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  • S. Karger AG  (27)
  • 1
    Online Resource
    Online Resource
    Long-Term Outcomes of Pulmonary Hypertension in Preterm Infants with Bronchopulmonary Dysplasia
    S. Karger AG ; 2016
    In:  Neonatology Vol. 110, No. 3 ( 2016), p. 181-189
    Details
    In: Neonatology, S. Karger AG, Vol. 110, No. 3 ( 2016), p. 181-189
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 The long-term cardiovascular outcomes of pulmonary hypertension (PH) in preterm infants with bronchopulmonary dysplasia (BPD) are uncertain. 〈 b 〉 〈 i 〉 Objectives: 〈 /i 〉 〈 /b 〉 The purpose of this study was to assess outcomes of PH in prematurely born children diagnosed with moderate to severe BPD. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 We retrospectively reviewed the medical records of patients born before 32 weeks of gestation and diagnosed with moderate to severe BPD from June 2004 to April 2008. Patients were recruited for a cross-sectional study from August to October 2014 and underwent echocardiography. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Forty-two children were enrolled. Their mean gestational age and birth weight were 26.2 ± 1.7 weeks and 753.1 ± 172.5 g, respectively. Sixteen patients (38%) were diagnosed with PH at a mean age of 3.3 ± 1.6 months, and the PH improved after a median of 12.3 months (range 0.7-46.6). Cardiovascular function was reassessed at a mean age of 7.7 ± 0.9 years, at which time 1 patient was taking a medication for recurrent PH, and 12 (28.6%) patients exhibited elevated blood pressure. Conventional 2-dimensional and Doppler echocardiography indicated normal ventricular function in all children. However, right ventricular longitudinal strains were decreased in children with previous PH. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 Subclinical ventricular dysfunction was detectable using sensitive echocardiographic techniques in children with previous BPD-associated PH. Long-term follow-up and meticulous cardiovascular function assessment are required in this population.
    Type of Medium: Online Resource
    ISSN: 1661-7800 , 1661-7819
    URL: Article
    DOI: 10.1159/000445476
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2016
    detail.hit.zdb_id: 2403535-X
    SSG: 12
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  • 2
    Online Resource
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    Early Response to Endovascular Thrombectomy after Stroke: Early, Late, and Very Late Time Windows
    S. Karger AG ; 2023
    In:  Cerebrovascular Diseases Vol. 52, No. 1 ( 2023), p. 28-35
    Details
    In: Cerebrovascular Diseases, S. Karger AG, Vol. 52, No. 1 ( 2023), p. 28-35
    Abstract: Background and Purpose: Endovascular thrombectomy (EVT) has benefits in selected patients 6–24 h after stroke onset. However, the response to EVT 〉 24 h after stroke onset is still unclear. We compared the early response to EVT in patients with different time windows. Methods: Patients who underwent EVT in an emergency setting were enrolled and categorized according to when EVT was performed: within 6 (early), 6–24 (late), and 〉 24 h (very late) after stroke onset. Early neurological improvement (ENI) and deterioration (END) were defined as improvement and worsening, respectively, of National Institutes of Health Stroke Scale (NIHSS) score by ≥4 points after EVT. The three groups’ clinical characteristics and response to EVT were compared. We also investigated factors associated with ENI and END. Results: During study period, 274 patients underwent EVT (109 early, 104 late, and 61 very late). Patients who underwent EVT very late were younger (p = 0.007), had smaller ischemic cores, and had lower initial NIHSS scores (8 ± 5) than those who underwent EVT early (14 ± 6) and late (13 ± 7; p 〈 0.001). Stroke mechanisms also differed according to the time window (p 〈 0.001): cardioembolism was more common after early EVT, whereas large-artery atherosclerosis was more prevalent among patients who underwent EVT very late. ENI was significantly more common after early (60.6%) and late EVT (51.0%) than after very late EVT (29.5%; p = 0.001); however, rates of END did not differ (11.0%, 13.5%, and 4.9%, respectively). ENI was independently associated with male, higher NIHSS score, and early and late EVT. END was associated with failure of recanalization. Conclusions: ENI was more observed and associated with early and late EVT. Highly selected patients receiving very late EVT may not benefit from ENI but may still have a chance to prevent END. The occurrence of END was associated not with time window but with failure of recanalization.
    Type of Medium: Online Resource
    ISSN: 1015-9770 , 1421-9786
    URL: Article
    DOI: 10.1159/000525083
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2023
    detail.hit.zdb_id: 1482069-9
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  • 3
    Online Resource
    Online Resource
    Renoprotective Effects of Sildenafil in DOCA-Salt Hypertensive Rats
    S. Karger AG ; 2012
    In:  Kidney and Blood Pressure Research Vol. 36, No. 1 ( 2012), p. 248-257
    Details
    In: Kidney and Blood Pressure Research, S. Karger AG, Vol. 36, No. 1 ( 2012), p. 248-257
    Type of Medium: Online Resource
    ISSN: 1423-0143 , 1420-4096
    URL: Article
    DOI: 10.1159/000343414
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2012
    detail.hit.zdb_id: 1482922-8
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  • 4
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    Primary Thyroid Marginal Zone B-Cell Lymphoma of the Mucosa-Associated Lymphoid Tissue Type: Clinical Manifestation and Outcome of a Rare Disease – Consortium for Improving Survival of Lymphoma Study
    S. Karger AG ; 2012
    In:  Acta Haematologica Vol. 127, No. 2 ( 2012), p. 100-104
    Details
    In: Acta Haematologica, S. Karger AG, Vol. 127, No. 2 ( 2012), p. 100-104
    Abstract: 〈 i 〉 Purpose: 〈 /i 〉 Primary thyroid marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue type (pTY-MZL) is an extremely uncommon form of lymphoma. Due to its rarity, the natural history and optimal treatment modality for this disease have yet to be clearly established. 〈 i 〉 Methods: 〈 /i 〉 A total of 27 patients with histologically confirmed pTY-MZL were retrospectively analyzed. 〈 i 〉 Results: 〈 /i 〉 The median age of our subjects was 53 years (range 25–82). This study involved 17 females (63.0%) and 10 males (37.0%). Twenty-four out of 27 patients (88.9%) initially presented with localized disease, defined by Ann Arbor stage I/II. Bone marrow involvement was detected in 8.3% of the patients (2 patients), and 91.7% of the patients (25 of 27) were categorized into the low or low-intermediate risk group, according to the International Prognostic Index criteria. Accompanying Hashimoto’s thyroiditis was detected in 72% of the patients, whereas thyroglobulin antibody levels were elevated in 70% of the patients. Twenty-six patients were treated with surgery, radiotherapy or chemotherapy, and 25 patients achieved complete remission. During the follow-up period, only 2 patients evidenced progression, and no deaths occurred over the course of the study. 〈 i 〉 Conclusion: 〈 /i 〉 pTY-MZL tends to be an indolent disease. However, unlike other mucosa-associated lymphoid tissue site MZLs, pTY-MZL was well controlled via several treatment modalities, and the patients’ responses were sustained for a prolonged period.
    Type of Medium: Online Resource
    ISSN: 0001-5792 , 1421-9662
    URL: Article
    DOI: 10.1159/000333113
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2012
    detail.hit.zdb_id: 1481888-7
    detail.hit.zdb_id: 80008-9
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  • 5
    Online Resource
    Online Resource
    Successful Hemostasis with Recombinant Activated Factor VII in a Patient with Massive Hepatic Subcapsular Hematoma
    S. Karger AG ; 2009
    In:  Case Reports in Gastroenterology Vol. 3, No. 1 ( 2009-2-20), p. 10-15
    Details
    In: Case Reports in Gastroenterology, S. Karger AG, Vol. 3, No. 1 ( 2009-2-20), p. 10-15
    Type of Medium: Online Resource
    ISSN: 1662-0631
    URL: Article
    DOI: 10.1159/000203078
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2009
    detail.hit.zdb_id: 2440540-1
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  • 6
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    Association of Age and BP Variability with Long-term Mortality in Hemodialysis Patients
    S. Karger AG ; 2013
    In:  Kidney and Blood Pressure Research Vol. 38, No. 2-3 ( 2013), p. 172-180
    Details
    In: Kidney and Blood Pressure Research, S. Karger AG, Vol. 38, No. 2-3 ( 2013), p. 172-180
    Abstract: 〈 b 〉 〈 i 〉 Background/Aims: 〈 /i 〉 〈 /b 〉 Blood pressure (BP) variability is known as a poor prognostic factor for cardiovascular outcomes. This study assessed the prognostic significance of BP variability in association with increasing age in hemodialysis patients. 〈 b 〉 〈 i 〉 Methods 〈 /i 〉 〈 /b 〉 〈 b 〉 〈 i 〉 : 〈 /i 〉 〈 /b 〉 We retrospectively analyzed 2,174 patients on hemodialysis from March 2005 to December 2012. The impact of intradialytic and interdialytic BP variability on all-cause mortality according to age groups was analyzed. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Kaplan-Meier survival curves for 5-year cumulative mortality showed higher mortality in patients with higher intradialytic systolic and diastolic BP variability as well as interdialytic systolic and diastolic BP variability (log-rank p=0.006, 〈 0.001, 0.018 and 〈 0.001) in patients aged 〈 55 years, but not in older age groups. Cox proportional analysis revealed that 5-year mortality was associated with intradialytic diastolic BP variability in patients aged 〈 55 years (HR, 2.03 CI, 1.24-3.32). 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 The overall mortality was associated with BP variability in patients aged 〈 55 years, but not in older ages. This result suggests that younger hemodialysis patients with BP variability require further medical attention and intervention to reduce BP variability.
    Type of Medium: Online Resource
    ISSN: 1420-4096 , 1423-0143
    URL: Article
    DOI: 10.1159/000355765
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2013
    detail.hit.zdb_id: 1482922-8
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  • 7
    Online Resource
    Online Resource
    Weight Change Alters the Small RNA Profile of Urinary Extracellular Vesicles in Obesity
    S. Karger AG ; 2022
    In:  Obesity Facts Vol. 15, No. 2 ( 2022), p. 292-301
    Details
    In: Obesity Facts, S. Karger AG, Vol. 15, No. 2 ( 2022), p. 292-301
    Abstract: 〈 b 〉 〈 i 〉 Introduction: 〈 /i 〉 〈 /b 〉 Various kidney diseases reportedly show different urinary extracellular vesicle (EV) RNA profiles. Although obesity is one of the main causes of chronic kidney disease, the expression pattern of urinary EV RNA in obesity is uncertain. Our aim was to sequence the small RNA profiles of urinary EVs in obese patients before and after weight reduction and compare them to those of healthy volunteers (HVs). 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 We recruited age-sex-matched obese patients and HVs. The small RNA profiles of urinary EVs were analyzed using RNA sequencing. To evaluate the effect of weight reduction, small RNA profiles of urinary EVs 6 months after bariatric surgery were also analyzed. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 The proportion of urinary EVs transfer RNA and microRNA of obese patients differed from that of HVs. Obese patients showed differential expression of 1,343 small RNAs in urinary EVs compared to HVs (fold change ≥2 and 〈 i 〉 p 〈 /i 〉 value & #x3c;0.05). Among those, 61 small RNAs were upregulated in obese patients and downregulated after weight reduction, whereas 167 small RNAs were downregulated in obese patients and upregulated after weight reduction. RNA sequencing revealed the correlation between the specific urinary EV small RNAs and clinical parameters including body weight, low-density lipoprotein cholesterol, triglyceride, high-density lipoprotein cholesterol, serum glucose, estimated glomerular filtration rate, and albuminuria. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 Obese patients showed distinct urinary EV small RNA profiles compared to HVs. Weight reduction altered urinary EV small-RNA profiles in obese patients.
    Type of Medium: Online Resource
    ISSN: 1662-4025 , 1662-4033
    URL: Article
    DOI: 10.1159/000521730
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2022
    detail.hit.zdb_id: 2455819-9
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  • 8
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    Online Resource
    PTEN Loss-Mediated Akt Activation Increases the Properties of Cancer Stem-Like Cell Populations in Prostate Cancer
    S. Karger AG ; 2014
    In:  Oncology Vol. 87, No. 5 ( 2014), p. 270-279
    Details
    In: Oncology, S. Karger AG, Vol. 87, No. 5 ( 2014), p. 270-279
    Abstract: 〈 b 〉 〈 i 〉 Objective: 〈 /i 〉 〈 /b 〉 To demonstrate that the PTEN/PI3K/Akt/NF- & #954;B pathway plays an important role in regulating the prostate cancer stem-like cell population by upregulating ABCG2. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Targeted PTEN knockdown in human prostate DU145 and 22Rv1 cells using a small interfering RNA were confirmed by immunoblot analysis using antibodies of PTEN, phospho-Akt, Akt, and a-tubulin. Knockdown PTEN DU145 and 22Rv1 cells were augmented, and the stem cell-like properties were examined by cell viability and tumor sphere formation and treated by Akt IV inhibitor to provide the signal transduction pathway. Luciferase activity assays were performed. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 The knockdown of PTEN in prostate cancer cell lines increased the stem-like properties of the cells, including their sphere-forming ability, stem cell population number, epithelial-mesenchymal transition-related gene expression, and ABCG2 expression. Additionally, PTEN expression was highly associated with elevated expression of phospho-Akt. Treatment with an Akt inhibitor suppressed the PTEN-mediated effects on the properties of these stem-like cells as well as drug resistance, ABCG2 expression, and the NF- & #954;B pathway. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 The loss of PTEN in prostate cancer cells resulted in an increased PI3K/Akt pathway. Due to the Akt activation, PTEN loss may play an important role in prostate cancer by promoting cancer stemness through a mechanism that involves enhanced NF- & #954;B signaling.
    Type of Medium: Online Resource
    ISSN: 0030-2414 , 1423-0232
    URL: Article
    DOI: 10.1159/000363186
    RVK:
    XH 3305
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2014
    detail.hit.zdb_id: 1483096-6
    detail.hit.zdb_id: 250101-6
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  • 9
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    Gentamicin Decreases Guanylyl Cyclase Activity in Rat Glomerulus
    S. Karger AG ; 2007
    In:  Kidney and Blood Pressure Research Vol. 30, No. 2 ( 2007), p. 81-87
    Details
    In: Kidney and Blood Pressure Research, S. Karger AG, Vol. 30, No. 2 ( 2007), p. 81-87
    Abstract: 〈 i 〉 Background: 〈 /i 〉 Effects of gentamicin (GM) on the local natriuretic peptide (NP) and nitric oxide (NO) systems in the kidney were investigated. 〈 i 〉 Methods: 〈 /i 〉 Male Sprague-Dawley rats (180–200 g) were intramuscularly injected with GM (100 mg/kg/day) for 5 days. The expression of NO synthase (NOS) isoforms was determined by Western blot analysis, and that of NPs by real-time polymerase chain reaction. The activity of guanylyl cyclase was also determined by the amount of guanosine 3′,5′-cyclic monophosphate (cGMP) generated in responses to atrial natriuretic peptide (ANP) or sodium nitroprusside (SNP). 〈 i 〉 Results: 〈 /i 〉 GM treatment resulted in renal failure in association with increases in urinary flow and the fractional excretion of sodium. Accordingly, the expression of inducible NOS was increased in the cortex, while that of endothelial NOS remained unchanged. The urinary excretion of NO metabolites was increased. The expression of ANP, brain natriuretic peptide and C-type natriuretic peptide mRNA was increased in the kidney. The cGMP production provoked by either ANP or SNP was decreased in the glomerulus, but not in the papilla. 〈 i 〉 Conclusion: 〈 /i 〉 GM-induced nephropathy may be causally related with decreased guanylyl cyclase activities in the glomerulus.
    Type of Medium: Online Resource
    ISSN: 1420-4096 , 1423-0143
    URL: Article
    DOI: 10.1159/000100010
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2007
    detail.hit.zdb_id: 1482922-8
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  • 10
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    Altered Regulation of Renin-Angiotensin, Endothelin and Natriuretic Peptide Systems in Rat Kidney with Chronic Unilateral Ureteral Obstruction
    S. Karger AG ; 2007
    In:  Urologia Internationalis Vol. 79, No. 2 ( 2007), p. 170-176
    Details
    In: Urologia Internationalis, S. Karger AG, Vol. 79, No. 2 ( 2007), p. 170-176
    Abstract: 〈 i 〉 Background: 〈 /i 〉 The present study was designed to investigate the role of the local renin-angiotensin-aldosterone system (RAAS), endothelin (ET) and the natriuretic peptide system (NPS) for the development of renal fibrosis and progressive renal disease in experimental unilateral ureteral obstructed (UUO) rats. 〈 i 〉 Methods: 〈 /i 〉 Male Sprague-Dawley rats (180–200 g) were unilaterally obstructed by ligation of the proximal ureters for 14 days. Control rats were treated in the same way, except that no ligature was made. The mRNA expressions of local renin-angiotensin system, aldosterone synthase (CYP11B2), ET-1 and NPS was determined in the cortex by real-time polymerase chain reaction. 〈 i 〉 Results: 〈 /i 〉 Following the unilateral ureteral obstruction, the mRNA expressions of angiotensin-converting enzyme 1, ET-1 and transforming growth factor-β 〈 sub 〉 1 〈 /sub 〉 (TGF-β 〈 sub 〉 1 〈 /sub 〉 ) were increased, while angiotensin-converting enzyme 2 was decreased in the obstructed kidney compared with the controls. Angiotensin II type 1 receptor was decreased and TGF-β 〈 sub 〉 1 〈 /sub 〉 was not changed in contralateral kidney compared with the controls. Atrial natriuretic peptide, brain natriuretic peptide, and C-type natri- uretic peptide expressions were increased in UUO kidneys compared with the controls, while natriuretic peptide receptor-A was decreased in UUO kidneys. 〈 i 〉 Conclusion: 〈 /i 〉 The local RAAS and ET-1 was upregulated which may play a role in the progressive renal fibrosis in obstructed kidneys in rats with UUO. The enhanced activity of NPS in UUO kidney may play a role to compensate against progressive renal fibrosis in chronic obstructive uropathy.
    Type of Medium: Online Resource
    ISSN: 0042-1138 , 1423-0399
    URL: Article
    DOI: 10.1159/000106333
    RVK:
    XA 10000
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2007
    detail.hit.zdb_id: 1464417-4
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