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  • 1
    In: Respiration, S. Karger AG, Vol. 87, No. 6 ( 2014), p. 513-521
    Abstract: The use of endoscopically placed unidirectional valves for the treatment of emphysema is increasing. With better patient selection, there is also an increased likelihood of complications associated with the procedure, such as postprocedural pneumothorax. There is, however, little evidence of pneumothorax management in patients with severe COPD and emphysema. This report describes an expert recommendation that has been developed to outline pneumothorax management after valve placement to inform physicians and patients of the risk-benefit profile and to assist them in decision making. Skilled and aggressive pneumothorax management is necessary in this patient population, and by following these recommendations traumatic scenarios, prolonged drainage, extended hospitalizations, and/or surgery might be avoided in many cases.
    Type of Medium: Online Resource
    ISSN: 0025-7931 , 1423-0356
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2014
    detail.hit.zdb_id: 1464419-8
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  • 2
    Online Resource
    Online Resource
    S. Karger AG ; 2021
    In:  Kompass Pneumologie Vol. 9, No. 1 ( 2021), p. 39-47
    In: Kompass Pneumologie, S. Karger AG, Vol. 9, No. 1 ( 2021), p. 39-47
    Abstract: Hintergrund: Der Spontanpneumothorax ist eine selten auftretende Komplikation der Viruspneumonie bei COVID-19. Die genaue Inzidenz sowie die Risikofaktoren sind weiter unklar. In der vorliegenden Arbeit untersuchen wir die Inzidenz und die Outcomes von mehr als 3.000 Patienten mit Pneumothorax, die mit Verdacht auf COVID-19-Pneumonie in unsere Klinik aufgenommen wurden. Methoden: Wir überprüften retrospektiv die Fälle von COVID-19-Patienten, die in unsere Klinik aufgenommen worden waren. Zur Berechnung der Inzidenz dieses Ereignisses wurden Patienten mit diagnostiziertem Spontanpneumothorax identifiziert und ihre klinischen Merkmale wurden umfassend dokumentiert. Es wurden Daten zum klinischen Outcome erhoben. Die einzelnen Fälle werden jeweils in Form einer kurzen Zusammenfassung vorgestellt. Ergebnisse: Zwischen 1. März und 8. Juni 2020 wurden 3368 Patienten mit Verdacht auf eine COVID-19-Pneumonie in unsere Klinik aufgenommen; von diesen wiesen 902 Patienten einen positiven Nasopharyngealabstrich auf. Es wurden sechs COVID-19-Patienten, die einen Spontanpneumothorax entwickelten, identifiziert (0,66 %). Die Baseline-Bildgebung zeigte bei diesen Patienten diffuse bilaterale Milchglastrübungen und Konsolidierungen, überwiegend in den posterioren und peripheren Lungenregionen. Vier der sechs Patienten wurden mechanisch beatmet. Bei allen Patienten war eine Thoraxdrainage erforderlich. In allen Fällen bestand kein direkter Zusammenhang zwischen dem Pneumothorax und der Mortalität (66,6%). Schlussfolgerung: Der Spontanpneumothorax ist eine seltene Komplikation der Viruspneumonie bei COVID-19, die auch ohne mechanische Beatmung auftreten kann. Kliniker sollten im Hinblick auf die Diagnose und Behandlung dieser Komplikation wachsam sein.
    Type of Medium: Online Resource
    ISSN: 2296-0368 , 2296-0317
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2021
    detail.hit.zdb_id: 3052384-9
    detail.hit.zdb_id: 2724124-5
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  • 3
    In: Respiration, S. Karger AG, Vol. 97, No. 6 ( 2019), p. 548-557
    Abstract: Endoscopic lung volume reduction (ELVR) therapies are gaining prominence as a treatment option with guideline recommendations by COPD GOLD and NICE and the recent FDA approval for endobronchial valves. The transition from an experiment-based therapy only to clinical care comes with new challenges. A significant volume of evidence-based data has been published; all data demonstrate consistent improvements in several aspects of patient outcomes. Patients suffering from severe air trapping and thoracic hyperinflation seem to benefit the most from ELVR. In addition to lung function, baseline assessment should ideally include cardiopulmonary exercise testing, high-resolution computer tomography scan, perfusion scintigraphy, and echocardiography. This expert ELVR statement updates best practice recommendations from 2017 regarding patient selection and utilization of these various techniques for treating patients with advanced emphysema.
    Type of Medium: Online Resource
    ISSN: 0025-7931 , 1423-0356
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2019
    detail.hit.zdb_id: 1464419-8
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  • 4
    In: Respiration, S. Karger AG, Vol. 100, No. 10 ( 2021), p. 969-978
    Abstract: For selected patients with advanced emphysema, bronchoscopic lung volume reduction with one-way valves can lead to clinically relevant improvements of airflow obstruction, hyperinflation, exercise capacity, and quality of life. The most common complication of this procedure is pneumothorax with a prevalence of up to ±34% of the treated patients. Patients who develop a pneumothorax also experience meaningful clinical benefits once the pneumothorax is resolved. Timely resolution of a post-valve treatment pneumothorax requires skilled and adequate pneumothorax management. This expert panel statement is an updated recommendation of the 2014 statement developed to help guide pneumothorax management after valve placement. Additionally, mechanisms for pneumothorax development, risk assessment, prevention of pneumothorax, and outcomes after pneumothorax are addressed. This recommendation is based on a combination of the current scientific literature and expert opinion, which was obtained through a modified Delphi method.
    Type of Medium: Online Resource
    ISSN: 0025-7931 , 1423-0356
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2021
    detail.hit.zdb_id: 1464419-8
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  • 5
    Online Resource
    Online Resource
    S. Karger AG ; 2021
    In:  Respiration Vol. 100, No. 11 ( 2021), p. 1146-1148
    In: Respiration, S. Karger AG, Vol. 100, No. 11 ( 2021), p. 1146-1148
    Type of Medium: Online Resource
    ISSN: 0025-7931 , 1423-0356
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2021
    detail.hit.zdb_id: 1464419-8
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  • 6
    Online Resource
    Online Resource
    S. Karger AG ; 2019
    In:  Respiration Vol. 97, No. 3 ( 2019), p. 197-198
    In: Respiration, S. Karger AG, Vol. 97, No. 3 ( 2019), p. 197-198
    Type of Medium: Online Resource
    ISSN: 0025-7931 , 1423-0356
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2019
    detail.hit.zdb_id: 1464419-8
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  • 7
    In: Respiration, S. Karger AG, Vol. 87, No. 6 ( 2014), p. 485-491
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 Patients who achieve significant target lobe volume reduction (TLVR) following endobronchial valve (EBV) treatment may experience substantial improvements in clinical outcome measures. However, in cases of rapid TLVR, the risk of pneumothorax increases due to parenchymal rupture of the adjacent untreated lobe. Target lobe collapse may be more likely in EBV-treated patients who have low collateral ventilation. 〈 b 〉 〈 i 〉 Objectives: 〈 /i 〉 〈 /b 〉 The aim of this study was to evaluate the impact of pneumothorax on outcome following EBV treatment. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Data from three prospective clinical trials (the US and European cohorts of VENT and the Multicenter Chartis study) were retrieved for the analysis. All patients had undergone chest X-ray within 24 h of EBV implantation to explore the presence of pneumothorax. TLVR was assessed at either 30 (Chartis study) or 180 days (VENT), and clinical outcome measures (forced expiratory volume in 1 s (FEV 〈 sub 〉 1 〈 /sub 〉 ), St. George's Respiratory Questionnaire (SGRQ) and 6-min-walk distance (6-MWD)) were assessed 180 days after implantation. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 The overall rate of pneumothorax following valve therapy was 5.9% (25/421). Among these patients, 68% had a prolonged air leak for 〉 7 days. However, patients who experienced a pneumothorax benefitted from EBV therapy, with a mean TLVR of 65% (n = 20). The mean percent change in FEV 〈 sub 〉 1 〈 /sub 〉 was 15 ± 15%, and the mean change in SGRQ was -7 ± 12 points. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 Although pneumothorax is a complication of EBV placement, it does not appear to have a negative impact on clinical outcome in terms of FEV 〈 sub 〉 1 〈 /sub 〉 and health-related quality of life.
    Type of Medium: Online Resource
    ISSN: 0025-7931 , 1423-0356
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2014
    detail.hit.zdb_id: 1464419-8
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  • 8
    Online Resource
    Online Resource
    S. Karger AG ; 2017
    In:  Respiration Vol. 94, No. 4 ( 2017), p. 380-388
    In: Respiration, S. Karger AG, Vol. 94, No. 4 ( 2017), p. 380-388
    Abstract: Interest in endoscopic lung volume reduction (ELVR) technologies for emphysema is consistently growing. In the last couple of months, several endoscopic options (e.g., endo- or intrabronchial valves, coil implants, and thermal vapor ablation) that have been evaluated in randomized controlled trials have been reported with the ultimate goal of improving respiratory mechanics and alleviating chronic dyspnea. Patients presenting with severe air trapping and thoracic hyperinflation have the greatest potential to derive benefit from ELVR procedures. Baseline assessment should ideally include cardiological evaluation, high-resolution computed tomography scan and perfusion scintigraphy, full pulmonary function tests, and cardiopulmonary exercise testing. This expert statement updates best practice recommendations regarding patient selection and utilization of these various techniques for the treatment of patients with advanced emphysema.
    Type of Medium: Online Resource
    ISSN: 0025-7931 , 1423-0356
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2017
    detail.hit.zdb_id: 1464419-8
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