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  • 1
    Online Resource
    Online Resource
    Urodynamic Evaluation of Patients with Lower Urinary Tract Symptoms and Small Prostate Volume
    S. Karger AG ; 2008
    In:  Urologia Internationalis Vol. 81, No. 2 ( 2008), p. 129-134
    Details
    In: Urologia Internationalis, S. Karger AG, Vol. 81, No. 2 ( 2008), p. 129-134
    Abstract: 〈 i 〉 Introduction: 〈 /i 〉 The relevance of prostate size in the pathophysiology of lower urinary tract symptoms (LUTS) is controversial. We evaluated the urodynamic findings in patients with LUTS and small prostate volumes. 〈 i 〉 Materials and Methods: 〈 /i 〉 84 patients aged ≧50 years with LUTS and prostates 〈 40 ml were evaluated. All had an International Prostate Symptom Score (IPSS) ≧8. Average age was 62.0 ± 8.1 years. We evaluated the impact of bladder outlet obstruction (BOO) and detrusor overactivity (DO) on the voiding symptoms and urodynamic findings. 〈 i 〉 Results: 〈 /i 〉 Mean prostate volume was 29.2 ± 7.2 ml and mean IPSS was 13.5 ± 4.6. BOO was the main finding, affecting 42 (50.0%) patients, followed by detrusor underactivity (DU) in 41 (48.8%) and DO in 28 (33.3%) patients. Patients without BOO were significantly older than the obstructed (64.0 ± 8.8 and 60.1 ± 6.9 years, respectively; p = 0.026) and had an increased prevalence of DU (76.2 and 21.4%, respectively; p 〈 0.001). Comparison of patients with and without DO showed reduced bladder capacity and compliance in the DO group (p 〈 0.001). No other comparisons were significant. 〈 i 〉 Conclusion: 〈 /i 〉 Half of the patients with LUTS and small prostates are not obstructed and may have DO or decreased detrusor contractility as the basis for their voiding symptoms. Our results emphasize the value of urodynamics in this population, especially when invasive treatments are being considered.
    Type of Medium: Online Resource
    ISSN: 0042-1138 , 1423-0399
    URL: Article
    DOI: 10.1159/000144049
    RVK:
    XA 10000
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2008
    detail.hit.zdb_id: 1464417-4
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  • 2
    Online Resource
    Online Resource
    Contemporary Trends in the Epidemiology of Traumatic Spinal Cord Injury: Changes in Age and Etiology
    S. Karger AG ; 2015
    In:  Neuroepidemiology Vol. 44, No. 2 ( 2015), p. 85-90
    Details
    In: Neuroepidemiology, S. Karger AG, Vol. 44, No. 2 ( 2015), p. 85-90
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 Epidemiological features of spinal cord injury (SCI) have been changing over the last decades. We evaluated the contemporary trends in the epidemiology of traumatic SCI patients from a rehabilitation center. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 In a cross-sectional study, a consecutive series of 348 patients with traumatic SCI were evaluated. Variables were collected through an epidemiological form, which included gender, age at injury, duration and cause of SCI. We investigated SCI epidemiological trends over time including the association between gender and age at injury with SCI features such as etiology, injury severity and level. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 The mean age at SCI has increased from 26.0 ± 11.8 in patients with SCI before 2003 to 37.9 ± 15.7 in those with SCI after 2009 (p 〈 0.001). Gunshot wounds were the main cause of injury in patients with SCI before 2003, dropping from 40.6 to 16.9% after 2009 and being surpassed by road traffic injuries (38.6%) and falls (31.4%) after 2009 (p 〈 0.001). Gender, SCI severity and level have not changed significantly over the time. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 There was a major increase in the average age of patients as well as changes in the etiology of SCI over the past fifteen years, including a significant decrease in gunshot wounds and an increase in the frequency of road traffic injuries and falls. These changes and accompanying risk factors must be taken into consideration when planning measures to prevent SCI.
    Type of Medium: Online Resource
    ISSN: 0251-5350 , 1423-0208
    URL: Article
    DOI: 10.1159/000371519
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2015
    detail.hit.zdb_id: 1483032-2
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  • 3
    Online Resource
    Online Resource
    Urodynamic Evaluation in Diabetic Patients with Prostate Enlargement and Lower Urinary Tract Symptoms
    S. Karger AG ; 2008
    In:  Urologia Internationalis Vol. 80, No. 4 ( 2008), p. 378-382
    Details
    In: Urologia Internationalis, S. Karger AG, Vol. 80, No. 4 ( 2008), p. 378-382
    Abstract: 〈 i 〉 Introduction: 〈 /i 〉 Lower urinary tract symptoms (LUTS) are common in men over 50 years of age due to prostate enlargement. Diabetes mellitus is also more prevalent in this group. LUTS may result from bladder outlet obstruction (BOO) secondary to prostate enlargement or bladder dysfunction secondary to diabetes or even from a combination of both. 〈 i 〉 Objectives: 〈 /i 〉 The objective of this study was to determine the prevalence of BOO and other urodynamic abnormalities in diabetic patients with LUTS and enlarged prostate. A secondary objective was to assess the predictive value of non-invasive tests for BOO diagnosis in this group of patients. 〈 i 〉 Patients and Methods: 〈 /i 〉 50 consecutive diabetic patients with enlarged prostate and LUTS were evaluated by the International Prostate Symptom Score (IPSS), ultrasonography and urodynamics. BOO diagnosis was based on pressure/flow measurements according to the International Continence Society’s standards. 〈 i 〉 Results: 〈 /i 〉 Of the 50 patients in the study, 23 (46%) had BOO. There was no correlation between the IPSS, uroflowmetry, post-voiding residual urine or prostate volume and the presence of BOO (p 〉 0.05). 〈 i 〉 Conclusions: 〈 /i 〉 There is a relatively low prevalence of BOO in diabetic patients with prostate enlargement and LUTS. Non-invasive tests did not allow the identification of these subjects. Only urodynamic evaluation is able to determine symptom etiology.
    Type of Medium: Online Resource
    ISSN: 0042-1138 , 1423-0399
    URL: Article
    DOI: 10.1159/000132695
    RVK:
    XA 10000
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2008
    detail.hit.zdb_id: 1464417-4
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  • 4
    Online Resource
    Online Resource
    Tadalafil and Fluoxetine in Premature Ejaculation: Prospective, Randomized, Double-Blind, Placebo-Controlled Study
    S. Karger AG ; 2008
    In:  Urologia Internationalis Vol. 80, No. 2 ( 2008), p. 162-165
    Details
    In: Urologia Internationalis, S. Karger AG, Vol. 80, No. 2 ( 2008), p. 162-165
    Abstract: 〈 i 〉 Introduction: 〈 /i 〉 Premature ejaculation (PE) is a common male sexual disorder. An ideal, reliable and effective treatment is desired by many men and couples affected by this condition. 〈 i 〉 Aim: 〈 /i 〉 Evaluate if the association of a phosphodiesterase-5 inhibitor, tadalafil, and a selective serotonin reuptake inhibitor, fluoxetine, can prolong the intravaginal ejaculatory latency time (IELT) in men with lifelong premature ejaculation. 〈 i 〉 Methods: 〈 /i 〉 Sixty patients with lifelong premature ejaculation and without erectile dysfunction (ED) with IELT less than 90 s were enrolled in the protocol and randomized into 4 groups to use a combination of medications: (1) tadalafil 20 mg plus fluoxetine 90 mg, (2) fluoxetine 90 mg plus placebo, (3) tadalafil 20 mg plus placebo, and (4) two different placebo capsules (control). Before starting the medications, each man timed his IELT with a stopwatch, and likewise during the treatment period. Fluoxetine 90 mg or placebo was taken once a week plus tadalafil 20 mg or placebo within a 36-hour frame of intended sexual intercourse with a steady partner. Patients were prospectively followed for 12 weeks. One-way ANOVA was used for statistical comparisons of IELT results in each group. 〈 i 〉 Results: 〈 /i 〉 Mean IELT before starting treatment was 51.3 ± 23 s. Withone-way ANOVA, a statistically significant difference in post-treatment IELT was seen with combination treatment compared to placebo (p 〈 0.001). There were increases in IELT from baseline in patients using fluoxetine plus tadalafil (49.57 ± 25.87 to 336.13 ± 224.77) (p 〈 0.001), fluoxetine (56.55 ± 18.55 to 233.62 ± 105.08) (p 〈 0.001) and tadalafil (49.26 ± 19.43 to 186.53 ± 159.05) (p = 0.001). The increases in each group were statistically significant compared to the placebo (49.86 ± 19.43 to 67.82 ± 46.18) (p = 0.042). 〈 i 〉 Conclusion: 〈 /i 〉 Fluoxetine plus tadalafil significantly increased the IELT from baseline in men with lifelong premature ejaculation when compared to placebo, tadalafil or fluoxetine.
    Type of Medium: Online Resource
    ISSN: 0042-1138 , 1423-0399
    URL: Article
    DOI: 10.1159/000112607
    RVK:
    XA 10000
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2008
    detail.hit.zdb_id: 1464417-4
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  • 5
    Online Resource
    Online Resource
    Prostate Cryoablation: Prospective Analysis Comparing High- and Low-Risk Prostate Cancer Outcomes
    S. Karger AG ; 2008
    In:  Urologia Internationalis Vol. 81, No. 2 ( 2008), p. 186-190
    Details
    In: Urologia Internationalis, S. Karger AG, Vol. 81, No. 2 ( 2008), p. 186-190
    Abstract: 〈 i 〉 Aim: 〈 /i 〉 To evaluate percutaneous cryotherapy as a primary treatment option for prostate cancer, comparing different risk groups. 〈 i 〉 Patients and Methods: 〈 /i 〉 Forty-seven prostate cryoablation procedures were performed on 44 patients. Patients median age was 70.9, and average pretreatment PSA of 13.8 ng/dl. Patients were divided into low-risk (13 patients), high-risk (24 patients) and radiation failure patients (7 patients). The follow-up period ranged from 18 to 60 months (median 41 months). 〈 i 〉 Results: 〈 /i 〉 In the low-risk group, we found after 12 and 24 months of follow-up, 92 and 86% of patients free of PSA relapse (PSA 〈 1 ng/ml), respectively. In the high-risk group, the PSA failure was 39 and 52.9%. For the radiation failure group, 86 and 71.4% of patients had PSA below 1 ng/dl. At 48 months of follow-up, 80% of the low-risk patients, 42.8% of the high-risk group and 71.4% of the radiation failure group were free of PSA relapse. The complication rates were low, with 13% of urinary incontinence and no cases of rectal injury. 〈 i 〉 Conclusion: 〈 /i 〉 Prostate cryoablation is a viable and promising minimally invasive alternative for localized or locally advanced prostate cancer patients.
    Type of Medium: Online Resource
    ISSN: 0042-1138 , 1423-0399
    URL: Article
    DOI: 10.1159/000144058
    RVK:
    XA 10000
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2008
    detail.hit.zdb_id: 1464417-4
    Location Call Number Limitation Availability
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