In:
Human Heredity, S. Karger AG, Vol. 59, No. 1 ( 2005), p. 34-40
Abstract:
〈 i 〉 Objective: 〈 /i 〉 Despite the well known genetic component influencing plasma lipid-lipoprotein levels and the observed correlations among these traits, little is known about pleiotropic heritable determinants among them. Our aim is to investigate pair-wise polygenic and environmental correlations among lipid-lipoprotein levels at baseline and in response to regular exercise in Whites and Blacks. 〈 i 〉 Methods: 〈 /i 〉 Common pair-wise genetic and environmental correlations among levels of total cholesterol (TC), LDL-C, ApoB, HDL-C (also HDL 〈 sub 〉 2 〈 /sub 〉 -C and HDL 〈 sub 〉 3 〈 /sub 〉 -C), triglycerides (TG, HDL-TG and LDL-TG) and ApoA-1 were investigated at baseline and again after a 20-week endurance exercise program using a variance-components-decomposition. 〈 i 〉 Results: 〈 /i 〉 With a few exceptions, all lipid phenotypes were heritable at baseline and for training responses in Blacks and Whites. Strong to high genetic and environmental correlations (0.4 〈 ρ 〈 sub 〉 g 〈 /sub 〉 〈 0.7) were observed for the majority of the baseline pair-wise traits. For training responses, many of the same patterns were noted, although fewer genetic correlations were significant as compared to the baseline results. 〈 i 〉 Conclusions: 〈 /i 〉 Results suggest that the observed phenotypic correlations among many of these traits may be due to in part to pleiotropic genes, in particular between LDL-C and ApoB and between TG and HDL-C. This shared genetic architecture should be considered in follow-up gene finding studies.
Type of Medium:
Online Resource
ISSN:
0001-5652
,
1423-0062
Language:
English
Publisher:
S. Karger AG
Publication Date:
2005
detail.hit.zdb_id:
1482710-4
SSG:
12
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