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  • 1
    In: Digestive Surgery, S. Karger AG, Vol. 40, No. 1-2 ( 2023), p. 57-67
    Abstract: 〈 b 〉 〈 i 〉 Introduction: 〈 /i 〉 〈 /b 〉 The balance between potential oncological merits and surgical risks is unclear for the additional step of performing paratracheal lymphadenectomy during esophagectomy for cancer. This study aimed to investigate the impact of paratracheal lymphadenectomy on lymph node yield and short-term outcomes in patients who underwent this procedure in the Netherlands. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Patients who underwent neoadjuvant chemoradiotherapy followed by transthoracic esophagectomy were included from the Dutch Upper Gastrointestinal Cancer Audit (DUCA). After propensity score matching Ivor Lewis and McKeown approaches separately, lymph node yield and short-term outcomes were compared between patients who underwent paratracheal lymphadenectomy versus patients who did not. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Between 2011 and 2017, 2,128 patients were included. Some 770 patients ( 〈 i 〉 n 〈 /i 〉 = 385 vs. 〈 i 〉 n 〈 /i 〉 = 385) and 516 patients ( 〈 i 〉 n 〈 /i 〉 = 258 vs. 〈 i 〉 n 〈 /i 〉 = 258) were matched for the Ivor Lewis and McKeown approaches, respectively. Paratracheal lymphadenectomy was associated with a higher lymph node yield in Ivor Lewis (23 vs. 19 nodes, 〈 i 〉 p 〈 /i 〉 & lt; 0.001) and McKeown (21 vs. 19 nodes, 〈 i 〉 p 〈 /i 〉 = 0.015) esophagectomy. There were no significant differences in complications or mortality. After Ivor Lewis esophagectomy, paratracheal lymphadenectomy was associated with longer length of stay (12 vs. 11 days, 〈 i 〉 p 〈 /i 〉 & lt; 0.048). After McKeown esophagectomy, paratracheal lymphadenectomy was associated with more re-interventions (30% vs. 18%, 〈 i 〉 p 〈 /i 〉 = 0.002). 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 Paratracheal lymphadenectomy resulted in a higher lymph node yield but also in longer length of stay after Ivor Lewis and more re-interventions following McKeown esophagectomy.
    Type of Medium: Online Resource
    ISSN: 0253-4886 , 1421-9883
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2023
    detail.hit.zdb_id: 1468560-7
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  • 2
    In: Digestive Surgery, S. Karger AG, Vol. 32, No. 5 ( 2015), p. 361-366
    Abstract: 〈 b 〉 〈 i 〉 Background/Aims: 〈 /i 〉 〈 /b 〉 Esophagectomies are associated with high morbidity. To assess the complication severity, the Clavien-Dindo classification (CDC) grades the most severe complication. However, it ignores additional complications that are equal or less severe. The comprehensive complication index (CCI) incorporates all complication severities. It might therefore be a better system to assess the severities. The aim of this study was to validate the CCI compared to the CDC. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 A prospective database was used to analyze 621 patients, who underwent an esophagectomy between 1993 and 2005. The CCI was calculated and the relation with traditional parameters was assessed and compared to the relation of the CDC with these parameters. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Complications occurred in 429 patients (69.1%). The correlation between the CCI and the CDC was r = 0.987, p 〈 0.01. The relation of the CCI with 3 out of 7 parameters was not significantly different compared to the relation of the CDC (p 〉 0.05). There was a significantly stronger relation (p 〈 0.05) of the CCI with length of stay (LOS) (r = 0.663 vs. 0.646), a prolonged LOS (r = 0.542 vs. 0.530), reintervention, (r = 0.437 vs. 0.422) and reoperation rate (0.489 vs. 0.471) than the CDC. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 Therefore, the CCI could be a promising scoring system that could be used to identify risks in surgical patient groups.
    Type of Medium: Online Resource
    ISSN: 0253-4886 , 1421-9883
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2015
    detail.hit.zdb_id: 1468560-7
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  • 3
    Online Resource
    Online Resource
    S. Karger AG ; 2005
    In:  Digestive Surgery Vol. 22, No. 1-2 ( 2005), p. 91-94
    In: Digestive Surgery, S. Karger AG, Vol. 22, No. 1-2 ( 2005), p. 91-94
    Abstract: 〈 i 〉 Background: 〈 /i 〉 Recent publications show promising results using fibrin glue in the treatment of anal fistulas. The technique is simple, repeatable, with minor surgical trauma so that sphincter function is preserved and further treatment options are not compromised. The aim of this pilot study was to analyse if we could reproduce the results reported in the literature, using this simple technique. 〈 i 〉 Methods: 〈 /i 〉 Patients with a primary or recurrent anal fistula were included in this trial. Patients with a complex fistula were excluded. Under general or spinal anaesthesia, the fistulas were curetted and injected with fibrin glue. Follow-up visits were scheduled for 1 week, 6 weeks and 6 months. 〈 i 〉 Results: 〈 /i 〉 Twenty-seven patients were included. The overall success rate was 33% after a mean follow-up of 27 weeks. Patients with a recurrent fistula had a poorer outcome (success rate 14%). None of the patients suffered from postoperative continence problems, and no other complications were recorded. 〈 i 〉 Conclusion: 〈 /i 〉 This study confirms the safety of fibrin glue in the treatment of anal fistulas. However, a high success rate could not be reproduced.
    Type of Medium: Online Resource
    ISSN: 0253-4886 , 1421-9883
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2005
    detail.hit.zdb_id: 1468560-7
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  • 4
    In: Digestive Surgery, S. Karger AG, Vol. 40, No. 1-2 ( 2023), p. 76-83
    Abstract: Introduction: Curative therapy for gastric cancer usually consists of perioperative chemotherapy combined with a radical (R0) gastrectomy. In addition to a modified D2 lymphadenectomy, a complete omentectomy is recommended. However, there is little evidence for a survival benefit of omentectomy. This study presents the follow-up data of the OMEGA study. Methods: This multicenter prospective cohort study included 100 consecutive patients with gastric cancer undergoing (sub)total gastrectomy with complete en bloc omentectomy and modified D2 lymphadenectomy. Primary outcome of the current study was 5-year overall survival. Patients with or without omental metastases were compared. Pathological factors associated with locoregional recurrence and/or metastases were tested with multivariable regression analysis. Results: Of 100 included patients, five had metastases in the greater omentum. Five-year overall survival was 0.0% in patients with omental metastases and 44.2% in patients without omental metastases (p = 0.001). Median overall survival time for patients with or without omental metastases was 7 months and 53 months. A (y)pT3–4 stage tumor and vasoinvasive growth were associated with locoregional recurrence and/or metastases in patients without omental metastases. Conclusion: The presence of omental metastases in gastric cancer patients who underwent potentially curative surgery was associated with impaired overall survival. Omentectomy as part of radical gastrectomy for gastric cancer might not contribute to a survival benefit in case of undetected omental metastases.
    Type of Medium: Online Resource
    ISSN: 0253-4886 , 1421-9883
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2023
    detail.hit.zdb_id: 1468560-7
    Location Call Number Limitation Availability
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