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  • 1
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    Online Resource
    Arsenic Methylation Capability, Heme Oxygenase-1 and NADPH Quinone Oxidoreductase-1 Genetic Polymorphisms and the Stage and Grade of Urothelial Carcinomas
    S. Karger AG ; 2008
    In:  Urologia Internationalis Vol. 80, No. 4 ( 2008), p. 405-412
    Details
    In: Urologia Internationalis, S. Karger AG, Vol. 80, No. 4 ( 2008), p. 405-412
    Abstract: 〈 i 〉 Background: 〈 /i 〉 Arsenic exposure is associated with an increased risk of urothelial carcinoma (UC). To explore the distribution of the arsenic methylation capability in patients with different stages and grades of UCs, 100 UC cases were recruited between September 2002 and May 2004 for this study. 〈 i 〉 Methods: 〈 /i 〉 Urinary arsenic species, including inorganic arsenic (As 〈 sup 〉 III 〈 /sup 〉 + As 〈 sup 〉 V 〈 /sup 〉 ), monomethylarsonic acid (MMA), and dimethylarsinic acid (DMA), were determined with a high-performance liquid chromatography-linked hydride generator and atomic absorption spectrometry. Determining the percentages of various arsenic species among the total urinary arsenic amount assessed the arsenic methylation capability. The primary methylation index (PMI) was defined as the ratio between MMA and inorganic arsenic. The secondary methylation index (SMI) was determined as the ratio between DMA and MMA. 〈 i 〉 Results: 〈 /i 〉 Differential effects of the arsenic methylation capability were found among patients with different stages of UCs; however, none was found among different grades. 〈 i 〉 Conclusion: 〈 /i 〉 A significantly different distribution of the HO-1 genotype was found in subjects with different-stage UCs; however, it was not related to the NAD(P)H:quinone oxidoreductase 1 genotype.
    Type of Medium: Online Resource
    ISSN: 0042-1138 , 1423-0399
    URL: Article
    DOI: 10.1159/000132699
    RVK:
    XA 10000
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2008
    detail.hit.zdb_id: 1464417-4
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  • 2
    Online Resource
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    Perianal Infections in the Phase before Engraftment after Allogeneic Hematopoietic Stem Cell Transplantations: A Study of the Incidence, Risk Factors, and Clinical Outcomes
    S. Karger AG ; 2018
    In:  Acta Haematologica Vol. 139, No. 1 ( 2018), p. 19-27
    Details
    In: Acta Haematologica, S. Karger AG, Vol. 139, No. 1 ( 2018), p. 19-27
    Abstract: In this study, we aimed to investigate the incidence, risk factors, and clinical outcomes of perianal infections during the pre-engraftment phase after allogeneic hematopoietic stem cell transplantation (allo-HSCT). 〈 b 〉 〈 /b 〉 Consecutive patients who underwent non-T-cell-depleted allo-HSCT at the Peking University Institute of Hematology from January 1 to December 31, 2016 were enrolled ( 〈 i 〉 n 〈 /i 〉 = 646). Ninety-nine patients were found to have perianal infections during the pre-engraftment phase, and 80 were found to have neutropenia on perianal infection diagnosis. The cumulative incidence of perianal infection during the pre-engraftment phase after allo-HSCT was 15.3%. A history of perianal infection (hazard ratio [HR] = 15.28, 〈 i 〉 p 〈 /i 〉 〈 0.001) or hemorrhoids before allo-HSCT (HR = 3.09, 〈 i 〉 p 〈 /i 〉 = 0.001) was significantly associated with the new occurrence of perianal infection after allo-HSCT. All patients received empirical broad-spectrum antimicrobial therapies, and 97 were cured after treatment. The clinical outcomes at 100 days after allo-HSCT were comparable in patients with and without perianal infections. 〈 b 〉 〈 /b 〉 In summary, patients who had perianal infection or hemorrhoids before allo-HSCT had a higher risk of new occurrence of perianal infection after allo-HSCT. With appropriate treatment, perianal infection during the pre-engraftment phase did not influence the clinical outcomes.
    Type of Medium: Online Resource
    ISSN: 0001-5792 , 1421-9662
    URL: Article
    DOI: 10.1159/000481723
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2018
    detail.hit.zdb_id: 1481888-7
    detail.hit.zdb_id: 80008-9
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  • 3
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    High-Dose Cyclophosphamide Therapy Associated with Diffuse Alveolar Hemorrhage after Allogeneic Hematopoietic Stem Cell Transplantation
    S. Karger AG ; 2013
    In:  Respiration Vol. 86, No. 6 ( 2013), p. 453-461
    Details
    In: Respiration, S. Karger AG, Vol. 86, No. 6 ( 2013), p. 453-461
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 The occurrence of diffuse alveolar hemorrhage (DAH) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is rare but severe. There are few reports that have examined the correlation between pre-HSCT chemotherapeutic exposure and DAH. 〈 b 〉 〈 i 〉 Objectives: 〈 /i 〉 〈 /b 〉 We examine the role of pre-HSCT chemotherapeutic exposure, conditioning regimens, pre-HSCT comorbidities and transplant-related complications in the development of DAH after allo-HSCT and evaluate the effect of the high-dose corticosteroid strategy on DAH. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 A retrospective nested case-control study was designed. Cases with DAH and controls matched for year of allo-HSCT and length of follow-up were identified from a cohort of 597 patients who underwent allo-HSCT between 2006 and 2011 for acute leukemia. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Twenty-two patients suffered from DAH; the mean age at the time of presentation was 30.4 years (±12.9) and the mean time to presentation was 7.8 months (±8.1) post-HSCT. The pre-HSCT cyclophosphamide exposure and the cumulative cyclophosphamide dose were significantly higher among the DAH cases compared with the controls, and the cumulative cyclophosphamide dose of ≥5 g/m 〈 sup 〉 2 〈 /sup 〉 was independently associated with DAH (OR = 3.4, p = 0.030). High-dose corticosteroid treatment did not significantly improve survival. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 From these results we can identify patients who are at a higher risk of developing DAH after allo-HSCT, and we found that high-dose corticosteroid therapy may not alter the poor outcome associated with this syndrome.
    Type of Medium: Online Resource
    ISSN: 0025-7931 , 1423-0356
    URL: Article
    DOI: 10.1159/000345592
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2013
    detail.hit.zdb_id: 1464419-8
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  • 4
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    Online Resource
    Lymph Node Metastases in Gastric Cancer: Significance of Positive Number
    S. Karger AG ; 1995
    In:  Oncology Vol. 52, No. 1 ( 1995), p. 45-50
    Details
    In: Oncology, S. Karger AG, Vol. 52, No. 1 ( 1995), p. 45-50
    Type of Medium: Online Resource
    ISSN: 0030-2414 , 1423-0232
    URL: Article
    DOI: 10.1159/000227426
    RVK:
    XH 3305
    Language: English
    Publisher: S. Karger AG
    Publication Date: 1995
    detail.hit.zdb_id: 1483096-6
    detail.hit.zdb_id: 250101-6
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  • 5
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    Establishment of a Systemic Inflammatory Response Syndrome Model and Evaluation of the Efficacy of Umbilical Cord Mesenchymal Stem Cell Transplantation
    S. Karger AG ; 2021
    In:  Cells Tissues Organs Vol. 210, No. 2 ( 2021), p. 118-134
    Details
    In: Cells Tissues Organs, S. Karger AG, Vol. 210, No. 2 ( 2021), p. 118-134
    Abstract: Based on the characteristics of modern weapon injury, a repetitive model of traumatic systemic inflammatory response syndrome (SIRS) and an evaluation system were established. The models were treated with GFP-labeled tree shrew umbilical cord mesenchymal stem cells (UCMSCs). Forty out of 50 tree shrews were used to make a unilateral femoral comminuted fracture. Lipopolysaccharide was injected intravenously to create a traumatic SIRS model. The other 10 shrews were used as normal controls. After the model was established for 10 days, 20 tree shrews were injected intravenously with GFP-labeled UCMSCs, and 18 tree shrews were not injected as the model control group. The distribution of GFP-labeled cells in vivo was measured at 2 and 10 days after injection. Twenty days after treatment, the model group, the normal control group, and the treatment group were taken to observe the pathological changes in each tissue, and blood samples were taken for the changes in liver, renal, and heart function. Distribution of GFP-positive cells was observed in all tissues at 2 and 10 days after injection. After treatment, the HE staining results of the treatment group were close to those of the normal group, and the model group had a certain degree of lesions. The results of liver, renal, and heart function tests in the treatment group were returned to normal, and the results in the model group were abnormally increased. UCMSCs have a certain effect on the treatment of traumatic SIRS and provide a new technical solution for modern weapon trauma treatment.
    Type of Medium: Online Resource
    ISSN: 1422-6405 , 1422-6421
    URL: Article
    DOI: 10.1159/000514619
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2021
    detail.hit.zdb_id: 1481840-1
    SSG: 12
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  • 6
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    Translation and Validation of a Chinese Version of the Parental Self-Efficacy with Eczema Care Index
    S. Karger AG ; 2020
    In:  Dermatology Vol. 236, No. 4 ( 2020), p. 361-368
    Details
    In: Dermatology, S. Karger AG, Vol. 236, No. 4 ( 2020), p. 361-368
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 Parental self-efficacy has been found to be a critical determinant of the efficacy of interventions intended to enhance the parental management of childhood eczema. 〈 b 〉 〈 i 〉 Objectives: 〈 /i 〉 〈 /b 〉 The psychometric properties of a translated Chinese version of the Parental Self-Efficacy with Eczema Care Index (C-PASECI) were examined. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 The PASECI was translated in a 2-stage process involving both forward and backward translation. Subsequently, the psychometric properties of the C-PASECI were examined in a cohort of 147 Chinese parents or caregivers of children with eczema. Specifically, the internal consistency, 2-day test-retest reliability and construct validity were assessed. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 The C-PASECI received a Cronbach’s αof 0.97, and the intraclass correlation coefficients of each item ranged from 0.93 to 0.99. Negative correlations were observed among the C-PASECI, Children’s Dermatology Life Quality Index and Scoring Atopic Dermatitis Scale scores, indicating the acceptable convergent validity of the C-PASECI. The moderate correlation observed between the C-PASECI and General Self-Efficacy Scale (Pearson’s 〈 i 〉 r 〈 /i 〉 = 0.53, 〈 i 〉 p 〈 /i 〉 & #x3c; 0.001) reflected the acceptable concurrent validity of the C-PASECI. The results of confirmatory factor analysis supported the factorial validity of the C-PASECI. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 The C-PASECI appears to be a reliable and valid measure of parental self-efficacy in Chinese parents or caregivers of children with eczema.
    Type of Medium: Online Resource
    ISSN: 1018-8665 , 1421-9832
    URL: Article
    DOI: 10.1159/000505450
    RVK:
    XA 37700
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2020
    detail.hit.zdb_id: 1482189-8
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  • 7
    Online Resource
    Online Resource
    Arsenic Methylation Capability, Myeloperoxidase and Sulfotransferase Genetic Polymorphisms, and the Stage and Grade of Urothelial Carcinoma
    S. Karger AG ; 2009
    In:  Urologia Internationalis Vol. 82, No. 2 ( 2009), p. 227-234
    Details
    In: Urologia Internationalis, S. Karger AG, Vol. 82, No. 2 ( 2009), p. 227-234
    Abstract: Arsenic exposure is associated with an increased risk of bladder cancer. To explore the distribution of the arsenic methylation capability and myeloperoxidase 〈 i 〉 (MPO) 〈 /i 〉 and sulfotransferase 〈 i 〉 (SULT) 1A1 〈 /i 〉 genotypes in patients at different stages and grades of urothelial carcinoma (UC), 112 UC cases were recruited between September 2002 and May 2004 for this study. Urinary arsenic species, including inorganic arsenic (As 〈 sup 〉 III 〈 /sup 〉 + As 〈 sup 〉 V 〈 /sup 〉 ), monomethylarsonic acid, and dimethylarsinic acid, were determined with a high-performance liquid chromatography-linked hydride generator and atomic absorption spectrometry. The 〈 i 〉 MPO 〈 /i 〉 and 〈 i 〉 SULT1A1 〈 /i 〉 genotypes were examined with polymerase chain reaction and restriction fragment length polymorphism. Differential effects of the arsenic methylation capability were found among patients with different stages of UC; however, urinary arsenic concentrations were borderline significantly increased with the progress of UC patients regardless of whether or not they had been exposed to arsenic from drinking water. The 〈 i 〉 MPO 〈 /i 〉 and 〈 i 〉 SULT 〈 /i 〉 genetic polymorphisms might modify the arsenic methylation profile and UC progression, and thus are worthy of further investigation.
    Type of Medium: Online Resource
    ISSN: 0042-1138 , 1423-0399
    URL: Article
    DOI: 10.1159/000200805
    RVK:
    XA 10000
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2009
    detail.hit.zdb_id: 1464417-4
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  • 8
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    Genome-Wide Association Study of MKI67 Expression and its Clinical Implications in HBV-Related Hepatocellular Carcinoma in Southern China
    S. Karger AG ; 2017
    In:  Cellular Physiology and Biochemistry Vol. 42, No. 4 ( 2017), p. 1342-1357
    Details
    In: Cellular Physiology and Biochemistry, S. Karger AG, Vol. 42, No. 4 ( 2017), p. 1342-1357
    Abstract: Background/Aims: Hepatocellular carcinoma (HCC) is a common malignant tumor with a high rate of recurrence. Immunohistochemical analysis of the marker of proliferation Ki-67 (MKI67) is used to assess proliferation activity of HCC The regulation of MKI67 expression remains unclear in HCC This study aims to explore the association between MKI67 expression and gene variants. Methods: A total of 195 hepatitis B virus (HBV)-related HCC patients were genotyped using Illumina HumanExome BeadChip-12-1_A (242,901 markers). An independent cohort (97 subjects) validated the association of polymorphism determinants and candidate genes with MKI67 expression. The relationships between MKI67 with p53 and variants of candidate genes in the clinical outcomes of HCC patients were analyzed. Results: We found that MKI67 combined with p53 was associated with a 3-year recurrence-free survival and five variants near TTN and CCDC8 were associated with MKI67 expression. TTN harboring rs2288563-TT and rs2562832-AA+CA indicated a favorable outcome for HCC patients. Conclusion: Variants near TTN and CCDC8 were associated with MKI67 expression, and rs2288563 and rs2562832 in TTN are potential biomarkers for the prediction of clinical outcomes in HBV-related HCC patients.
    Type of Medium: Online Resource
    ISSN: 1015-8987 , 1421-9778
    URL: Article
    DOI: 10.1159/000478963
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2017
    detail.hit.zdb_id: 1482056-0
    SSG: 12
    SSG: 15,3
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  • 9
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    Online Resource
    A Meta-Analysis of Prognostic Factors in Patients with Posterior Circulation Stroke after Mechanical Thrombectomy
    S. Karger AG ; 2021
    In:  Cerebrovascular Diseases Vol. 50, No. 2 ( 2021), p. 185-199
    Details
    In: Cerebrovascular Diseases, S. Karger AG, Vol. 50, No. 2 ( 2021), p. 185-199
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 Posterior circulation stroke is characterized by poor prognosis because its optimal thrombolysis “time window” is always missed. After mechanical thrombectomy (MT), the recanalization rate of posterior circulation obstruction is significantly increased, but prognosis remains poor. To best manage patients, prognostic factors are needed to inform MT triaging after posterior circulation stroke. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 A systematic literature search was done for the period through April 2020. Studies included those with posterior circulation stroke cases that underwent MT. The primary outcome measure in this study was the modified Rankin Scale on day 90. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 No outcome differences were found in gender, atrial fibrillation, smoking, and coronary artery disease (OR = 1.07, 95% CI: 0.90–1.28; OR = 1.02, 95% CI: 0.82–1.26; OR = 1.26, 95% CI: 0.94–1.68; and OR = 0.84, 95% CI: 0.58–1.22, respectively). Hypertension, diabetes mellitus, and previous stroke correlated with poorer prognosis (OR = 0.61, 95% CI: 0.48–0.77; OR = 0.60, 95% CI: 0.50–0.73; and OR = 0.74, 95% CI: 0.55–0.99, respectively). However, hyperlipidemia correlated with better prognosis (OR = 1.28, 95% CI: 1.04–1.58). 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 Our analysis indicates that hypertension, diabetes mellitus, or previous stroke correlate with poorer outcomes. Intriguingly, hyperlipidemia correlates with better prognosis. These factors may help inform triage decisions when considering MT for posterior circulation stroke patients. However, large, multicenter, randomized controlled trials are needed to validate these observations.
    Type of Medium: Online Resource
    ISSN: 1015-9770 , 1421-9786
    URL: Article
    DOI: 10.1159/000512609
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2021
    detail.hit.zdb_id: 1482069-9
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  • 10
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    Online Resource
    Pim1 Overexpression Prevents Apoptosis in Cardiomyocytes After Exposure to Hypoxia and Oxidative Stress via Upregulating Cell Autophagy
    S. Karger AG ; 2018
    In:  Cellular Physiology and Biochemistry Vol. 49, No. 6 ( 2018), p. 2138-2150
    Details
    In: Cellular Physiology and Biochemistry, S. Karger AG, Vol. 49, No. 6 ( 2018), p. 2138-2150
    Abstract: Background/Aims: Microvascular obstruction (MVO), an undesirable complication of percutaneous coronary intervention, is independently associated with adverse left ventricle remodeling and poor prognosis after acute myocardial infarction. Hypoxia and oxidative stress major roles in the pathophysiology of MVO. Pim1 serves an important protective role in the ischemic myocardium, but the underlying mechanisms remain poorly defined. Autophagy in early hypoxia or during moderate oxidative stress has been demonstrated to protect the myocardium. In this study, we investigated the association between the protective effect of Pim1 and autophagy after hypoxia and oxidative stress. Methods: Ventricular myocytes from neonatal rat heart (NRVMs) were isolated. NRVMs were exposed to hypoxia and H2O2. Rapamycin and 3-methyladenine (3-MA) were used as an activator and inhibitor of autophagy, respectively. pHBAd-Pim1 was transfected into NRVMs. We assessed cardiomyocyte apoptosis by Annexin V-FITC/PI flow cytometry. Autophagy was evaluated by mRFP-GFP-LC3 adenovirus infection by confocal microscopy. Western blotting was used to quantify apoptosis or autophagy protein (caspase-3, LC3, P62, AMPK, mTOR, ATG5) concentrations. Results: Autophagy and apoptosis in NRVMs significantly increased and peaked at 3 h and 6 h, respectively, after exposure to hypoxia and H2O2. The mTOR inhibitor rapamycin induced autophagy and decreased cardiomyocyte apoptosis, but the autophagy inhibitor 3-MA decreased autophagy and increased apoptosis at 3 h after exposure to hypoxia and H2O2. Pim1 levels in NRVMs increased at 3 h and decreased gradually after exposure to hypoxia and H2O2. Pim1 overexpression enhanced autophagy and decreased apoptosis. Pim1-induced promotion of autophagy is partly the result of activation of the AMPK/mTOR/ATG5 pathway after exposure to hypoxia and H2O2. Conclusion: Our results revealed that Pim1 overexpression prevented NRVMs from apoptosis via upregulating autophagy after exposure to hypoxia and oxidative stress, partly through activation of the AMPK/mTOR/ATG5 autophagy pathway.
    Type of Medium: Online Resource
    ISSN: 1015-8987 , 1421-9778
    URL: Article
    DOI: 10.1159/000493817
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2018
    detail.hit.zdb_id: 1482056-0
    SSG: 12
    SSG: 15,3
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