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  • S. Karger AG  (4)
  • 1
    Online Resource
    Online Resource
    High Mobility Group B-1 (HMGB-1) Promotes Apoptosis of Macrophage-Derived Foam Cells by Inducing Endoplasmic Reticulum Stress
    S. Karger AG ; 2018
    In:  Cellular Physiology and Biochemistry Vol. 48, No. 3 ( 2018), p. 1019-1029
    Details
    In: Cellular Physiology and Biochemistry, S. Karger AG, Vol. 48, No. 3 ( 2018), p. 1019-1029
    Abstract: Background/Aims: High mobility group B-1 (HMGB-1)-induced endoplasmic reticulum stress (ERS) has been implicated in inflammation and dendritic cell maturation. C/EBP-homologous protein (CHOP) is a vital component of ERS and apoptosis and plays a critical role in atherosclerosis. However, only a little information is available about the role of HMGB-1 in foam cell formation. Thus, the role of HMGB-1-induced ERS/CHOP pathway in apoptosis and formation of macrophage-derived foam cells is investigated. Methods: RAW264.7 cells were treated with oxidized low-density lipoprotein (oxLDL) in the absence and/or presence of HMGB-1, N-acetylcysteine (NAC, an antioxidant), glycyrrhizin (Gly, an HMGB-1 inhibitor), tunicamycin (TM, an ERS inducer), and 4-phenylbutyrate (4-PBA, an ERS inhibitor). Reactive oxygen species (ROS) production was examined by dihydroethidium (DHE) staining. Oil Red O staining, intracellular total cholesterol assay, and Dil-oxLDL uptake assay evaluated the accumulation of lipids in macrophages. Cell apoptosis was measured by flow cytometry and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining. Western blot detected the expression of HMGB-1/ERS/CHOP pathway. Results: oxLDL induced HMGB-1 translocation and secretion in a dose- and time-dependent manner, which was inhibited by NAC. oxLDL-induced lipid accumulation in macrophages was promoted synergistically by HMGB-1 that was attenuated by Gly. Moreover, TM synergized with oxLDL induced lipid accumulation and apoptosis of macrophages; however, 4-PBA alleviated the oxLDL-induced apoptotic foam cells. Additionally, the inhibition of ERS with 4-PBA suppressed the expression of HMGB-1-induced CHOP. Conclusions: OxLDL triggered HMGB-1 secretion in macrophages via oxidative stress. Furthermore, HMGB-1 promoted the formation and apoptosis of macrophage-derived foam cells via activation of ERS/CHOP pathway.
    Type of Medium: Online Resource
    ISSN: 1015-8987 , 1421-9778
    URL: Article
    DOI: 10.1159/000491970
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2018
    detail.hit.zdb_id: 1482056-0
    SSG: 12
    SSG: 15,3
    Location Call Number Limitation Availability
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    Online Resource
  • 2
    Online Resource
    Online Resource
    Emerging Role of High Mobility Group Box-1 in Thrombosis-Related Diseases
    S. Karger AG ; 2018
    In:  Cellular Physiology and Biochemistry Vol. 47, No. 4 ( 2018), p. 1319-1337
    Details
    In: Cellular Physiology and Biochemistry, S. Karger AG, Vol. 47, No. 4 ( 2018), p. 1319-1337
    Abstract: High mobility group box-1 (HMGB-1), a typical damage-associated molecular pattern protein released from various cells, was first identified in 1973. It is usually stored in the nuclei of cells. Several modifications of HMGB-1 promote its translocation to the cytosol, and it is actively or passively released from cells. When outside of the cells, HMGB-1is crucial in inflammation. It exerts its biological functions via interaction with its receptors, including receptor for advanced glycation end products (RAGE) and Toll-like receptor 4(TLR4). A large number of studies showed a close link between inflammation and thrombosis. This review demonstrated the increased expression of HMGB-1 in thrombosis-related diseases, including coronary artery disease, stroke, peripheral arterial disease, disseminated intravascular coagulation, and venous thrombosis. Besides, it summarized the current understanding of the emerging link between HMGB-1 and thrombosis from three aspects: platelet, NETs, and coagulation and fibrinolysis factors. Finally, it explored the possible therapeutic strategies targeting HMGB-1 for treating thrombosis-related diseases.
    Type of Medium: Online Resource
    ISSN: 1015-8987 , 1421-9778
    URL: Article
    DOI: 10.1159/000490818
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2018
    detail.hit.zdb_id: 1482056-0
    SSG: 12
    SSG: 15,3
    Location Call Number Limitation Availability
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    Online Resource
  • 3
    Online Resource
    Online Resource
    High Renal Mast Cell Density Is Associated with Poor Prognosis in Patients with Immunoglobulin A Nephropathy
    S. Karger AG ; 2023
    In:  American Journal of Nephrology
    Details
    In: American Journal of Nephrology, S. Karger AG
    Abstract: Introduction: This observational cohort study evaluated the prognostic value of mast cells in the pathogenesis and progression of IgA nephropathy. Methods: A total of 76 adult IgAN patients were enrolled into this study from Jan 2007 and June 2010. Immunohistochemistry and immunofluorescence were used to identify tryptase-positive mast cells in renal biopsy samples. Patients were classified into Tryptasehigh and Tryptaselow groups. Depending on an average of 96-month follow-up, the predictive value of tryptase-positive mast cells in IgAN progression was analyzed. Results: Tryptase-positive mast cells were found frequently in IgAN kidneys while rarely observed in normal kidneys. We also found IgAN patients in Tryptasehigh group presented both severe clinical and pathological renal manifestations. Furthermore, Tryptasehigh group contained more interstitial macrophages and lymphocytes infiltration than Tryptaselow group. Higher tryptase-positive cells density is associated with poor prognosis in patients with IgAN. Conclusions: High renal mast cells density is associated with severe renal lesions and poor prognosis in patients with Immunoglobulin A nephropathy. High renal mast cells density might be used as a predictor of poor prognosis in patients with IgAN.
    Type of Medium: Online Resource
    ISSN: 0250-8095 , 1421-9670
    URL: Article
    DOI: 10.1159/000531243
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2023
    detail.hit.zdb_id: 1468523-1
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  • 4
    Online Resource
    Online Resource
    Genetic Variations rs859, rs4646, and rs372883 in the 3′-Untranslated Regions of Genes Are Associated with a Risk of IgA Nephropathy
    S. Karger AG ; 2019
    In:  Kidney and Blood Pressure Research Vol. 44, No. 2 ( 2019), p. 233-244
    Details
    In: Kidney and Blood Pressure Research, S. Karger AG, Vol. 44, No. 2 ( 2019), p. 233-244
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 Previous studies indicate that genetic factors play an important role in the pathogenesis of IgA nephropathy (IgAN). To evaluate the association between single nucleotide polymorphisms (SNPs) in the 3′-untranslated region (3′-UTR) of genes and IgAN risk, we performed a case-control study in a Chinese Han population. 〈 b 〉 〈 i 〉 Materials: 〈 /i 〉 〈 /b 〉 Twelve SNPs were selected and genotyped in 384 IgAN patients and 357 healthy controls. Odds ratio (OR) and 95% confidence intervals (CI) were calculated by logistic regression adjusted for age and gender. Multifactor dimensionality reduction (MDR) was used to analyze the interaction of SNP-SNP with IgAN risk. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Our study demonstrated that 〈 i 〉 IL-16 〈 /i 〉 rs859 (OR = 0.75, 〈 i 〉 p 〈 /i 〉 = 0.040) and 〈 i 〉 CYP19A1 〈 /i 〉 rs4646 (OR = 2.58, 〈 i 〉 p 〈 /i 〉 = 0.017) polymorphism were related to the risk of IgAN. In stratified analyses by gender, 〈 i 〉 CYP19A1 〈 /i 〉 rs4646 (OR = 2.96, 〈 i 〉 p 〈 /i 〉 = 0.015) and 〈 i 〉 BACH1 〈 /i 〉 rs372883 (OR = 1.81, 〈 i 〉 p 〈 /i 〉 = 0.038) polymorphisms conferred susceptibility to IgAN in males. Besides, rs372883 reduced IgAN risk in females (OR = 0.44, 〈 i 〉 p 〈 /i 〉 = 0.042). We also found rs859 polymorphism was correlated with grade I-II (OR = 0.42, 〈 i 〉 p 〈 /i 〉 = 0.028) in subgroup analysis of Lee’s classification. Additionally, we found rs4646 polymorphism was correlated with serum creatinine ( 〈 i 〉 p 〈 /i 〉 = 0.035). 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 Our results suggested that the 〈 i 〉 IL-16 〈 /i 〉 rs859, 〈 i 〉 CYP19A1 〈 /i 〉 rs4646, and 〈 i 〉 BACH1 〈 /i 〉 rs372883 polymorphisms have potential roles in the genetic susceptibility to IgAN in Chinese Han population.
    Type of Medium: Online Resource
    ISSN: 1420-4096 , 1423-0143
    URL: Article
    DOI: 10.1159/000498961
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2019
    detail.hit.zdb_id: 1482922-8
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