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  • 1
    Online Resource
    Online Resource
    Mortality and Blood Pressure in Elderly People with and without Cognitive Impairment
    S. Karger AG ; 2005
    In:  Gerontology Vol. 51, No. 1 ( 2005), p. 53-61
    Details
    In: Gerontology, S. Karger AG, Vol. 51, No. 1 ( 2005), p. 53-61
    Abstract: 〈 i 〉 Background: 〈 /i 〉 Controversial data are available on the association between mortality, blood pressure and cognitive impairment in the elderly. 〈 i 〉 Objective: 〈 /i 〉 To verify the role of blood pressure on mortality in an elderly population with and without cognitive impairment. 〈 i 〉 Methods: 〈 /i 〉 A cross-sectional survey with a 6-year mortality evaluation was conducted in a region of southern Italy in elderly subjects with and without cognitive impairment. Subjects were divided into 4 groups on the basis of systolic, diastolic, mean and pulse blood pressure values. 〈 i 〉 Results: 〈 /i 〉 Mortality shows a linear relationship with pulse blood pressure and a U-curve shape for diastolic blood pressure. This phenomenon was more evident in subjects with cognitive impairment showing the greatest risk of mortality at the lowest and highest levels of diastolic blood pressure. 〈 i 〉 Conclusion: 〈 /i 〉 The study shows that mortality increases linearly with increasing blood pressure in the elderly. In contrast, mortality shows a U-shape curve for diastolic blood pressure; cognitively impaired patients with the lowest and highest diastolic blood pressures show the greatest relative risk of mortality.
    Type of Medium: Online Resource
    ISSN: 0304-324X , 1423-0003
    URL: Article
    DOI: 10.1159/000081436
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2005
    detail.hit.zdb_id: 1482689-6
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  • 2
    Online Resource
    Online Resource
    Efficacy, Safety and Outcomes of ‘Inject and Cut’ Endoscopic Mucosal Resection for Large Sessile and Flat Colorectal Polyps
    S. Karger AG ; 2010
    In:  Digestion Vol. 82, No. 4 ( 2010), p. 213-220
    Details
    In: Digestion, S. Karger AG, Vol. 82, No. 4 ( 2010), p. 213-220
    Abstract: 〈 i 〉 Background and Study Aims: 〈 /i 〉 The study examines the outcomes of the ‘inject and cut’ endoscopic mucosal resection (EMR), for large sessile and flat colorectal polyps. 〈 i 〉 Patients and Methods: 〈 /i 〉 Between January 2006 and December 2008 all patients referred to our institution for EMR of large polyps were prospectively evaluated. The accuracy of lifting sign and the rate of en bloc and piecemeal resection, complications and recurrence were analyzed. 〈 i 〉 Results: 〈 /i 〉 A total of 157 patients with 182 lesions (median size 24.7 ± 10.2 mm) were included in the study. The most frequent location was the sigmoid colon in 30.2%. Because of non-lifting sign, 5/182 lesions were referred to surgical resection and 177 (43 flat and 134 sessile) were resected, 79 (44.6%) en bloc and 98 (55.4%) piecemeal. There were 20 procedural (11.3%) and 2 late (1.1%) bleeding, 4 post-polypectomy syndrome (2.2%) and 2 perforations (1.1%). Bleeding was related to malignancy (p = 0.01). Intramucosal cancer was observed in 5 cases (2.8%) while invasive cancer was seen in 8 (4.5%). Malignancy was related to polyp size ≧30 mm (p = 0.002). Follow-up colonoscopy was performed in 147 patients with 172 EMR for a mean of 19.8 months. Recurrence was observed in 12/172 (6.9%) polyps. 〈 i 〉 Conclusion: 〈 /i 〉 Inject and cut EMR is practical and effective with a low risk of complication and local recurrence.
    Type of Medium: Online Resource
    ISSN: 0012-2823 , 1421-9867
    URL: Article
    DOI: 10.1159/000284397
    RVK:
    XA 40650
    RVK:
    XA 10000
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2010
    detail.hit.zdb_id: 1482218-0
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  • 3
    Online Resource
    Online Resource
    Reference Ranges and Determinants of Tricuspid Regurgitation Velocity in Healthy Adults Assessed by Two-Dimensional Doppler-Echocardiography
    S. Karger AG ; 2018
    In:  Respiration Vol. 96, No. 5 ( 2018), p. 425-433
    Details
    In: Respiration, S. Karger AG, Vol. 96, No. 5 ( 2018), p. 425-433
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 Tricuspid regurgitation velocity (TRV) is the most widely used parameter by transthoracic echocardiography (TTE) in the evaluation of patients with suspected pulmonary hypertension (PH). 〈 b 〉 〈 i 〉 Objectives: 〈 /i 〉 〈 /b 〉 To explore the physiologic range of TRV in healthy adults and to investigate its clinical determinants. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 In the first part of the study, 614 healthy individuals (age 45.7± 14.7 years, 60.26% women) were prospectively assessed by TTE. In the second part, a pooled meta-analysis of 16 already published studies with TRV values in healthy subjects ( 〈 i 〉 n 〈 /i 〉 = 981) was performed. Statistical analysis included the calculation of 95% quantiles for defining reference ranges. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 In the prospectively enrolled cohort, mean TRV was 2.01 ± 0.29 m/s (5–95% CI 1.987–2.033 m/s). It was significantly but weakly positively correlated with age, body mass index, systolic blood pressure, diastolic blood pressure, left atrial volume and negative with mitral inflow E/A ratio. No significant differences were found between males and females. The prospectively enrolled data revealed similar values to the literature-based datasets resulting in a mean TRV of 1.96 m/s (95% CI 1.91–2.02 m/s) and a 95% quantile of 2.55 m/s. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 To the best of our knowledge, this is the largest dataset to describe reference ranges of TRV and their clinical determinants in healthy adults years. The determined cut-off value of 2.55 m/s of this study has to be confirmed in specific pathologies such as patients at risk of PH.
    Type of Medium: Online Resource
    ISSN: 0025-7931 , 1423-0356
    URL: Article
    DOI: 10.1159/000490191
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2018
    detail.hit.zdb_id: 1464419-8
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  • 4
    Online Resource
    Online Resource
    A Point Prevalence Study of Delirium in Italian Nursing Homes
    S. Karger AG ; 2018
    In:  Dementia and Geriatric Cognitive Disorders Vol. 46, No. 1-2 ( 2018), p. 27-41
    Details
    In: Dementia and Geriatric Cognitive Disorders, S. Karger AG, Vol. 46, No. 1-2 ( 2018), p. 27-41
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 Delirium is a common geriatric syndrome. Few studies have been conducted in nursing home (NH) residents. The aim of this project was to perform a point prevalence study of delirium in Italian NHs. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Data collected in 71 NHs are presented. Inclusion criteria were age ≥65 years and native Italian speaker. Exclusion criteria were coma, aphasia, and end-of-life status. Sociodemographic and medical data were recorded. Delirium was assessed using the Assessment Test for Delirium and Cognitive Impairment (4-AT). Patients with a 4-AT score ≥4 were considered to have delirium. Motor subtype was evaluated using the Delirium Motor Subtype Scale (DMSS). 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 A total of 1,454 patients were evaluated (mean age 84.4 ± 7.4 years, 70.2% female), of whom 535 (36.8%) had delirium. In multivariate logistic regression analysis, variables significantly associated with delirium were education (OR 0.94, 95% CI 0.91–0.97), dementia (OR 3.12, 95% CI 2.38–4.09), functional dependence (OR 6.13, 95% CI 3.08–12.19 for ADL score 0; OR 1.99, 95% CI 1.03–3.84 for ADL score 1–5), malnutrition (OR 4.87, 95% CI 2.68–8.84), antipsychotics (OR 2.40, 95% CI 1.81–3.18), and physical restraints (OR 2.48, 95% CI 1.71–3.59). 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 Delirium is common in older NH residents. Simple assessment tools might facilitate its recognition in this vulnerable population.
    Type of Medium: Online Resource
    ISSN: 1420-8008 , 1421-9824
    URL: Article
    DOI: 10.1159/000490722
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2018
    detail.hit.zdb_id: 1482186-2
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  • 5
    Online Resource
    Online Resource
    Screening of Depressive Symptoms in Young–Old Hemodialysis Patients: Relationship between Beck Depression Inventory and 15-Item Geriatric Depression Scale
    S. Karger AG ; 2007
    In:  Nephron Clinical Practice Vol. 106, No. 4 ( 2007-6-26), p. c187-c192
    Details
    In: Nephron Clinical Practice, S. Karger AG, Vol. 106, No. 4 ( 2007-6-26), p. c187-c192
    Abstract: 〈 i 〉 Aims: 〈 /i 〉 We studied the relationship between the Beck Depression Inventory (BDI) and the 15-item Geriatric Depression Scale (GDS-15) in young–old hemodialysis and hospitalized patients in order to evaluate the possible usefulness of GDS-15 in hemodialysis patients. 〈 i 〉 Methods: 〈 /i 〉 Thirty-one hospitalized and 31 young–old hemodialysis patients aged 65–74 (young–old) were enrolled in the study. Comprehensive geriatric assessment (Mini Mental State Examination (MMSE), BDI, GDS-15, Cumulative Illness Rating Scale (CIRS) and Activities of Daily Living (ADL)) was made for all patients. The internal consistency between BDI and GDS-15 was evaluated with Cronbach’s α coefficient. Sensitivity, specificity and receiver operating characteristic (ROC) curves for GDS-15 were determined using BDI as the standard. 〈 i 〉 Results: 〈 /i 〉 In the hospitalized group, the prevalence of depressive symptoms, as evaluated by BDI (≧14) and GDS-15 (≧6), were 29 and 32%, respectively. In the hemodialysis group, the prevalence of depressive symptoms, as evaluated by BDI and GDS-15, were 61 and 58%, respectively. A significantly positive correlation between the BDI and GDS-15 was found in hospitalized (r = 0.808; p 〈 0.001), hemodialysis (r = 0.692; p 〈 0.001) and both patient groups together (r = 0.777; p 〈 0.001). The area under the ROC curve was 0.99 in the hospitalized and 0.95 in the hemodialysis groups. The ROC curves indicate a best effectiveness cutoff point (balancing sensitivity and specificity) of ≧6 for GDS-15 compared to BDI. 〈 i 〉 Conclusions: 〈 /i 〉 The GDS-15 could be a useful instrument for evaluating depressive symptoms in young–old hemodialysis patients.
    Type of Medium: Online Resource
    ISSN: 1660-2110
    URL: Article
    DOI: 10.1159/000104430
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2007
    detail.hit.zdb_id: 2098336-0
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  • 6
    Online Resource
    Online Resource
    A Preventive Intervention Program in Adolescent Schoolgirls:A Longitudin al Study
    S. Karger AG ; 1999
    In:  Psychotherapy and Psychosomatics Vol. 68, No. 1 ( 1999), p. 46-50
    Details
    In: Psychotherapy and Psychosomatics, S. Karger AG, Vol. 68, No. 1 ( 1999), p. 46-50
    Abstract: 〈 i 〉 Background: 〈 /i 〉 To explore the impact of a prevention program on the eating and body attitudes of a sample of adolescent schoolgirls. 〈 i 〉 Methods: 〈 /i 〉 The program involved lessons and group discussions of general adolescent problems and eating disorders. A total of 254 16-year-old schoolgirls were evaluated, of whom 154 participated in the program and a further 154 subjects formed the control group. Variations in weight, Eating Attitudes Test and Eating Disorders Inventory at a 1-year follow-up were compared for the two groups. 〈 i 〉 Results: 〈 /i 〉 Among high-risk subjects, no significant differences were found between the prevention and the control group. The preventive program appeared to reduce significantly body dissatisfaction and to decrease the risk of bulimic attitudes in low-risk subjects. 〈 i 〉 Conclusions: 〈 /i 〉 Providing schoolgirls with the correct information about eating disorders did not encourage unhealthy attitudes to eating and weight regulation practices. However, for high-risk subjects more intensive and specific intervention may be required, for which further research is needed.
    Type of Medium: Online Resource
    ISSN: 0033-3190 , 1423-0348
    URL: Article
    DOI: 10.1159/000012310
    RVK:
    CU 5500
    RVK:
    XA 10000
    Language: English
    Publisher: S. Karger AG
    Publication Date: 1999
    detail.hit.zdb_id: 1472321-9
    SSG: 5,2
    SSG: 15,3
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  • 7
    Online Resource
    Online Resource
    Is the Sympathetic Nervous System Altered in Children with Familial History of Arterial Hypertension?
    S. Karger AG ; 1988
    In:  Cardiology Vol. 75, No. 3 ( 1988), p. 200-205
    Details
    In: Cardiology, S. Karger AG, Vol. 75, No. 3 ( 1988), p. 200-205
    Type of Medium: Online Resource
    ISSN: 1421-9751 , 0008-6312
    URL: Article
    DOI: 10.1159/000174371
    RVK:
    XA 36200
    Language: English
    Publisher: S. Karger AG
    Publication Date: 1988
    detail.hit.zdb_id: 1482041-9
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