In:
Dementia and Geriatric Cognitive Disorders, S. Karger AG, Vol. 23, No. 1 ( 2007), p. 60-66
Abstract:
The age distribution of the & #917;4 allelic form of the apolipoprotein E gene 〈 i 〉 (APOE) 〈 /i 〉 was investigated in 630 patients with Alzheimer’s disease (AD) with onset age ranging from 35 to 90 years. Overall, mean age at onset in 〈 i 〉 APOE 〈 /i 〉 & #917;4 allele bearers was significantly later than that in nonbearers. However, when stratified into early onset AD (EOAD) and late onset (LOAD) groups, mean age at onset in EOAD cases bearing 〈 i 〉 APOE 〈 /i 〉 & #917;4 allele was later than that in those EOAD cases without & #917;4 allele, whereas in LOAD mean age at onset in cases bearing 〈 i 〉 APOE 〈 /i 〉 & #917;4 allele was earlier than in those without & #917;4 allele. When analysed by decade, it was observed that 37% of the total number of 〈 i 〉 APOE 〈 /i 〉 & #917;4 allele bearers, and 43% of total number of cases with 〈 i 〉 APOE 〈 /i 〉 & #917;4/ & #917;4 genotype fell into the 60–69 years age class. Hence, 〈 i 〉 APOE 〈 /i 〉 & #917;4 allele frequency, at 0.44, was highest in the 60–69 years age class, progressively decreasing either side of this age group. 〈 i 〉 APOE 〈 /i 〉 & #917;4 allele therefore has its maximum impact between onset ages of between 60 and 70 years.
Type of Medium:
Online Resource
ISSN:
1420-8008
,
1421-9824
Language:
English
Publisher:
S. Karger AG
Publication Date:
2007
detail.hit.zdb_id:
1482186-2
detail.hit.zdb_id:
1360843-5
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