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  • 1
    Online Resource
    Online Resource
    Reductions in Platelet 18-kDa Translocator Protein Density Are Associated with Adult Separation Anxiety in Patients with Bipolar Disorder
    S. Karger AG ; 2010
    In:  Neuropsychobiology Vol. 62, No. 2 ( 2010), p. 98-103
    Details
    In: Neuropsychobiology, S. Karger AG, Vol. 62, No. 2 ( 2010), p. 98-103
    Abstract: 〈 i 〉 Background: 〈 /i 〉 Recent studies indicate that adult separation anxiety disorder is a discrete diagnostic entity and worthy of attention. Previously, we found a significant association between platelet expression of the 18-kDa translocator protein (TSPO) and adult separation anxiety in patients with panic disorder or major depression. The aim of this study was to explore whether adult separation anxiety might be a factor differentiating TSPO expression in a sample of patients with bipolar disorder. 〈 i 〉 Methods: 〈 /i 〉 The equilibrium binding parameters of the specific TSPO ligand [ 〈 sup 〉 3 〈 /sup 〉 H]PK 11195 were estimated on the platelet membranes of 24 adult outpatients with a DSM-IV diagnosis of bipolar disorder (with or without separation anxiety disorder) and 14 healthy controls. Patients were assessed by SCID-I, HAM-D, YMRS, the Structured Clinical Interview for Separation Anxiety Symptoms (SCI-SAS-A) and the Adult Separation Anxiety Self-Report Checklist (ASA-27). 〈 i 〉 Results: 〈 /i 〉 A significant reduction in mean platelet TSPO density was found in bipolar patients with respect to controls. However, the lower density was only evident in the subgroup of bipolar patients who also fulfilled DSM-IV criteria for adult separation anxiety disorder. Individual TSPO density values correlated significantly and negatively with both SCI-SAS-A and ASA-27 total scores. 〈 i 〉 Conclusions: 〈 /i 〉 TSPO expression may be a useful biological marker of adult separation anxiety co-occurring with other anxiety and mood disorders, including bipolar disorder.
    Type of Medium: Online Resource
    ISSN: 0302-282X , 1423-0224
    URL: Article
    DOI: 10.1159/000315440
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2010
    detail.hit.zdb_id: 1483094-2
    SSG: 5,2
    SSG: 15,3
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  • 2
    Online Resource
    Online Resource
    UltraPulse Carbon Dioxide Laser Plus Methyl Aminolevulinate-Photodynamic Therapy for the Treatment of Penile Cancer
    S. Karger AG ; 2022
    In:  Case Reports in Dermatology Vol. 14, No. 2 ( 2022-8-5), p. 210-213
    Details
    In: Case Reports in Dermatology, S. Karger AG, Vol. 14, No. 2 ( 2022-8-5), p. 210-213
    Abstract: The treatment of early-stage penile carcinoma is usually represented by wide excision or partial penectomy with or without inguinal lymph node dissection. However, laser ablation of the tumor may have a prominent role as an organ-sparing approach. In this regard, the combination of UltraPulse CO 〈 sub 〉 2 〈 /sub 〉 laser and photodynamic therapy (PDT) may be a valid option, especially when surgery is not feasible or refused. UltraPulse CO 〈 sub 〉 2 〈 /sub 〉 laser allows for the formation of gentle cutaneous abrasion that destroys the malignant tissue and, at the same time, improving the uptake of methyl aminolevulinate and amplifying the photochemical reaction of PDT in the tumor and surrounding tissue.
    Type of Medium: Online Resource
    ISSN: 1662-6567
    URL: Article
    DOI: 10.1159/000524963
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2022
    detail.hit.zdb_id: 2505300-0
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  • 3
    Online Resource
    Online Resource
    CAP-Inhibition, Molecular Diagnostics, and Total IgE in the Evaluation of 〈b〉〈i〉Polistes〈/i〉〈/b〉 and 〈b〉〈i〉Vespula〈/i〉〈/b〉 Double Sensitization
    S. Karger AG ; 2018
    In:  International Archives of Allergy and Immunology Vol. 177, No. 4 ( 2018), p. 365-369
    Details
    In: International Archives of Allergy and Immunology, S. Karger AG, Vol. 177, No. 4 ( 2018), p. 365-369
    Abstract: Cross-reactions between 〈 i 〉 Polistes dominula 〈 /i 〉 and 〈 i 〉 Vespula 〈 /i 〉 species are common in southern Europe. Currently, only CAP-inhibition demonstrates high accuracy in identifying genuine sensitizations, but this method is time-consuming and expensive, so a new approach is required. This study investigates skin tests, molecular diagnostics, total IgE (tIgE), and the Ves v 5/Pol d 5 (or vice versa) ratio. The ratio generated low-accuracy results and poor agreement with CAP-inhibition, and we did not find any agreement between CAP-inhibition test and double values of Ves v 5/Pol d 5. Nevertheless, a slight diagnostic improvement was obtained when Ves v 5/tIgE and Pol d 5/tIgE were measured.
    Type of Medium: Online Resource
    ISSN: 1018-2438 , 1423-0097
    URL: Article
    DOI: 10.1159/000491939
    RVK:
    XA 49650
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2018
    detail.hit.zdb_id: 1482722-0
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  • 4
    Online Resource
    Online Resource
    Auditory Outcome after Cochlear Implantation in Children with DFNB7/11 Caused by Pathogenic Variants in 〈b〉〈i〉TMC1〈/i〉〈/b〉 Gene
    S. Karger AG ; 2021
    In:  Audiology and Neurotology Vol. 26, No. 3 ( 2021), p. 157-163
    Details
    In: Audiology and Neurotology, S. Karger AG, Vol. 26, No. 3 ( 2021), p. 157-163
    Abstract: 〈 b 〉 〈 i 〉 Introduction: 〈 /i 〉 〈 /b 〉 Non-syndromic hereditary hearing loss is characterized by extreme genetic heterogeneity. So far, more than 100 pathogenic or likely pathogenic variants in 〈 i 〉 TMC1 〈 /i 〉 gene have been reported in patients with autosomal recessive hearing loss (HL) DFNB7/11. The prevailing auditory phenotype of individuals with DFNB7/11 is congenital, profound, bilateral HL, but the functional outcome after cochlear implantation (CI) described in the literature is variable. The objective of this work is to evaluate the auditory outcome after CI in pediatric patients with DFNB7/11, born to non-consanguineous parents. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 A retrospective analysis of genetic and audiological data of DFNB7/11 patients followed up in a single Italian otolaryngology clinic was performed. Cases with biallelic pathogenic variants in 〈 i 〉 TMC1 〈 /i 〉 were selected from the cohort of children with non-syndromic hearing loss who had undergone CI and had been molecularly characterized by multigene panel testing. All patients underwent extensive audiological assessment, and the auditory outcome after CI was evaluated. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 DFNB7/11 was diagnosed in a total of 3 patients from 2 non-consanguineous families; a novel disease-causing variant in 〈 i 〉 TMC1 〈 /i 〉 was detected [c.962G & #x3e;A p.(Trp321*)]. All the affected children showed the typical DFNB7/11 phenotype characterized by prelingual, severe-to-profound HL. The patients showed an excellent functional outcome after CI; speech perception, nonverbal cognition, and speech performance were comparable to those of patients with DFNB1 deafness. 〈 b 〉 〈 i 〉 Discussion/Conclusion: 〈 /i 〉 〈 /b 〉 Our results do not support the variable auditory outcome reported in the literature, which may be affected by several social and environmental factors and by the genetic background.
    Type of Medium: Online Resource
    ISSN: 1420-3030 , 1421-9700
    URL: Article
    DOI: 10.1159/000510156
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2021
    detail.hit.zdb_id: 1481979-X
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  • 5
    Online Resource
    Online Resource
    Identification of a Prognostic Signature Based on the Expression of Genes Related to the Insulin Pathway in Early Breast Cancer
    S. Karger AG ; 2021
    In:  Breast Care Vol. 16, No. 3 ( 2021), p. 299-306
    Details
    In: Breast Care, S. Karger AG, Vol. 16, No. 3 ( 2021), p. 299-306
    Abstract: 〈 b 〉 〈 i 〉 Introduction: 〈 /i 〉 〈 /b 〉 Insulin and the insulin-like growth factor (IGF) family play a key role in breast cancer (BC). 〈 b 〉 〈 i 〉 Objective: 〈 /i 〉 〈 /b 〉 In this study, we evaluated on a genomic scale the potential prognostic value of insulin signaling in early BC. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Candidate genes were selected from the published literature and gene expression profiling experiments. Three publicly available BC datasets, containing gene expression data on 502 cases, were used to test the prognostic ability of the score. The gene signature was developed on GSE1456, containing microarray data from 159 patients, split into a training set (102 breast tumors) and a validation set ( 〈 i 〉 n 〈 /i 〉 = 57). GSE3494 and GSE2990 (350 patients) were used for external validation. Univariate Mann-Whitney test was used to identify genes differentially expressed between relapsed and nonrelapsed patients. Expression of genes significantly correlated with relapse was combined in a linear score. Patients were classified as low or high risk with respect to the median value. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 On the training set, 15 genes turned out to be differentially expressed: 8-year disease-free survival (DFS) was 51 and 91% in the high- and low-risk group ( 〈 i 〉 p 〈 /i 〉 & #x3c; 0.001), respectively. In the validation set, DFS was 97 and 54% ( 〈 i 〉 p 〈 /i 〉 = 0.009), respectively. External validation: 8-year DFS was 72 and 61%, respectively, in GSE3494 ( 〈 i 〉 p 〈 /i 〉 = 0.03) and 74 and 55% in GSE2990 ( 〈 i 〉 p 〈 /i 〉 = 0.03). By multivariate analyses, the insulin signature was significantly associated with DFS, independently of age, hormone receptor status, nodal status, and grade. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 Our findings indicate that the insulin pathway is involved in BC prognosis at a genomic level and provide a window of selectivity for preventive and treatment strategies targeting the insulin/IGF pathway in BC patients.
    Type of Medium: Online Resource
    ISSN: 1661-3791 , 1661-3805
    URL: Article
    DOI: 10.1159/000509207
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2021
    detail.hit.zdb_id: 2205941-6
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  • 6
    Online Resource
    Online Resource
    Patients with Cardiorenal Syndrome Revealed Increased Neurohormonal Activity, Tubular and Myocardial Damage Compared to Heart Failure Patients with Preserved Renal Function
    S. Karger AG ; 2014
    In:  Cardiorenal Medicine Vol. 4, No. 3-4 ( 2014), p. 257-268
    Details
    In: Cardiorenal Medicine, S. Karger AG, Vol. 4, No. 3-4 ( 2014), p. 257-268
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 Cardiorenal syndrome (CRS) is associated with increased cardiovascular morbidity and mortality; still, its biomarker pattern has been poorly evaluated so far. The aim of this study was to measure the inflammatory activation, neurohormonal status and kidney and myocardial damage in patients with CRS compared to patients with heart failure (HF) without renal impairment (RI). 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 We analyzed 246 patients on the basis of renal function (group 1: 120 HF patients without RI; group 2: 126 CRS patients). In each group, interleukin-6, tumor necrosis factor-E, B-type natriuretic peptide (BNP), neutrophil gelatinase-associated lipocalin (NGAL), troponin T (TnT), osteoprotegerin and blood urea nitrogen (BUN) were measured. The diagnostic power of all laboratory parameters to detect CRS was evaluated by the receiver operating characteristic (ROC) curve and logistic regression analysis. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 A significant increase in BNP [626.4 pg/ml, confidence interval (CI) 518-749 vs. 487.8 pg/ml, CI 411-578; p 〈 0.05], NGAL (156 ng/ml, CI 129-186 vs. 89.1 ng/ml, CI 72-109; p 〈 0.0001), BUN (108.9 mg/dl, CI 98-120 vs. 51 mg/dl, CI 46-55; p 〈 0,0001) and TnT (0.62 ng/ml, CI 0.51-0.75 vs. 0.21 ng/ml, CI 0.15-0.28; p 〈 0.001) was seen in CRS patients compared to HF patients without RI. ROC curve analysis showed that only NGAL, BUN, BUN/creatinine ratio and TnT can discriminate patients with CRS from patients without RI. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 In CRS patients, renal tubular damage and neurohormonal and cardiac injury activation are increased compared to patients without RI. The current biomarker pattern could be used for an early diagnosis of RI in acute and chronic HF. i 2014 S. Karger AG, Basel
    Type of Medium: Online Resource
    ISSN: 1664-3828 , 1664-5502
    URL: Article
    DOI: 10.1159/000368375
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2014
    detail.hit.zdb_id: 2595659-0
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