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  • 1
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    Lipoprotein(a) and LDL Particle Size Are Related to the Severity of Coronary Artery Disease
    S. Karger AG ; 2007
    In:  Cardiology Vol. 108, No. 4 ( 2007), p. 282-289
    Details
    In: Cardiology, S. Karger AG, Vol. 108, No. 4 ( 2007), p. 282-289
    Abstract: 〈 i 〉 Background: 〈 /i 〉 The pathophysiological role and metabolic pathway of Lp(a) have not been clearly defined. An association between Lp(a) and oxidative low-density lipoprotein (LDL) were recently reported. And small dense LDL (sd-LDL) were associated with circulating malondialdehyde-modified LDL. We investigated the relationships between serum Lp(a) level and LDL particle size in coronary artery disease (CAD) patients. Further, we investigated the relationships of sd-LDL and Lp(a) with the extent and severity of CAD. 〈 i 〉 Methods: 〈 /i 〉 A total of 490 patients (mean: 60.5 ± 11.5 years old) who underwent coronary angiography to evaluate chest pain were investigated. Patients were classified into two groups, a CAD group (n = 256), who had significant stenosis observed by coronary angiogram, and a control group (n = 234), who had normal, or minimal coronary arteries. CAD severity was measured by Gensini scores. The distribution of the LDL subfraction was analyzed using a Quantimetrix Lipoprint LDL System. 〈 i 〉 Results: 〈 /i 〉 The serum Lp(a) concentration was correlated with the fraction of sd-LDL (r = 0.193, p 〈 0.001) and mean LDL size (r = 0.160, p = 0.003). The Lp(a) level and mean LDL particle size were significantly correlated with a high Gensini score. LDL particle size in the CAD group was smaller than in the control group (26.74 ± 0.64 vs. 26.43 ± 0.93 nm, p 〈 0.001). The Gensini score was significantly higher in small LDL with high Lp(a) level groups. 〈 i 〉 Conclusion: 〈 /i 〉 The positive correlation of the level of Lp(a) and sd-LDL fraction were demonstrated. The mechanism of this association is not clearly defined; we can suggest that it may stem from the individual atherogenic condition that linked to increased oxidative stress. Both increased Lp(a) and sd-LDL fraction were correlated with the severity of CAD.
    Type of Medium: Online Resource
    ISSN: 0008-6312 , 1421-9751
    URL: Article
    DOI: 10.1159/000099097
    RVK:
    XA 36200
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2007
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  • 2
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    Prospective Phase II Trial of Gemcitabine in Combination with Irinotecan as First-Line Chemotherapy in Patients with Advanced Biliary Tract Cancer
    S. Karger AG ; 2011
    In:  Chemotherapy Vol. 57, No. 3 ( 2011), p. 236-243
    Details
    In: Chemotherapy, S. Karger AG, Vol. 57, No. 3 ( 2011), p. 236-243
    Abstract: 〈 i 〉 Background: 〈 /i 〉 Chemotherapy is a critical treatment option in advanced biliary tract cancer (BTC), which is often diagnosed at advanced stage and is therefore inoperable. The aim of this phase II trial was to evaluate the efficacy and safety of a combination therapy with gemcitabine and irinotecan as the first-line chemotherapy in patients with previously untreated advanced BTC. 〈 i 〉 Patients and Methods: 〈 /i 〉 Patients with pathologically confirmed advanced BTC received gemcitabine (1,000 mg/m 〈 sup 〉 2 〈 /sup 〉 over 30 min) and irinotecan (100 mg/m 〈 sup 〉 2 〈 /sup 〉 over 2 h) on days 1 and 8 every 3 weeks. 〈 i 〉 Results: 〈 /i 〉 Of 39 patients eligible for this trial, 6 had intrahepatic bile duct cancer, 2 had extrahepatic bile duct cancer and 31 had gallbladder cancer. A total of 193 cycles of chemotherapy were administered, with a median of 4 cycles per patient (range 1–18). The objective response rate was 20.5%, and the disease control rate was 66.7% in intention-to-treat analysis. The median progression-free survival was 4.3 months (95% CI 2.70–5.90), and overall survival was 7.6 months (95% CI 4.56–10.64). Grade 3 and 4 toxicities included anemia (20.5% of patients), thrombocytopenia (2.3%), neutropenia (10.3%), aspartate transaminase increase (10.3%), alanine transaminase increase (5.1%) and emesis (5.1%). 〈 i 〉 Conclusion: 〈 /i 〉 Combination therapy of gemcitabine and irinotecan had an efficacy comparable to historic control and can be a viable treatment option. It was well tolerated by patients with advanced BTC.
    Type of Medium: Online Resource
    ISSN: 0009-3157 , 1421-9794
    URL: Article
    DOI: 10.1159/000328021
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2011
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    SSG: 15,3
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  • 3
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    Effect of High Glucose on Basal Intracellular Calcium Regulation in Rat Mesangial Cell
    S. Karger AG ; 2003
    In:  American Journal of Nephrology Vol. 23, No. 5 ( 2003), p. 343-352
    Details
    In: American Journal of Nephrology, S. Karger AG, Vol. 23, No. 5 ( 2003), p. 343-352
    Abstract: 〈 i 〉 Background: 〈 /i 〉 A number of cellular mechanisms are critically dependent on intracellular Ca 〈 sup 〉 2+ 〈 /sup 〉 homeostasis. A sustained increase in the intracellular Ca 〈 sup 〉 2+ 〈 /sup 〉 concentration ([Ca 〈 sup 〉 2+ 〈 /sup 〉 ] 〈 sub 〉 i 〈 /sub 〉 ) is capable of activating a number of potentially harmful processes including phenotype change to secretory type, dysregulated cell proliferation, and cell injury and death. Mesangial cells (MCs) play an important role in the pathophysiology of diabetic nephropathy. 〈 i 〉 Methods: 〈 /i 〉 We evaluated the effect of high glucose on basal [Ca 〈 sup 〉 2+ 〈 /sup 〉 ] 〈 sub 〉 i 〈 /sub 〉 in the unstimulated state and identified its contributing pathways. MCs were isolated and cultured from Sprague-Dawley rats. [Ca 〈 sup 〉 2+ 〈 /sup 〉 ] 〈 sub 〉 i 〈 /sub 〉 was measured by fluorometric technique with fura-2AM. 〈 i 〉 Results: 〈 /i 〉 In a dose-dependent manner, superfusion of MCs with Tyrode’s solution containing high glucose (30 and 50 m 〈 i 〉 M 〈 /i 〉 ) induced a delayed spontaneous increase in [Ca 〈 sup 〉 2+ 〈 /sup 〉 ] 〈 sub 〉 i 〈 /sub 〉 , which was not found in those with normal (5.5 m 〈 i 〉 M 〈 /i 〉 ) glucose or mannitol. The high glucose-induced increase in [Ca 〈 sup 〉 2+ 〈 /sup 〉 ] 〈 sub 〉 i 〈 /sub 〉 〈 sup 〉 〈 /sup 〉 occurred through transmembrane influx of extracellular Ca 〈 sup 〉 2+ 〈 /sup 〉 and was blocked by SKF96365, an inhibitor of store-operated Ca 〈 sup 〉 2+ 〈 /sup 〉 influx. Na 〈 sup 〉 + 〈 /sup 〉 -Ca 〈 sup 〉 2+ 〈 /sup 〉 exchanger (NCX) activity, a major channel regulating basal [Ca 〈 sup 〉 2+ 〈 /sup 〉 ] 〈 sub 〉 i 〈 /sub 〉 , and the clearing ability of intracellular Ca 〈 sup 〉 2+ 〈 /sup 〉 were depressed after MCs were cultured in high-glucose medium. Western blot analysis revealed the decreased expression of a 70-kD NCX protein in MCs cultured in high-glucose medium. 〈 i 〉 Conclusions: 〈 /i 〉 A high-glucose concentration induced a spontaneous increase in basal [Ca 〈 sup 〉 2+ 〈 /sup 〉 ] 〈 sub 〉 i 〈 /sub 〉 of MCs without stimulation. There was a decrease in the activity of NCX in the high-glucose condition, which seems to occur at the level of protein expression. The present results provide a novel insight into the mechanisms of diabetic nephropathy in that intracellular Ca 〈 sup 〉 2+ 〈 /sup 〉 homeostasis is an important secondary messenger and a mediator in hormonal signaling.
    Type of Medium: Online Resource
    ISSN: 0250-8095 , 1421-9670
    URL: Article
    DOI: 10.1159/000072916
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2003
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  • 4
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    The Derived Neutrophil-to-Lymphocyte Ratio Is an Independent Prognostic Factor in Transplantation Ineligible Patients with Multiple Myeloma
    S. Karger AG ; 2018
    In:  Acta Haematologica Vol. 140, No. 3 ( 2018), p. 146-156
    Details
    In: Acta Haematologica, S. Karger AG, Vol. 140, No. 3 ( 2018), p. 146-156
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 The neutrophil-to-lymphocyte ratio (NLR) is an independent prognostic marker in solid and hematological cancers. While the derived NLR (dNLR) was shown to be non-inferior to the NLR in large cohorts of patients with different cancer types, it has not been validated as a prognostic marker for multiple myeloma (MM) to date. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Between May 22, 2011 and May 29, 2014, 176 patients with MM from 38 centers who were ineligible for autologous stem cell transplantation were analyzed. The dNLR was calculated using complete blood count differential data. The optimal dNLR cut-off value according to receiver operating characteristic analysis of overall survival (OS) was 1.51. All patients were treated with melphalan and prednisone combined with bortezomib. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 The complete response rate was lower in the high dNLR group compared to the low dNLR group (7 vs. 26.1%, respectively; 〈 i 〉 p 〈 /i 〉  = 0.0148); the corresponding 2-year OS rates were 72.2 and 84.7%, respectively ( 〈 i 〉 p 〈 /i 〉  = 0.0354). A high dNLR was an independent poor prognostic factor for OS (hazard ratio 2.217, 95% CI 1.015–4.842; 〈 i 〉 p 〈 /i 〉  = 0.0458). 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 The dNLR is a readily available and cheaply obtained parameter in clinical studies, and shows considerable potential as a new prognostic marker for transplantation-ineligible patients with MM.
    Type of Medium: Online Resource
    ISSN: 0001-5792 , 1421-9662
    URL: Article
    DOI: 10.1159/000490488
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2018
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    detail.hit.zdb_id: 80008-9
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  • 5
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    Subepithelial Spread of Early Gastric Signet Ring Cell Carcinoma: How Far They Can Reach?
    S. Karger AG ; 2020
    In:  Digestive Diseases Vol. 38, No. 6 ( 2020), p. 442-448
    Details
    In: Digestive Diseases, S. Karger AG, Vol. 38, No. 6 ( 2020), p. 442-448
    Abstract: 〈 b 〉 〈 i 〉 Introduction: 〈 /i 〉 〈 /b 〉 Although signet ring cell carcinoma (SRC) is a poorly differentiated cancer subtype, recent studies suggest that endoscopic resection can be applied in small, mucosal early gastric SRC. However, other studies report frequent positive lines at the lateral resection margin after endoscopic treatment. Subepithelial spread beneath normal mucosa can exist in SRC, and such lesions may be the cause of positive margins after endoscopic resection. Thus, we conducted a retrospective study in order to evaluate the significance of subepithelial spread in early gastric SRC. 〈 b 〉 〈 i 〉 Method: 〈 /i 〉 〈 /b 〉 Medical records of early gastric SRC patients who underwent surgery or endoscopic resection from January 2011 to December 2016 at a single tertiary hospital (Daejeon, South Korea) were reviewed to examine subepithelial spread and clinical datum. Two expert pathologists reviewed all pathologic specimens, and only patients showing a pure SRC component were included. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Eighty-six patients were initially enrolled, and subepithelial spread existed in 62 patients (72.1%). The mean distance of subepithelial spread was 1,132.1 µm, and the maximal distance was 6,000 μm. Only discoloration was significantly associated with the presence of a subepithelial spread ( 〈 i 〉 p 〈 /i 〉 & #x3c; 0.05, χ 〈 sup 〉 2 〈 /sup 〉 test, and logistic regression test). Distance of subepithelial spread did not correlate with total lesion size. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 Subepithelial spread of early gastric SRC occurs frequently and can reach up to 6 mm. Lesion discoloration may be associated with the presence of subepithelial spread. Our results suggest that careful decision of the margin is needed when performing endoscopic resection of early gastric SRC.
    Type of Medium: Online Resource
    ISSN: 0257-2753 , 1421-9875
    URL: Article
    DOI: 10.1159/000507322
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2020
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    detail.hit.zdb_id: 632798-9
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  • 6
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    Prevalence Rates of Dementia and Mild Cognitive Impairment Are Affected by the Diagnostic Parameter Changes for Neurocognitive Disorders in the DSM-5 in a Korean Population
    S. Karger AG ; 2017
    In:  Dementia and Geriatric Cognitive Disorders Vol. 43, No. 3-4 ( 2017), p. 193-203
    Details
    In: Dementia and Geriatric Cognitive Disorders, S. Karger AG, Vol. 43, No. 3-4 ( 2017), p. 193-203
    Abstract: 〈 b 〉 〈 i 〉 Aim: 〈 /i 〉 〈 /b 〉 To examine the impact of the revised diagnostic criteria for neurocognitive disorders (NCDs) in the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5) on the prevalence of dementia and mild cognitive impairment (MCI). 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 A total of 755 participants aged 65 years or older in the Nationwide Survey on Dementia Epidemiology in Korea 2012 were rediagnosed according to the DSM-5 criteria. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 The estimated age-, gender-, education-, and urbanicity-standardized prevalence rates of major and mild NCDs were 8.35 and 11.10%, respectively, and those of dementia and MCI were 8.74 and 31.85%, respectively. Cohen's & #x03BA; for dementia and major NCD was 0.988, and that for MCI and mild NCD was 0.273. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 Diagnostic discrepancies between major/mild NCDs and dementia/MCI might depend on the operationalization of neuropsychological performance criteria.
    Type of Medium: Online Resource
    ISSN: 1420-8008 , 1421-9824
    URL: Article
    DOI: 10.1159/000458408
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2017
    detail.hit.zdb_id: 1482186-2
    detail.hit.zdb_id: 1360843-5
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  • 7
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    Preceding Intravenous Thrombolysis in Patients Receiving Endovascular Therapy
    S. Karger AG ; 2017
    In:  Cerebrovascular Diseases Vol. 44, No. 1-2 ( 2017), p. 51-58
    Details
    In: Cerebrovascular Diseases, S. Karger AG, Vol. 44, No. 1-2 ( 2017), p. 51-58
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 The beneficial effects of endovascular therapy (EVT) in acute ischemic stroke have been demonstrated in recent clinical trials using new-generation thrombectomy devices. However, the comparative effectiveness and safety of preceding intravenous thrombolysis (IVT) in this population has rarely been evaluated. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 From a prospective multicenter stroke registry database in Korea, we identified patients with acute ischemic stroke who were treated with EVT within 8 h of onset and admitted to 14 participating centers during 2008-2013. The primary outcome was a modified Rankin Scale (mRS) score at 3 months. Major secondary outcomes were successful recanalization defined as a modified Treatment in Cerebral Ischemia score of 2b-3, functional independence (mRS score 0-2), mortality at 3 months, and symptomatic hemorrhagic transformation (SHT) during hospitalization. Multivariable logistic regression analyses using generalized linear mixed models were performed to estimate the adjusted odds ratios (ORs) of preceding IVT. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Of the 639 patients (male, 61%; age 69 ± 12; National Institutes of Health Stroke Scale score of 15 [11-19]) who met the eligibility criteria, 458 received preceding IVT. These patients showed lower mRS scores (adjusted common OR, 1.38 [95% CI 0.98-1.96] ). Preceding IVT was associated with successful recanalization (1.96 [1.23-3.11]) and reduced 3-month mortality (0.58 [0.35-0.97] ) but not with SHT (0.96 [0.48-1.93]). 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 In patients treated with EVT within 8 of acute ischemic stroke onset, preceding IVT may enhance survival and successful recanalization without additional risk of SHT, and mitigate disability at 3 months.
    Type of Medium: Online Resource
    ISSN: 1015-9770 , 1421-9786
    URL: Article
    DOI: 10.1159/000471492
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2017
    detail.hit.zdb_id: 1482069-9
    detail.hit.zdb_id: 1069462-6
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  • 8
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    Clusters of Severe Eosinophilic Asthma in a Korean Asthma Cohort
    S. Karger AG ; 2022
    In:  Respiration Vol. 101, No. 5 ( 2022), p. 465-475
    Details
    In: Respiration, S. Karger AG, Vol. 101, No. 5 ( 2022), p. 465-475
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 Targeted therapies have broadened the available treatment options for patients with severe eosinophilic asthma (SEA). However, differences in the magnitude of treatment responses among patients indicate the presence of various underlying pathophysiological processes and patient subgroups. 〈 b 〉 〈 i 〉 Objectives: 〈 /i 〉 〈 /b 〉 We aimed to describe the characteristics of SEA and identify its patient subgroups. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Clinical data from the Cohort for Reality and Evolution of Adult Asthma in Korea were analyzed. Cluster analysis was performed among those with SEA using 5 variables, namely, prebronchodilator forced expiratory volume in 1 s, body mass index, age at symptom onset, smoking amount, and blood eosinophil counts. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Patients with SEA showed prevalent sensitization to aeroallergens, decreased lung function, and poor asthma control status. Cluster analysis revealed 3 distinctive subgroups among patients with SEA. Cluster 1 ( 〈 i 〉 n 〈 /i 〉 = 177) consisted of patients reporting the lowest blood eosinophils (median, 346.8 cells/μL) and modest severe asthma with preserved lung function during the 12-month treatment period. Cluster 2 ( 〈 i 〉 n 〈 /i 〉 = 42) predominantly included smoking males with severe persistent airway obstruction and moderate eosinophilia (median, 451.8 cells/μL). Lastly, cluster 3 ( 〈 i 〉 n 〈 /i 〉 = 95) included patients with the most severe asthma, the highest eosinophil levels (median, 817.5 cells/μL), and good treatment response in terms of improved lung function and control status. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 Three subgroups were identified in SEA through the cluster analysis. The distinctive features of each cluster may help physicians predict patients who will respond to biologics with greater magnitude of clinical improvement. Further research regarding the underlying pathophysiology and clinical importance of each subgroup is warranted.
    Type of Medium: Online Resource
    ISSN: 0025-7931 , 1423-0356
    URL: Article
    DOI: 10.1159/000520492
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2022
    detail.hit.zdb_id: 1464419-8
    detail.hit.zdb_id: 206674-9
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  • 9
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    Gene-Based Single Nucleotide Polymorphisms and Linkage Disequilibrium Patterns of 29 Asthma Candidate Genes in the Chromosome 5q31–33 Region in Koreans
    S. Karger AG ; 2006
    In:  International Archives of Allergy and Immunology Vol. 139, No. 3 ( 2006), p. 209-216
    Details
    In: International Archives of Allergy and Immunology, S. Karger AG, Vol. 139, No. 3 ( 2006), p. 209-216
    Abstract: 〈 i 〉 Background and Methods: 〈 /i 〉 Numerous genetic studies have mapped asthma susceptibility genes to a region on chromosome 5q31–33 in several populations. This region contains a cluster of cytokines and other immune-related genes important in immune response. In the present study, to determine the genetic variations and patterns of linkage disequilibrium (LD), we resequenced all the exons and promoter regions of the 29 asthma candidate genes in the chromosome 5q31–33 region. 〈 i 〉 Results: 〈 /i 〉 We identified a total of 314 genetic variants, including 289 single nucleotide polymorphisms (SNPs), 22 insertion/deletion polymorphisms and 3 microsatellites. Standardized variance data for allele frequency revealed substantial differences in SNP allele frequencies among different ethnic groups. Interestingly, significant ethnic differences were observed mainly in intron SNPs. LD block analysis using 174 common SNPs with a frequency of 〉 10% disclosed strong LD within most candidate genes. No significant LD was observed across genes, except for one LD block (CD14-IK block). Gene-based haplotype analyses showed that 1–5 haplotype-tagging SNPs may be used to define the six or fewer common haplotypes with a frequency of 〉 5%, regardless of the number of SNPs. 〈 i 〉 Conclusion: 〈 /i 〉 Overall, our results provide useful information for the identification of immune-mediated disease genes in the chromosome 5q31–33 region, as well as valuable evidence for gene-based haplotype analysis in disease association studies.
    Type of Medium: Online Resource
    ISSN: 1018-2438 , 1423-0097
    URL: Article
    DOI: 10.1159/000091166
    RVK:
    XA 49650
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2006
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  • 10
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    Endovascular Treatment in Patients with Persistent Internal Carotid Artery Occlusion after Intravenous Tissue Plasminogen Activator: A Clinical Effectiveness Study
    S. Karger AG ; 2016
    In:  Cerebrovascular Diseases Vol. 42, No. 5-6 ( 2016), p. 387-394
    Details
    In: Cerebrovascular Diseases, S. Karger AG, Vol. 42, No. 5-6 ( 2016), p. 387-394
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 There has been no large-scale trial comparing endovascular treatment (add-on EVT) after intravenous tissue plasminogen activator (IV tPA) and IV tPA alone in acute ischemic stroke (AIS) caused by internal carotid artery occlusion (ICAO). We aimed at investigating the effectiveness and safety of add-on EVT after IV tPA in AIS patients with ICAO. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Between March 2010 and March 2013, 3,689 consecutive ischemic stroke patients who were hospitalized within 4.5 h of onset were identified using a prospective stroke registry at 11 centers in Korea. Among them, patients with persistent ICAO after receiving IV tPA and whose 3-month modified Rankin Scale (mRS) was available were finally enrolled. A propensity score analysis with inverse-probability of treatment weighting was used to eliminate baseline imbalances between those receiving add-on EVT and IV tPA alone. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Among 264 patients enrolled in this study (mean age 71.4; male 56.4%; median National Institute of Health Stroke Scale score 15), 117 (44.3%) received add-on EVT. The add-on EVT group had a higher frequency of favorable outcome on the mRS ≤2 (35.0 vs. 18.4%; adjusted OR (aOR) 2.79; 95% CI 1.66-4.67) and lower mortality (17.9 vs. 35.4%; aOR 0.24; 95% CI 0.13-0.42) at 3 months, when compared to the IV tPA-alone group. Add-on EVT did not significantly increase the risk of symptomatic hemorrhage (5.1 vs. 4.1%; aOR 1.01; 95% CI 0.37-2.70). The rate of successful recanalization (thrombolysis in cerebral infarction grade ≥2b) in the add-on EVT group was 69.2%. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 Compared to an IV tPA alone, add-on EVT can improve clinical outcomes in patients with symptomatic ICAO within 4.5 h of onset without a significant increase of symptomatic hemorrhage.
    Type of Medium: Online Resource
    ISSN: 1015-9770 , 1421-9786
    URL: Article
    DOI: 10.1159/000447599
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2016
    detail.hit.zdb_id: 1482069-9
    detail.hit.zdb_id: 1069462-6
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