In:
Neuropsychobiology, S. Karger AG, Vol. 55, No. 2 ( 2007), p. 89-95
Abstract:
〈 i 〉 Background/Aims: 〈 /i 〉 Different neuroimaging techniques have indicated that auditory association and language cortices are active in patients with schizophrenia and auditory hallucinations. Auditory verbal hallucinations are thought to arise from a disorder of inner speech, but little is known about their origin. 〈 i 〉 Methods: 〈 /i 〉 Spontaneous magnetoencephalographic (MEG) measurements were recorded with a 74-channel two-sensor system (BIOMAGNES II) in 16 patients with schizophrenia and 8 healthy subjects in frequency ranges from 2 to 6 and 12.5 to 30 Hz. Eight patients had auditory hallucinations during the MEG recordings. 〈 i 〉 Results: 〈 /i 〉 The total group of patients with schizophrenia showed a statistically significant elevation of the number of dipoles and dipole density maxima in slow frequency ranges compared to healthy subjects (p 〈 0.001). Significant dipole activities in the fast frequency range were only found during auditory hallucinations (p 〈 0.001). Dipole localization was concentrated in frontal and temporal regions depending on different qualities of hallucinations. In patients with external imperative voices we found a parallel activation of the dorsolateral frontal and temporal cortex. 〈 i 〉 Conclusion: 〈 /i 〉 We conclude that various auditory hallucinations in schizophrenia are induced by different neuronal activities and may be represented by different cortical regions.
Type of Medium:
Online Resource
ISSN:
0302-282X
,
1423-0224
Language:
English
Publisher:
S. Karger AG
Publication Date:
2007
detail.hit.zdb_id:
1483094-2
SSG:
5,2
SSG:
15,3
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