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  • 1
    Online Resource
    Online Resource
    Pancreatic Fistulae after Urologic Surgery - A Single Centre Experience
    S. Karger AG ; 2015
    In:  Urologia Internationalis Vol. 95, No. 3 ( 2015), p. 346-351
    Details
    In: Urologia Internationalis, S. Karger AG, Vol. 95, No. 3 ( 2015), p. 346-351
    Abstract: 〈 b 〉 〈 i 〉 Introduction: 〈 /i 〉 〈 /b 〉 To evaluate incidence, symptoms and management of postoperative pancreatic fistula (POPF) after urologic surgery based on our experience. 〈 b 〉 〈 i 〉 Material and Methods: 〈 /i 〉 〈 /b 〉 Database was searched for clinically evident POPF after urologic surgery between 1998 and 2014. Fistulae were graded using the POPF classification. Clinical course of every POPF patient was evaluated. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 During this time, 3,200 surgeries for renal, adrenal and retroperitoneal pathologies were performed. Twelve POPF occurred postoperatively in this series. Eight fistulae were POPF grade A, 3 POPF grade B and one POPF grade C. POPF became clinically evident after a median of 3 days (IQR 2-3). In all POPF grade A/B patients, secretion from the pancreatic fistula completely subsided under conservative therapy. In one POPF grade C patient with positive surgical margins of urothelial cancer, conservative treatment failed and the patient died due to POPF-related sepsis. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 POPF is a rare complication after urologic surgery. Conservative therapy is the first choice of treatment and will be successful in the majority of cases. Pancreatic fistula after surgery of recurrent malignancy may have a poor outcome.
    Type of Medium: Online Resource
    ISSN: 0042-1138 , 1423-0399
    URL: Article
    DOI: 10.1159/000381561
    RVK:
    XA 10000
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2015
    detail.hit.zdb_id: 1464417-4
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  • 2
    Online Resource
    Online Resource
    Immunotherapy of Peritoneal Carcinomatosis with the Antibody Catumaxomab in Colon, Gastric, or Pancreatic Cancer: An Open-Label, Multicenter, Phase I/II Trial
    S. Karger AG ; 2011
    In:  Onkologie Vol. 34, No. 3 ( 2011), p. 101-108
    Details
    In: Onkologie, S. Karger AG, Vol. 34, No. 3 ( 2011), p. 101-108
    Type of Medium: Online Resource
    ISSN: 1423-0240 , 0378-584X
    URL: Article
    DOI: 10.1159/000324667
    RVK:
    XA 10000
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2011
    detail.hit.zdb_id: 1483097-8
    detail.hit.zdb_id: 2749752-5
    detail.hit.zdb_id: 549601-9
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  • 3
    Online Resource
    Online Resource
    Psychoanalytic-Interactional Therapy versus Psychodynamic Therapy by Experts for Personality Disorders: A Randomized Controlled Efficacy-Effectiveness Study in Cluster B Personality Disorders
    S. Karger AG ; 2016
    In:  Psychotherapy and Psychosomatics Vol. 85, No. 2 ( 2016), p. 71-80
    Details
    In: Psychotherapy and Psychosomatics, S. Karger AG, Vol. 85, No. 2 ( 2016), p. 71-80
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 With regard to cluster B personality disorders, most psychotherapeutic treatments focus on borderline personality disorder. Evidence-based treatments for patients with other cluster B personality disorders are not yet available. Psychoanalytic-interactional therapy (PIT) represents a transdiagnostic treatment for severe personality disorders. PIT has been applied in clinical practice for many years and has proven effective in open studies. In a randomized controlled trial, we compared manual-guided PIT to nonmanualized pychodynamic therapy by experts in personality disorders (E-PDT) in patients with cluster B personality disorders. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 In an inpatient setting, patients with cluster B personality disorders were randomly assigned to manual-guided PIT (n = 64) or nonmanualized E-PDT (n = 58). In addition, a quasi-experimental control condition was used (n = 46) including both patients receiving treatment as usual and patients waiting for treatment. Primary outcomes were level of personality organization and overall psychological distress. As secondary outcomes, depression, anxiety and interpersonal problems were examined. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 No significant improvements were found in the control patients. Both PIT and E-PDT achieved significant improvements in all outcome measures and were superior to the control condition. No differences were found between PIT and E-PDT in any outcome measure at the end of treatment. The type of cluster B personality disorder had no impact on the results. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 In an inpatient setting, both PIT and E-PDT proved to be superior to a control condition in cluster B personality disorders. In a head-to-head comparison, both treatments appeared to be equally effective. Further research on the treatment of cluster B personality disorders is required.
    Type of Medium: Online Resource
    ISSN: 0033-3190 , 1423-0348
    URL: Article
    DOI: 10.1159/000441731
    RVK:
    CU 5500
    RVK:
    XA 10000
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2016
    detail.hit.zdb_id: 1472321-9
    SSG: 5,2
    SSG: 15,3
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  • 4
    Online Resource
    Online Resource
    Calcitonin Gene-Related Peptide Modulates the Production of Pro-Inflammatory Cytokines Associated with Periprosthetic Osteolysis by THP-1 Macrophage-Like Cells
    S. Karger AG ; 2015
    In:  Neuroimmunomodulation Vol. 22, No. 3 ( 2015), p. 152-165
    Details
    In: Neuroimmunomodulation, S. Karger AG, Vol. 22, No. 3 ( 2015), p. 152-165
    Abstract: 〈 b 〉 〈 i 〉 Objective: 〈 /i 〉 〈 /b 〉 An anti-resorptive impact of the neuropeptide calcitonin gene-related peptide (CGRP) on periprosthetic osteolysis, the leading cause of early prosthesis loosening, has been shown previously. In this study, the impact of CGRP on pro-inflammatory cytokine production associated with periprosthetic osteolysis was analysed using THP-1 macrophage-like cells. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Cells were stimulated with ultra-high-molecular-weight polyethylene (UHMWPE) particles (cell-to-particle ratios of 1:100 and 1:500) and lipopolysaccharides (LPS; 1 µg/ml) to establish osteolytic conditions, and simultaneously treated with CGRP (10 〈 sup 〉 -8 〈 /sup 〉 〈 smlcap 〉 M 〈 /smlcap 〉 ). Receptor activator of nuclear factor- & #954;B 〈 i 〉 (RANK) 〈 /i 〉 , RANK ligand 〈 i 〉 (RANKL) 〈 /i 〉 and tumour necrosis factor 〈 i 〉 (TNF) 〈 /i 〉 - 〈 i 〉 a 〈 /i 〉 mRNA expression were measured by quantitative RT-PCR. RANK protein was detected by Western blot. Secreted protein levels of TNF-a as well as interleukin (IL)-1ß and IL-6 were quantified in cell culture supernatants by ELISA and Bio-Plex cytokine assay, respectively. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Activation of macrophage-like cells failed to enhance the production of RANK but led to a dose- and time-dependent increase of 〈 i 〉 TNF 〈 /i 〉 - 〈 i 〉 a 〈 /i 〉 mRNA and secreted protein levels of TNF-a, IL-1ß and IL-6. Application of CGRP time-dependently suppressed 〈 i 〉 TNF-a 〈 /i 〉 mRNA expression induced by low-particle concentrations and LPS, while both particle- and LPS-induced secretion of TNF-a was inhibited. A pronounced inhibitory effect of CGRP on LPS-induced cytokine production at 24 h of incubation was also observed with IL-1ß and IL-6. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 CGRP shows a time-dependent inhibitory effect on the secretion of osteolysis-associated pro-inflammatory cytokines, indicating an indirect anti-resorptive influence of the neuropeptide on both aseptic prosthesis loosening and bacterially induced bone resorption which might enhance the life time of total joint replacements.
    Type of Medium: Online Resource
    ISSN: 1021-7401 , 1423-0216
    URL: Article
    DOI: 10.1159/000360988
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2015
    detail.hit.zdb_id: 1483035-8
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  • 5
    Online Resource
    Online Resource
    Marathon Run under Chemotherapy: Is It Possible?
    S. Karger AG ; 2011
    In:  Onkologie Vol. 34, No. 5 ( 2011), p. 259-261
    Details
    In: Onkologie, S. Karger AG, Vol. 34, No. 5 ( 2011), p. 259-261
    Type of Medium: Online Resource
    ISSN: 1423-0240 , 0378-584X
    URL: Article
    DOI: 10.1159/000327804
    RVK:
    XA 10000
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2011
    detail.hit.zdb_id: 1483097-8
    detail.hit.zdb_id: 2749752-5
    detail.hit.zdb_id: 549601-9
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  • 6
    Online Resource
    Online Resource
    BDD-NET – Ein internetbasiertes Programm bei Körperunzufriedenheit zur niedrigschwelligen Behandlung der körperdysmorphen Störung für den deutschen Sprachraum
    S. Karger AG ; 2022
    In:  Verhaltenstherapie Vol. 32, No. 1-2 ( 2022), p. 1-10
    Details
    In: Verhaltenstherapie, S. Karger AG, Vol. 32, No. 1-2 ( 2022), p. 1-10
    Abstract: 〈 b 〉 〈 i 〉 Hintergrund: 〈 /i 〉 〈 /b 〉 Die Körperdysmorphe Störung (KDS) ist eine schwerwiegende psychische Störung, die mit starker Scham sowie Leidensdruck und Funktionseinschränkungen einhergeht. Kognitive Verhaltenstherapie stellt die aktuell wirksamste evidenzbasierte Behandlungsmethode dar. Aufgrund zahlreicher Behandlungsbarrieren kommen KDS-Betroffene jedoch selten in der psychotherapeutischen Behandlung an, weshalb niedrigschwelligen Behandlungsmethoden (z.B. aus dem Bereich E-Mental-Health) eine wichtige Rolle zukommen könnten. Erste internationale Studien weisen auf die Wirksamkeit von E-Mental-Health-Angeboten bei KDS hin. 〈 b 〉 〈 i 〉 Material und Methoden: 〈 /i 〉 〈 /b 〉 Dieser Beitrag gibt eine Übersicht zur bisherigen Umsetzung und Evidenz von E-Mental-Health-Angeboten für KDS und stellt die ins Deutsche übersetzte Version des BDD-NET-Programms, eines internetbasierten, manuali­sierten, therapeutenbegleiteten Interventionsprogramms, für die KDS vor, welches aus dem Englischen für den deutschen Sprachraum übersetzt und adaptiert wurde. 〈 b 〉 〈 i 〉 Ergebnisse: 〈 /i 〉 〈 /b 〉 BDD-NET umfasst acht Module, die binnen einer 12-wöchigen Behandlung online bearbeitet werden. Die Online-Plattform bietet für die Patienten die Möglichkeit, mit dem BDD-NET-Therapeuten mittels persönlicher Nachrichten zu kommunizieren. Sämtliche Materialien wurden aus dem Englischen übersetzt und vor allem in kultureller Hinsicht adaptiert. 〈 b 〉 〈 i 〉 Schlussfolgerungen: 〈 /i 〉 〈 /b 〉 BDD-NET könnte ein wichtiger Baustein in der Versorgung von KDS-Betroffenen sein. Die Evaluation steht für den deutschen Sprachraum noch aus. Auf Besonderheiten des Settings (z.B. Störungseinsicht als möglicher Behandlungsfokus) sowie praktische Implikationen wird eingegangen. Zudem werden Voraussetzungen und Rahmenbedingungen für eine perspektivische Dissemination diskutiert.
    Type of Medium: Online Resource
    ISSN: 1016-6262 , 1423-0402
    URL: Article
    DOI: 10.1159/000520345
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2022
    detail.hit.zdb_id: 1483583-6
    SSG: 5,2
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  • 7
    Online Resource
    Online Resource
    Pulmonary Diffusing Capacity and Physical Working Capacity in Swimmers and Non-Swimmers during Growth
    S. Karger AG ; 1981
    In:  Respiration Vol. 42, No. 1 ( 1981), p. 8-14
    Details
    In: Respiration, S. Karger AG, Vol. 42, No. 1 ( 1981), p. 8-14
    Type of Medium: Online Resource
    ISSN: 0025-7931 , 1423-0356
    URL: Article
    DOI: 10.1159/000194397
    Language: English
    Publisher: S. Karger AG
    Publication Date: 1981
    detail.hit.zdb_id: 1464419-8
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  • 8
    Online Resource
    Online Resource
    Specific Immunotherapy for Common Grass Pollen Allergies: Pertinence of a Five Grass Pollen Vaccine
    S. Karger AG ; 2008
    In:  International Archives of Allergy and Immunology Vol. 146, No. 4 ( 2008), p. 338-342
    Details
    In: International Archives of Allergy and Immunology, S. Karger AG, Vol. 146, No. 4 ( 2008), p. 338-342
    Abstract: Patients throughout Europe are concomitantly exposed to multiple pollens from distinct Pooideae species. Given the overlap in pollination calendars and similar grain morphology, it is not possible to identify which grass species are present in the environment from pollen counts. Furthermore, neither serum IgE reactivity nor skin prick testing allow the identification of which grass species are involved in patient sensitisation. Due to their high level of amino acid sequence homology (e.g., 〉 90% for group 1, 55–80% for group 5), significant cross-immunogenicity is observed between allergens from Pooideae pollens. Nevertheless, pollen allergens also contain species-specific T or B cell epitopes, and substantial quantitative differences exist in allergen (e.g., groups 1 and 5) composition between pollens from distinct grass species. In this context, a mixture of pollens from common and well-characterised Pooideae such as 〈 i 〉 Anthoxanthum odoratum, Dactylis glomerata, Lolium perenne, Phleum pratense 〈 /i 〉 and 〈 i 〉 Poa pratensis 〈 /i 〉 is suitable for immunotherapy purposes because (1) it has been validated, both in terms of safety and efficacy, by established clinical practice; (2) it reflects natural exposure and sensitisation conditions; (3) it ensures a consistent and well-balanced composition of critical allergens, thus extending the repertoire of T and B cell epitopes present in the vaccine.
    Type of Medium: Online Resource
    ISSN: 1018-2438 , 1423-0097
    URL: Article
    DOI: 10.1159/000121468
    RVK:
    XA 49650
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2008
    detail.hit.zdb_id: 1482722-0
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  • 9
    Online Resource
    Online Resource
    To Be or Not to Be Improved: Patients’ Perception of Symptom Improvement – Linking the SCL-90-R to Patient-Rated Global Improvement in a Large Real-World Treatment Sample
    S. Karger AG ; 2020
    In:  Psychotherapy and Psychosomatics Vol. 89, No. 6 ( 2020), p. 357-362
    Details
    In: Psychotherapy and Psychosomatics, S. Karger AG, Vol. 89, No. 6 ( 2020), p. 357-362
    Abstract: 〈 b 〉 〈 i 〉 Introduction: 〈 /i 〉 〈 /b 〉 From both a clinical and research perspective, it is important to determine what constitutes a perceivable change in commonly used outcome measures. 〈 b 〉 〈 i 〉 Objective: 〈 /i 〉 〈 /b 〉 We aimed to do so for the Symptom Checklist-90-Revised (SCL-90-R). 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Patients from a large real-world sample treated with inpatient psychotherapy ( 〈 i 〉 n 〈 /i 〉 = 4,791) rated improvements in symptoms on a global 5-point Likert scale at discharge. These ratings were related to pre-post changes in the Global Severity Index (GSI) of the SCL-90-R by use of equipercentile linking. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 A patient rating of 5 (“clearly improved”) was found to be equivalent to an absolute pre-post difference in the GSI of 0.67 or to a percentage improvement of 54%, with the latter corresponding to the common definition of response as a 50% reduction in symptoms. A rating of 1 (“clearly worse”) was equivalent to an increase in the GSI & #x3e;0.50 and to a percentage worsening & #x3e;55%. “Slightly improved” or “slightly worse” (ratings of 4 or 2) corresponded to pre-post changes in the GSI of 0.07 and 0.50. For severely disordered patients, larger changes were required for ratings of improvement, and for less severely disordered patients, larger changes were required for ratings of worsening. Results for depressive, anxiety, and personality disorders were widely consistent with those of the total sample. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 This study is the first to link patient ratings of improvement or worsening to changes in the SCL-90-R. Results are relevant to both the interpretation of changes in individual patients and of effect sizes in outcome research. Results require replication.
    Type of Medium: Online Resource
    ISSN: 0033-3190 , 1423-0348
    URL: Article
    DOI: 10.1159/000509213
    RVK:
    CU 5500
    RVK:
    XA 10000
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2020
    detail.hit.zdb_id: 1472321-9
    SSG: 5,2
    SSG: 15,3
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