In:
Stereotactic and Functional Neurosurgery, S. Karger AG, Vol. 88, No. 1 ( 2010), p. 56-63
Abstract:
〈 i 〉 Background: 〈 /i 〉 A new intracerebral microinjection instrument (IMI) allowing multiple electrophysiologically guided microvolume injections from a single proximal injection path in rats has been adapted to clinical use by coupling the IMI to an FHC microTargeting Manual Drive, designed to be used with standard stereotactic frame-based systems and FHC frameless microTargeting Platforms. 〈 i 〉 Methods: 〈 /i 〉 The function and safety of the device was tested by conducting bilateral electrophysiologically guided microinjections of fluorescent microspheres in the substantia nigra of 4 Göttingen minipigs. 〈 i 〉 Results: 〈 /i 〉 The device was easy to handle and enabled accurate electrophysiologically guided targeting of the substantia nigra with minimal local tissue damage. 〈 i 〉 Conclusion: 〈 /i 〉 The IMI is suitable for clinical use and may prove useful for various stereotactic procedures that require high levels of precision and/or three-dimensional distribution of therapeutics within the brain.
Type of Medium:
Online Resource
ISSN:
1011-6125
,
1423-0372
Language:
English
Publisher:
S. Karger AG
Publication Date:
2010
detail.hit.zdb_id:
1483576-9
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