In:
Cerebrovascular Diseases, S. Karger AG, Vol. 52, No. 1 ( 2023), p. 75-80
Abstract:
〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 The peak oxygen consumption (V.O 〈 sub 〉 2peak 〈 /sub 〉 ) and blood hemoglobin concentration [Hb] are lower in stroke patients than in age-matched healthy subjects. The ability of skeletal muscles to extract oxygen is diminished after stroke. We hypothesized that the oxygen extraction capacity of skeletal muscles in stroke patients depends on [Hb] . To test the hypothesis, we determined the relationship between V.O 〈 sub 〉 2peak 〈 /sub 〉 and total hemoglobin mass (tHb-mass) in stroke patients. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 The subjects were 19 stroke patients (age: 74 ± 2, mean ± SD, 10 males) and 11 age-matched normal subjects (age 76 ± 3, 6 males). Plasma volume (PV) and V.O 〈 sub 〉 2peak 〈 /sub 〉 were measured on the same day. PV was measured using Evans Blue dye dilution method. Blood volume (BV) was calculated from PV and hematocrit, while tHb-mass was estimated from BV and [Hb]. Each subject underwent cardiopulmonary exercise test on a bicycle ergometer using a V.O 〈 sub 〉 2peak 〈 /sub 〉 respiratory gas analyzer. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 There were no differences in age, height, and weight between the two groups. V.O 〈 sub 〉 2peak 〈 /sub 〉 was lower in stroke patients than in the control. BV and tHb mass were not significantly different between the two groups, but [Hb] was significantly lower in stroke patients. In stroke patients, V.O 〈 sub 〉 2peak 〈 /sub 〉 correlated significantly with tHb-mass ( 〈 i 〉 r 〈 /i 〉 = 0.497, 〈 i 〉 p 〈 /i 〉 & #x3c; 0.05), but not with BV. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 Our results suggested that low [Hb] seems to contribute to V.O 〈 sub 〉 2peak 〈 /sub 〉 in stroke patients. The significant correlation between tHb-mass and V.O 〈 sub 〉 2peak 〈 /sub 〉 suggested that treatment to improve [Hb] can potentially improve V.O 〈 sub 〉 2peak 〈 /sub 〉 in stroke patients.
Type of Medium:
Online Resource
ISSN:
1015-9770
,
1421-9786
Language:
English
Publisher:
S. Karger AG
Publication Date:
2023
detail.hit.zdb_id:
1482069-9
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