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  • 1
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    Online Resource
    In vivo Lipopolysaccharide Tolerance Recruits CD11b〈sup〉+〈/sup〉 Macrophages to the Liver with Enhanced Bactericidal Activity and Low Tumor Necrosis Factor-Releasing Capability, Resulting in Drastic Resistance to Lethal Septicemia
    S. Karger AG ; 2017
    In:  Journal of Innate Immunity Vol. 9, No. 5 ( 2017), p. 493-510
    Details
    In: Journal of Innate Immunity, S. Karger AG, Vol. 9, No. 5 ( 2017), p. 493-510
    Abstract: 〈 b 〉 〈 i 〉 Objectives: 〈 /i 〉 〈 /b 〉 In vivo lipopolysaccharide (LPS) tolerance on bacterial infection was investigated, focusing on liver macrophages. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 LPS tolerance was induced by intraperitoneal injections with 5 μg/kg of LPS for 3 consecutive days, and then mice were intravenously infected with 〈 i 〉 Escherichia coli 〈 /i 〉 . 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 All LPS-primed mice survived lethal bacterial infection. Drastic enhancement of bactericidal activity of liver macrophages strongly contributed to bacterial clearance. Although LPS-primed mice produced substantial amounts of tumor necrosis factor (TNF) inside the liver, TNF efflux into the systemic circulation was markedly suppressed. These mice showed a dramatic increase in CD11b 〈 sup 〉 + 〈 /sup 〉 monocyte- derived macrophages in the liver. The CD11b 〈 sup 〉 + 〈 /sup 〉 macrophages that increased in LPS-primed mice were those with strong phagocytic/bactericidal activity and an upregulated expression of Fc & #x03B3; receptor I, but the subfraction with a potent TNF-producing capacity and poor phagocytic activity diminished. The adoptive transfer of CD11b 〈 sup 〉 + 〈 /sup 〉 macrophages from LPS-primed mice to control mice increased survival after bacterial infection and reduced the elevation of plasma TNF. LPS priming did not affect the CD68 〈 sup 〉 + 〈 /sup 〉 resident Kupffer cells, and CD68 〈 sup 〉 + 〈 /sup 〉 Kupffer cell-depleted mice still exhibited LPS tolerance with strong resistance to bacteremia. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 LPS tolerance recruits CD11b 〈 sup 〉 + 〈 /sup 〉 macrophages to the liver with enhanced bactericidal activity, which plays a central role in resistance to lethal bacteremia.
    Type of Medium: Online Resource
    ISSN: 1662-811X , 1662-8128
    URL: Article
    DOI: 10.1159/000475931
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2017
    detail.hit.zdb_id: 2455818-7
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  • 2
    Online Resource
    Online Resource
    Clinicopathological Significance of S100A14 Expression in Lung Adenocarcinoma
    S. Karger AG ; 2017
    In:  Oncology Research and Treatment Vol. 40, No. 10 ( 2017), p. 594-602
    Details
    In: Oncology Research and Treatment, S. Karger AG, Vol. 40, No. 10 ( 2017), p. 594-602
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 Several studies have reported that S100A14 plays important roles during different steps of the tumorigenic process and tumor progression of several types of cancer. The aim of the present study was to investigate the clinicopathological and prognostic significance and functional roles of S100A14 in lung adenocarcinoma. 〈 b 〉 〈 i 〉 Patients and Methods: 〈 /i 〉 〈 /b 〉 S100A14 expression was immunohistochemically studied in 166 consecutive resected lung adenocarcinomas, and its correlation with clinicopathological parameters was evaluated. Functional roles of S100A14 in lung adenocarcinoma were investigated based on invasion and migration assays on a small interfering (si)RNA-treated lung adenocarcinoma cell line. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 S100A14 expression was detected in 82 of the 166 (49.4%) lung adenocarcinomas. S100A14 expression was significantly correlated with sex, poorer tumor differentiation, higher disease stages, larger tumor size, lymph node metastasis, intratumoral vascular invasion, intratumoral lymphatic invasion, pleural invasion, and poorer prognosis. Invasion and wound healing assays showed that S100A14 siRNA knockdown cells had significantly decreased invasion and migration abilities compared with siRNA control cells. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 S100A14 is expressed in a subset of lung adenocarcinoma, and its expression is related to certain clinicopathological parameters. Furthermore, S100A14 expression was strongly correlated with migration and invasion in lung adenocarcinoma cells.
    Type of Medium: Online Resource
    ISSN: 2296-5270 , 2296-5262
    URL: Article
    DOI: 10.1159/000478100
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2017
    detail.hit.zdb_id: 2749752-5
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  • 3
    Online Resource
    Online Resource
    Effect of Cevimeline on Salivary Components in Patients with Sjögren Syndrome
    S. Karger AG ; 2005
    In:  Pharmacology Vol. 74, No. 2 ( 2005), p. 100-105
    Details
    In: Pharmacology, S. Karger AG, Vol. 74, No. 2 ( 2005), p. 100-105
    Abstract: The aim of this study is to clarify the effects of cevimeline on various components in human saliva, such as immunoglobulin A (IgA), lysozyme, α-amylase and squamous cell carcinoma (SCC) antigen. Twelve female patients with Sjögren syndrome (SS) and 14 healthy women were enrolled. After the first saliva collection, one capsule (30 mg) of cevimeline was administered to each subject. Saliva was collected again after 90 min. The salivary flow rate and concentration of each component were measured. In both groups the salivary flow rate and amylase concentration were significantly increased by cevimeline. The lysozyme and IgA concentrations did not change significantly in both groups. The SCC antigen concentration did not change significantly in the SS group, but it decreased significantly in the control group. The secretion rates of amylase and IgA showed significant increases in both groups. The secretion rate of lysozyme significantly increased only in the control group, while the secretion rate of SCC significantly increased only in the SS group. Cevimeline augments not only the salivary flow rate but also the secretion rate of some digestive and/or defense factors from infections. It may be beneficial for SS patients to continue taking cevimeline to prevent oral infections, and other serious sequelae.
    Type of Medium: Online Resource
    ISSN: 0031-7012 , 1423-0313
    URL: Article
    DOI: 10.1159/000084031
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2005
    detail.hit.zdb_id: 1483550-2
    SSG: 15,3
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  • 4
    Online Resource
    Online Resource
    Nivolumab-Induced Myocarditis Concomitant with Myasthenia Gravis
    S. Karger AG ; 2017
    In:  Case Reports in Oncology Vol. 10, No. 3 ( 2017-9-6), p. 809-812
    Details
    In: Case Reports in Oncology, S. Karger AG, Vol. 10, No. 3 ( 2017-9-6), p. 809-812
    Abstract: We report a 69-year-old female patient with advanced lung cancer who developed myocarditis concomitant with myasthenia gravis (MG), also known as “Herzmyasthenie,” after 3 cycles of nivolumab administration. Her initial symptoms were general malaise and double vision. However, her myocarditis deteriorated rapidly the following day, necessitating a temporary pacemaker and noninvasive positive pressure ventilation in the intensive care unit. Immunohistochemical examination of a myocardial biopsy suggested an immune response on the basis of 〈 i 〉 HLA 〈 /i 〉 associations. The patient also developed impaired adduction of her left eye and elevated serum levels of acetylcholine receptor antibody, suggesting the onset of MG. Her condition gradually improved after immediate methylprednisolone pulse therapy. This case of nivolumab-induced “Herzmyasthenie” highlights the need to be aware that fulminant myocarditis might occur at the same time as MG during treatment with anti-programmed cell death-1 monoclonal antibodies.
    Type of Medium: Online Resource
    ISSN: 1662-6575
    URL: Article
    DOI: 10.1159/000479958
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2017
    detail.hit.zdb_id: 2458961-5
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  • 5
    Online Resource
    Online Resource
    An Analysis of 20 Cases of Radiation-Associated Sarcoma, Including 4 Cases Treated by Carbon Ion Radiotherapy
    S. Karger AG ; 2022
    In:  Oncology Vol. 100, No. 3 ( 2022), p. 148-154
    Details
    In: Oncology, S. Karger AG, Vol. 100, No. 3 ( 2022), p. 148-154
    Abstract: 〈 b 〉 〈 i 〉 Introduction: 〈 /i 〉 〈 /b 〉 Radiation-associated sarcoma (RAS) is one of the most life-threatening complications associated with the treatment of malignant neoplasms. Because all RAS patients have a history of radiotherapy, there have been no effective treatment options when RAS is not completely resected. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 We retrospectively reviewed 20 RAS patients, including 4 unresectable cases treated by carbon ion radiotherapy (CIRT). 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 The primary diseases targeted by radiotherapy included malignant lymphoma ( 〈 i 〉 n 〈 /i 〉 = 4), cervical cancer ( 〈 i 〉 n 〈 /i 〉 = 3), pharyngeal cancer ( 〈 i 〉 n 〈 /i 〉 = 3), breast cancer ( 〈 i 〉 n 〈 /i 〉 = 2), lung cancer ( 〈 i 〉 n 〈 /i 〉 = 1), rectal cancer ( 〈 i 〉 n 〈 /i 〉 = 1), maxillary cancer ( 〈 i 〉 n 〈 /i 〉 = 1), synovial sarcoma ( 〈 i 〉 n 〈 /i 〉 = 1), and benign neoplasms ( 〈 i 〉 n 〈 /i 〉 = 4). The histological diagnoses of RAS included osteosarcoma ( 〈 i 〉 n 〈 /i 〉 = 8), leiomyosarcoma ( 〈 i 〉 n 〈 /i 〉 = 3), undifferentiated pleomorphic sarcoma ( 〈 i 〉 n 〈 /i 〉 = 3), rhabdomyosarcoma ( 〈 i 〉 n 〈 /i 〉 = 1), angiosarcoma ( 〈 i 〉 n 〈 /i 〉 = 1), malignant peripheral nerve sheath tumor ( 〈 i 〉 n 〈 /i 〉 = 1), spindle cell sarcoma NOS ( 〈 i 〉 n 〈 /i 〉 = 1), and sarcoma not further specified ( 〈 i 〉 n 〈 /i 〉 = 2). The median survival time from the diagnosis of RAS was 26 months. Eleven patients underwent surgery. Five of these patients achieved a continuous disease free (CDF) status or showed no evidence disease. Four patients underwent CIRT. One of these patients with leiomyosarcoma achieved a CDF status, and the other patient with osteosarcoma achieved a partial response. On the other hand, 2 patients experienced grade 3 toxicities that required surgical treatment. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 RAS originates from various types of diseases that are treated by radiotherapy and shows diverse pathological features. Complete resection achieves a good prognosis. CIRT can be an effective and feasible option for unresectable RAS.
    Type of Medium: Online Resource
    ISSN: 0030-2414 , 1423-0232
    URL: Article
    DOI: 10.1159/000521504
    RVK:
    XH 3305
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2022
    detail.hit.zdb_id: 1483096-6
    detail.hit.zdb_id: 250101-6
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  • 6
    Online Resource
    Online Resource
    Epitope Analysis of Human T-Cell Response to MSP-1 of 〈i〉Plasmodium falciparum〈/i〉 in Malaria-Nonexposed Individuals
    S. Karger AG ; 1997
    In:  International Archives of Allergy and Immunology Vol. 114, No. 1 ( 1997), p. 15-22
    Details
    In: International Archives of Allergy and Immunology, S. Karger AG, Vol. 114, No. 1 ( 1997), p. 15-22
    Type of Medium: Online Resource
    ISSN: 1018-2438 , 1423-0097
    URL: Article
    DOI: 10.1159/000237637
    RVK:
    XA 49650
    Language: English
    Publisher: S. Karger AG
    Publication Date: 1997
    detail.hit.zdb_id: 1482722-0
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  • 7
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    Online Resource
    Bifidobacterium-Rich Fecal Donor May Be a Positive Predictor for Successful Fecal Microbiota Transplantation in Patients with Irritable Bowel Syndrome
    S. Karger AG ; 2017
    In:  Digestion Vol. 96, No. 1 ( 2017), p. 29-38
    Details
    In: Digestion, S. Karger AG, Vol. 96, No. 1 ( 2017), p. 29-38
    Abstract: 〈 b 〉 〈 i 〉 Background/Aims: 〈 /i 〉 〈 /b 〉 Dysbiosis is associated with various systemic disorders including irritable bowel syndrome (IBS). Fecal microbiota transplantation (FMT) might restore intestinal microbial balance. The study aimed to determine the safety and efficacy of FMT in IBS patients, as well as also positive predictors for FMT. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 This was a single-arm, open-label study. Eligible patients were diagnosed based on Rome III Diagnostic Criteria. Fecal materials were administered to the patient via colonoscopy. The primary end point was a change in the Bristol stool form scale at 4 weeks after FMT. Recovery to types 3-4 was considered a clinical response. The secondary end point was a change in intestinal microbiota and psychological status using the Hamilton Rating Scale. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Ten patients were enrolled. Six patients achieved a clinical response. The diversity of patients 4 weeks after FMT increased significantly compared with patients before FMT, and that of responding patients was significantly higher than non-responder patients. The abundance of 〈 i 〉 Bifidobacterium 〈 /i 〉 in effective donors was significantly higher than in ineffective donors and patients. Psychological status of all patients was significantly improved after FMT. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 FMT for patients with IBS is safe, and relatively effective. 〈 i 〉 Bifidobacterium 〈 /i 〉 -rich fecal donor may be a positive predictor for successful FMT. 〈 b 〉 〈 i 〉 Key Summary: 〈 /i 〉 〈 /b 〉 (1) Dysbiosis is associated with various gastrointestinal disorders including IBS. (2) FMT has potential to restore intestinal microbial balance. (3) We showed that FMT improved stool form and psychological status of IBS patients. (4) 〈 i 〉 Bifidobacterium 〈 /i 〉 -rich donor efficiently induced symbiosis in IBS patients.
    Type of Medium: Online Resource
    ISSN: 0012-2823 , 1421-9867
    URL: Article
    DOI: 10.1159/000471919
    RVK:
    XA 40650
    RVK:
    XA 10000
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2017
    detail.hit.zdb_id: 1482218-0
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  • 8
    Online Resource
    Online Resource
    Relationship between the Degree of Endolymphatic Hydrops and Electrocochleography
    S. Karger AG ; 2010
    In:  Audiology and Neurotology Vol. 15, No. 4 ( 2010), p. 254-260
    Details
    In: Audiology and Neurotology, S. Karger AG, Vol. 15, No. 4 ( 2010), p. 254-260
    Abstract: The purpose of this study was to evaluate the relationship between the endolymphatic space image obtained using magnetic resonance imaging (MRI) and the results of electrocochleography. Electrocochleography recordings were obtained from 25 ears of 24 patients, who underwent MRI 1 day after the intratympanic injection of gadolinium diethylenetriamine pentaacetic acid bismethylamide. The average summating potential to action potential (SP/AP) ratio in patients with significant endolymphatic hydrops in the cochlea was 54 ± 17%. However, in some patients who had significant endolymphatic hydrops in the cochlea, the SP/AP ratio was not enlarged. This may imply that elevation of the SP/AP ratio is related to not only the degree of endolymphatic hydrops but also to the persistence of hydrops.
    Type of Medium: Online Resource
    ISSN: 1420-3030 , 1421-9700
    URL: Article
    DOI: 10.1159/000258681
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2010
    detail.hit.zdb_id: 1481979-X
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  • 9
    Online Resource
    Online Resource
    Monitoring Sleep-Wake Rhythm with Actigraphy in Patients on Continuous Positive Airway Pressure Therapy
    S. Karger AG ; 2011
    In:  Respiration Vol. 82, No. 2 ( 2011), p. 136-141
    Details
    In: Respiration, S. Karger AG, Vol. 82, No. 2 ( 2011), p. 136-141
    Abstract: 〈 i 〉 Background: 〈 /i 〉 Continuous positive airway pressure (CPAP) therapy has been shown to be effective in alleviating the underlying obstruction as well as reducing patients’ excessive sleepiness and improving their functioning and health-related quality of life. However, residual excessive sleepiness is observed in some patients even though CPAP therapy eliminates sleep apnea and desaturation. 〈 i 〉 Objectives: 〈 /i 〉 The aim of this study was to determine the prognostic effect of actigraphic sleep-wake rhythm evaluation in the management of patients with obstructive sleep apnea syndrome (OSAS) treated with CPAP. 〈 i 〉 Methods: 〈 /i 〉 Eighteen patients with OSAS diagnosed by standard polysomnography (PSG; 48.1 ± 12.5 years) were enrolled in this study. The sleep-wake parameters were determined by actigraphy before and after 1 month of CPAP treatment, and results were compared with PSG data. In addition, data obtained before CPAP were compared with those measured after 1 month of CPAP treatment. 〈 i 〉 Results: 〈 /i 〉 The total sleep time (TST) and sleep efficiency using PSG were significantly correlated with those using actigraphy. Bland-Altman plots of TST and sleep efficiency confirmed good agreement between PSG and actigraphy data. Sleep efficiency significantly improved following CPAP compared to baseline, and sleep fragmentation and sleep fragmentation 〉 5 min determined by actigraphy were significantly lower during CPAP therapy than at baseline. Movement was significantly lower on CPAP therapy than at baseline. 〈 i 〉 Conclusions: 〈 /i 〉 Actigraphy provides a valuable sleep-wake rhythm assessment in outpatients with OSAS where PSG is difficult to perform.
    Type of Medium: Online Resource
    ISSN: 0025-7931 , 1423-0356
    URL: Article
    DOI: 10.1159/000321238
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2011
    detail.hit.zdb_id: 1464419-8
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  • 10
    Online Resource
    Online Resource
    Magnetic Resonance Imaging of Endolymphatic Sac in Acute Low-Tone Sensorineural Hearing Loss without Vertigo
    S. Karger AG ; 2003
    In:  ORL Vol. 65, No. 5 ( 2003), p. 254-260
    Details
    In: ORL, S. Karger AG, Vol. 65, No. 5 ( 2003), p. 254-260
    Abstract: The etiology of acute low-tone sensorineural hearing loss (ALHL) may be associated with deteriorated function of the endolymphatic sac. Using magnetic resonance (MR) imaging on a 1.5-tesla MR system, we evaluated the frequency of visualization and contrast enhancement of the endolymphatic sac in 25 patients (9 men and 16 women; age range 11–64 years) with ALHL and 21 control subjects. The present study demonstrated that the frequency of visualization and enhancement of the endolymphatic sac in patients with ALHL was not significantly higher than in control subjects.
    Type of Medium: Online Resource
    ISSN: 0301-1569 , 1423-0275
    URL: Article
    DOI: 10.1159/000075222
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2003
    detail.hit.zdb_id: 1483533-2
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