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  • 1
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    Online Resource
    Athymic Nude Rats Develop Severe Pulmonary Hypertension following Monocrotaline Administration
    S. Karger AG ; 2000
    In:  International Archives of Allergy and Immunology Vol. 121, No. 3 ( 2000), p. 246-252
    Details
    In: International Archives of Allergy and Immunology, S. Karger AG, Vol. 121, No. 3 ( 2000), p. 246-252
    Abstract: 〈 i 〉 Objective: 〈 /i 〉 To investigate the significance of the presence or absence of the thymus in the development of pulmonary hypertension (PH) following monocrotaline (MCT) administration, the degree of MCT-induced PH (MCT-PH) in athymic nude (F344/N Jcl-rnu) rats was compared with that in their euthymic (rnu/+) littermates. 〈 i 〉 Methods: 〈 /i 〉 Histopathological studies of the lung in terms of interstitial edema, congestion, thickening of the alveolar wall, inflammatory cell infiltration and degeneration of arteries were performed by staining with hematoxylin-eosin (HE), elastin van Gieson and Masson’s trichrome. The medial wall thickness of the small pulmonary arteries and the weight ratio of the right ventricular free wall (RV) to that of the left ventricle plus septum [RV/(LV + S) weight ratio] were used as indices of the degree of PH. Toluidine blue staining was performed to estimate the number of the mast cells in the lung interstitium. 〈 i 〉 Results: 〈 /i 〉 Interstitial edema was significantly severer in MCT- injected euthymic rats than in MCT-injected athymic nude rats (p 〈 0.01); in contrast, the thickening of the alveolar wall was severer in MCT-injected athymic nude rats than in MCT-injected euthymic rats (p 〈 0.05). The degree of MCT-PH, as determined by the medial wall thickness of the small pulmonary arteries and RV/(LV + S) weight ratio in MCT-injected athymic nude rats, was significantly severer than in MCT-injected euthymic rats (p 〈 0.05 and p 〈 0.01, respectively). The number of mast cells was significantly greater in MCT-injected athymic nude rats than in MCT-injected euthymic rats (p 〈 0.01). The degree of the medial wall thickness of the small pulmonary arteries was significantly correlated with RV/(LV + S) weight ratio (p 〈 0.05) as well as with the number of mast cells in MCT-injected rats. 〈 i 〉 Conclusions: 〈 /i 〉 Athymic nude rats developed severer PH than euthymic rats along with a greater number of mast cells and severer histopathological changes, such as thickening of the alveolar wall. Mast cell proliferation was considered to play a pivotal role in the development of PH in MCT-PH.
    Type of Medium: Online Resource
    ISSN: 1018-2438 , 1423-0097
    URL: Article
    DOI: 10.1159/000024324
    RVK:
    XA 49650
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2000
    detail.hit.zdb_id: 1482722-0
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  • 2
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    A Case of Gastric Cancer with Residual Tumor Only in the Para-Aortic Lymph Nodes after Systemic Chemotherapy followed by Conversion Surgery
    S. Karger AG ; 2015
    In:  Case Reports in Oncology Vol. 8, No. 2 ( 2015-7-31), p. 312-322
    Details
    In: Case Reports in Oncology, S. Karger AG, Vol. 8, No. 2 ( 2015-7-31), p. 312-322
    Abstract: We report the case of a 60-year-old male who was diagnosed with gastric cancer. Upper gastrointestinal endoscopy indicated advanced cancer in the posterior wall of the gastric body. Biopsy revealed poorly differentiated adenocarcinoma. Abdominal computed tomography demonstrated thickening of the gastric wall and enlargement of the regional lymph nodes and of the para-aortic lymph nodes (PAN). The involvement of the PAN extended from the celiac axis to the caudal area of the inferior mesenteric artery [cT3N3aH0P0M1(LYM), stage IV]. Systemic chemotherapy was initiated. After 3 courses of S-1 plus cisplatin combination chemotherapy, the primary lesion and the enlarged lymph nodes revealed marked regression except for a minute residual lesion in the lymph nodes. Upon obtaining informed consent, open distal gastrectomy, D2 lymphadenectomy with PAN dissection, and Roux-en-Y reconstruction were performed. The patient was discharged from the hospital 35 days after the operation. Histopathological examination of the resected samples revealed malignant cells only in the PAN, not in the stomach or in the regional lymph nodes [ypT0N0M1(LYM), stage IV] . Currently, the patient is undergoing postoperative adjuvant chemotherapy with S-1 and has remained well without any recurrence after 6 months following surgery.
    Type of Medium: Online Resource
    ISSN: 1662-6575
    URL: Article
    DOI: 10.1159/000438698
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2015
    detail.hit.zdb_id: 2458961-5
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  • 3
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    Recovery from Choriocarcinoma Syndrome Associated with a Metastatic Extragonadal Germ Cell Tumor Hemorrhage
    S. Karger AG ; 2016
    In:  Case Reports in Gastroenterology Vol. 10, No. 1 ( 2016-5-4), p. 198-203
    Details
    In: Case Reports in Gastroenterology, S. Karger AG, Vol. 10, No. 1 ( 2016-5-4), p. 198-203
    Abstract: A germ cell tumor is the most common form of malignancy in early male life, and can be classified as either seminomatous or nonseminomatous. Choriocarcinoma, comprised of nonseminomatous germ cells, is the most aggressive type of germ cell tumor and characteristically metastasizes to the retroperitoneal lymph nodes and less frequently to the lungs, liver, bone or brain [Shibuya et al., 2009;48: 551–554] . A 56-year-old man was admitted to another hospital complaining of abdominal distension. Symptoms included anorexia, vomiting, and diarrhea. The patient was diagnosed with an extragonadal germ cell tumor and referred to our hospital to receive chemotherapy. The day after admission, the patient’s abdominal distension gradually worsened. An emergency operation revealed venous hemorrhage from the surface of a metastatic extragonadal germ cell tumor between the ligament of Treitz and the inferior mesenteric vein in a horizontal position. Hemostatic treatment was performed with 4-0 proline thread attached to a medicated cotton sponge, rather than using a simple proline thread, and the closure area was manually compressed. Chemotherapy was initiated on postoperative day 10. A metastatic extragonadal germ cell tumor that causes massive hemorrhage and gastrointestinal hemorrhage is very rare, and represents a life-threatening emergency. If the patient’s condition carries a substantial risk of bleeding to death, it may be worthwhile to attempt abdominal operations.
    Type of Medium: Online Resource
    ISSN: 1662-0631
    URL: Article
    DOI: 10.1159/000446017
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2016
    detail.hit.zdb_id: 2440540-1
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  • 4
    Online Resource
    Online Resource
    Use of Multidetector Row CT to Evaluate the Need for Bronchial Arterial Embolization in Hemoptysis Patients
    S. Karger AG ; 2010
    In:  Respiration Vol. 80, No. 1 ( 2010), p. 24-31
    Details
    In: Respiration, S. Karger AG, Vol. 80, No. 1 ( 2010), p. 24-31
    Abstract: 〈 i 〉 Background: 〈 /i 〉 Bronchial artery (BA) embolization (BAE) is recommended as a minimally invasive therapy for hemoptysis, though some patients recover after only conservative treatment. 〈 i 〉 Objectives: 〈 /i 〉 The purpose of our study was to assess the characteristics of BAs using multidetector row computed tomography (MDCT) and identify BAs requiring BAE without BA angiography (BAG). 〈 i 〉 Methods: 〈 /i 〉 We retrospectively studied 41 patients and classified the visualized BAs into groups based on their BAE and bleeding statuses. Patients presenting with massive hemoptysis requiring emergency BAE were excluded. Patients presenting with persistent hemoptysis that was resistant to conservative treatment received BAE. Radiologists measured BA diameters at the ostium, bronchial bifurcation and pulmonary hilum, and also evaluated the degree of vascularization. 〈 i 〉 Results: 〈 /i 〉 MDCT enabled visualization of 102 ostia and 96 traceable BAs. Among the participating patients, 13 had at least one ectopic origin. We obtained a good correlation between BAG and MDCT diameters (r = 0.709, p 〈 0.001). The diameters of BAs responsible for bleeding and receiving BAE were apparently larger in each measured segment than those that were not (p 〈 0.05). Moreover, the diameters of arteries receiving BAE remained largely unchanged from the origin to the hilum and through the mediastinum. BAs with low MDCT scores were significantly less likely to required BAE than those with high scores (p = 0.004), and in multiple logistic regression analysis, ostium diameter and bleeding status were independent predictive factors for BAE. 〈 i 〉 Conclusions: 〈 /i 〉 Evaluation of BAs on MDCT could be useful for identifying the anatomical characteristics of bleeding-related BAs and determining whether BAE is indicated or whether conservative treatment is sufficient.
    Type of Medium: Online Resource
    ISSN: 0025-7931 , 1423-0356
    URL: Article
    DOI: 10.1159/000253882
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2010
    detail.hit.zdb_id: 1464419-8
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  • 5
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    Online Resource
    Preventive Effect of Diethyldithiocarbamate on Selenite-Induced Opacity in Cultured Rat Lenses
    S. Karger AG ; 2001
    In:  Ophthalmic Research Vol. 33, No. 1 ( 2001), p. 52-59
    Details
    In: Ophthalmic Research, S. Karger AG, Vol. 33, No. 1 ( 2001), p. 52-59
    Abstract: Increasing evidence suggests the involvement of reactive oxygen species in the development of cataracts. In this study, we investigated the preventive effect of diethyldithiocarbamate (DDC) on the selenite-induced opacification of cultured rat lenses. Lens opacity was produced by incubation with 0.2 m 〈 i 〉 M 〈 /i 〉 selenite for 24 h, which resulted in an increase in selenium content in the cultured lenses. The increase in selenium content and the onset of opacification and lens membrane damage were inhibited by preincubation with DDC. It is reasonable to assume that DDC contributed to anticataract ability. In addition, selenite resulted in a significant decrease in glutathione and protein thiol content and an increase in lipid peroxidation levels in the lenses. These alterations were also depressed by DDC, suggesting a contribution of an antioxidative effect by DDC in the inhibition of lens opacification. At the same lens selenium content, DDC treatment inhibited opacification and lipid peroxide. In conclusion, we propose that the antioxidative properties of DDC play a major role in its contribution to the anticataract effect.
    Type of Medium: Online Resource
    ISSN: 0030-3747 , 1423-0259
    URL: Article
    DOI: 10.1159/000055642
    RVK:
    XA 10000
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2001
    detail.hit.zdb_id: 1483177-6
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  • 6
    Online Resource
    Online Resource
    Binding of Dihydrotestosterone, R 1881 and R 5020 in Cytosols from Normal, Benign Hypertrophic and Cancerous Human Prostates
    S. Karger AG ; 1981
    In:  Urologia Internationalis Vol. 36, No. 2 ( 1981), p. 79-87
    Details
    In: Urologia Internationalis, S. Karger AG, Vol. 36, No. 2 ( 1981), p. 79-87
    Type of Medium: Online Resource
    ISSN: 1423-0399 , 0042-1138
    URL: Article
    DOI: 10.1159/000280398
    RVK:
    XA 10000
    Language: English
    Publisher: S. Karger AG
    Publication Date: 1981
    detail.hit.zdb_id: 1464417-4
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  • 7
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    Online Resource
    Role of Cytokines in Progression of Endometriosis
    S. Karger AG ; 1999
    In:  Gynecologic and Obstetric Investigation Vol. 47, No. Suppl. 1 ( 1999), p. 34-40
    Details
    In: Gynecologic and Obstetric Investigation, S. Karger AG, Vol. 47, No. Suppl. 1 ( 1999), p. 34-40
    Abstract: Peritoneal fluid in women with endometriosis contains an increased number of activated macrophages that secrete a variety of cytokines, including interleukin (IL)-6, IL-8, vascular endothelial growth factor, and tumor necrosis factor-α (TNF-α). Cytokines may be involved in the control of implantation and the growth of endometrial cells outside the uterus. In addition, several cytokines have been implicated in or directly associated with angiogenic activity in endometriosis. There could be a relationship between the levels of cytokines in the peritoneal fluid of patients with endometriosis and the status of the lesions in such patients. Peritoneal endometriosis can be classified as having red, black, or white lesions. Red lesions are known to be an active form of early endometriosis, because vascularization and mitotic activity are shown to be most prominent in these lesions. We found that the peritoneal fluid levels of TNF-α and IL-8 were significantly higher in patients with endometriosis, and correlated with the size and number of active lesions. In addition, TNF-α and IL-8 stimulated the growth of ectopic endometrial stromal cells. These cytokines with angiogenic activity may therefore have significant roles in the pathogenesis of endometriosis.
    Type of Medium: Online Resource
    ISSN: 0378-7346 , 1423-002X
    URL: Article
    DOI: 10.1159/000052857
    RVK:
    XA 45603
    Language: English
    Publisher: S. Karger AG
    Publication Date: 1999
    detail.hit.zdb_id: 1482695-1
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  • 8
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    Online Resource
    Efficient Delivery of siRNA by Atelocollagen in a Murine Laser-Induced Choroidal Neovascularization Model
    S. Karger AG ; 2013
    In:  Ophthalmologica Vol. 230, No. 4 ( 2013), p. 215-221
    Details
    In: Ophthalmologica, S. Karger AG, Vol. 230, No. 4 ( 2013), p. 215-221
    Abstract: 〈 b 〉 〈 i 〉 Purpose: 〈 /i 〉 〈 /b 〉 Previous studies have shown that small interfering RNAs (siRNAs) could suppress angiogenesis via stimulation of toll-like receptor-3 (TLR3). The purpose of this study was to determine the efficacy of atelocollagen to deliver siRNA without TLR3 stimulation in the laser-induced choroidal neovascularization (CNV) model. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 CNV was induced by laser injury in C57BL/6J mice and volumes were measured 7 days later. Nontargeted siRNA, 21-nucleotide (nt) siRNA- 〈 i 〉 Luc 〈 /i 〉 (Luciferase) and 21-nt siRNA- 〈 i 〉 Vegfa 〈 /i 〉 were injected into the vitreous following injury. Atelocollagen was incubated with naked 21-nt siRNAs before injection. To block TLR3 endosomal activity, chloroquine was injected intravitreously after laser injury. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 The mean CNV volumes were significantly smaller in the naked siRNA- 〈 i 〉 Luc 〈 /i 〉 , naked siRNA- 〈 i 〉 Vegfa 〈 /i 〉 , or siRNA- 〈 i 〉 Vegfa 〈 /i 〉 /atelocollagen complex compared with PBS, atelocollagen or siRNA- 〈 i 〉 Luc 〈 /i 〉 /atelocollagen complex-injected mice (p 〈 0.05). 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 These findings demonstrate that atelocollagen may deliver siRNA without nonspecific TLR3 stimulation in the murine laser-CNV model.
    Type of Medium: Online Resource
    ISSN: 0030-3755 , 1423-0267
    URL: Article
    DOI: 10.1159/000354092
    RVK:
    XA 10000
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2013
    detail.hit.zdb_id: 1483531-9
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  • 9
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    Predicted Markers of Overall Survival in Pancreatic Cancer Patients Receiving Dendritic Cell Vaccinations Targeting WT1
    S. Karger AG ; 2019
    In:  Oncology Vol. 97, No. 3 ( 2019), p. 135-148
    Details
    In: Oncology, S. Karger AG, Vol. 97, No. 3 ( 2019), p. 135-148
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 We have developed a Wilms’ tumor 1 (WT1)-targeting dendritic cell (DC)-based cancer vaccine combined with standard chemotherapy for patients with advanced pancreatic ductal adenocarcinoma (PDA). 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 We evaluated predictive markers of overall survival (OS) in PDA patients treated with multiple major histocompatibility complex class I/II-restricted, WT1 peptide-pulsed DC vaccinations (DC/WT1-I/II) in combination with chemotherapy. Throughout the entire period of immunochemotherapy, the plasma levels of soluble factors derived from granulocytes of 7 eligible PDA patients were examined. Moreover, systemic inflammatory response markers (neutrophil-to-lymphocyte ratio [NLR], monocyte-to-lymphocyte ratio [MLR] , and granulocyte-to-lymphocyte ratio [GLR]) were assessed. In addition, cytoplasmic WT1 expression in PDA cells was examined. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Compared to the 4 non-super-responders (OS & #x3c;1 year), the remaining 3 super-responders (OS ≥1 year) showed significantly decreased low plasma matrix metalloproteinase-9 levels throughout long-term therapy. The NLR, MLR, and GLR after 5 DC/WT1-I/II vaccinations and 3 cycles of gemcitabine were significantly lower in the super-responders than in the non-super-responders. Furthermore, the cytoplasmic WT1 expression in the PDA cells of super-responders was relatively weak compared to that in the PDA cells of non-super-responders. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 Prolonged low levels of a granulocyte-related systemic inflammatory response after the early period of therapy and low cytoplasmic WT1 expression in PDA cells may be markers predictive of OS in PDA patients receiving WT1-targeting immunochemotherapy.
    Type of Medium: Online Resource
    ISSN: 0030-2414 , 1423-0232
    URL: Article
    DOI: 10.1159/000500359
    RVK:
    XH 3305
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2019
    detail.hit.zdb_id: 1483096-6
    detail.hit.zdb_id: 250101-6
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  • 10
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    Oblique View Dermoscopy Changes Regular Fibrillar Pattern into Parallel Furrow Pattern
    S. Karger AG ; 2009
    In:  Dermatology Vol. 218, No. 4 ( 2009), p. 385-386
    Details
    In: Dermatology, S. Karger AG, Vol. 218, No. 4 ( 2009), p. 385-386
    Type of Medium: Online Resource
    ISSN: 1421-9832 , 1018-8665
    URL: Article
    DOI: 10.1159/000202986
    RVK:
    XA 37700
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2009
    detail.hit.zdb_id: 1482189-8
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