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  • 1
    Online Resource
    Online Resource
    Precancerous Lesions and Carcinoma of the Pancreas
    S. Karger AG ; 2015
    In:  Visceral Medicine Vol. 31, No. 1 ( 2015), p. 53-57
    Details
    In: Visceral Medicine, S. Karger AG, Vol. 31, No. 1 ( 2015), p. 53-57
    Type of Medium: Online Resource
    ISSN: 2297-4725 , 2297-475X
    URL: Article
    DOI: 10.1159/000375245
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2015
    detail.hit.zdb_id: 2850734-4
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  • 2
    Online Resource
    Online Resource
    Evaluation of a Product Containing Xyloglucan and Pea Protein on Skin Barrier Permeability
    S. Karger AG ; 2020
    In:  Skin Pharmacology and Physiology Vol. 33, No. 4 ( 2020), p. 231-236
    Details
    In: Skin Pharmacology and Physiology, S. Karger AG, Vol. 33, No. 4 ( 2020), p. 231-236
    Abstract: 〈 b 〉 〈 i 〉 Objective: 〈 /i 〉 〈 /b 〉 The skin acts as a mechanical and protective barrier against viral, fungal, and bacterial infections. Skin conditions such as atopic dermatitis and psoriasis are characterized by alterations of the skin barrier, often caused by injury and by bacterial infections. In the last years, non-pharmacological interventions have gained great importance in epidermis-related diseases. Xyloglucan (XG) is a polysaccharide that possesses a “mucin-like” molecular structure that confers mucoadhesive properties, allowing XG-containing formulations to act as a protective barrier for the management of different diseases. Moreover, there is also increasing interest in the use of proteins due to their film-forming features. This study aimed to evaluate the barrier-protective properties of a product containing XG and pea protein (PP) in an in vitro model, assessing its effects on the membrane permeability of keratinocytes infected by 〈 i 〉 Staphylococcus aureus 〈 /i 〉 . 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 HaCaT keratinocytes were pretreated with XG and PP for 3 h and then infected with 〈 i 〉 S. aureus 〈 /i 〉 cells (10 〈 sup 〉 6 〈 /sup 〉 bacteria/well) at a multiplicity of infection of 10 for 1 h. The number of bacterial colonies and membrane integrity were measured, respectively. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 We observed that pretreatment with XG and PP in human HaCaT keratinocytes infected with 〈 i 〉 S. aureus 〈 /i 〉 significantly increased trans-epithelial electrical resistance (a marker of skin barrier function) measurement, reduced lucifer yellow (a marker of membrane integrity) permeation across the monolayer, and released lactate dehydrogenase (a marker of tissue damage). Moreover, XG and PP pretreatment was able to reduce bacterial adherence, avoiding 〈 i 〉 S. aureus 〈 /i 〉 infection. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 In summary, we demonstrated that the product containing XG and PP was able to maintain barrier permeability preserving its integrity, and therefore, it can be considered as an interesting approach for the management of epidermis-related diseases.
    Type of Medium: Online Resource
    ISSN: 1660-5527 , 1660-5535
    URL: Article
    DOI: 10.1159/000509372
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2020
    detail.hit.zdb_id: 1483572-1
    SSG: 15,3
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  • 3
    Online Resource
    Online Resource
    Efficacy of Xyloglucan against 〈b〉〈i〉Escherichia coli〈/i〉〈/b〉 Extraintestinal Urinary Tract Infection: An in vivo Study
    S. Karger AG ; 2020
    In:  Microbial Physiology Vol. 30, No. 1-6 ( 2020), p. 50-60
    Details
    In: Microbial Physiology, S. Karger AG, Vol. 30, No. 1-6 ( 2020), p. 50-60
    Abstract: Natural approaches to conventional pharmaceutical treatments for urinary tract infections (UTIs) have focused attention toward reducing the colonization of intestinal 〈 i 〉 Escheri­chia coli 〈 /i 〉 reservoirs, the cause of ascending and hematogenous UTIs. In this study, we evaluated the protective effect of xyloglucan and xyloglucan plus gelose on intestinal and urinary epithelia in an in vivo 〈 i 〉 E. coli 〈 /i 〉 infection model. Preventative xyloglucan and xyloglucan plus gelose oral treatments were performed by gavage 2 days before 〈 i 〉 E. coli 〈 /i 〉 administration and every day until day 7. In vitro, xyloglucan had no effect on bacterial growth, cell morphology, or integrity. The results clearly demonstrated the protective barrier effect of xyloglucan in the bladder and intestine, as evidenced by a reduction in histological changes, neutrophil infiltration, and tight junction permeability in the intestine following 〈 i 〉 E. coli 〈 /i 〉 infection. The potential beneficial effect of xyloglucan in preventing UTIs was supported by a reduction of 〈 i 〉 E. coli 〈 /i 〉 -positive colony-forming units in the urinary tract. We consider xyloglucan in association with gelose to be an effective oral medical device for the prevention of extraintestinal UTIs.
    Type of Medium: Online Resource
    ISSN: 2673-1665 , 2673-1673
    URL: Article
    DOI: 10.1159/000510874
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2020
    detail.hit.zdb_id: 3042601-7
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  • 4
    Online Resource
    Online Resource
    Preoperative Acute Pancreatitis in Periampullary Tumors: Implications for Surgical Management
    S. Karger AG ; 2007
    In:  Digestion Vol. 75, No. 2-3 ( 2007), p. 165-171
    Details
    In: Digestion, S. Karger AG, Vol. 75, No. 2-3 ( 2007), p. 165-171
    Abstract: 〈 i 〉 Background: 〈 /i 〉 Pancreatitis is the most serious complication of endoscopic retrograde cholangiopancreatography (ERCP), occurring in 2–20% of the patients. Currently there is no information about the impact of preoperative pancreatitis on the surgical management of periampullary tumors. 〈 i 〉 Methods: 〈 /i 〉 Ten patients with periampullary tumors and preoperative acute pancreatitis were retrospectively analyzed. Four patients who underwent pylorus-preserving pancreaticoduodenectomy (group A) and 6 patients who underwent total pancreatectomy (group B) were compared with a matching control group (age, gender, stage, tumor and operation type) of 30 patients without pancreatitis (group C) who underwent an operation during the same period. Parameters analyzed were C-reactive protein (CRP), leukocytes, aminotransferases, amylase, lipase, operative time, blood loss, hospital stay, morbidity, and mortality. 〈 i 〉 Results: 〈 /i 〉 In the study group, 5 patients had pancreatic adenocarcinoma, 3 had distal bile duct cancers, and 2 had ampullary tumors. None of the patients had severe acute necrotizing pancreatitis that necessitated intervention prior to tumor resection. Preoperative median CRP levels in group B were 8.4- and 5.6-fold higher than those of groups A and C, respectively. In contrast, leukocytes, aminotransferases, amylase, and lipase levels were not significantly different. The presence of acute pancreatitis slightly prolonged the duration of the operation (+15 min), increased morbidity (60 vs. 33%) and lengthened median hospital stay (19.5 vs. 14.5 days) in groups A and B vs. group C. All patients with preoperative pancreatitis were managed without mortality. 〈 i 〉 Conclusion: 〈 /i 〉 Preoperative pancreatitis is more commonly seen in patients with non-pancreatic periampullary tumors, and considerably influences surgical management. High preoperative CRP levels indicate a more severe form of pancreatic damage that may necessitate a total pancreatectomy.
    Type of Medium: Online Resource
    ISSN: 0012-2823 , 1421-9867
    URL: Article
    DOI: 10.1159/000106799
    RVK:
    XA 40650
    RVK:
    XA 10000
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2007
    detail.hit.zdb_id: 1482218-0
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  • 5
    Online Resource
    Online Resource
    Klassifikation und Diagnose zystischer Pankreastumoren
    S. Karger AG ; 2011
    In:  Viszeralmedizin Vol. 27, No. 3 ( 2011), p. 5-5
    Details
    In: Viszeralmedizin, S. Karger AG, Vol. 27, No. 3 ( 2011), p. 5-5
    Type of Medium: Online Resource
    ISSN: 1662-6672 , 1662-6664
    URL: Article
    DOI: 10.1159/000329194
    Language: German
    Publisher: S. Karger AG
    Publication Date: 2011
    detail.hit.zdb_id: 2487201-5
    detail.hit.zdb_id: 2850734-4
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  • 6
    Online Resource
    Online Resource
    Establishment and Characterization of a Novel Cell Line Derived from a Small Cell Neuroendocrine Carcinoma of the Anal Canal
    S. Karger AG ; 2018
    In:  Neuroendocrinology Vol. 107, No. 3 ( 2018), p. 246-256
    Details
    In: Neuroendocrinology, S. Karger AG, Vol. 107, No. 3 ( 2018), p. 246-256
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 Gastroenteropancreatic neuroendocrine carcinomas (GEP-NECs) are biologically aggressive tumors, associated with a very poor survival. Due to their rarity, our knowledge on GEP-NEC biology is very limited. The aim of this study was to establish a GEP-NEC cell line model that might contribute to a better understanding of this rare malignant disease to further develop novel therapeutic approaches in preclinical studies. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Small cell neuroendocrine cancer cell line NEC-DUE3 was derived from a lymph node metastasis of a neuroendocrine carcinoma (NEC) located at the anal canal. Morphological characteristics and the expression of neuroendocrine markers were comprehensively investigated. For genetic profiling, NEC-DUE3 cells were analyzed by DNA fingerprinting. Chromosomal aberrations were mapped by array comparative genomic hybridization. NEC-DUE3 cell tumorigenicity was evaluated in vivo and the sensitivity to chemotherapeutic agents was assessed in vitro. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 NEC-DUE3 cells were characterized by the expression of molecular markers that are commonly observed in GEP-NECs, were sensitive to treatment with cisplatin, and able to form tumors in immunodeficient mice. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 We established and characterized the first small cell GEP-NEC cell line that may serve as a valuable tool to create a better understanding of the biology of these rare tumors and to develop novel treatment strategies.
    Type of Medium: Online Resource
    ISSN: 0028-3835 , 1423-0194
    URL: Article
    DOI: 10.1159/000492222
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2018
    detail.hit.zdb_id: 1483028-0
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