In:
Gynecologic and Obstetric Investigation, S. Karger AG, Vol. 84, No. 5 ( 2019), p. 472-476
Abstract:
〈 b 〉 〈 i 〉 Aims: 〈 /i 〉 〈 /b 〉 To determine if findings at urodynamics prognosticate improvements in overactive bladder symptoms among women receiving mirabegron treatment. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Before treatment, women completed a urodynamic investigation, a micturition diary and the Urinary Distress Inventory (UDI) with the irritative subscale UDI 〈 sub 〉 OAB 〈 /sub 〉 . After 6 months mirabegron treatment, patients were clinically evaluated and completed the UDI. Associations were tested using regression analyses and nonparametric statistics. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Testing urodynamic variables for association with treatment effects in multiple linear regression analysis showed that lower volumes at first sensation to void significantly correlated with greater improvement in the UDI 〈 sub 〉 OAB 〈 /sub 〉 after 6 months mirabegron treatment (B = 0.026, 95% CI 0.002–0.049, 〈 i 〉 p 〈 /i 〉 = 0.034). Improvements in UDI 〈 sub 〉 OAB 〈 /sub 〉 showed no correlation with presence of nocturia ( 〈 i 〉 p 〈 /i 〉 = 0.65), previous use of anticholinergics ( 〈 i 〉 p 〈 /i 〉 = 1), menopausal status ( 〈 i 〉 p 〈 /i 〉 = 1), any detrusor overactivity during filling ( 〈 i 〉 p 〈 /i 〉 = 1), phasic detrusor contractions during filling ( 〈 i 〉 p 〈 /i 〉 = 1), or detrusor overactivity during inhibition ( 〈 i 〉 p 〈 /i 〉 = 1). 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 We found limited support for clinically relevant associations between findings at urodynamics and subsequent treatment outcomes for mirabegron in routine clinical practice. Our findings do not support the role of these investigations as predictors of outcomes in patients with overactive bladder symptoms.
Type of Medium:
Online Resource
ISSN:
0378-7346
,
1423-002X
Language:
English
Publisher:
S. Karger AG
Publication Date:
2019
detail.hit.zdb_id:
1482695-1
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