GLORIA

GEOMAR Library Ocean Research Information Access

X

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Online Resource
    Online Resource
    Autologous Stem Cell Transplantation in Multiple Myeloma in the Era of Novel Drug Induction: A Retrospective Single-Center Analysis
    S. Karger AG ; 2017
    In:  Acta Haematologica Vol. 137, No. 3 ( 2017), p. 163-172
    Details
    In: Acta Haematologica, S. Karger AG, Vol. 137, No. 3 ( 2017), p. 163-172
    Abstract: Within this retrospective single-center study, we analyzed the survival of 320 multiple myeloma (MM) patients receiving melphalan high-dose chemotherapy (HDCT) and either single ( 〈 i 〉 n 〈 /i 〉 = 286) or tandem ( 〈 i 〉 n 〈 /i 〉 = 34) autologous stem cell transplantation (ASCT) from 1996 to 2012. Additionally, the impact of novel induction regimens was assessed. Median follow-up was 67 months, median overall survival (OS) 62 months, median progression-free survival (PFS) 33 months (95% CI 27-39), and treatment-related death (TRD) 3%. Multivariate analysis revealed age ≥60 years ( 〈 i 〉 p = 〈 /i 〉 0.03) and stage 3 according to the International Staging System ( 〈 i 〉 p = 〈 /i 〉 0.006) as adverse risk factors regarding PFS. Median OS was significantly better in newly diagnosed MM patients receiving induction therapy with novel agents, e.g., bortezomib, thalidomide, or lenalidomide, compared with a traditional regimen (69 vs. 58 months; 〈 i 〉 p = 〈 /i 〉 0.01). More patients achieved at least a very good partial remission in the period from 2005 to 2012 than from 1996 to 2004 (65 vs. 30%; 〈 i 〉 p 〈 /i 〉 〈 0.001), with a longer median OS in the later period (71 vs. 52 months, 〈 i 〉 p 〈 /i 〉 = 0.027). In conclusion, our analysis confirms HDCT-ASCT as an effective therapeutic strategy in an unselected large myeloma patient cohort with a low TRD rate and improved prognosis due to novel induction strategies.
    Type of Medium: Online Resource
    ISSN: 0001-5792 , 1421-9662
    URL: Article
    DOI: 10.1159/000463534
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2017
    detail.hit.zdb_id: 1481888-7
    detail.hit.zdb_id: 80008-9
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 2
    Online Resource
    Online Resource
    Noninvasive Prediction of Twitch Transdiaphragmatic Pressure: Insights from Spirometry, Diaphragm Ultrasound, and Phrenic Nerve Stimulation Studies
    S. Karger AG ; 2019
    In:  Respiration Vol. 98, No. 4 ( 2019), p. 301-311
    Details
    In: Respiration, S. Karger AG, Vol. 98, No. 4 ( 2019), p. 301-311
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 Twitch transdiaphragmatic pressure (twPdi) following magnetic stimulation (MS) of the phrenic nerves is the gold standard for non-volitional assessment of diaphragm strength. Expiratory muscle function can be investigated using MS of the abdominal muscles and measurement of twitch gastric pressure (twPgas). 〈 b 〉 〈 i 〉 Objectives: 〈 /i 〉 〈 /b 〉 To investigate whether twitch pressures following MS of the phrenic and lower thoracic nerve roots can be predicted noninvasively by diaphragm ultrasound parameters and volitional tests of respiratory muscle strength. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Sixty-three healthy subjects underwent standard spirometry, measurement of maximum inspiratory (PI 〈 sub 〉 max 〈 /sub 〉 ) and expiratory pressure (PE 〈 sub 〉 max 〈 /sub 〉 ), and diaphragm ultrasound. TwPdi following cervical MS of the phrenic nerve roots and twPgas after lower thoracic MS (twPgas-Thor) were measured using esophageal and gastric balloon catheters inserted transnasally. Using surface electrodes, compound muscle action potentials (CMAP) were simultaneously recorded from the diaphragm or obliquus abdominis muscles, respectively. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Forced expiratory flow (FEF 〈 sub 〉 25–75 〈 /sub 〉 ) was significantly correlated with twPdi ( 〈 i 〉 r 〈 /i 〉 = 0.37; 〈 i 〉 p 〈 /i 〉 = 0.003) and its components (twPgas and twitch esophageal pressure, twPes). Diaphragm excursion velocity during tidal breathing was correlated to twPes ( 〈 i 〉 r 〈 /i 〉 = 0.44; 〈 i 〉 p 〈 /i 〉 = 0.02). No prediction of twitch pressures was possible from CMAP amplitude, forced vital capacity (FVC), or PI 〈 sub 〉 max 〈 /sub 〉 . TwPgas-Thor was correlated with FEF 〈 sub 〉 25–75 〈 /sub 〉 ( 〈 i 〉 r 〈 /i 〉 = 0.46; 〈 i 〉 p 〈 /i 〉 = 0.05) and diaphragm thickness at total lung capacity ( 〈 i 〉 r 〈 /i 〉 = 0.38; 〈 i 〉 p 〈 /i 〉 = 0.04) but could not be predicted from CMAP amplitude, FVC, or PE 〈 sub 〉 max 〈 /sub 〉 . 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 TwPdi and twPgas-Thor cannot be predicted from volitional measures of respiratory muscle strength, diaphragm and abdominal CMAP, or diaphragm ultrasound. Invasive recording of esophageal and gastric pressures following MS remains indispensable for objective assessment of respiratory muscle strength.
    Type of Medium: Online Resource
    ISSN: 0025-7931 , 1423-0356
    URL: Article
    DOI: 10.1159/000501171
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2019
    detail.hit.zdb_id: 1464419-8
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 3
    Online Resource
    Online Resource
    Validation of a Nomogram Predicting Non-Sentinel Lymph Node Metastases among Patients with Breast Cancer after Primary Systemic Therapy - a transSENTINA Substudy
    S. Karger AG ; 2018
    In:  Breast Care Vol. 13, No. 6 ( 2018), p. 440-446
    Details
    In: Breast Care, S. Karger AG, Vol. 13, No. 6 ( 2018), p. 440-446
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 Prediction of non-sentinel lymph node (SLN) status after primary systemic therapy (PST) may allow tailored axillary staging. The aim of this analysis was to compare established nomograms from i) the primary operative (n = 6) and ii) the neoadjuvant (n = 1) setting with an optimized nomogram to predict non-SLN status in patients after PST. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 181 patients converting from cN1 prior to PST to ycN0 but found to have a histologically positive SLN in the SENTINA trial were analyzed. Established models were applied. An optimized model was compiled using univariate and subsequent multivariable logistic regression (backward selection, likelihood ratio test). 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Area-under-the-curve (AUC) values from the primary operative models showed sufficient performance (0.82-0.71). For the neoadjuvant model, the AUC was found to be inferior to prior analyses (0.66) but within published confidence intervals. The SENTINA nomogram comprised the diameter of the largest lymph node (p = 0.006, odds ratio (OR) = 1.19), tumor size prior to PST (p = 0.085, OR = 1.31), and number of all positive SLN (p = 0.083, OR = 2.04). This model was validated using a separate cohort of arm C (n = 168, AUC 0.79, 95% confidence interval 0.74-0.85). 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 We validated 7 models of prediction of non-SLN among patients showing axillary conversion through PST. Our own ‘SENTINA nomogram' yielded AUC values comparable to previous nomograms.
    Type of Medium: Online Resource
    ISSN: 1661-3791 , 1661-3805
    URL: Article
    DOI: 10.1159/000489565
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2018
    detail.hit.zdb_id: 2205941-6
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...