In:
Neuropsychobiology, S. Karger AG, Vol. 78, No. 3 ( 2019), p. 113-117
Abstract:
〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 Schizophrenia (SCZ) is a complex, heritable, and devastating psychiatric disorder. Mutations in the members of ABC transporters have been associated with psychiatric illnesses. 〈 b 〉 〈 i 〉 Aims: 〈 /i 〉 〈 /b 〉 In this study, we investigated whether 9 SNPs in 〈 i 〉 ABCB1 〈 /i 〉 (rs6946119, rs28401781, rs4148739, and rs3747802), 〈 i 〉 ABCB6 〈 /i 〉 (rs1109866, rs1109867, rs3731885, and rs3755047), and 〈 i 〉 ABCG1 〈 /i 〉 (rs182694) contribute to the risk of SCZ in a Han Chinese population. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 We conducted a case-control study in a Han Chinese population, involving 1,034 SCZ patients and 1,034 unrelated healthy controls to genotype 9 SNPs. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 The analysis demonstrated that rs182694 of 〈 i 〉 ABCG1 〈 /i 〉 was significantly different between SCZ patients and controls as to allele (rs182694: 〈 i 〉 p 〈 /i 〉 = 0.0070, χ 〈 sup 〉 2 〈 /sup 〉 = 7.27) and genotype frequencies (rs182694: 〈 i 〉 p 〈 /i 〉 = 0.0013, χ 〈 sup 〉 2 〈 /sup 〉 = 13.35). 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 Our findings support an association between 〈 i 〉 ABCG1 〈 /i 〉 polymorphism and SCZ in a Han Chinese population.
Type of Medium:
Online Resource
ISSN:
0302-282X
,
1423-0224
Language:
English
Publisher:
S. Karger AG
Publication Date:
2019
detail.hit.zdb_id:
1483094-2
SSG:
5,2
SSG:
15,3
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