In:
Neonatology, S. Karger AG, Vol. 64, No. 5 ( 1993), p. 331-340
Abstract:
We quantified circulating and storage neutrophils, their precursors and progenitors, and mRNA for some of the cytokines involved in granulocytopoiesis, in newborn and adult mice following intrapulmonary inoculation of 〈 i 〉 Escherichia coli 〈 /i 〉 . Four hours following inoculation of adult and newborn mice with a quantity of organisms 2 logs below the LD 〈 sub 〉 100 〈 /sub 〉 , all animals were neutropenic. After 24 h, adults had recovered from the neutropenia but neonates had not (p 〈 0.001). Accelerated neutrophil production was evident in the infected adults, and correlated with the appearance of granulocyte colony-stimulating factor (G-CSF) transcripts in the liver, spleen, and lung, and interleukin-6 (IL·6) transcripts in the spleen and lung. An increase in neutrophil production was not observed in the neonates, and none of their organs tested had transcripts for either G-CSF or IL·6, but they did have transcripts for cytokines not involved in granulocytopoiesis; macrophage colony-stimulating factor and its receptor (c-fms). We speculate that the failure to increase neutrophil production in infected neonatal mice is the result of failure to increase production of relevant cytokines.
Type of Medium:
Online Resource
ISSN:
1661-7800
,
1661-7819
Language:
English
Publisher:
S. Karger AG
Publication Date:
1993
detail.hit.zdb_id:
2403535-X
SSG:
12
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