GLORIA

GEOMAR Library Ocean Research Information Access

X

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Online Resource
    Online Resource
    Health-Related Quality of Life of Hemodialysis Patients in Taiwan: A Multicenter Study
    S. Karger AG ; 2004
    In:  Blood Purification Vol. 22, No. 6 ( 2004), p. 490-498
    Details
    In: Blood Purification, S. Karger AG, Vol. 22, No. 6 ( 2004), p. 490-498
    Abstract: 〈 i 〉 Background/Aims: 〈 /i 〉 Health-related quality of life (HRQOL) is an important determinant of treatment effectiveness in dialysis patients. To our knowledge, there are no reports evaluating HRQOL of hemodialysis (HD) in Chinese patients. The purpose of this study is to present our results about HRQOL using the 36-Item Short-Form (SF-36) questionnaire on Taiwanese hemodialysis patients. 〈 i 〉 Methods: 〈 /i 〉 HRQOL was measured by using the SF-36 questionnaire in 497 HD patients in five hospitals. 〈 i 〉 Results: 〈 /i 〉 The following attributes, male gender, age 〈 50 years old, higher education level (HEL), marriage status, employment status (EPS), less comorbid medical condition (CMC), and non-diabetic patients (NDP) were all predicted on a better Physical Component Scale (PCS). Age 〈 50 years old, body mass index 〉 18.5, HEL, EPS and NDP were all predicted on a higher Mental Component Scale (MCS). Scales contributing to a summary measure of physical health, the PCS score was significantly lower in women (35.0 ± 12.3) than in men (37.9 ± 12.3). However, there was no difference in the MCS score between women and men. In multivariate analysis, age, CMC, diabetes, serum creatinine (SCr), and erythropoietin responsiveness were significant independent predictors of PCS. Diabetes, educational level, SCr, and erythropoietin responsiveness were significant independent predictors of MCS. All of the individual scales were lower in Taiwanese HD patients than in both the general Taiwanese and US population. Each of the individual scales and MCS scores were substantially lower in the Taiwan HD group than in the US HD cohort. However, the bodily pain of PCS was significantly higher in the Taiwan HD group, although the mean PCS scores for the Taiwan HD group and the US HD study participants were nearly equal at 36.3 and 36.1, respectively. 〈 i 〉 Conclusion: 〈 /i 〉 The physical and mental aspects of quality of life are substantially lower for Taiwanese HD patients, except for higher bodily pain tolerance. A number of demographic and clinical characteristics have a significant impact on HRQOL in Taiwanese HD patients.
    Type of Medium: Online Resource
    ISSN: 0253-5068 , 1421-9735
    URL: Article
    DOI: 10.1159/000081730
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2004
    detail.hit.zdb_id: 1482025-0
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 2
    Online Resource
    Online Resource
    Plasma Prohepcidin Positively Correlates with Hematocrit in Chronic Hemodialysis Patients
    S. Karger AG ; 2006
    In:  Blood Purification Vol. 24, No. 3 ( 2006), p. 311-316
    Details
    In: Blood Purification, S. Karger AG, Vol. 24, No. 3 ( 2006), p. 311-316
    Abstract: 〈 i 〉 Background/Aims: 〈 /i 〉 Experimental studies have demonstrated interleukin-6 and iron load induce expression of hepcidin (an iron regulatory peptide), whereas anemia and erythropoietin (EPO) suppress its expression. We are the first to explore the relationships of plasma prohepcidin (the pro-hormone of hepcidin) in patients undergoing chronic hemodialysis (HD). 〈 i 〉 Methods: 〈 /i 〉 We enrolled 71 chronic HD patients. During the preceding 3 months before enrollment, they all had steady weekly levels of haematocrit (Hct) and fixed subcutaneous doses of recombinant human EPO. Plasma levels of prohepcidin, proinflammatory cytokines, and EPO were determined by ELISA kits. 〈 i 〉 Results: 〈 /i 〉 Of the patients, prohepcidin levels correlated positively with Hct, and negatively with interleukin-6 and EPO. Examined by a multivariate lineal regression method, we found Hct was the only significant predictor of plasma prohepcidin level. However, prohepcidin had no significant correlation with iron profiles. 〈 i 〉 Conclusion: 〈 /i 〉 Our findings suggest prohepcidin expression in chronic HD patients might be positively regulated by Hct.
    Type of Medium: Online Resource
    ISSN: 0253-5068 , 1421-9735
    URL: Article
    DOI: 10.1159/000091453
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2006
    detail.hit.zdb_id: 1482025-0
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 3
    Online Resource
    Online Resource
    N-Acetylcysteine for the Management of Anemia and Oxidative Stress in Hemodialysis Patients
    S. Karger AG ; 2010
    In:  Nephron Clinical Practice Vol. 116, No. 3 ( 2010-7-2), p. c207-c216
    Details
    In: Nephron Clinical Practice, S. Karger AG, Vol. 116, No. 3 ( 2010-7-2), p. c207-c216
    Abstract: 〈 i 〉 Background/Aims: 〈 /i 〉 To explore the efficacy of oral N-acetylcysteine (NAC) supplementation for anemia and oxidative stress in hemodialysis (HD) patients. 〈 i 〉 Methods: 〈 /i 〉 Of the eligible patients (n = 325) in an outpatient HD unit, 49 received NAC 200 mg orally thrice a day during the first 3 months, while the other 276 patients not receiving NAC were observed. 〈 i 〉 Results: 〈 /i 〉 During the 4-month study, 11 patients receiving NAC withdrew but had no severe adverse effects, while 49 patients not receiving NAC had negative confounding events. Thus only the data of the remaining patients, 38 taking NAC and 227 not taking NAC, were analyzed for efficacy. The demographic and laboratory data of both groups were similar at baseline. When the erythropoietin dosage was stable throughout, only the NAC group had a significant increase in hematocrit, accompanied with a decrease in plasma levels of 8-isoprostane and oxidized low-density lipoprotein. Analyzed as a nested case-control study, NAC supplementation was also found to be a significant predictor of positive outcomes in uremic anemia. 〈 i 〉 Conclusions: 〈 /i 〉 Oral NAC supplementation may be a promising therapy for uremic anemia and oxidative stress in HD patients.
    Type of Medium: Online Resource
    ISSN: 1660-2110
    URL: Article
    DOI: 10.1159/000317201
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2010
    detail.hit.zdb_id: 2098336-0
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 4
    Online Resource
    Online Resource
    Reply to the Letter of Eleftheriadis et al.
    S. Karger AG ; 2006
    In:  Blood Purification Vol. 24, No. 5-6 ( 2006), p. 539-539
    Details
    In: Blood Purification, S. Karger AG, Vol. 24, No. 5-6 ( 2006), p. 539-539
    Type of Medium: Online Resource
    ISSN: 0253-5068 , 1421-9735
    URL: Article
    DOI: 10.1159/000097280
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2006
    detail.hit.zdb_id: 1482025-0
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 5
    Online Resource
    Online Resource
    Are Both Psychological and Physical Dimensions in Health-Related Quality of Life Associated with Mortality in Hemodialysis Patients: A 7-Year Taiwan Cohort Study
    S. Karger AG ; 2010
    In:  Blood Purification Vol. 30, No. 2 ( 2010), p. 98-105
    Details
    In: Blood Purification, S. Karger AG, Vol. 30, No. 2 ( 2010), p. 98-105
    Abstract: 〈 i 〉 Background: 〈 /i 〉 Psychological depression and physical disability are closely correlated in hemodialysis patients. A retrospective cohort study was conducted to examine the independent association of physical and psychological functioning with mortality in a hemodialysis cohort in Taiwan. 〈 i 〉 Methods: 〈 /i 〉 A total of 888 stable hemodialysis patients were included. Patients completed two questionnaires: the 36-item Short Form Health Survey Questionnaire (SF-36, Taiwan Standard Version 1.0) and the Beck Depression Inventory (BDI, Chinese Version). Mortality outcomes were recorded for a seven-year follow-up period. 〈 i 〉 Results: 〈 /i 〉 There were 303 deaths recorded. BDI scores were inversely related to all health-related quality of life (HRQoL) domains (p 〈 0.001). In the Cox-proportional hazard model, only poor physical dimension of HRQoL was independently associated with higher mortality. 〈 i 〉 Conclusion: 〈 /i 〉 Poor physical dimension in HRQoL is a strong predictor of mortality among hemodialysis patients in Taiwan. Psychological depression is closely correlated with poor HRQoL but does not predict mortality.
    Type of Medium: Online Resource
    ISSN: 0253-5068 , 1421-9735
    URL: Article
    DOI: 10.1159/000319002
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2010
    detail.hit.zdb_id: 1482025-0
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 6
    Online Resource
    Online Resource
    N-Acetylcysteine-Mediated Antioxidation Prevents Hyperglycemia-Induced Apoptosis and Collagen Synthesis in Rat Mesangial Cells
    S. Karger AG ; 2009
    In:  American Journal of Nephrology Vol. 29, No. 3 ( 2009), p. 192-202
    Details
    In: American Journal of Nephrology, S. Karger AG, Vol. 29, No. 3 ( 2009), p. 192-202
    Abstract: 〈 i 〉 Background/Aims: 〈 /i 〉 High-glucose (HG)-induced mesangial apoptosis and fibrogenesis possibly involves reactive oxygen species (ROS) formation and activated mitochondrial stress. We investigated the therapeutic effect of the antioxidant N-acetylcysteine (NAC) on cellular apoptosis and matrix accumulation in HG-treated rat mesangial cells (RMCs). 〈 i 〉 Methods: 〈 /i 〉 RMCs were cultured in media containing 5 (control) or 35 m 〈 i 〉 M 〈 /i 〉 (HG) glucose. Cellular apoptosis was assayed by TdT-mediated dUTP nick-end labeling staining. Collagen and transforming growth factor-1 gene expression were measured by reverse transcriptase-polymerase chain reaction or Northern blotting. Mitochondrial capacity and intracellular ROS generation was assayed by fluorescence microscopy and flow cytometry, respectively. Cellular ATP production and malondialdehyde (MDA) formation were determined by a luciferin-luciferase reaction and high-performance liquid chromatography, respectively. Cytochrome c release, caspase activation and poly(ADP)ribose polymerase cleavage were assayed by Western blotting. 〈 i 〉 Results: 〈 /i 〉 HG-treated RMCs displayed enhanced cellular apoptosis (65%) and collagen gene expression (1.8-fold increase); these reactions could be significantly suppressed by 1 m 〈 i 〉 M 〈 /i 〉 NAC (p 〈 0.05). Intracellular ROS generation, production of ATP and MDA, and caspase-3, -8 and -9 activities were significantly increased in HG-treated RMCs, and were effectively attenuated by addition of NAC. 〈 i 〉 Conclusion: 〈 /i 〉 It is concluded that NAC prevents HG-induced mesangial apoptosis and fibrogenesis pathways by the reduction of oxidative stress.
    Type of Medium: Online Resource
    ISSN: 0250-8095 , 1421-9670
    URL: Article
    DOI: 10.1159/000155657
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2009
    detail.hit.zdb_id: 1468523-1
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 7
    Online Resource
    Online Resource
    Plasma Interleukin-18 Levels in Chronic Renal Failure and Continuous Ambulatory Peritoneal Dialysis
    S. Karger AG ; 2005
    In:  Blood Purification Vol. 23, No. 2 ( 2005), p. 144-148
    Details
    In: Blood Purification, S. Karger AG, Vol. 23, No. 2 ( 2005), p. 144-148
    Abstract: 〈 i 〉 Background/Aims: 〈 /i 〉 Based on associations of interleukin (IL)-18 with chronic inflammation, we investigated IL-18, IL-6, and tumor necrosis factor-α (TNF-α) in patients with chronic renal failure (CRF) and patients undergoing continuous ambulatory peritoneal dialysis (CAPD). 〈 i 〉 Methods: 〈 /i 〉 Plasma was evaluated by ELISA methodology in 15 healthy controls, 27 CRF and 15 CAPD patients. 〈 i 〉 Results: 〈 /i 〉 Plasma IL-18 levels in CRF (572.5 ± 41.9 pg/ml) or CAPD (479.2 ± 47.4 pg/ml) were significantly higher than normal (263.6 ± 20.0 pg/ml), but there was no difference in IL-18 between CRF and CAPD patients. The IL-18 concentration negatively correlated with creatinine clearance (Ccr). However, the duration of dialysis, normalized protein nitrogen appearance, weekly Ccr, and K 〈 sub 〉 t 〈 /sub 〉 /V 〈 sub 〉 urea 〈 /sub 〉 were not correlated with plasma IL-18 in CAPD. The plasma IL-18 concentration was positively correlated with TNF-α but not with IL-6 in renal failure patients with or without CAPD. 〈 i 〉 Conclusion: 〈 /i 〉 Uremia is the principal origin of increased plasma IL-18 in these patients. Increased IL-18 levels may be associated with Th1 differentiation and elevated TNF-α.
    Type of Medium: Online Resource
    ISSN: 0253-5068 , 1421-9735
    URL: Article
    DOI: 10.1159/000083620
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2005
    detail.hit.zdb_id: 1482025-0
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 8
    Online Resource
    Online Resource
    Low-Density Lipoprotein Cholesterol: Association with Mortality and Hospitalization in Hemodialysis Patients
    S. Karger AG ; 2005
    In:  Blood Purification Vol. 23, No. 2 ( 2005), p. 134-140
    Details
    In: Blood Purification, S. Karger AG, Vol. 23, No. 2 ( 2005), p. 134-140
    Abstract: 〈 i 〉 Background/Aims: 〈 /i 〉 Hypocholesterolemia is a common finding in hospitalized elderly people, critically ill surgical patients, septic patients and end-stage renal disease patients. The different effect of lipid subfractions on patients with end-stage renal disease has never been demonstrated. We aim to study the effect of lipid subfractions on hospitalization and mortality in maintenance hemodialysis (MHD) patients. 〈 i 〉 Methods: 〈 /i 〉 Lipid subfractions, including total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) were measured in 210 patients with MHD in a single dialysis center. Patients were stratified into three groups based on the tertiles of lipid levels, and differences in patient characteristics and survival were evaluated. 〈 i 〉 Results: 〈 /i 〉 Of a total of 22 deceased patients in our MHD cohort, infection-related mortality (50%) was higher than cardiovascular-related mortality (18.2%). Significant differences (p 〈 0.05) in the duration and frequency of hospitalization and in mortality events were observed when patients were divided into different subgroups according to the tertiles of baseline TC and LDL-C levels. Patients with lower LDL had significantly lower levels of albumin, TC and TG. The LDL-C tertiles were similar in terms of age, hypertension, diabetes, biochemical results, hematocrit, adequacy of hemodialysis and normalized protein catabolism rate. Both TC and LDL-C predicted survival (p 〈 0.001), but not TG and HDL-C in the Kaplan-Meier model. The Cox proportional hazard model demonstrated that baseline serum LDL-C was the best lipid subfraction in predicting all-cause death with an adjusted hazard ratio (95% confidence interval) for each 10 mg/dl of 0.752 (0.631–0.898; p = 0.002). 〈 i 〉 Conclusions: 〈 /i 〉 We firstly demonstrated that lipid subfractions, including TC and LDL-C, predict poor outcomes in a MHD cohort with high infection-related mortality.
    Type of Medium: Online Resource
    ISSN: 0253-5068 , 1421-9735
    URL: Article
    DOI: 10.1159/000083529
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2005
    detail.hit.zdb_id: 1482025-0
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 9
    Online Resource
    Online Resource
    Malnutrition-Inflammation Score Independently Determined Cardiovascular and Infection Risk in Peritoneal Dialysis Patients
    S. Karger AG ; 2010
    In:  Blood Purification Vol. 29, No. 3 ( 2010), p. 308-316
    Details
    In: Blood Purification, S. Karger AG, Vol. 29, No. 3 ( 2010), p. 308-316
    Abstract: 〈 i 〉 Background: 〈 /i 〉 The malnutrition-inflammation score (MIS) is an indicator of malnutrition-inflammation complex syndrome and an outcome predictor in maintenance hemodialysis patients. However, its utility in peritoneal dialysis (PD) patients and its association with the Charlson comorbidity index (CCI) have not yet been examined. 〈 i 〉 Methods: 〈 /i 〉 All chronic stable PD outpatients in the PD center of the National Taiwan University Hospital in January 2006 were studied and followed for up to 18 months. The baseline MIS and CCI at the beginning of the study and the dates and causes of mortality or hospitalization during the study period were obtained. 〈 i 〉 Results: 〈 /i 〉 A total of 141 PD patients were enrolled. During the study period, 8 patients died and 40 patients had at least one fatal or nonfatal major cardiovascular or infection event. The CCI correlated positively and significantly with the MIS (r = +0.344, p 〈 0.001). The MIS and CCI were both independent predictors of cardiovascular and infection events in the multivariate Cox proportional hazard model. For every unit increase in the MIS, the adjusted hazard ratio for mortality was 1.177 (95% confidence interval, CI, 1.050–1.320, p = 0.005). For every unit increase in the CCI, the adjusted hazard ratio for mortality was 1.180 (95% CI, 1.046–1.330, p = 0.007). 〈 i 〉 Conclusions: 〈 /i 〉 MIS can predict fatal and nonfatal cardiovascular and infection events in chronic stable PD patients. The CCI, which is closely associated with the MIS, is an independent determinant of cardiovascular and infection events as well. Interventional studies are indicated to confirm the utility of the MIS in PD populations who undergo nutritional or anti-inflammatory treatments.
    Type of Medium: Online Resource
    ISSN: 0253-5068 , 1421-9735
    URL: Article
    DOI: 10.1159/000280641
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2010
    detail.hit.zdb_id: 1482025-0
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 10
    Online Resource
    Online Resource
    Malnutrition-Inflammation Score Independently Determined Cardiovascular and Infection Risk in Peritoneal Dialysis Patients
    S. Karger AG ; 2010
    In:  Blood Purification Vol. 30, No. 1 ( 2010), p. 16-24
    Details
    In: Blood Purification, S. Karger AG, Vol. 30, No. 1 ( 2010), p. 16-24
    Abstract: 〈 i 〉 Background: 〈 /i 〉 The malnutrition-inflammation score (MIS) is an indicator of malnutrition-inflammation complex syndrome and an outcome-predictor in maintenance hemodialysis (MHD) patients. However, its utility in peritoneal dialysis (PD) patients and its association with the Charlson comorbidity index (CCI) have not yet been examined. 〈 i 〉 Methods: 〈 /i 〉 All chronic stable PD outpatients in the PD center of National Taiwan University Hospital in January 2006 were studied and followed for up to 18 months. The baseline MIS and CCI at the beginning of the study and the dates and causes of mortality or hospitalization during the study period were obtained. 〈 i 〉 Results: 〈 /i 〉 A total of 141 PD patients were enrolled. During the study period, 8 patients died and 40 patients had major cardiovascular or infection events. The CCI correlated positively and significantly with the MIS (r = +0.344, p 〈 0.001). The MIS and CCI were both independent predictors of cardiovascular and infection events in the multivariate Cox proportional hazard model. For every one unit increase in the MIS, the adjusted hazard ratio for mortality was 1.177 (95% CI 1.050–1.320, p = 0.005). For every one unit increase in the CCI, the adjusted hazard ratio for mortality was 1.180 (95% CI 1.046–1.330, p = 0.007). 〈 i 〉 Conclusions: 〈 /i 〉 MIS can predict fatal and nonfatal cardiovascular and infection events in chronic stable PD patients. The CCI, which is closely associated with the MIS, is an independent determinant of cardiovascular and infection events as well. Interventional studies are indicated to confirm the utility of the MIS in PD populations who undergo nutritional or anti-inflammatory treatments.
    Type of Medium: Online Resource
    ISSN: 0253-5068 , 1421-9735
    URL: Article
    DOI: 10.1159/000316682
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2010
    detail.hit.zdb_id: 1482025-0
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...