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  • 1
    Online Resource
    Online Resource
    Reliability of EMA Binding Test in the Diagnosis of Hereditary Spherocytosis in Italian Patients
    S. Karger AG ; 2011
    In:  Acta Haematologica Vol. 125, No. 3 ( 2011), p. 136-140
    Details
    In: Acta Haematologica, S. Karger AG, Vol. 125, No. 3 ( 2011), p. 136-140
    Type of Medium: Online Resource
    ISSN: 1421-9662 , 0001-5792
    URL: Article
    DOI: 10.1159/000322253
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2011
    detail.hit.zdb_id: 1481888-7
    detail.hit.zdb_id: 80008-9
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  • 2
    Online Resource
    Online Resource
    Mother-Infant Emotion Regulation at Three Months: The Role of Maternal Anxiety, Depression and Parenting Stress
    S. Karger AG ; 2016
    In:  Psychopathology Vol. 49, No. 4 ( 2016), p. 285-294
    Details
    In: Psychopathology, S. Karger AG, Vol. 49, No. 4 ( 2016), p. 285-294
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 While the association between anxiety and postpartum depression is well known, few studies have investigated the relationship between these two states and parenting stress. Furthermore, a number of studies have found that postpartum depression affects mother-infant emotion regulation, but there has been only one study on anxiety and emotion regulation and no studies at all on parenting stress and emotion regulation. Therefore, the primary aim of our study is to identify, in a community sample of 71 mothers, the relationship between maternal depression, anxiety, and parenting stress. The second aim is to examine the relationship between anxiety, postpartum depression, and parenting stress and mother-infant emotion regulation assessed at 3 months. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Mother-infant interaction was coded with a modified version of the Infant Caregiver and Engagement Phases (ICEP) using a microanalytic approach. The Edinburgh Postnatal Depression Scale (EPDS), State-Trait Anxiety Inventory (STAI), and Parenting Stress Index-Short Form (PSI-SF) were administered to the mothers to assess depression, anxiety, and parenting stress, respectively. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Analysis revealed correlations between anxiety and depression, showing that parenting stress is associated with both states. In a laboratory observation, depression was correlated with both negative maternal states and negative dyadic matches as well as infant positive/mother negative mismatches; anxiety was correlated with both negative maternal states and infant negative states as well as mismatches involving one of the partners having a negative state. Multiple regression analysis showed that anxiety is a greater predictor than depression of less adequate styles of mother-infant emotion regulation. Parenting stress was not shown to predict such regulation.
    Type of Medium: Online Resource
    ISSN: 0254-4962 , 1423-033X
    URL: Article
    DOI: 10.1159/000446811
    RVK:
    XA 10000
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2016
    detail.hit.zdb_id: 1483565-4
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  • 3
    Online Resource
    Online Resource
    Hypothalamic-Pituitary Axis in Non-Functioning Pituitary Adenomas: Focus on the Prevalence of Isolated Central Hypoadrenalism
    S. Karger AG ; 2015
    In:  Neuroendocrinology Vol. 102, No. 4 ( 2015), p. 267-273
    Details
    In: Neuroendocrinology, S. Karger AG, Vol. 102, No. 4 ( 2015), p. 267-273
    Abstract: 〈 b 〉 〈 i 〉 Introduction: 〈 /i 〉 〈 /b 〉 Non-functioning pituitary adenomas (NFPA) account for about 40% of pituitary tumors. Pituitary deficiencies are present at diagnosis in 60-80% of NFPA, and, classically, growth hormone (GH) secretion is lost first, while adrenocorticotropic hormone is expected to disappear last. The aim of this study was to evaluate the incidence of multiple or isolated pituitary deficiencies in a large series of NFPA. 〈 b 〉 〈 i 〉 Materials and Methods: 〈 /i 〉 〈 /b 〉 We retrospectively analyzed data on 218 NFPA cases (59% females, 59% with macroadenomas, average age: 50.2 ± 17 years) followed up at our center from 1990 to 2013. At diagnosis all patients had a complete evaluation of pituitary function in basal conditions and provocative tests for the hypothalamic-pituitary-adrenal axis, while tests for GH deficiency (GHD) were carried out in 38%. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 52.3% of patients (65.6% of macroadenomas, 33.3% of microadenomas) presented at least 1 pituitary deficiency: isolated deficiency in 29.8%, multiple deficiencies in 30% and panhypopituitarism in 9%. Isolated deficiencies were hypogonadism in 11.5% of patients (8% in micro-, 14% in macroadenomas), hypoadrenalism in 10.1% (14% in micro-, 7% in macroadenomas) and GHD in 8.3% (8.9% in micro-, 7.8% in macroadenomas). About 30% of microadenomas had at least 1 pituitary deficiency at diagnosis, independently of tumor localization within the sellar region. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 The presence of isolated hypoadrenalism suggests that the order of appearance of hypopituitarism does not always follow the one expected. Given the relatively high prevalence of isolated hypoadrenalism even in microadenomas, we suggest a full assessment of basal and dynamic pituitary function in all NFPA regardless of tumor size.
    Type of Medium: Online Resource
    ISSN: 0028-3835 , 1423-0194
    URL: Article
    DOI: 10.1159/000430815
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2015
    detail.hit.zdb_id: 1483028-0
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  • 4
    Online Resource
    Online Resource
    Polyarticular Ochronotic Arthritis: A Case Report
    S. Karger AG ; 2019
    In:  Case Reports in Orthopedic Research Vol. 2, No. 1-3 ( 2019-4-30), p. 1-13
    Details
    In: Case Reports in Orthopedic Research, S. Karger AG, Vol. 2, No. 1-3 ( 2019-4-30), p. 1-13
    Abstract: Alkaptonuria is an inherited disease due to the lack of homogentisic acid oxidase enzyme. The most common clinical presentations are a brownish-grey color of the sclera, dark skin, kidney stones, aortic calcifications, and ochronotic arthropathy. Ochronotic arthropathy is characterized by the accumulation of homogentisic acid in the connective tissue determining severe joint degeneration. We present the case of a woman affected by ochronosis since the age of 30 years. The patient showed a severe degeneration of the hip and knee joints bilaterally, associated with an important and painful functional limitation. Conservative care did not achieve good results. We performed bilateral cementless total knee arthroplasty and bilateral cementless total hip arthroplasty. We report satisfactory outcomes in terms of range of motion and pain control in a 6-year follow-up. Our approach to this pathology is the same we adopt with rheumatoid arthritis after our decennial experience. We suggest that prosthetic replacement represents a definitive way to treat ochronotic arthropathy.
    Type of Medium: Online Resource
    ISSN: 2296-9373
    URL: Article
    DOI: 10.1159/000500236
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2019
    detail.hit.zdb_id: 2908414-3
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  • 5
    Online Resource
    Online Resource
    Effect of Lesion Size on the Diagnostic Performance of Dermoscopy in Melanoma Detection
    S. Karger AG ; 2003
    In:  Dermatology Vol. 206, No. 4 ( 2003), p. 292-296
    Details
    In: Dermatology, S. Karger AG, Vol. 206, No. 4 ( 2003), p. 292-296
    Abstract: 〈 i 〉 Background: 〈 /i 〉 Dermoscopy is able to correctly classify a higher number of melanomas than naked-eye examination. Little is known however about factors which may influence the diagnostic performance during practice. The aim of the study was to analyze the effect of size of the lesion on diagnostic performance of dermoscopy in melanoma detection. 〈 i 〉 Methods: 〈 /i 〉 Eight dermatologists examined clinical and, separately, clinical and dermoscopic (combined examination) images of 200 melanocytic lesions previously excised [64 melanomas, 24 in situ and 40 invasive (median thickness 0.30 mm) and 136 melanocytic nevi]. After examination, diagnostic performance was analyzed in accordance with the major diameter of the lesions divided into 3 groups, i.e. small (less than 6 mm), intermediate (between 6 and 9 mm) and large (10 mm or more) lesions. These groups were shown to be highly comparable concerning the microstaging of melanomas (median thickness value 0.30, 0.22 and 0.32 mm, respectively). 〈 i 〉 Results: 〈 /i 〉 Dermoscopy increased the diagnostic performance of naked-eye examination of both intermediate and large lesions [sensitivity value: +19.3 (p = 0.002) and +10.3 (p = 0.007); diagnostic accuracy value: +7.4 (p = 0.004) and +6.1 (p = 0.07)]. On the contrary, no statistically significant increase was found dealing with small lesions (sensitivity +3.7, p = 0.66; diagnostic accuracy –1.7, p = 0.55). 〈 i 〉 Conclusions: 〈 /i 〉 The diagnostic improvement associated with the addition of dermoscopy to naked-eye examination is influenced by the size of the lesion, i.e. it is lacking with lesions up to 6 mm in diameter. The optimized use of dermoscopy in melanoma detection is obtained dealing with melanocytic lesions 6 mm in diameter or larger.
    Type of Medium: Online Resource
    ISSN: 1018-8665 , 1421-9832
    URL: Article
    DOI: 10.1159/000069939
    RVK:
    XA 37700
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2003
    detail.hit.zdb_id: 1482189-8
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  • 6
    Online Resource
    Online Resource
    Muscular Abnormalities as a Cause of the Tarsal Tunnel Syndrome: An Infrequent Bilateral Clinical Case
    S. Karger AG ; 2019
    In:  Case Reports in Orthopedic Research Vol. 2, No. 1-3 ( 2019-9-11), p. 75-81
    Details
    In: Case Reports in Orthopedic Research, S. Karger AG, Vol. 2, No. 1-3 ( 2019-9-11), p. 75-81
    Abstract: A clinical case of a female patient affected by bilateral tarsal tunnel syndrome is described. The peculiarity of this case is the difference in the observed anatomopathological muscular abnormalities between the two feet. On one side, an accessory muscular venter of the toes’ long flexor was identified. On the other side, posterior tibial nerve compression was determined by an accessory venter of the hallux long flexor, associated with an abnormal venter of the toes’ long flexor, with a minor extent if compared to contralateral findings.
    Type of Medium: Online Resource
    ISSN: 2296-9373
    URL: Article
    DOI: 10.1159/000502734
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2019
    detail.hit.zdb_id: 2908414-3
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  • 7
    Online Resource
    Online Resource
    ADAM10 in Synaptic Physiology and Pathology
    S. Karger AG ; 2014
    In:  Neurodegenerative Diseases Vol. 13, No. 2-3 ( 2014), p. 72-74
    Details
    In: Neurodegenerative Diseases, S. Karger AG, Vol. 13, No. 2-3 ( 2014), p. 72-74
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 Generation of amyloid-β peptide is at the beginning of a cascade that leads to Alzheimer's disease. Amyloid precursor protein (APP) as well as β- and & #947;-secretases are the principal players involved in amyloid-β (Aβ) production, while α-secretase cleavage on APP prevents Aβ deposition. A disintegrin and metalloproteinase 10 (ADAM10) has been demonstrated to act as α-secretase in neurons. 〈 b 〉 〈 i 〉 Objective: 〈 /i 〉 〈 /b 〉 Although localization of ADAM10 in the synaptic membrane is the key for its shedding activity, currently, very little is known about the mechanisms that control the synaptic abundance of ADAM10. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Two established forms of long-term activity-dependent plasticity, i.e. long-term potentiation and long-term depression (LTD), differentially regulate the synaptic availability and activity of ADAM10. Long-term potentiation decreases ADAM10 surface levels and activity by promoting its endocytosis. This process is mediated by activity-regulated association of ADAM10 with the clathrin adaptor protein 2 (AP2) complex. Conversely, LTD fosters ADAM10 insertion in the membrane and stimulates its activity. Furthermore, ADAM10 interaction with synapse-associated protein 97 (SAP97) is necessary for LTD-induced ADAM10 trafficking and required for LTD maintenance and LTD-induced spine morphology changes. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 Regulated interaction of ADAM10 with SAP97 and AP2 discloses a novel physiological mechanism of ADAM10 activity regulation at the synapses. This phenomenon produces a situation whereby synaptically regulated ADAM10 activity is positioned to modulate synaptic functioning.
    Type of Medium: Online Resource
    ISSN: 1660-2854 , 1660-2862
    URL: Article
    DOI: 10.1159/000354233
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2014
    detail.hit.zdb_id: 2126858-7
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