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  • 1
    In: Urologia Internationalis, S. Karger AG, Vol. 76, No. 3 ( 2006), p. 227-231
    Abstract: 〈 i 〉 Introduction: 〈 /i 〉 The objective of this study was to determine whether the nadir value of serum prostate-specific antigen (PSA) measured by an ultrasensitive assay could be a useful predictor of biochemical recurrence after radical prostatectomy for clinically localized prostate cancer. 〈 i 〉 Materials and Methods: 〈 /i 〉 This study included 127 patients who underwent radical prostatectomy for clinically localized prostate cancer without neoadjuvant hormonal therapy and were pathologically diagnosed as negative for lymph node metastasis. The serum PSA value was measured using an ultrasensitive PSA assay system (Roche Diagnostics, Mannheim, Germany), and the findings were analyzed with respect to several clinicopathological factors. In this series, biochemical recurrence was defined as PSA persistently 〉 0.2 ng/ml. 〈 i 〉 Results: 〈 /i 〉 Based on the nadir PSA value, we divided 127 patients into three groups as follows: group A (n = 99): ≤0.01 ng/ml; group B (n = 16): 0.01–0.05 ng/ml, and group C (n = 12): ≧0.05 ng/ml. The nadir PSA value was significantly associated with preoperative PSA value, but not other conventional clinicopathological prognostic parameters. During the observation period (median 31 months, range 6–75 months), biochemical recurrence occurred in 16 patients, that is, 1 in group A (6.3%), 4 in group B (25.0%), and 11 in group C (91.7%). Multivariate analysis using the Cox proportional hazards regression model indicated that the nadir PSA value was an independent predictor for biochemical recurrence after radical prostatectomy. 〈 i 〉 Conclusion: 〈 /i 〉 These findings suggest that the nadir serum PSA value measured by an ultrasensitive assay could be a useful predictor of biochemical recurrence after radical prostatectomy for clinically localized prostate cancer, and that careful follow-up should be considered in cases demonstrating a nadir PSA value 〉 0.01 ng/ml because of the significantly higher probability of biochemical recurrence in such cases.
    Type of Medium: Online Resource
    ISSN: 0042-1138 , 1423-0399
    RVK:
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2006
    detail.hit.zdb_id: 1464417-4
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  • 2
    In: Human Heredity, S. Karger AG, Vol. 45, No. 4 ( 1995), p. 181-185
    Type of Medium: Online Resource
    ISSN: 1423-0062 , 0001-5652
    RVK:
    Language: English
    Publisher: S. Karger AG
    Publication Date: 1995
    detail.hit.zdb_id: 1482710-4
    SSG: 12
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  • 3
    In: Urologia Internationalis, S. Karger AG, Vol. 76, No. 1 ( 2006), p. 82-86
    Abstract: 〈 i 〉 Introduction: 〈 /i 〉 The objective of this study was to review our experience with urinary reconstruction in patients undergoing surgical management for locally advanced pelvic cancer, and to evaluate the role of urologists in these procedures. 〈 i 〉 Materials and Methods: 〈 /i 〉 This study included a total of 37 patients undergoing some type of urinary reconstruction due to invasion of the urological organs by locally advanced pelvic cancers, including 17 rectal cancers, 9 cervical cancers, 4 sigmoid cancers, 4 retroperitoneal sarcomas, 2 ovarian cancers and 1 appendiceal cancer. Among these 37, 18 were recurrent cancers following initial surgery for primary tumors. The clinical outcomes of these approaches were retrospectively analyzed. 〈 i 〉 Results: 〈 /i 〉 Of the 37 patients, 9 underwent cystectomy (group A) with the following urinary diversions: ileal neobladder in 3, ileal conduit in 5 and colon conduit in 1, and 12 underwent partial cystectomy (group B), among whom 11 received additional urinary reconstruction as follows: bladder flap repair in 5, psoas hitch in 2, ileal ureter in 2, bladder augmentation in 1 and ureteroureterostomy in 1, while the remaining 16 (group C), in whom complete bladder preservation was possible, underwent the following types of urinary reconstruction: bladder flap repair in 6, psoas hitch in 3, en bloc removal of the rectum with prostate in 3, ileal ureter in 2, and ureteroureterostomy in 2. There were 10 early urological complications, including leakage of urine in 7 and acute pyelonephritis in 3. As a late urological complication, hydronephrosis was observed in 8 patients, but ureteral stent was not required in any of these 8. There were no significant differences in the incidence of postoperative complications, the status of surgical margin and the survival among groups A–C. 〈 i 〉 Conclusion: 〈 /i 〉 Our experience with extended surgical management of non-urological pelvic cancer with reconstruction of the urinary tract suggests that the urological portion of this procedure can be performed with acceptable morbidity, and that the role of the urological surgeon during this procedure is potentially important.
    Type of Medium: Online Resource
    ISSN: 0042-1138 , 1423-0399
    RVK:
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2006
    detail.hit.zdb_id: 1464417-4
    Location Call Number Limitation Availability
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  • 4
    In: ORL, S. Karger AG, Vol. 52, No. 6 ( 1990), p. 341-349
    Type of Medium: Online Resource
    ISSN: 1423-0275 , 0301-1569
    Language: English
    Publisher: S. Karger AG
    Publication Date: 1990
    detail.hit.zdb_id: 1483533-2
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  • 5
    In: Urologia Internationalis, S. Karger AG, Vol. 74, No. 1 ( 2005), p. 27-31
    Abstract: 〈 i 〉 Introduction: 〈 /i 〉 The objective of this study was to determine whether the tumor volume in radical prostatectomy specimens of patients with prostate cancer who underwent neoadjuvant hormonal therapy (NHT) could be used as a prognostic predictor. 〈 i 〉 Patients and Methods: 〈 /i 〉 In this study, we included 96 patients who underwent NHT followed by radical prostatectomy between January 1995 and July 2003 in our institutions. Several clinicopathological factors of these patients were analyzed, focusing on the association between tumor volume in radical prostatectomy specimens and disease recurrence. 〈 i 〉 Results: 〈 /i 〉 The tumor volume in radical prostatectomy specimens after NHT was significantly associated with capsular penetration, seminal vesicle invasion, and lymph node metastases, among the factors examined in this study. The biochemical recurrence-free survival rates in patients with tumor volumes 〈 1.0 cm 〈 sup 〉 3 〈 /sup 〉 were significantly higher than in those having tumor volumes ≧1.0 cm 〈 sup 〉 3 〈 /sup 〉 . However, multivariate analysis showed that the tumor volume could not be used as an independent predictor for biochemical recurrence. 〈 i 〉 Conclusions: 〈 /i 〉 In patients who received NHT prior to radical prostatectomy, the tumor volume was shown to correlate with other prognostic indicators. Furthermore, a higher probability of biochemical recurrence was noted, when there was a residual tumor volume ≧1.0 cm 〈 sup 〉 3 〈 /sup 〉 after NHT. Thus, careful follow-up and, if necessary, additional treatment should be considered in cases demonstrating tumor volumes ≧1.0 cm 〈 sup 〉 3 〈 /sup 〉 after NHT.
    Type of Medium: Online Resource
    ISSN: 0042-1138 , 1423-0399
    RVK:
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2005
    detail.hit.zdb_id: 1464417-4
    Location Call Number Limitation Availability
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