.zdb_id: 1483550-2
    SSG: 15,3
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 4
    Online Resource
    Online Resource
    Standing Posture at Work Does Not Increase the Risk of Varicose Veins among Health Care Providers in Taiwan
    S. Karger AG ; 2017
    In:  Medical Principles and Practice Vol. 26, No. 3 ( 2017), p. 266-272
    Details
    In: Medical Principles and Practice, S. Karger AG, Vol. 26, No. 3 ( 2017), p. 266-272
    Abstract: 〈 b 〉 〈 i 〉 Objective: 〈 /i 〉 〈 /b 〉 This study compared the risk of varicose veins (VV) among physicians, nonphysician health care providers (HCP), and the general population. 〈 b 〉 〈 i 〉 Subjects and Methods: 〈 /i 〉 〈 /b 〉 The Taiwan National Health Insurance Research Database was used to identify 28,844 physicians and 26,099 nonphysician HCP and an identical number of age- and sex-matched patients from the general population. Using logistic regression analyses, VV risks between physicians and the general population, nonphysician HCP and the general population, and physicians and nonphysician HCP, and among physician specialists were compared by tracing their medical histories between 2007 and 2011. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Physicians and nonphysician HCP had cumulative VV incidences of 0.12% (34/28,844) and 0.13% (33/26,099), respectively, during the 5-year period, compared to that of the general population within the same 5-year period. Physicians and nonphysician HCP did not have a higher VV risk than the general population after adjusting for deep vein thrombosis (DVT) history (adjusted odds ratio [AOR] 0.86; 95% confidence interval [CI] 0.53-1.40, and AOR 1.43; 95% CI 0.82-2.50, respectively). Physicians did not a have higher VV risk than nonphysician HCP (AOR 0.80; 95% CI 0.43-1.51) after adjusting for age, sex, and DVT history. Surgery had the highest incidence (0.22%) while pediatrics and emergency medicine had the lowest incidence (0%) of VV risk among physician specialists; however, the difference was not significant (all 〈 i 〉 p 〈 /i 〉 values 〉 0.05). 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 In this study, VV risk did not differ among physicians, nonphysician HCP, and the general population.
    Type of Medium: Online Resource
    ISSN: 1011-7571 , 1423-0151
    URL: Article
    DOI: 10.1159/000466696
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2017
    detail.hit.zdb_id: 1482963-0
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 5
    Online Resource
    Online Resource
    A Taiwan Nationwide Population-Based Study of Socio-Demographic Factors and Comorbid Conditions Associated with Non-Arteritic Anterior Ischaemic Optic Neuropathy
    S. Karger AG ; 2023
    In:  Neuroepidemiology Vol. 57, No. 1 ( 2023), p. 35-42
    Details
    In: Neuroepidemiology, S. Karger AG, Vol. 57, No. 1 ( 2023), p. 35-42
    Abstract: 〈 b 〉 〈 i 〉 Aims: 〈 /i 〉 〈 /b 〉 The aim of the study was to investigate the socio-demographic factors and systemic conditions associated with non-arteritic anterior ischaemic optic neuropathy (NAION). 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 This was a nationwide population-based retrospective case-controlled study that recruited 9,261 NAION patients selected from the Taiwan National Health Insurance Research Database. The control group consisted of 9,261 age-, sex-, and index date-matched non-NAION patients recruited from the Taiwan Longitudinal Health Insurance Database, 2000. NAION was designated in the database by the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) as “code 377.41: ischaemic optic neuropathy without ICD-9-CM code 446.5: giant cell arteritis.” Associated socio-demographic factors and systemic medical conditions were analysed using the McNemar’s test, and continuous variables were analysed using the paired 〈 i 〉 t 〈 /i 〉 test. The odds ratio (OR) and adjusted OR of developing NAION were compared using univariate logistic regression and multivariable logistic regression analyses, respectively. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Patients with systemic conditions such as diabetes mellitus, hypertension, hyperlipidaemia, chronic kidney disease, and hypotension were more likely to develop NAION than controls (adjusted OR = 1.81, 95% confidence interval [CI] = 1.67–1.97, 〈 i 〉 p 〈 /i 〉 & #x3c; 0.0001; adjusted OR = 1.46, 95% CI = 1.36–1.57, 〈 i 〉 p 〈 /i 〉 & #x3c; 0.0001; adjusted OR = 1.44, 95% CI = 1.33–1.57, 〈 i 〉 p 〈 /i 〉 & #x3c; 0.0001; adjusted OR = 3.26, 95% CI = 2.65–4.01, 〈 i 〉 p 〈 /i 〉 & #x3c; 0.0001; adjusted OR = 2.32, 95% CI = 1.31–4.10, 〈 i 〉 p 〈 /i 〉 = 0.0039, respectively). 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 NAION is strongly associated with diabetes mellitus, hypertension, hyperlipidaemia, chronic kidney disease, and hypotension.
    Type of Medium: Online Resource
    ISSN: 0251-5350 , 1423-0208
    URL: Article
    DOI: 10.1159/000528833
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2023
    detail.hit.zdb_id: 1483032-2
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...