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  • 1
    Online Resource
    Online Resource
    Plasma-Assisted Hydrophilization of Cochlear Implant Electrode Array Surfaces Enables Adhesion of Neurotrophin-Secreting Cells
    S. Karger AG ; 2014
    In:  ORL Vol. 76, No. 5 ( 2014), p. 257-265
    Details
    In: ORL, S. Karger AG, Vol. 76, No. 5 ( 2014), p. 257-265
    Abstract: 〈 b 〉 〈 i 〉 Objective: 〈 /i 〉 〈 /b 〉 To evaluate plasma treatment for enhancing the biocompatibility of cochlear implant (CI) silicone surfaces, thus allowing colonization with human adipose-derived stem cells (hASCs) that are known to provide neurotrophic support. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Silicone samples and CI electrode arrays were treated with 4 low-pressure plasmas of different characteristics. The hydrophilicity of plasma-treated and control surfaces as well as the adherence and morphology of hASCs were assessed. Finally, the insertion forces of electrode arrays were determined and the colonization potential of the electrode arrays with hASCs were tested. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 The hydrophilicity of the silicone surfaces was significantly enhanced after plasma treatment, as was the adherence of hASCs. The characteristic morphology of hASCs was observed when grown on plasma-treated but not on untreated silicone surfaces. The insertion forces of plasma-treated electrode arrays were similar to those of untreated arrays, and the colonization of plasma-treated electrode arrays with hASCs was feasible. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 Plasma treatment of CI electrode arrays enhances their biocompatibility and allows for the colonization with hASCs that are known to produce neurotrophic factors. i 2014 S. Karger AG, Basel
    Type of Medium: Online Resource
    ISSN: 0301-1569 , 1423-0275
    URL: Article
    DOI: 10.1159/000368321
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2014
    detail.hit.zdb_id: 1483533-2
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  • 2
    Online Resource
    Online Resource
    Multipotent Stromal Cells for Autologous Cell Therapy Approaches in the Guinea Pig Model
    S. Karger AG ; 2011
    In:  ORL Vol. 73, No. 1 ( 2011), p. 9-16
    Details
    In: ORL, S. Karger AG, Vol. 73, No. 1 ( 2011), p. 9-16
    Abstract: Multipotent stromal cells have become of increasing interest due to their potential to provide therapeutic approaches for autologous tissue repair. However, these cells are not well defined in the guinea pig, which represents an important model in hearing research. Adipose-tissue-derived stem cells (ADSC) and bone-marrow-derived stem cells (BMSC) were isolated from different donor sites, and growth curves were generated to judge the proliferation potential. Adipogenic, chondrogenic and osteogenic differentiation was induced and confirmed histologically. Finally, the capability of guinea pig ADSC to differentiate into neuron-like cells was investigated. With regard to the expansion potential, total cell number and doubling time, ADSC from the neck were the most suitable cells of the tested donor sites. Both ADSC and BMSC showed nearly identical behaviour and ability to undergo multilineage differentiation. Thus, we identified ADSC from the neck as a promising cell source for autologous cell-based approaches in hearing research using the guinea pig model.
    Type of Medium: Online Resource
    ISSN: 0301-1569 , 1423-0275
    URL: Article
    DOI: 10.1159/000320598
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2011
    detail.hit.zdb_id: 1483533-2
    Location Call Number Limitation Availability
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