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  • 1
    In: Psychopathology, S. Karger AG, Vol. 37, No. 4 ( 2004), p. 181-189
    Abstract: Although obsessive-compulsive disorder (OCD) is regarded as a unitary nosological entity, it encompasses a rich variety of heterogeneous mental and behavioural phenomena. The identification of clinical subtypes within this broad concept has been a focus of attention in recent years. In the present study, we administered a clinician-rated scale, the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) with the Y-BOCS Symptom Checklist (Y-BOCS CL), as well as a self-report questionnaire, the Padua Inventory revised (PI-R), to 150 outpatients with OCD. A principal component analysis on the Y-BOCS CL, along with the PI-R, identified 6 consistent symptom clusters: (1) contamination obsessions and cleaning compulsions, (2) sexual/religious/somatic obsessions and checking, (3) high risk assessment and checking, (4) impulses and fear of loss of control, (5) need for symmetry and exactness, and ordering and counting compulsions, and finally (6) rumination. The Y-BOCS CL and PI-R showed great overlap and consistency regarding content and severity of the OCD symptoms. On inspection of items with identical content, only half of the items showed significant agreement. Both inventories have unique factors: rumination is represented solely in the PI-R, somatic obsessions and checking solely in the Y-BOCS CL. This means that the use of both clinician-administered and self-report measures is recommended, so that the entire spectrum of symptoms is represented.
    Type of Medium: Online Resource
    ISSN: 0254-4962 , 1423-033X
    RVK:
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2004
    detail.hit.zdb_id: 1483565-4
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  • 2
    In: Psychotherapy and Psychosomatics, S. Karger AG, Vol. 92, No. 1 ( 2023), p. 55-64
    Abstract: 〈 b 〉 〈 i 〉 Introduction: 〈 /i 〉 〈 /b 〉 Major depressive disorder (MDD) is common, and recurrence rates are high. Preventive Cognitive Therapy (PCT), has been shown to prolong time to recurrence and reduce risk of recurrence(s) over 2–10 years in patients with recurrent depression. 〈 b 〉 〈 i 〉 Objective: 〈 /i 〉 〈 /b 〉 The aim of the study was to examine the effectiveness of PCT over 20 years on time to first recurrence, cumulative proportion of first recurrences, percentage of depression-free time, mean severity of recurrences, and the number of recurrences within a patient. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Adults remitted from recurrent MDD were randomized to PCT or Treatment As Usual (TAU). Clinical outcomes were assessed using the SCID over 20 years. We used Cox regression analyses, Kaplan-Meier analyses, ANOVA, and negative binomial regression and tested for interaction with the number of previous episodes. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 There was a significant interaction effect for number of previous episodes with treatment condition on time to first recurrence (Wald[1, 〈 i 〉 n 〈 /i 〉 = 172] = 8.840, 〈 i 〉 p 〈 /i 〉 = 0.003). For participants with more than 3 previous episodes, the mean time to recurrence was 4.8 years for PCT versus 1.6 years for TAU; the cumulative proportion of first recurrences was 87.5% for PCT and 100% for TAU. For participants with more than 3 previous episodes, exploratory analyses suggest that PCT had 53% less recurrences and percentage of depression-free time was significantly higher compared to TAU. There were no significant effects on mean severity. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 Up to 20 years, for MDD patients with more than 3 previous episodes, those who received PCT had significantly longer time to a first recurrence and lower recurrence risk and may have less recurrences and more depression-free time compared to TAU. This suggests long term protective effects of PCT up to 20-years.
    Type of Medium: Online Resource
    ISSN: 0033-3190 , 1423-0348
    RVK:
    RVK:
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2023
    detail.hit.zdb_id: 1472321-9
    SSG: 5,2
    SSG: 15,3
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  • 3
    In: Stereotactic and Functional Neurosurgery, S. Karger AG, Vol. 95, No. 5 ( 2017), p. 348-351
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 In 2010, we published an often-cited case report describing smoking cessation and substantial weight loss after deep brain stimulation (DBS) for obsessive-compulsive disorder (OCD) in an obese patient. To test whether this single observation was also observed in the treated population at large, the weight changes of a larger cohort of patients who underwent DBS for OCD or major depressive disorder (MDD) were studied. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Data were available for 46 patients (30 OCD and 16 MDD patients; mean age 46.2 years, SD 10.9) with an average baseline body mass index (BMI) of 28.0 (SD 7.3), 26 of whom (57%) were overweight ( 〈 i 〉 n 〈 /i 〉 = 11), obese ( 〈 i 〉 n 〈 /i 〉 = 12), or morbidly obese ( 〈 i 〉 n 〈 /i 〉 = 3). Mean follow-up was 3.8 years (range 10 months to 8.7 years, SD 2.3), after which the average BMI was 28.1 (SD 7.0), not significantly different from baseline. The average BMI of the 15 patients with (morbid) obesity at baseline decreased from 36.8 to 34.6 (ns), while the average BMI of the 31 normal or “only” overweight patients at baseline increased from 23.8 to 25.0 (ns). 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 There was no significant change in body weight on group level after DBS for either OCD or MDD.
    Type of Medium: Online Resource
    ISSN: 1011-6125 , 1423-0372
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2017
    detail.hit.zdb_id: 1483576-9
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  • 4
    Online Resource
    Online Resource
    S. Karger AG ; 2018
    In:  Stereotactic and Functional Neurosurgery Vol. 96, No. 4 ( 2018), p. 272-273
    In: Stereotactic and Functional Neurosurgery, S. Karger AG, Vol. 96, No. 4 ( 2018), p. 272-273
    Type of Medium: Online Resource
    ISSN: 1011-6125 , 1423-0372
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2018
    detail.hit.zdb_id: 1483576-9
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  • 5
    Online Resource
    Online Resource
    S. Karger AG ; 2015
    In:  Stereotactic and Functional Neurosurgery Vol. 93, No. 2 ( 2015), p. 147-147
    In: Stereotactic and Functional Neurosurgery, S. Karger AG, Vol. 93, No. 2 ( 2015), p. 147-147
    Type of Medium: Online Resource
    ISSN: 1011-6125 , 1423-0372
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2015
    detail.hit.zdb_id: 1483576-9
    Location Call Number Limitation Availability
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